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Aurora/IPL1-related protein kinase 2 (EC 2.7.11.1) (Serine/threonine-protein kinase aurora-B)

 AIR2_CAEEL              Reviewed;         305 AA.
O01427;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 2.
02-DEC-2020, entry version 171.
RecName: Full=Aurora/IPL1-related protein kinase 2;
EC=2.7.11.1;
AltName: Full=Serine/threonine-protein kinase aurora-B;
Name=air-2 {ECO:0000312|WormBase:B0207.4};
Synonyms=stu-7 {ECO:0000312|WormBase:B0207.4};
ORFNames=B0207.4 {ECO:0000312|WormBase:B0207.4};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
DEVELOPMENTAL STAGE.
STRAIN=Bristol N2;
PubMed=9852156; DOI=10.1083/jcb.143.6.1635;
Schumacher J.M., Golden A., Donovan P.J.;
"AIR-2: an Aurora/Ipl1-related protein kinase associated with chromosomes
and midbody microtubules is required for polar body extrusion and
cytokinesis in Caenorhabditis elegans embryos.";
J. Cell Biol. 143:1635-1646(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating
biology.";
Science 282:2012-2018(1998).
[3]
IDENTIFICATION, AND FUNCTION.
PubMed=10354474; DOI=10.1016/s0925-4773(99)00020-9;
Woollard A., Hodgkin J.;
"Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome
segregation during embryonic and post-embryonic development.";
Mech. Dev. 82:95-108(1999).
[4]
FUNCTION.
PubMed=10975519; DOI=10.1016/s0092-8674(00)00034-9;
Hsu J.-Y., Sun Z.-W., Li X., Reuben M., Tatchell K., Bishop D.K.,
Grushcow J.M., Brame C.J., Caldwell J.A., Hunt D.F., Lin R., Smith M.M.,
Allis C.D.;
"Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase
and Glc7/PP1 phosphatase in budding yeast and nematodes.";
Cell 102:279-291(2000).
[5]
FUNCTION, AND INTERACTION WITH ZEN-4.
PubMed=11050384; DOI=10.1016/s0960-9822(00)00715-6;
Severson A.F., Hamill D.R., Carter J.C., Schumacher J., Bowerman B.;
"The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic
spindle at metaphase and is required for cytokinesis.";
Curr. Biol. 10:1162-1171(2000).
[6]
FUNCTION, AND INTERACTION WITH ICP-1.
PubMed=11050385; DOI=10.1016/s0960-9822(00)00721-1;
Kaitna S., Mendoza M., Jantsch-Plunger V., Glotzer M.;
"Incenp and an aurora-like kinase form a complex essential for chromosome
segregation and efficient completion of cytokinesis.";
Curr. Biol. 10:1172-1181(2000).
[7]
FUNCTION.
PubMed=10983970; DOI=10.1016/s1097-2765(00)00023-x;
Speliotes E.K., Uren A., Vaux D., Horvitz H.R.;
"The survivin-like C. elegans BIR-1 protein acts with the Aurora-like
kinase AIR-2 to affect chromosomes and the spindle midzone.";
Mol. Cell 6:211-223(2000).
[8]
FUNCTION.
PubMed=12015116; DOI=10.1016/s0960-9822(02)00820-5;
Kaitna S., Pasierbek P., Jantsch M., Loidl J., Glotzer M.;
"The aurora B kinase AIR-2 regulates kinetochores during mitosis and is
required for separation of homologous Chromosomes during meiosis.";
Curr. Biol. 12:798-812(2002).
[9]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=11914278; DOI=10.1101/gad.968302;
Hagstrom K.A., Holmes V.F., Cozzarelli N.R., Meyer B.J.;
"C. elegans condensin promotes mitotic chromosome architecture, centromere
organization, and sister chromatid segregation during mitosis and
meiosis.";
Genes Dev. 16:729-742(2002).
[10]
FUNCTION.
PubMed=11940606; DOI=10.1083/jcb.200110045;
Rogers E., Bishop J.D., Waddle J.A., Schumacher J.M., Lin R.;
"The aurora kinase AIR-2 functions in the release of chromosome cohesion in
Caenorhabditis elegans meiosis.";
J. Cell Biol. 157:219-229(2002).
[11]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=12213836; DOI=10.1083/jcb.200202054;
Gruneberg U., Glotzer M., Gartner A., Nigg E.A.;
"The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis
elegans embryo.";
J. Cell Biol. 158:901-914(2002).
[12]
FUNCTION, IDENTIFICATION IN THE CHROMOSOMAL PASSENGER COMPLEX, AND
INTERACTION WITH ICP-1; CSC-1 AND BIR-1.
PubMed=12707312; DOI=10.1083/jcb.200207117;
Romano A., Guse A., Krascenicova I., Schnabel H., Schnabel R., Glotzer M.;
"CSC-1: a subunit of the Aurora B kinase complex that binds to the
survivin-like protein BIR-1 and the incenp-like protein ICP-1.";
J. Cell Biol. 161:229-236(2003).
[13]
FUNCTION.
PubMed=15854913; DOI=10.1016/j.cub.2005.03.041;
Guse A., Mishima M., Glotzer M.;
"Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of
cytokinesis.";
Curr. Biol. 15:778-786(2005).
[14]
FUNCTION, AND INTERACTION WITH TLK-1.
PubMed=15916946; DOI=10.1016/j.cub.2005.04.019;
Han Z., Riefler G.M., Saam J.R., Mango S.E., Schumacher J.M.;
"The C. elegans Tousled-like kinase contributes to chromosome segregation
as a substrate and regulator of the Aurora B kinase.";
Curr. Biol. 15:894-904(2005).
[15]
INTERACTION WITH BMK-1.
PubMed=15548597; DOI=10.1091/mbc.e04-08-0682;
Bishop J.D., Han Z., Schumacher J.M.;
"The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is
required for the localization of a BimC kinesin to meiotic and mitotic
spindles.";
Mol. Biol. Cell 16:742-756(2005).
[16]
FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF PRO-265.
PubMed=18923084; DOI=10.1101/gad.1691208;
de Carvalho C.E., Zaaijer S., Smolikov S., Gu Y., Schumacher J.M.,
Colaiacovo M.P.;
"LAB-1 antagonizes the Aurora B kinase in C. elegans.";
Genes Dev. 22:2869-2885(2008).
[17]
FUNCTION.
PubMed=20729837; DOI=10.1038/ncb2093;
Dumont J., Oegema K., Desai A.;
"A kinetochore-independent mechanism drives anaphase chromosome separation
during acentrosomal meiosis.";
Nat. Cell Biol. 12:894-901(2010).
[18]
FUNCTION, SUBCELLULAR LOCATION, AND PHOSPHORYLATION.
PubMed=23684975; DOI=10.1016/j.cub.2013.04.028;
Bembenek J.N., Verbrugghe K.J., Khanikar J., Csankovszki G., Chan R.C.;
"Condensin and the spindle midzone prevent cytokinesis failure induced by
chromatin bridges in C. elegans embryos.";
Curr. Biol. 23:937-946(2013).
[19]
SUBCELLULAR LOCATION, AND MUTAGENESIS OF LYS-155 AND LYS-168.
PubMed=25475837; DOI=10.1038/ncomms6485;
Pelisch F., Sonneville R., Pourkarimi E., Agostinho A., Blow J.J.,
Gartner A., Hay R.T.;
"Dynamic SUMO modification regulates mitotic chromosome assembly and cell
cycle progression in Caenorhabditis elegans.";
Nat. Commun. 5:5485-5485(2014).
-!- FUNCTION: Serine/threonine-protein kinase component of the chromosomal
passenger complex (CPC), a complex that acts as a key regulator of
chromosome segregation and cytokinesis (PubMed:12707312,
PubMed:11050385, PubMed:10983970, PubMed:9852156, PubMed:10354474,
PubMed:10975519, PubMed:11050384). The CPC complex has essential
functions at the centromere in ensuring correct chromosome alignment
and segregation (PubMed:12707312, PubMed:10983970). Required for
histone H3 phosphorylation during segregation of homologous chromosomes
in meiosis and mitosis (PubMed:18923084). Required for histone H3 'Ser-
10' phosphorylation (PubMed:9852156, PubMed:10354474, PubMed:10975519,
PubMed:11050384, PubMed:11050385, PubMed:10983970, PubMed:12015116,
PubMed:11940606). Phosphorylates tlk-1 at 'Ser-634', which enhances its
activity (PubMed:15916946). Phosphorylates zen-4 at 'Ser-
680'(PubMed:15854913). Required for the recruitment of bub-1 to the
ring-shaped domain between chromosomes during meiotic anaphase I
(PubMed:20729837). Also required for the localization of the condensin
I complex subunit smc-4 to mitotic chromosomes (PubMed:11914278). Acts
at the spindle midzone and the midbody to prevent cleavage furrow
regression upon chromatin obstructions during cytokinesis
(PubMed:12213836, PubMed:23684975). {ECO:0000269|PubMed:10354474,
ECO:0000269|PubMed:10975519, ECO:0000269|PubMed:10983970,
ECO:0000269|PubMed:11050384, ECO:0000269|PubMed:11050385,
ECO:0000269|PubMed:11914278, ECO:0000269|PubMed:11940606,
ECO:0000269|PubMed:12015116, ECO:0000269|PubMed:12213836,
ECO:0000269|PubMed:12707312, ECO:0000269|PubMed:15854913,
ECO:0000269|PubMed:15916946, ECO:0000269|PubMed:18923084,
ECO:0000269|PubMed:20729837, ECO:0000269|PubMed:23684975,
ECO:0000269|PubMed:9852156}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1;
-!- SUBUNIT: Component of the CPC complex which consists of icp-1; csc-1;
bir-1 and air-2 (PubMed:12707312). Within the complex, interacts with
icp-1; csc-1 and bir-1 (PubMed:12707312, PubMed:11050385). Interacts
with zen-4 (PubMed:11050384). Interacts with tlk-1 and bmk-1
(PubMed:15548597, PubMed:15916946). {ECO:0000269|PubMed:11050384,
ECO:0000269|PubMed:11050385, ECO:0000269|PubMed:12707312,
ECO:0000269|PubMed:15548597, ECO:0000269|PubMed:15916946}.
-!- INTERACTION:
O01427; G5EE37: icp-1; NbExp=4; IntAct=EBI-312947, EBI-312981;
O01427; O17583: lin-10; NbExp=2; IntAct=EBI-312947, EBI-313389;
O01427; P34314: tlk-1; NbExp=3; IntAct=EBI-312947, EBI-3890382;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
{ECO:0000269|PubMed:9852156}. Chromosome {ECO:0000269|PubMed:18923084,
ECO:0000269|PubMed:23684975, ECO:0000269|PubMed:25475837,
ECO:0000269|PubMed:9852156}. Midbody {ECO:0000269|PubMed:23684975,
ECO:0000269|PubMed:9852156}. Cytoplasm, cytoskeleton, spindle
{ECO:0000269|PubMed:23684975, ECO:0000269|PubMed:9852156}. Note=Meiotic
and mitotic chromosomes (PubMed:9852156, PubMed:18923084). During each
division, relocates to the midbody microtubules (PubMed:9852156,
PubMed:23684975). Localizes on chromosomes during metaphase and on the
central spindle during anaphase (PubMed:25475837, PubMed:23684975).
Localization to homologous chromosomes during segregation is dependent
on lab-1 (PubMed:18923084). {ECO:0000269|PubMed:18923084,
ECO:0000269|PubMed:23684975, ECO:0000269|PubMed:25475837,
ECO:0000269|PubMed:9852156}.
-!- DEVELOPMENTAL STAGE: Present during gametogenesis and throughout
embryogenesis (at protein level). {ECO:0000269|PubMed:9852156}.
-!- PTM: Phosphorylated. Increased phosphorylation upon chromatin
obstructions at anaphase. {ECO:0000269|PubMed:23684975}.
-!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown disrupts the localization
of the condensin subunit smc-4 to mitotic chromosomes
(PubMed:11914278). RNAi-mediated knockdown causes failure in mitotic
chromosome segregation and cytokinesis, leading to aneuploidy
(PubMed:11914278, PubMed:12213836). {ECO:0000269|PubMed:11914278,
ECO:0000269|PubMed:12213836}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
kinase family. Aurora subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
---------------------------------------------------------------------------
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EMBL; AF071207; AAC70945.1; -; mRNA.
EMBL; BX284601; CCD61317.1; -; Genomic_DNA.
PIR; B87790; B87790.
PIR; T43221; T43221.
RefSeq; NP_491714.1; NM_059313.5.
SMR; O01427; -.
BioGRID; 37722; 3.
ComplexPortal; CPX-3461; Chromosomal passenger complex.
DIP; DIP-25477N; -.
IntAct; O01427; 7.
MINT; O01427; -.
STRING; 6239.B0207.4; -.
EPD; O01427; -.
PaxDb; O01427; -.
PeptideAtlas; O01427; -.
EnsemblMetazoa; B0207.4.1; B0207.4.1; WBGene00000099.
GeneID; 172268; -.
KEGG; cel:CELE_B0207.4; -.
UCSC; B0207.4; c. elegans.
CTD; 172268; -.
WormBase; B0207.4; CE24761; WBGene00000099; air-2.
eggNOG; KOG0580; Eukaryota.
GeneTree; ENSGT00940000158980; -.
HOGENOM; CLU_000288_63_0_1; -.
InParanoid; O01427; -.
OMA; MYEIADA; -.
OrthoDB; 954262at2759; -.
PhylomeDB; O01427; -.
Reactome; R-CEL-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
SignaLink; O01427; -.
PRO; PR:O01427; -.
Proteomes; UP000001940; Chromosome I.
Bgee; WBGene00000099; Expressed in multi-cellular organism and 5 other tissues.
GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
GO; GO:0000793; C:condensed chromosome; IDA:WormBase.
GO; GO:0000794; C:condensed nuclear chromosome; IDA:WormBase.
GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
GO; GO:0005819; C:spindle; IDA:WormBase.
GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
GO; GO:0051233; C:spindle midzone; IDA:WormBase.
GO; GO:0031616; C:spindle pole centrosome; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0051117; F:ATPase binding; IPI:WormBase.
GO; GO:0035174; F:histone serine kinase activity; IBA:GO_Central.
GO; GO:0019894; F:kinesin binding; IPI:WormBase.
GO; GO:0004672; F:protein kinase activity; IDA:WormBase.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:WormBase.
GO; GO:0030261; P:chromosome condensation; IMP:WormBase.
GO; GO:0007059; P:chromosome segregation; IMP:WormBase.
GO; GO:0045184; P:establishment of protein localization; IMP:WormBase.
GO; GO:0051257; P:meiotic spindle midzone assembly; IMP:UniProtKB.
GO; GO:0051256; P:mitotic spindle midzone assembly; IMP:WormBase.
GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IDA:WormBase.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IDA:WormBase.
GO; GO:0046777; P:protein autophosphorylation; IDA:WormBase.
GO; GO:0006468; P:protein phosphorylation; IDA:WormBase.
GO; GO:0031991; P:regulation of actomyosin contractile ring contraction; IMP:WormBase.
GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
InterPro; IPR030616; Aur.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24350; PTHR24350; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Cell cycle; Cell division; Chromatin regulator; Chromosome;
Chromosome partition; Cytoplasm; Cytoskeleton; Developmental protein;
Kinase; Meiosis; Mitosis; Nucleotide-binding; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Transferase.
CHAIN 1..305
/note="Aurora/IPL1-related protein kinase 2"
/id="PRO_0000268640"
DOMAIN 30..280
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 36..44
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
ACT_SITE 153
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 59
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MUTAGEN 155
/note="K->R: Reduced in vitro sumo-1 conjugation."
/evidence="ECO:0000269|PubMed:25475837"
MUTAGEN 168
/note="K->R: Reduced in vitro sumo-1 conjugation."
/evidence="ECO:0000269|PubMed:25475837"
MUTAGEN 265
/note="P->L: In or207; temperature sensitive. At 15 degrees
Celsius, there are no observed changed in meiosis or
mitosis. At 20 or 25 degrees Celsius, meiosis appears
normal, embryos are not viable and eggs do not complete the
first embryonic division due to defects in chromosome
segregation and cytokinesis. In these embryos,
phosphorylation of histone H3 is abrogated, but this is not
abrogated in germ line nuclei. Embryonic viability is
increased in a lab-1 tm1791 mutant background and 17% of
embryos complete embryogenesis and reach adulthood as
fertile animals. Moreover, the phosphorylation of histone
H3 defect is rescued in 30% of these embryos."
/evidence="ECO:0000269|PubMed:18923084"
SEQUENCE 305 AA; 34749 MW; 1635EB60D2E14011 CRC64;
MENKPPVINL PEKETVNTPQ KGGKFTINDF EIGRPLGKGK FGSVYLARTK TGHFHVAIKV
LFKSQLISGG VEHQLEREIE IQSHLNHPNI IKLYTYFWDA KKIYLVLEYA PGGEMYKQLT
VSKRFSEPTA AKYMYEIADA LSYCHRKNVI HRDIKPENLL IGSQGELKIG DFGWSVHAPS
NKRQTMCGTM DYLPPEMVNG ADHSDAVDLW AIGVLCYEFL VGKPPFEHED QSKTYAAIKA
ARFTYPDSVK KGARDLIGRL LVVDPKARCT LEQVKEHYWI QGMMEAKIRA EKQQKIEKEA
SLRNH


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MKNK2_MOUSE ELISA Kit FOR MAP kinase-interacting serine per threonine-protein kinase 2; organism: Mouse; gene name: Mknk2 96T
MA-20115 Mouse Monoclonal Anti-Human aurora kinase B, AIK2 or aurora-B (AURKB) Species Reactivity: Human 100 ul Product tipe: Antibodies
EIAAB24970 Leucine zipper- and sterile alpha motif kinase ZAK,Mitogen-activated protein kinase kinase kinase MLT,Mixed lineage kinase-related kinase,MLK-like mitogen-activated protein triple kinase,MLK-related k
Pathways :
WP2199: Seed Development
WP1659: Glycine, serine and threonine metabolism
WP1493: Carbon assimilation C4 pathway
WP2272: Pathogenic Escherichia coli infection
WP731: Sterol regulatory element binding protein related
WP1939: Unfolded Protein Response
WP1049: G Protein Signaling Pathways
WP1689: Porphyrin and chlorophyll metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1644: DNA replication
WP253: Glycolysis
WP1654: gamma-Hexachlorocyclohexane degradation
WP2032: TSH signaling pathway
WP1438: Influenza A virus infection
WP1693: Purine metabolism
WP1502: Mitochondrial biogenesis
WP1701: Starch and sucrose metabolism
WP346: Protein Modifications
WP1661: Glyoxylate and dicarboxylate metabolism
WP211: BMP signaling pathway
WP1672: Mismatch repair
WP1566: Citrate cycle (TCA cycle)
WP1714: Tyrosine metabolism
WP1616: ABC transporters
WP1888: Post-translational protein modification

Related Genes :
[AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[AURKC AIE2 AIK3 AIRK3 ARK3 STK13] Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)
[air-2 stu-7 B0207.4] Aurora/IPL1-related protein kinase 2 (EC 2.7.11.1) (Serine/threonine-protein kinase aurora-B)
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[Aurkb Aik2 Aim1 Airk2 Ark2 Stk1 Stk12 Stk5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[Aurka Aik Airk Ark1 Aura Ayk1 Btak Iak1 Stk15 Stk6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora family kinase 1) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
[Aurkc Aie1 Aik3 Airk3 Ark3 Stk13] Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 1) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)
[AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[Aurkb Aik2 Aim1 Airk2 Ark2 Stk1 Stk12 Stk5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[aurkb-a airk2-a] Aurora kinase B-A (EC 2.7.11.1) (Aurora/IPL1-related kinase 2-A) (AIRK2-A) (XAIRK2-A) (Serine/threonine-protein kinase 12-A) (Serine/threonine-protein kinase aurora-B-A) (xAurora-B)
[aurka-a aurka eg2 stk6] Aurora kinase A-A (EC 2.7.11.1) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 6-A) (Serine/threonine-protein kinase Eg2-A) (pEg2) (Serine/threonine-protein kinase aurora-A) (p46Eg265)
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[aurkb-b airk2-b] Aurora kinase B-B (EC 2.7.11.1) (Aurora/IPL1-related kinase 2-B) (AIRK2-B) (XAIRK2-B) (Serine/threonine-protein kinase 12-B) (Serine/threonine-protein kinase aurora-B-B) (xAurora-B-B)
[Aurka Aik Airk Ark1 Aura Ayk1 Btak Iak1 Stk15 Stk6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) (ratAurA)
[aurkb airk2] Aurora kinase B (EC 2.7.11.1) (Aurora/IPL1-related kinase 2) (AIRK2) (XAIRK2) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase aurora-B) (xAurora-B)
[aurka-b aurka eg2 stk6] Aurora kinase A-B (EC 2.7.11.1) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 6-B) (Serine/threonine-protein kinase Eg2-B) (Serine/threonine-protein kinase aurora-A) (p46XlEg22)
[AUR3 At2g45490 F17K2.2] Serine/threonine-protein kinase Aurora-3 (AtAur3) (EC 2.7.11.1) (Aurora-like kinase 3)
[AUR1 At4g32830 T16I18.40] Serine/threonine-protein kinase Aurora-1 (AtAur1) (EC 2.7.11.1) (Aurora-like kinase 1)
[AUR2 At2g25880 F17H15.9] Serine/threonine-protein kinase Aurora-2 (AtAur2) (EC 2.7.11.1) (Aurora-like kinase 2)
[gsp-2 Ce-glc-7beta CeGLC-7beta glc-7 F56C9.1] Serine/threonine-protein phosphatase PP1-beta (EC 3.1.3.16) (CeGLC-7-beta) (Glc seven-like phosphatase 2)
[tlk-1 C07A9.3] Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled-like kinase 1)
[PLK1 PLK] Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
[Plk1 Plk] Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
[SRK2E OST1 SNRK2.6 At4g33950 F17I5.140] Serine/threonine-protein kinase SRK2E (EC 2.7.11.1) (Protein OPEN STOMATA 1) (SNF1-related kinase 2.6) (SnRK2.6) (Serine/threonine-protein kinase OST1)
[vrk-1 F28B12.3] Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1)
[lrk-1 T27C10.6] Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)
[mrck-1 K08B12.5] Serine/threonine-protein kinase mrck-1 (EC 2.7.11.1) (Myotonic dystrophy kinase-related CDC42-binding kinase homolog)
[LATS2 KPM] Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)

Bibliography :