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Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)

 ASAP1_MOUSE             Reviewed;        1147 AA.
Q9QWY8; O08612; Q505F0; Q80TG8; Q80UV6; Q99LV8; Q9Z2B6;
26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 2.
02-JUN-2021, entry version 185.
RecName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1;
AltName: Full=130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein;
AltName: Full=ADP-ribosylation factor-directed GTPase-activating protein 1;
Short=ARF GTPase-activating protein 1;
AltName: Full=Development and differentiation-enhancing factor 1;
Short=DEF-1;
Short=Differentiation-enhancing factor 1;
AltName: Full=PIP2-dependent ARF1 GAP;
Name=Asap1; Synonyms=Ddef1, Kiaa1249, Shag1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION, AND
MUTAGENESIS OF ARG-811; PRO-910 AND PRO-913.
TISSUE=Brain, and Embryo;
PubMed=9819391; DOI=10.1128/mcb.18.12.7038;
Brown M.T., Andrade J., Radhakrishna H., Donaldson J.G., Cooper J.A.,
Randazzo P.A.;
"ASAP1, a phospholipid-dependent arf GTPase-activating protein that
associates with and is phosphorylated by Src.";
Mol. Cell. Biol. 18:7038-7051(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
[LARGE SCALE MRNA] OF 20-1147 (ISOFORM 4).
STRAIN=C57BL/6J; TISSUE=Eye, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-1147 (ISOFORM 3).
TISSUE=Brain;
PubMed=12693553; DOI=10.1093/dnares/10.1.35;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
Nakajima D., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene: II.
The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
identified by screening of terminal sequences of cDNA clones randomly
sampled from size-fractionated libraries.";
DNA Res. 10:35-48(2003).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 654-1147 (ISOFORM 1).
PubMed=9126384; DOI=10.1006/abio.1997.2040;
Yamabhai M., Kay B.K.;
"Examining the specificity of Src homology 3 domain -- ligand interactions
with alkaline phosphatase fusion proteins.";
Anal. Biochem. 247:143-151(1997).
[6]
TISSUE SPECIFICITY.
PubMed=10022919; DOI=10.1128/mcb.19.3.2330;
King F.J., Hu E., Harris D.F., Sarraf P., Spiegelman B.M., Roberts T.M.;
"DEF-1, a novel src SH3 binding protein that promotes adipogenesis in
fibroblastic cell lines.";
Mol. Cell. Biol. 19:2330-2337(1999).
[7]
INTERACTION WITH REPS2.
PubMed=12149250; DOI=10.1074/jbc.m203453200;
Oshiro T., Koyama S., Sugiyama S., Kondo A., Onodera Y., Asahara T.,
Sabe H., Kikuchi A.;
"Interaction of POB1, a downstream molecule of small G protein Ral, with
PAG2, a paxillin-binding protein, is involved in cell migration.";
J. Biol. Chem. 277:38618-38626(2002).
[8]
PHOSPHORYLATION AT TYR-308, AND INTERACTION WITH PTK2B/PYK2.
PubMed=12771146; DOI=10.1074/jbc.m302278200;
Kruljac-Letunic A., Moelleken J., Kallin A., Wieland F., Blaukat A.;
"The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and
inhibition of the Arf-GTPase-activating protein ASAP1.";
J. Biol. Chem. 278:29560-29570(2003).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-732 AND SER-858, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[10]
INTERACTION WITH RAB11FIP3.
PubMed=18685082; DOI=10.1091/mbc.e08-03-0290;
Inoue H., Ha V.L., Prekeris R., Randazzo P.A.;
"Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and
regulates pericentrosomal localization of transferrin receptor-positive
recycling endosome.";
Mol. Biol. Cell 19:4224-4237(2008).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-732; SER-858; SER-1045;
SER-1059; THR-1066 AND SER-1146, AND IDENTIFICATION BY MASS SPECTROMETRY
[LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May function as a signal transduction protein involved in the
differentiation of fibroblasts into adipocytes and possibly other cell
types. Plays a role in ciliogenesis (By similarity). Posseses
phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating
protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a
lesser activity towards ARF6. May coordinate membrane trafficking with
cell growth or actin cytoskeleton remodeling by binding to both SRC and
PIP2. {ECO:0000250}.
-!- ACTIVITY REGULATION: Activity stimulated by phosphatidylinositol 4,5-
bisphosphate (PIP2).
-!- SUBUNIT: Homodimer. Interacts with SRC and CRK. Interacts with
RAB11FIP3. Interacts with PTK2B/PYK2. Interacts with REPS2; the
interaction is direct (PubMed:12149250). {ECO:0000269|PubMed:12149250,
ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:18685082}.
-!- INTERACTION:
Q9QWY8-1; P00523: SRC; Xeno; NbExp=3; IntAct=EBI-698517, EBI-848039;
Q9QWY8-2; P00523: SRC; Xeno; NbExp=2; IntAct=EBI-698524, EBI-848039;
-!- SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Predominantly
cytoplasmic. Partially membrane-associated.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1; Synonyms=SHAG1a, ASAP1a;
IsoId=Q9QWY8-1; Sequence=Displayed;
Name=2; Synonyms=SHAG1b, ASAP1b;
IsoId=Q9QWY8-2; Sequence=VSP_008368;
Name=3;
IsoId=Q9QWY8-3; Sequence=VSP_008366;
Name=4;
IsoId=Q9QWY8-4; Sequence=VSP_008367;
-!- TISSUE SPECIFICITY: Expressed in all tissues examined but a most
abundant expression was found in the testis, brain, lung and spleen. A
heightened expression was seen in the adipose tissue from obese (ob)
and diabetic (db) animals. {ECO:0000269|PubMed:10022919}.
-!- DOMAIN: The PH domain most probably contributes to the
phosphoinositide-dependent regulation of ADP ribosylation factors.
-!- PTM: Phosphorylated on tyrosine residues by SRC.
{ECO:0000269|PubMed:12771146}.
-!- SEQUENCE CAUTION:
Sequence=AAH02201.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=AAH48818.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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EMBL; AF075461; AAC98349.1; -; mRNA.
EMBL; AF075462; AAC98350.1; -; mRNA.
EMBL; AC098728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC131710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC156573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC002201; AAH02201.1; ALT_INIT; mRNA.
EMBL; BC048818; AAH48818.1; ALT_INIT; mRNA.
EMBL; BC094581; AAH94581.1; -; mRNA.
EMBL; AK122477; BAC65759.1; -; mRNA.
EMBL; U92478; AAB82338.1; -; mRNA.
CCDS; CCDS56986.1; -. [Q9QWY8-1]
CCDS; CCDS70634.1; -. [Q9QWY8-2]
PIR; T42627; T42627.
RefSeq; NP_001263390.1; NM_001276461.1.
RefSeq; NP_001263391.1; NM_001276462.1.
RefSeq; NP_001263396.1; NM_001276467.1. [Q9QWY8-2]
RefSeq; NP_034156.2; NM_010026.3. [Q9QWY8-1]
PDB; 5C6R; X-ray; 1.80 A; A/B=325-451.
PDB; 5C79; X-ray; 1.60 A; A/B=325-451.
PDBsum; 5C6R; -.
PDBsum; 5C79; -.
BMRB; Q9QWY8; -.
SMR; Q9QWY8; -.
BioGRID; 199076; 46.
IntAct; Q9QWY8; 10.
MINT; Q9QWY8; -.
STRING; 10090.ENSMUSP00000134825; -.
iPTMnet; Q9QWY8; -.
PhosphoSitePlus; Q9QWY8; -.
jPOST; Q9QWY8; -.
PaxDb; Q9QWY8; -.
PRIDE; Q9QWY8; -.
ProteomicsDB; 281910; -. [Q9QWY8-1]
ProteomicsDB; 281911; -. [Q9QWY8-2]
ProteomicsDB; 281912; -. [Q9QWY8-3]
ProteomicsDB; 281913; -. [Q9QWY8-4]
Antibodypedia; 27290; 232 antibodies.
DNASU; 13196; -.
Ensembl; ENSMUST00000110115; ENSMUSP00000105742; ENSMUSG00000022377. [Q9QWY8-4]
Ensembl; ENSMUST00000175793; ENSMUSP00000135718; ENSMUSG00000022377. [Q9QWY8-3]
Ensembl; ENSMUST00000176384; ENSMUSP00000135190; ENSMUSG00000022377. [Q9QWY8-2]
Ensembl; ENSMUST00000177374; ENSMUSP00000134825; ENSMUSG00000022377. [Q9QWY8-1]
GeneID; 13196; -.
KEGG; mmu:13196; -.
UCSC; uc007vzh.2; mouse. [Q9QWY8-3]
UCSC; uc007vzk.2; mouse. [Q9QWY8-1]
UCSC; uc007vzl.2; mouse. [Q9QWY8-2]
CTD; 50807; -.
MGI; MGI:1342335; Asap1.
eggNOG; KOG0521; Eukaryota.
GeneTree; ENSGT00940000158547; -.
InParanoid; Q9QWY8; -.
OrthoDB; 751525at2759; -.
TreeFam; TF325156; -.
Reactome; R-MMU-5620916; VxPx cargo-targeting to cilium.
BioGRID-ORCS; 13196; 5 hits in 52 CRISPR screens.
ChiTaRS; Asap1; mouse.
PRO; PR:Q9QWY8; -.
Proteomes; UP000000589; Chromosome 15.
RNAct; Q9QWY8; protein.
Bgee; ENSMUSG00000022377; Expressed in cochlea and 305 other tissues.
ExpressionAtlas; Q9QWY8; baseline and differential.
Genevisible; Q9QWY8; MM.
GO; GO:0031253; C:cell projection membrane; IDA:MGI.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0043197; C:dendritic spine; IDA:MGI.
GO; GO:0002102; C:podosome; IDA:MGI.
GO; GO:0005096; F:GTPase activator activity; IDA:FlyBase.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:FlyBase.
GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:FlyBase.
GO; GO:0001786; F:phosphatidylserine binding; IDA:MGI.
GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
GO; GO:0061000; P:negative regulation of dendritic spine development; IDA:MGI.
GO; GO:1903527; P:positive regulation of membrane tubulation; IDA:MGI.
GO; GO:0071803; P:positive regulation of podosome assembly; IMP:MGI.
CDD; cd07641; BAR_ASAP1; 1.
CDD; cd13251; PH_ASAP; 1.
CDD; cd11965; SH3_ASAP1; 1.
Gene3D; 1.20.1270.60; -; 1.
Gene3D; 2.30.29.30; -; 1.
Gene3D; 3.30.40.160; -; 1.
InterPro; IPR027267; AH/BAR_dom_sf.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR037278; ARFGAP/RecO.
InterPro; IPR001164; ArfGAP_dom.
InterPro; IPR038508; ArfGAP_dom_sf.
InterPro; IPR043593; ASAP.
InterPro; IPR037928; ASAP1_BAR.
InterPro; IPR038016; ASAP1_SH3.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR037844; PH_ASAP.
InterPro; IPR001849; PH_domain.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR45854; PTHR45854; 1.
Pfam; PF12796; Ank_2; 1.
Pfam; PF01412; ArfGap; 1.
Pfam; PF00169; PH; 1.
Pfam; PF00018; SH3_1; 1.
PRINTS; PR00405; REVINTRACTNG.
SMART; SM00248; ANK; 2.
SMART; SM00105; ArfGap; 1.
SMART; SM00233; PH; 1.
SMART; SM00326; SH3; 1.
SUPFAM; SSF103657; SSF103657; 1.
SUPFAM; SSF48403; SSF48403; 1.
SUPFAM; SSF50044; SSF50044; 1.
SUPFAM; SSF57863; SSF57863; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 2.
PROSITE; PS50115; ARFGAP; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS50002; SH3; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; ANK repeat;
Cilium biogenesis/degradation; Cytoplasm; GTPase activation; Membrane;
Metal-binding; Phosphoprotein; Reference proteome; Repeat; SH3 domain;
Zinc; Zinc-finger.
CHAIN 1..1147
/note="Arf-GAP with SH3 domain, ANK repeat and PH domain-
containing protein 1"
/id="PRO_0000074197"
DOMAIN 339..431
/note="PH"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
DOMAIN 454..577
/note="Arf-GAP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
REPEAT 615..647
/note="ANK 1"
REPEAT 651..680
/note="ANK 2"
DOMAIN 1085..1147
/note="SH3"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
ZN_FING 469..492
/note="C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
REGION 310..333
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 725..775
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 792..1080
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 313..333
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 737..751
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 752..766
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 802..816
/note="Pro residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 822..838
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 839..866
/note="Pro residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 877..903
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 928..949
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 952..1007
/note="Pro residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1026..1069
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 308
/note="Phosphotyrosine; by FAK2"
/evidence="ECO:0000269|PubMed:12771146"
MOD_RES 732
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:17242355,
ECO:0007744|PubMed:21183079"
MOD_RES 741
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q1AAU6"
MOD_RES 854
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9ULH1"
MOD_RES 858
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:17242355,
ECO:0007744|PubMed:21183079"
MOD_RES 1026
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9ULH1"
MOD_RES 1045
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 1059
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 1066
/note="Phosphothreonine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 1146
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
VAR_SEQ 304..318
/note="Missing (in isoform 4)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_008367"
VAR_SEQ 304..315
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:12693553"
/id="VSP_008366"
VAR_SEQ 816..872
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:9819391"
/id="VSP_008368"
MUTAGEN 811
/note="R->A: Significant reduction in binding to SRC and
CRK and loss of phosphorylation. Loss of binding and
phosphorylation; when associated with A-910 and A-913."
/evidence="ECO:0000269|PubMed:9819391"
MUTAGEN 910
/note="P->A: Significant reduction in binding to SRC and
CRK and decrease in phosphorylation; when associated with
A-913. Loss of binding and phosphorylation; when associated
with A-811 and A-913."
/evidence="ECO:0000269|PubMed:9819391"
MUTAGEN 913
/note="P->A: Significant reduction in binding to SRC and
CRK and decrease in phosphorylation; when associated with
A-910. Loss of binding and phosphorylation; when associated
with A-811 and A-910."
/evidence="ECO:0000269|PubMed:9819391"
CONFLICT 654
/note="T -> S (in Ref. 5; AAB82338)"
/evidence="ECO:0000305"
CONFLICT 879
/note="L -> S (in Ref. 1; AAC98349/AAC98350)"
/evidence="ECO:0000305"
CONFLICT 1051
/note="R -> I (in Ref. 5; AAB82338)"
/evidence="ECO:0000305"
HELIX 335..337
/evidence="ECO:0007829|PDB:5C79"
STRAND 342..349
/evidence="ECO:0007829|PDB:5C79"
STRAND 351..354
/evidence="ECO:0007829|PDB:5C6R"
STRAND 357..365
/evidence="ECO:0007829|PDB:5C79"
STRAND 368..371
/evidence="ECO:0007829|PDB:5C79"
STRAND 374..378
/evidence="ECO:0007829|PDB:5C6R"
STRAND 381..384
/evidence="ECO:0007829|PDB:5C79"
HELIX 385..387
/evidence="ECO:0007829|PDB:5C79"
STRAND 389..392
/evidence="ECO:0007829|PDB:5C79"
STRAND 394..404
/evidence="ECO:0007829|PDB:5C79"
STRAND 407..412
/evidence="ECO:0007829|PDB:5C79"
HELIX 416..436
/evidence="ECO:0007829|PDB:5C79"
SEQUENCE 1147 AA; 127421 MW; 12950D1C4F49A909 CRC64;
MRSSASRLSS FSSRDSLWNR MPDQISVSEF IAETTEDYNS PTTSSFTTRL HNCRNTVTLL
EEALDQDRTA LQKVKKSVKA IYNSGQDHVQ NEENYAQVLD KFGSNFLSRD NPDLGTAFVK
FSTLTKELST LLKNLLQGLS HNVIFTLDSL LKGDLKGVKG DLKKPFDKAW KDYETKFTKI
EKEKREHAKQ HGMIRTEITG AEIAEEMEKE RRLFQLQMCE YLIKVNEIKT KKGVDLLQNL
IKYYHAQCNF FQDGLKTADK LKQYIEKLAA DLYNIKQTQD EEKKQLTALR DLIKSSLQLD
PKEVGGLYVA SRANSSRRDS QSRQGGYSMH QLQGNKEYGS EKKGFLLKKS DGIRKVWQRR
KCAVKNGILT ISHATSNRQP AKLNLLTCQV KPNAEDKKSF DLISHNRTYH FQAEDEQDYI
AWISVLTNSK EEALTMAFRG EQSTGENSLE DLTKAIIEDV QRLPGNDICC DCGSSEPTWL
STNLGILTCI ECSGIHREMG VHISRIQSLE LDKLGTSELL LAKNVGNNSF NDIMEANLPS
PSPKPTPSSD MTVRKEYITA KYVDHRFSRK TCASSSAKLN ELLEAIKSRD LLALIQVYAE
GVELMEPLLE PGQELGETAL HLAVRTADQT SLHLVDFLVQ NCGNLDKQTS VGNTVLHYCS
MYGKPECLKL LLRSKPTVDI VNQNGETALD IAKRLKATQC EDLLSQAKSG KFNPHVHVEY
EWNLRQDEMD ESDDDLDDKP SPIKKERSPR PQSFCHSSSI SPQDKLALPG FSTPRDKQRL
SYGAFTNQIF ASTSTDLPTS PTSEAPPLPP RNAGKGPTGP PSTLPLGTQT SSGSSTLSKK
RPPPPPPGHK RTLSDPPSPL PHGPPNKGAI PWGNDVGPLS SSKTANKFEG LSQQASTSSA
KTALGPRVLP KLPQKVALRK TETSHHLSLD RTNIPPETFQ KSSQLTELPQ KPPLGELPPK
PVELAPKPQV GELPPKPGEL PPKPQLGDLP PKPQLSDLPP KPQMKDLPPK PQLGDLLAKS
QAGDVSAKVQ PPSEVTQRSH TGDLSPNVQS RDAIQKQASE DSNDLTPTLP ETPVPLPRKI
NTGKNKVRRV KTIYDCQADN DDELTFIEGE VIIVTGEEDQ EWWIGHIEGQ PERKGVFPVS
FVHILSD


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Catalog number Product name Quantity
EIAAB34704 ARHGAP27,CAMGAP1,CIN85-associated multi-domain-containing Rho GTPase-activating protein 1,Homo sapiens,Human,PP905,Rho GTPase-activating protein 27,Rho-type GTPase-activating protein 27,SH3 domain-con
EIAAB34705 Arhgap27,Camgap1,CIN85-associated multi-domain-containing Rho GTPase-activating protein 1,Rat,Rattus norvegicus,Rho GTPase-activating protein 27,Rho-type GTPase-activating protein 27
EIAAB34703 Arhgap27,Camgap1,CIN85-associated multi-domain-containing Rho GTPase-activating protein 1,Mouse,Mus musculus,Rho GTPase-activating protein 27,Rho-type GTPase-activating protein 27
EIAAB34654 ARHGAP1,CDC42 GTPase-activating protein,CDC42GAP,GTPase-activating protein rhoOGAP,Homo sapiens,Human,p50-RhoGAP,Rho GTPase-activating protein 1,RHOGAP1,Rho-related small GTPase protein activator,Rho-
EIAAB34719 ARHGAP33,Homo sapiens,Human,Rho GTPase-activating protein 33,Rho-type GTPase-activating protein 33,SNX26,Sorting nexin-26,Tc10_CDC42 GTPase-activating protein,TCGAP
EIAAB34717 Arhgap32,Brain-specific Rho GTPase-activating protein,GAB-associated Cdc42_Rac GTPase-activating protein,GC-GAP,Grit,Kiaa0712,Mouse,Mus musculus,p200RhoGAP,p250GAP,Rho GTPase-activating protein 32,Rho
EIAAB34718 Arhgap33,Mouse,Mus musculus,Rho GTPase-activating protein 33,Rho-type GTPase-activating protein 33,Snx26,Sorting nexin-26,Tc10_CDC42 GTPase-activating protein,Tcgap
EIAAB34690 ARHGAP10,ARHGAP21,Homo sapiens,Human,KIAA1424,Rho GTPase-activating protein 10,Rho GTPase-activating protein 21,Rho-type GTPase-activating protein 21
EIAAB34688 Arhgap20,Kiaa1391,Mouse,Mus musculus,RA and RhoGAP domain-containing protein,RARhoGAP,Rho GTPase-activating protein 20,Rho-type GTPase-activating protein 20
EIAAB34689 Arhgap10,Arhgap21,Kiaa1424,Mouse,Mus musculus,Rho GTPase-activating protein 10,Rho GTPase-activating protein 21,Rho-type GTPase-activating protein 21
EIAAB34670 Arhgap10,Mouse,Mus musculus,PH and SH3 domain-containing rhoGAP protein,PSGAP,PS-GAP,Rho GTPase-activating protein 10,Rho-type GTPase-activating protein 10
EIAAB34687 Arhgap20,RA and RhoGAP domain-containing protein,RARhoGAP,Rat,Rattus norvegicus,Rho GTPase-activating protein 20,Rho-type GTPase-activating protein 20
EIAAB34500 GAP-related-interacting partner to E12,GARNL1,GRIPE,GTPase-activating Rap_Ran-GAP domain-like 1,p240,Pig,Ral GTPase-activating protein subunit alpha-1,RALGAPA1,Sus scrofa,Tuberin-like protein 1,TULIP1
EIAAB34669 ARHGAP10,GRAF2,Graf-related protein 2,GTPase regulator associated with focal adhesion kinase 2,Homo sapiens,Human,Rho GTPase-activating protein 10,Rho-type GTPase-activating protein 10
EIAAB34731 ARHGAP42,Homo sapiens,Human,Rho GTPase-activating protein 10-like,Rho GTPase-activating protein 42,Rho-type GTPase-activating protein 42
EIAAB34700 ARHGAP26,GRAF,GTPase regulator associated with focal adhesion kinase,Homo sapiens,Human,KIAA0621,Oligophrenin-1-like protein,OPHN1L,Rho GTPase-activating protein 26,Rho-type GTPase-activating protein
EIAAB34502 GAP-related-interacting partner to E12,Garnl1,GRIPE,GTPase-activating RapGAP domain-like 1,p240,Ral GTPase-activating protein subunit alpha-1,Ralgapa1,Rat,Rattus norvegicus,Tuberin-like protein 1,Tuli
EIAAB34501 GAP-related-interacting partner to E12,Garnl1,GRIPE,GTPase-activating RapGAP domain-like 1,Kiaa0884,Mouse,Mus musculus,p240,Ral GTPase-activating protein subunit alpha-1,Ralgapa1,Tuberin-like protein
EIAAB34659 ARHGAP6,Homo sapiens,Human,Rho GTPase-activating protein 6,RHOGAP6,Rho-type GTPase-activating protein 6,Rho-type GTPase-activating protein RhoGAPX-1
EIAAB34716 ARHGAP32,Brain-specific Rho GTPase-activating protein,GAB-associated Cdc42_Rac GTPase-activating protein,GC-GAP,GRIT,GTPase regulator interacting with TrkA,Homo sapiens,Human,KIAA0712,p200RhoGAP,p250G
AGAP3 AGAP11 Gene ankyrin repeat and GTPase domain Arf GTPase activating protein 11
EIAAB35871 GARNL4,GTPase-activating Rap_Ran-GAP domain-like protein 4,Homo sapiens,Human,KIAA1039,Rap1 GTPase-activating protein 2,RAP1GA2,Rap1GAP2,RAP1GAP2
EIAAB35872 Garnl4,GTPase-activating Rap_Ran-GAP domain-like protein 4,Kiaa1039,Mouse,Mus musculus,Rap1 GTPase-activating protein 2,Rap1ga2,Rap1GAP2,Rap1gap2
EIAAB39891 Arhgap14,Kiaa0411,Mouse,Mus musculus,Rho GTPase-activating protein 14,SLIT-ROBO Rho GTPase-activating protein 3,srGAP2,Srgap2,srGAP3,Srgap3,WAVE-associated Rac GTPase-activating protein,WRP
EIAAB34499 GAP-related-interacting partner to E12,GARNL1,GRIPE,GTPase-activating Rap_Ran-GAP domain-like 1,Homo sapiens,Human,KIAA0884,p240,Ral GTPase-activating protein subunit alpha-1,RALGAPA1,Tuberin-like pro
Pathways :
WP1493: Carbon assimilation C4 pathway
WP1678: Nucleotide excision repair
WP1625: Base excision repair
WP1672: Mismatch repair
WP1676: Non-homologous end-joining
WP1689: Porphyrin and chlorophyll metabolism
WP2199: Seed Development
WP1665: Limonene and pinene degradation
WP2032: TSH signaling pathway
WP1502: Mitochondrial biogenesis
WP813: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1675: Nitrogen metabolism
WP2292: Chemokine signaling pathway
WP1685: Peptidoglycan biosynthesis
WP346: Protein Modifications
WP931: G Protein Signaling Pathways
WP1644: DNA replication
WP1692: Protein export
WP211: BMP signaling pathway
WP1438: Influenza A virus infection
WP1700: Selenoamino acid metabolism
WP525: Mitochondrial Unfolded-Protein Response
WP1657: Glycerolipid metabolism
WP1663: Homologous recombination

Related Genes :
[ASAP1 DDEF1 KIAA1249 PAG2] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[Asap1 Ddef1 Kiaa1249 Shag1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[Asap1 Ddef1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[ASAP1 DDEF1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[Arfgap1 Arf1gap] ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
[ARFGAP1 ARF1GAP] ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
[Arfgap1 Arf1gap] ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
[AGD3 FKD2 SFC VAN3 At5g13300 T31B5.120] ADP-ribosylation factor GTPase-activating protein AGD3 (ARF GAP AGD3) (Protein ARF-GAP DOMAIN 3) (AtAGD3) (Protein FORKED 2) (Protein SCARFACE) (Protein VASCULAR NETWORK 3)
[arf-1.2 arf-1 B0336.2] ADP-ribosylation factor 1-like 2 (ADP-ribosylation factor-related protein 1.2)
[ARF1] ADP-ribosylation factor 1
[AGD1 At5g61980 K22G18.9] ADP-ribosylation factor GTPase-activating protein AGD1 (ARF GAP AGD1) (Protein ARF-GAP DOMAIN 1) (AtAGD1)
[G3bp1 G3bp] Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (GAP SH3 domain-binding protein 1) (HDH-VIII)
[G3BP1 G3BP] Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
[ACAP1 CENTB1 KIAA0050] Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1)
[Git arfgap2 CG16728] ARF GTPase-activating protein Git (ARF GAP GIT) (dGIT protein) (G protein-coupled receptor kinase interacting ArfGAP)
[AGAP3 CENTG3] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)
[ARFGEF1 ARFGEP1 BIG1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)
[ARF2 MNT At5g62000 MTG10.3] Auxin response factor 2 (ARF1-binding protein) (ARF1-BP) (Protein MEGAINTEGUMENTA)
[RASA1 GAP RASA] Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
[ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP] Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)
[Arhgap35 Grlf1 P190A p190ARHOGAP] Rho GTPase-activating protein 35 (GAP-associated protein p190) (Glucocorticoid receptor DNA-binding factor 1)
[ARHGAP35 GRLF1 P190A p190ARHOGAP] Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Rho GAP p190A) (p190-A)
[ARHGAP21 ARHGAP10 KIAA1424] Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)
[Arhgap32 Grit Kiaa0712 Rics] Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)
[ARHGAP24 FILGAP] Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)
[ARFGEF1 ARFGEP1 BIG1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)
[SYNGAP1 KIAA1938] Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
[Syngap1] Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (p135 SynGAP)
[GGA1] ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
[Syngap1] Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)

Bibliography :