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B-lymphocyte activation antigen B7-1 (CD80)

 Q9GMZ8_FELCA            Unreviewed;       292 AA.
Q9GMZ8;
01-MAR-2001, integrated into UniProtKB/TrEMBL.
01-MAR-2001, sequence version 1.
08-MAY-2019, entry version 114.
SubName: Full=B-lymphocyte activation antigen B7-1 (CD80) {ECO:0000313|EMBL:BAB11687.1};
Name=CD80 {ECO:0000313|EMBL:BAB11687.1,
ECO:0000313|Ensembl:ENSFCAP00000008890};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|EMBL:BAB11687.1};
[1] {ECO:0000313|EMBL:BAB11687.1}
NUCLEOTIDE SEQUENCE.
PubMed=11029611; DOI=10.1046/j.1365-2370.2000.00221.x;
Nishimura Y., Shimojima M., Miyazawa T., Sato E., Nakamura K.,
Izumiya Y., Ikeda Y., Mikami T., Takahashi E.;
"Molecular cloning of the cDNAs encoding the feline B-lymphocyte
activation antigen B7-1 (CD80) and B7-2 (CD86) homologues which
interact with human CTLA4-Ig.";
Eur. J. Immunogenet. 27:427-430(2000).
[2] {ECO:0000313|Ensembl:ENSFCAP00000008890, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008890,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[3] {ECO:0000313|Ensembl:ENSFCAP00000008890}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008890};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSFCAP00000008890}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008890};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
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EMBL; AANG04001815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AB030651; BAB11687.1; -; mRNA.
RefSeq; XP_019694786.1; XM_019839227.1.
STRING; 9685.ENSFCAP00000008890; -.
MEROPS; I43.001; -.
Ensembl; ENSFCAT00000009587; ENSFCAP00000008890; ENSFCAG00000009585.
GeneID; 493786; -.
CTD; 941; -.
eggNOG; ENOG410J3XE; Eukaryota.
eggNOG; ENOG411154Z; LUCA.
GeneTree; ENSGT00940000162632; -.
OMA; HMTSVML; -.
OrthoDB; 1083437at2759; -.
Proteomes; UP000011712; Chromosome C2.
Bgee; ENSFCAG00000009585; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
GO; GO:0009986; C:cell surface; IBA:GO_Central.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0098636; C:protein complex involved in cell adhesion; IEA:Ensembl.
GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0042130; P:negative regulation of T cell proliferation; IBA:GO_Central.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
GO; GO:0031295; P:T cell costimulation; IBA:GO_Central.
CDD; cd16083; IgC_CD80; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR013162; CD80_C2-set.
InterPro; IPR037676; CD80_IgC.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
Pfam; PF08205; C2-set_2; 1.
SUPFAM; SSF48726; SSF48726; 2.
PROSITE; PS50835; IG_LIKE; 2.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Disulfide bond {ECO:0000256|SAAS:SAAS00289593};
Immunoglobulin domain {ECO:0000256|SAAS:SAAS01086444};
Membrane {ECO:0000256|SAAS:SAAS00555568, ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
Transmembrane {ECO:0000256|SAAS:SAAS00555568,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00555568,
ECO:0000256|SAM:Phobius}.
TRANSMEM 243 267 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 17 132 Ig-like. {ECO:0000259|PROSITE:PS50835}.
DOMAIN 145 226 Ig-like. {ECO:0000259|PROSITE:PS50835}.
SEQUENCE 292 AA; 33540 MW; ED9AEECE10D30401 CRC64;
MDHAAKWKTP LLKHPYPKLF PLLMLASLFY FCSGIIQVNK TVEEVAVLSC DYNISTKELT
EIRIYWQKDD EMVLAVMSGK VQVWPKYKNR TFTDVTDNHS IVIMALRLSD NGKYTCIIQK
IEKGSYKVKH LTSVMLLVRA DFPVPSITDL GNPSHNIKRI MCLTSGGFPK PHLSWLENEE
ELNAINTTVS QDPETELYTI SSELDFNMTN NHSFLCLVKY GNLLVSQIFN WQKSEPQPSN
NQLWIIILSS VVSGIVVITA LTLRCLVHRP AARWRQREMG RARKWKRSHL ST


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Pathways :
WP2328: Allograft rejection
WP2004: Lymphocyte TarBase
WP1040: Inflammatory Response Pathway
WP1156: Inflammatory Response Pathway
WP453: Inflammatory Response Pathway
WP75: Toll-like receptor signaling pathway
WP1309: Toll-like receptor signaling pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP829: Toll-like receptor signaling pathway
WP949: Toll-like receptor signaling pathway
WP1881: Platelet activation triggers
WP200: Complement Activation, Classical Pathway
WP1095: Complement Activation, Classical Pathway
WP40: Inflammatory Response Pathway
WP545: Complement Activation, Classical Pathway
WP1271: Toll-like receptor signaling pathway
WP1424: Globo Sphingolipid Metabolism
WP81: Complement Activation, Classical Pathway
WP920: Inflammatory Response Pathway
WP1826: GPVI-mediated activation cascade
WP1894: RAF activation
WP1067: Toll-like receptor signaling pathway
WP458: Inflammatory Response Pathway
WP1183: Toll-like receptor signaling pathway
WP751: Complement Activation, Classical Pathway

Related Genes :
[CD80 CD28LG CD28LG1 LAB7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
[Cd80 B7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (B7) (CD antigen CD80)
[CD86 CD28LG2] T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
[Cd86] T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (Early T-cell costimulatory molecule 1) (ETC-1) (CD antigen CD86)
[CD80] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (CD antigen CD80)
[CTLA4 CD152] Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)
[CD276 B7H3 PSEC0249 UNQ309/PRO352] CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
[Cd276 B7h3] CD276 antigen (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
[SLC3A2 MDU1] 4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
[LY9 CDABP0070] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
[Ly9 Ly-9] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
[Ms4a1 Cd20 Ly-44 Ms4a2] B-lymphocyte antigen CD20 (B-cell differentiation antigen Ly-44) (Lymphocyte antigen 44) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CD19] B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[Cd19] B-lymphocyte antigen CD19 (Differentiation antigen CD19) (CD antigen CD19)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[his-2 T10C6.13; his-6 F45F2.13; his-9 ZK131.3; his-13 ZK131.7; his-17 K06C4.5; his-25 ZK131.2; his-27 K06C4.13; his-32 F17E9.10; his-42 F08G2.3; his-45 B0035.10; his-49 F07B7.5; his-55 F54E12.1; his-59 F55G1.2; his-63 F22B3.2] Histone H3
[LAX1 LAX] Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Cd44 Ly-24] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[rpm-1 syd-3 C01B7.6] E3 ubiquitin-protein ligase rpm-1 (EC 2.3.2.-) (Pam/highwire/rpm-1 protein) (Regulator of presynaptic morphology protein 1) (Synapse defective protein 3)
[gcn2 ppk28 SPBC36B7.09 SPBP18G5.01] eIF-2-alpha kinase GCN2 (Serine/threonine-protein kinase gcn2) (EC 2.7.11.1) (Serine/threonine-protein kinase ppk28)
[CD69 CLEC2C] Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]

Bibliography :
[31092026] Interaction Between Regulatory T Cells and Antibody-Producing B Cells for Immune Responses at the Upper Respiratory Mucosa Against Nontypeable Haemophilus influenzae: In Vitro Assay Model.
[30670616] Effects of Friend Virus Infection and Regulatory T Cells on the Antigen Presentation Function of B Cells.
[30107249] Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates.
[29975708] B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses.
[28985996] TLR-induced secretion of novel cytokine IL-27 is defective in newly diagnosed type-2 diabetic subjects.
[28947093] Decreased TNF family receptor expression on B-cells is associated with reduced humoral responses to Streptococcus pneumoniae infections in young children.
[28584006] Activated B Cells Participating in the Anti-Myelin Response Are Excluded from the Inflamed Central Nervous System in a Model of Autoimmunity that Allows for B Cell Recognition of Autoantigen.
[28466138] A translational approach from an animal model identifies CD80 as a candidate gene for the study of bone phenotypes in postmenopausal women.
[28163195] Positive selection of type II collagen-reactive CD80 marginal zone B cells in DBA/1 mice.
[28017428] The induction of CD80 and apoptosis on B cells and CD40L in CD4+ T cells in response to seasonal influenza vaccination distinguishes responders versus non-responders in healthy controls and aviremic ART-treated HIV-infected individuals.