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Apoptotic protease-activating factor 1 (APAF-1)

 G1R2E0_NOMLE            Unreviewed;      1248 AA.
G1R2E0;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
10-APR-2019, entry version 60.
RecName: Full=Apoptotic protease-activating factor 1 {ECO:0000256|PIRNR:PIRNR037646};
Short=APAF-1 {ECO:0000256|PIRNR:PIRNR037646};
Name=APAF1 {ECO:0000313|Ensembl:ENSNLEP00000007362};
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
leucogenys).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hylobatidae; Nomascus.
NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007362, ECO:0000313|Proteomes:UP000001073};
[1] {ECO:0000313|Ensembl:ENSNLEP00000007362}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSNLEP00000007362}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Gibbon Genome Sequencing Consortium;
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent
autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the
activation of caspase-3 and apoptosis. This activation requires
ATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and
dATP. {ECO:0000256|PIRNR:PIRNR037646}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}.
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EMBL; ADFV01186983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01186984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01186985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01186986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01186987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01186988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01186989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01186990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003259754.1; XM_003259706.2.
STRING; 61853.ENSNLEP00000007362; -.
Ensembl; ENSNLET00000007727; ENSNLEP00000007362; ENSNLEG00000006016.
GeneID; 100590369; -.
CTD; 317; -.
eggNOG; KOG4155; Eukaryota.
eggNOG; KOG4658; Eukaryota.
eggNOG; ENOG410XP3K; LUCA.
GeneTree; ENSGT00940000157710; -.
InParanoid; G1R2E0; -.
OMA; SRIGHKK; -.
OrthoDB; 62693at2759; -.
TreeFam; TF323866; -.
Proteomes; UP000001073; Chromosome 10.
GO; GO:0043293; C:apoptosome; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043531; F:ADP binding; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1902510; P:regulation of apoptotic DNA fragmentation; IEA:Ensembl.
CDD; cd08323; CARD_APAF1; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.130.10.10; -; 2.
InterPro; IPR017251; Apaf-1.
InterPro; IPR041452; APAF1_C.
InterPro; IPR037963; APAF1_CARD_dom.
InterPro; IPR001315; CARD.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR002182; NB-ARC.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF17908; APAF1_C; 1.
Pfam; PF00619; CARD; 1.
Pfam; PF00931; NB-ARC; 1.
Pfam; PF00400; WD40; 9.
PIRSF; PIRSF037646; Apop_pept_activating-1; 1.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 13.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF50978; SSF50978; 2.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS00678; WD_REPEATS_1; 4.
PROSITE; PS50082; WD_REPEATS_2; 9.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
4: Predicted;
Apoptosis {ECO:0000256|PIRNR:PIRNR037646};
ATP-binding {ECO:0000256|PIRNR:PIRNR037646,
ECO:0000256|PIRSR:PIRSR037646-50};
Complete proteome {ECO:0000313|Proteomes:UP000001073};
Cytoplasm {ECO:0000256|PIRNR:PIRNR037646};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037646,
ECO:0000256|PIRSR:PIRSR037646-50};
Reference proteome {ECO:0000313|Proteomes:UP000001073};
WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
DOMAIN 1 90 CARD. {ECO:0000259|PROSITE:PS50209}.
DOMAIN 611 1212 WD_REPEATS_REGION.
{ECO:0000259|PROSITE:PS50294}.
REPEAT 611 652 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 653 694 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 695 738 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 739 780 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 878 910 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 999 1031 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1040 1080 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1081 1115 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
REPEAT 1123 1164 WD. {ECO:0000256|PROSITE-
ProRule:PRU00221}.
NP_BIND 154 161 ATP. {ECO:0000256|PIRSR:PIRSR037646-50}.
BINDING 265 265 ATP. {ECO:0000256|PIRSR:PIRSR037646-50}.
SEQUENCE 1248 AA; 141900 MW; 76D14E8E7289E62C CRC64;
MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI
LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP
QRPVVFVTRK KLVNAIQQKL SKLKGEPGWV TIHGMAGCGK SVLAAEVVRD HSLLEGCFPG
GVHWVSVGKQ DKSGLLMKLQ NLCTRLDQDE SFSQRLPLNI EEAKDRLRIL MLRKHPRSLL
ILDDVWDSWV LKAFDNQCQI LLTTRDKSVT DSVMGPKYVV PVESSLGKEK GLEILSLFVN
MKKADLPEQA HSIIKECKGS PLVVSLIGAL LRDFPNRWEY YLKQLQNKQF KRIRKSSSYD
YEALDEAMSI SVEMLREDIK DYYIDLSILQ KDVKVPTKVL CILWDMETEE VEDILQEFVN
KSLLFCDRNG KSFCYYLHDL QVDFLTEKNC SQLQDLHKKI ITQFQRYHQP HTLSPDQEDC
MYWCNFLAYH MASAKMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDCAV
SENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEVYQQA KLQAKQEVDN GMLYLEWINK
KNITNLSRLV VRPHTDAVYH ACFSEDGQRI ASCGADKTLQ VFKAETGEKL LEIKAHEDEV
LCCAFSTDDR FIATCSVDKK VKIWNSMTGE LVHTYDEHSE QVNCCHFTNS SRRLLLATGS
SDCFLKLWDL NQKECRNTMF GHTNSVNHCR FSPDDKLLAS CSADGTLKLW DVTSANERKS
INVKQFFLNS EDPQEDMEVI VKCCSWSADG ARIMVAAKNK IFLFDIHTSG ILREIHTGHH
STIQYCDFSP QNHLAVVALS QYCVELWNID SCSKVADCRG HLSWVHGVMF SPDGSSFLTS
SDDQTIRLWE TKKVCKNSAV MLKQEVDVVF QENEVMVLAV DHIRRLQLIN GKTGQINYLT
EAQVSCCCLS PHLQYIAFGD ENGAIEILEL VNNRIFQSRI RHKTTVWHIE FTADEKTLIS
SSDDSEIQVW NWHLDKFIFL RAHQETVKDF RLLKNSRLLS WSFDGTVKVW NIVTGNKEKD
FVCHQGTVLS CDISHDATKF SSTSADKTAK IWSFDLLLPL HELRGHNGCV RCSAFSVDST
LLATGDDNGE IRIWNVSNGE LLHLCAPLSE EGAATHGGWV TDLCFSPDGK MLISAGGYIK
WWNVVTGESS QTFYTNGTNL KKIHVSPDFK TYVTVDNLGI LYILQTLE


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WP470: Proteasome Degradation
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP712: Estrogen signaling pathway
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2231: Degradation of apoptotic cells
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP656: p53 signal pathway
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1784: Apoptotic execution phase
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP2199: Seed Development
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP655: p53 pathway
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Related Genes :
[NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215] NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (Clan protein) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[NLRP3 C1orf7 CIAS1 NALP3 PYPAF1] NACHT, LRR and PYD domains-containing protein 3 (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
[PPAF1 PPAF-I] Phenoloxidase-activating factor 1 (EC 3.4.21.-) (Prophenoloxidase-activating factor I) (Serine protease PPAF-1) [Cleaved into: Phenoloxidase-activating factor 1 light chain; Phenoloxidase-activating factor 1 heavy chain]
[Masp1 Crarf Masp3] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[MASP1 CRARF CRARF1 PRSS5] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[Masp1 Crarf Masp3] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[PPAF2 PPAF-II] Phenoloxidase-activating factor 2 (45 KDa PPAF) (Hd-45) (Prophenoloxidase-activating factor II) (Serine protease-like PPAF-2) [Cleaved into: Phenoloxidase-activating factor 2 light chain; Phenoloxidase-activating factor 2 heavy chain]
[HABP2 HGFAL PHBP] Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[GP1 MZ11_60484gpGP1 MZ11_60553gpGP1] Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (NS5)]
[ATF2 CREB2 CREBP1] Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (Histone acetyltransferase ATF2) (cAMP response element-binding protein CRE-BP1)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[BCL10 CIPER CLAP] B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)
[Nlrp3 Cias1 Mmig1 Nalp3 Pypaf1] NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)
[Atf5 Atfx Nap1] Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5-alpha/beta) (BZIP protein ATF7) (NAP1) (NRIF3-associated protein) (Transcription factor ATFx) (Transcription factor-like protein ODA-10)
[Nlrp3 Nalp3 Pypaf1] NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)
[Pafah1b1 Lis-1 Lis1 Pafaha] Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
[ARL6IP1 ARL6IP ARMER KIAA0069] ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum)
[Nlrc4 Card12 Ipaf] NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
[F10 FX] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Virus-activating protease) (VAP) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[Mnat1 Mat1] CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Menage a trois) (RING finger protein MAT1) (p35) (p36)
[CCL2 MCP1 SCYA2] C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]

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