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BHLH domain-containing protein

 G1KI29_ANOCA            Unreviewed;       248 AA.
G1KI29;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
07-APR-2021, entry version 63.
RecName: Full=BHLH domain-containing protein {ECO:0000259|PROSITE:PS50888};
Name=PTF1A {ECO:0000313|Ensembl:ENSACAP00000008520};
Anolis carolinensis (Green anole) (American chameleon).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
Iguania; Dactyloidae; Anolis.
NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008520, ECO:0000313|Proteomes:UP000001646};
[1] {ECO:0000313|Ensembl:ENSACAP00000008520, ECO:0000313|Proteomes:UP000001646}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008520,
ECO:0000313|Proteomes:UP000001646};
The Genome Sequencing Platform;
Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
Lander E.S., Lindblad-Toh K.;
"The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSACAP00000008520}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
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RefSeq; XP_003222113.1; XM_003222065.3.
STRING; 28377.ENSACAP00000008520; -.
Ensembl; ENSACAT00000008703; ENSACAP00000008520; ENSACAG00000008717.
GeneID; 100567005; -.
KEGG; acs:100567005; -.
CTD; 256297; -.
eggNOG; KOG4029; Eukaryota.
GeneTree; ENSGT00940000161000; -.
HOGENOM; CLU_053709_0_0_1; -.
InParanoid; G1KI29; -.
OMA; YCCEAGA; -.
OrthoDB; 1269550at2759; -.
TreeFam; TF315153; -.
Proteomes; UP000001646; Chromosome 6.
Bgee; ENSACAG00000008717; Expressed in female gonad and 4 other tissues.
GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0070888; F:E-box binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0035881; P:amacrine cell differentiation; IEA:Ensembl.
GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
GO; GO:0032502; P:developmental process; IBA:GO_Central.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEA:Ensembl.
GO; GO:0061074; P:regulation of neural retina development; IEA:Ensembl.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0010842; P:retina layer formation; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0009888; P:tissue development; IEA:Ensembl.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Reference proteome {ECO:0000313|Proteomes:UP000001646}.
DOMAIN 97..149
/note="BHLH"
/evidence="ECO:0000259|PROSITE:PS50888"
REGION 222..248
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 79..99
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 248 AA; 27399 MW; 1D236056982B3BA0 CRC64;
MEAVLLEHFP AGLDAFSSEP YFDDEDFFTD HSLDGDELPG FPEAPFHACF RGASEGASEG
SSPPLLPGFE GYSPGGGGLK AASRRRRRVR SEAELAQLRQ AANVRERRRM QSLNDAFEGL
RAHIPTLPYE KRLSKVDTLR LAIGYIHFLS ELLHAEAPLR GSGAGSSPCP PRKVIICHRG
TRSPSPSDPD YGLPPLAGHS LSWTDEKQLK EQNIIRTAKV WTPEDPRKLS NKPSLNNIEN
EPPFDFIS


Related products :

Catalog number Product name Quantity
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28-767 Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation.TWIST1 is a bHLH transcription factor and shares similarity with another bHLH 0.1 mg
27-561 ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH pr 0.1 mg
28-832 TCF3 contains 1 basic helix-loop-helix (bHLH) domain. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate dur 0.1 mg
31-209 TCF3 contains 1 basic helix-loop-helix (bHLH) domain. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate dur 0.1 mg
30-613 HELT belongs to the HEY family. It contains 1 basic helix-loop-helix (bHLH) domain and 1orange domain. HELT is a transcriptional repressor which binds preferentially to the canonical E box sequence 5' 0.05 mg
28-779 Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH protei 0.1 mg
25-056 Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH protei 0.05 mg
29-102 MXD3 contains 1 basic helix-loop-helix (bHLH) domain. It is a transcriptional repressor and binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5' 0.05 mg
27-286 MXD3 contains 1 basic helix-loop-helix (bHLH) domain. It is a transcriptional repressor and binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5' 0.1 mg
25-061 ATOH1 belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.This protein belongs to the basic helix-loop-helix (BHLH) 0.05 mg
26-890 SOHLH1 contains 1 basic helix-loop-helix (bHLH) domain. It is a probable transcription factor required during spermatogenesis and oogenesis. 0.05 mg
30-993 SOHLH1 contains 1 basic helix-loop-helix (bHLH) domain. It is a probable transcription factor required during spermatogenesis and oogenesis. 0.05 mg
18-003-42831 BHLH protein MesP2 - N_A Polyclonal 0.1 mg Protein A
27-591 NEUROD6 contains 1 basic helix-loop-helix (bHLH) domain. It activates E box-dependent transcription in collaboration with TCF3_E47 and may be a trans-acting factor involved in the development and main 0.05 mg
27-590 NEUROD6 contains 1 basic helix-loop-helix (bHLH) domain. It activates E box-dependent transcription in collaboration with TCF3_E47 and may be a trans-acting factor involved in the development and main 0.05 mg
25-065 NEUROD6 contains 1 basic helix-loop-helix (bHLH) domain. It activates E box-dependent transcription in collaboration with TCF3_E47 and may be a trans-acting factor involved in the development and main 0.05 mg
28-669 Spz1, a novel bHLH-Zip protein, is specifically expressed in testis. 0.1 mg
18-003-44083 Transcription factor 15 - bHLH-EC2 protein; Paraxis Polyclonal 0.1 mg Protein A
Y050678 Anti_SCX(human class II bHLH protein scleraxis)_(N_terminal) 100ug
28-833 TCF12 encodes a protein that is a member of the basic helix-loop-helix (bHLH) E-protein family which recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tis 0.05 mg
31-176 TCF12 encodes a protein that is a member of the basic helix-loop-helix (bHLH) E-protein family which recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tis 0.05 mg
18-003-44130 Williams-Beuren syndrome chromosome region 14 protein - WS basic-helix-loop-helix leucine zipper protein; WS-bHLH; Mlx interactor; MLX-interacting protein-like Polyclonal 0.1 mg Protein A
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Y050678 Anti-SCX(human class II bHLH protein scleraxis)-(N-terminal) Antibody 100ug
Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP163: Cytoplasmic Ribosomal Proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1692: Protein export
WP1239: Cytoplasmic Ribosomal Proteins

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[BHLH63 CIB1 EN84 At4g34530 T4L20.110] Transcription factor bHLH63 (Basic helix-loop-helix protein 63) (AtbHLH63) (bHLH 63) (Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 1) (Transcription factor EN 84) (bHLH transcription factor bHLH063)
[BHLH148 AIF2 EN143 RITF1 At3g06590 F5E6.8] Transcription factor bHLH148 (ATBS1 interacting factor 2) (Basic helix-loop-helix protein 148) (AtbHLH148) (bHLH 148) (Protein RSA1 INTERACTING TRANSCRIPTION FACTOR 1) (AtRITF1) (Transcription factor EN 143) (bHLH transcription factor bHLH148)
[BHLH95 EN21 RGE1 ZOU At1g49770 F14J22.2] Transcription factor bHLH95 (Basic helix-loop-helix protein 95) (AtbHLH95) (bHLH 95) (Protein RETARDED GROWTH OF EMBRYO 1) (Protein ZHOUPI) (Transcription factor EN 21) (bHLH transcription factor bHLH095)
[GL3 BHLH1 EN31 MYC6 SST At5g41315 MYC6.2] Transcription factor GLABRA 3 (Basic helix-loop-helix protein 1) (AtMYC6) (AtbHLH1) (bHLH 1) (Protein SHAPESHIFTER) (Transcription factor EN 31) (bHLH transcription factor bHLH001)
[PRE3 BHLH135 BS1 EN67 TMO7 At1g74500 F1M20.18] Transcription factor PRE3 (Basic helix-loop-helix protein 135) (AtbHLH135) (bHLH 135) (Protein ACTIVATION-TAGGED BRI1 SUPPRESSOR 1) (ATBS1) (Protein PACLOBUTRAZOL RESISTANCE 3) (Protein TARGET OF MOOPTEROS 7) (Transcription factor EN 67) (bHLH transcription factor bHLH135)
[MYC2 BHLH6 EN38 JAI1 JIN1 RAP1 RD22BP1 ZBF1 At1g32640 F6N18.4] Transcription factor MYC2 (AtMYC2) (Basic helix-loop-helix protein 6) (AtbHLH6) (bHLH 6) (Protein JASMONATE INSENSITIVE 1) (R-homologous Arabidopsis protein 1) (RAP-1) (Transcription factor EN 38) (Z-box binding factor 1 protein) (bHLH transcription factor bHLH006) (rd22BP1)
[LRL1 BHLH66 DROP1 EN95 At2g24260 F27D4.17] Transcription factor LRL1 (Basic helix-loop-helix protein 66) (AtbHLH66) (bHLH 66) (Protein DEFECTIVE REGION OF POLLEN 1) (Protein LJRHL1- LIKE 1) (AtLRL1) (Transcription factor EN 95) (Transcription factor bHLH66) (bHLH transcription factor bHLH066)
[HFR1 BHLH26 EN68 FBI1 REP1 RSF1 At1g02340 T6A9.4 T6A9_13] Transcription factor HFR1 (Basic helix-loop-helix protein 26) (AtbHLH26) (bHLH 26) (Protein LONG HYPOCOTYL IN FAR-RED 1) (Protein REDUCED PHYTOCHROME SIGNALING) (Reduced sensitivity to far-red light) (Transcription factor EN 68) (bHLH transcription factor bHLH026)
[BHLH2 EGL1 EGL3 EN30 MYC146 At1g63650 F24D7.16] Transcription factor EGL1 (Basic helix-loop-helix protein 2) (AtMYC146) (AtbHLH2) (bHLH 2) (Protein ENHANCER OF GLABRA 3) (Transcription factor EN 30) (bHLH transcription factor bHLH002)
[LHW BHLH156 At2g27230 F12K2] Transcription factor LHW (BHLH transcription factor delta) (bHLH delta) (Basic helix-loop-helix protein 156) (AtbHLH156) (bHLH 156) (Protein LONESOME HIGHWAY) (bHLH transcription factor bHLH156)
[BHLH13 EN39 At1g01260 F6F3.7] Transcription factor bHLH13 (Basic helix-loop-helix protein 13) (AtbHLH13) (bHLH 13) (Transcription factor EN 39) (bHLH transcription factor bHLH013)
[MYC3 ATR2 BHLH5 EN36 At5g46760 MZA15.18] Transcription factor MYC3 (Basic helix-loop-helix protein 5) (AtbHLH5) (bHLH 5) (Protein ALTERED TRYPTOPHAN REGULATION 2) (Transcription factor ATR2) (Transcription factor EN 36) (bHLH transcription factor bHLH005)
[PIF1 BHLH15 EN101 PIL5 At2g20180 T2G17.2] Transcription factor PIF1 (Basic helix-loop-helix protein 15) (AtbHLH15) (bHLH 15) (Protein PHY-INTERACTING FACTOR 1) (Protein PHYTOCHROME INTERACTING FACTOR 3-LIKE 5) (Transcription factor EN 101) (bHLH transcription factor bHLH015)
[ARNTL BHLHE5 BMAL1 MOP3 PASD3] Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)
[SPCH BHLH98 EN19 At5g53210 MFH8.15] Transcription factor SPEECHLESS (Basic helix-loop-helix protein 98) (AtbHLH98) (bHLH 98) (Transcription factor EN 19) (bHLH transcription factor bHLH098)
[TT8 BHLH42 EN32 At4g09820 F17A8.170] Transcription factor TT8 (Basic helix-loop-helix protein 42) (AtbHLH42) (bHLH 42) (Protein TRANSPARENT TESTA 8) (Transcription factor EN 32) (bHLH transcription factor bHLH042)
[FAMA BHLH97 EN14 FMA At3g24140 MUJ8.4] Transcription factor FAMA (Basic helix-loop-helix protein 97) (AtbHLH97) (bHLH 97) (Transcription factor EN 14) (bHLH transcription factor bHLH097)
[BEE2 BHLH58 EN80 At4g36540 AP22.3] Transcription factor BEE 2 (Basic helix-loop-helix protein 58) (AtbHLH58) (bHLH 58) (Protein Brassinosteroid enhanced expression 2) (Transcription factor EN 80) (bHLH transcription factor bHLH058)
[FIT BHLH29 EN43 FIT1 FRU At2g28160 F24D13.5] Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (Basic helix-loop-helix protein 29) (AtbHLH29) (bHLH 29) (FER-LIKE REGULATOR OF IRON UPTAKE) (Transcription factor EN 43) (Transcription factor Fe-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1) (bHLH transcription factor bHLH029)
[HEC3 BHLH43 EN119 At5g09750 F17I14.60] Transcription factor HEC3 (Basic helix-loop-helix protein 43) (AtbHLH43) (bHLH 43) (Protein HECATE 3) (Transcription factor EN 119) (bHLH transcription factor bHLH043)
[RSL4 BHLH54 EN114 At1g27740 T22C5.19] Transcription factor RSL3 (Basic helix-loop-helix protein 54) (AtbHLH54) (bHLH 54) (ROOT HAIR DEFECTIVE 6-LIKE 4) (Protein RHD SIX-LIKE 4) (Transcription factor EN 114) (Transcription factor bHLH54) (bHLH transcription factor bHLH054)
[MYC4 BHLH4 EN37 At4g17880 T6K21.60] Transcription factor MYC4 (AtMYC4) (Basic helix-loop-helix protein 4) (AtbHLH4) (bHLH 4) (Transcription factor EN 37) (bHLH transcription factor bHLH004)
[PIF4 BHLH9 EN102 SRL2 At2g43010 MFL8.13] Transcription factor PIF4 (Basic helix-loop-helix protein 9) (AtbHLH9) (bHLH 9) (Phytochrome-interacting factor 4) (Short under red-light 2) (Transcription factor EN 102) (bHLH transcription factor bHLH009)
[LRL2 BHLH69 DROP2 EN94 At4g30980 F6I18.110] Transcription factor LRL2 (Basic helix-loop-helix protein 69) (AtbHLH69) (bHLH 69) (Protein DEFECTIVE REGION OF POLLEN 2) (Protein LJRHL1- LIKE 2) (AtLRL2) (Transcription factor EN 94) (Transcription factor bHLH69) (bHLH transcription factor bHLH069)
[PIF5 BHLH65 EN103 PIL6 At3g59060 F17J16.110] Transcription factor PIF5 (Basic helix-loop-helix protein 65) (AtbHLH65) (bHLH 65) (Phytochrome interacting factor-like 6) (Phytochrome-interacting factor 5) (Transcription factor EN 103) (bHLH transcription factor bHLH065)
[BHLH6 BHLH006 RERJ1 Os04g0301500 LOC_Os04g23550 OSJNBb0018A10.7] Transcription factor BHLH6 (Basic helix-loop-helix protein 6) (OsbHLH6) (osbHLH006) (bHLH transcription factor 6)
[PIF3 BHLH8 EN100 PAP3 At1g09530 F14J9.19] Transcription factor PIF3 (Basic helix-loop-helix protein 8) (AtbHLH8) (bHLH 8) (Phytochrome-associated protein 3) (Phytochrome-interacting factor 3) (Transcription factor EN 100) (bHLH transcription factor bHLH008)
[SCRM BHLH116 EN45 ICE1 At3g26744 MDJ14.1 MLJ15.14] Transcription factor ICE1 (Basic helix-loop-helix protein 116) (AtbHLH116) (bHLH 116) (Inducer of CBF expression 1) (Transcription factor EN 45) (Transcription factor SCREAM) (bHLH transcription factor bHLH116)
[BHLH72 EN109 PIF7 At5g61270 MFB13.4] Transcription factor PIF7 (Basic helix-loop-helix protein 72) (AtbHLH72) (bHLH 72) (Phytochrome-interacting factor 7) (Transcription factor EN 109) (bHLH transcription factor bHLH072)
[BIM1 BHLH46 EN126 At5g08130 T22D6.70] Transcription factor BIM1 (BES1-interacting Myc-like protein 1) (Basic helix-loop-helix protein 46) (AtbHLH46) (bHLH 46) (Transcription factor EN 126) (bHLH transcription factor bHLH046)

Bibliography :
[33759814] Functional genomics study of protein inhibitor of activated STAT1 in mouse hippocampal neuronal cells revealed by RNA sequencing.
[33643814] Phosphorylation regulates cullin-based ubiquitination in tumorigenesis.
[33500544] Genomic analysis of WD40 protein family in the mango reveals a TTG1 protein enhances root growth and abiotic tolerance in Arabidopsis.
[33296551] Comparative transcriptome profile analysis of rice varieties with different tolerance to zinc deficiency.
[32445267] Arabidopsis JMJ29 is involved in trichome development by regulating the core trichome initiation gene GLABRA3.
[32352975] Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.
[31897123] Prognostic genes of triple-negative breast cancer identified by weighted gene co-expression network analysis.
[31817496] Insights into Barley Root Transcriptome under Mild Drought Stress with an Emphasis on Gene Expression Regulatory Mechanisms.
[31234698] Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.
[31189709] The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains.