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BMP4

 O13107_DANRE            Unreviewed;       400 AA.
O13107;
01-JUL-1997, integrated into UniProtKB/TrEMBL.
01-JUL-1997, sequence version 1.
12-AUG-2020, entry version 105.
SubName: Full=BMP4 {ECO:0000313|EMBL:AAC60285.1};
Name=bmp4 {ECO:0000313|ZFIN:ZDB-GENE-980528-2059};
Synonyms=BMP4 {ECO:0000313|EMBL:AAC60285.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAC60285.1};
[1] {ECO:0000313|EMBL:AAC60285.1}
NUCLEOTIDE SEQUENCE.
PubMed=9370264; DOI=10.1016/S0378-1119(97)00292-8;
Martinez-Barbera J.P., Toresson H., Da Rocha S., Krauss S.;
"Cloning and expression of three members of the zebrafish Bmp family:
Bmp2a, Bmp2b and Bmp4.";
Gene 198:53-59(1997).
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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EMBL; U82231; AAC60285.1; -; mRNA.
ZFIN; ZDB-GENE-980528-2059; bmp4.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0070700; F:BMP receptor binding; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IMP:ZFIN.
GO; GO:0003303; P:BMP signaling pathway involved in heart jogging; IMP:ZFIN.
GO; GO:0060803; P:BMP signaling pathway involved in mesodermal cell fate specification; IMP:ZFIN.
GO; GO:0045165; P:cell fate commitment; IGI:ZFIN.
GO; GO:0035844; P:cloaca development; IMP:ZFIN.
GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
GO; GO:0071910; P:determination of liver left/right asymmetry; IMP:ZFIN.
GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IMP:ZFIN.
GO; GO:0048264; P:determination of ventral identity; IDA:ZFIN.
GO; GO:0048565; P:digestive tract development; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0035125; P:embryonic anal fin morphogenesis; IMP:ZFIN.
GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
GO; GO:0007507; P:heart development; IEP:ZFIN.
GO; GO:0003146; P:heart jogging; IGI:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0001707; P:mesoderm formation; IMP:ZFIN.
GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IGI:ZFIN.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0060034; P:notochord cell differentiation; IMP:ZFIN.
GO; GO:0030903; P:notochord development; IMP:ZFIN.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IDA:ZFIN.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:ZFIN.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
GO; GO:0048793; P:pronephros development; IMP:ZFIN.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
Growth factor {ECO:0000256|ARBA:ARBA00023030,
ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..24
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 25..400
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5004157118"
DOMAIN 284..400
/note="TGF_BETA_2"
/evidence="ECO:0000259|PROSITE:PS51362"
REGION 276..297
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 280..297
/note="Basic"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 400 AA; 45758 MW; 427D1DB8FE12D025 CRC64;
MIPGNRMLMV ILLCQVLLGE SSYASLIPEE GKKKASALHL AQSHELLRDF EATLLHMFGL
QRRPRPSHSA VVPQYLLDLY RLQSGELEEA GAQHVSFDYP ERSTSRASTV RGFHHEEHLE
ELQSDGSQET PLRFVFNLSS IPEDELISTA DVRIYRQQID DAFSDPDQTG DHGLHRINIY
EVLKAPREGQ LITQLLDTRL VRPNTSKWES FDVSPAVLRW TQEKRSNHGL AVEVVQMKRN
PVQKGRHARV SRSVHPLPNE EWDHVRPLLV TFGHDGKSHP LTRRAKRSPK QRGRKRNRNC
RRHALYVDFS DVGWNDWIVA PPGYQAYYCH GECPFPLADH LNSTNHAIVQ TLVNSVNTNI
PKWCCVPTEL SAISMLYLDE TDRVVLKNYQ EMVVEGCGCR


Related products :

Catalog number Product name Quantity
A0424 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 100ug
A0425 BMP4 Polyclonal Antibody, Reactivity: H, Gene ID: 652, Synonyms: BMP4 100ug
A1565 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 100ug
A0424 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 200ug
A1565 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 200ug
A0425 BMP4 Polyclonal Antibody, Reactivity: H, Gene ID: 652, Synonyms: BMP4 200ug
DL-BMP4-Hu Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-Mu Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-b Bovine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-Rb Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-g Caprine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-P Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-CH Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-c Canine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-g Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
A1565 BMP4 Primary Antibody, BMP4, Species: Human Recombinant Protein Source: Rabbit Polyclonal 50ug
  P-5006-BMP4-96  QuantiSir Specific Gene Knockdown Quantification Kit For Cell Cycle Regulation _ BMP4 (96 assays)
A0424 BMP4 Primary Antibody, BMP4, Species: Human Recombinant Protein Source: Rabbit Polyclonal 100ug
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P-5006-BMP4-96 QuantiSir Specific Gene Knockdown Quantification Kit For Cell Cycle Regulation _ BMP4 96 assays 96 assays
P-5006-BMP4-96 QuantiSir Specific Gene Knockdown Quantification Kit For Cell Cycle Regulation - BMP4 (96 assays)
PC-BMP4 Rabbit BMP4 Antibody Positive Control 5 Applications
DL-BMP4-Ra Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
P-BMP4 Rabbit BMP4 Antibody Blocking Peptide 250
LF-PA40150 anti-BMP4, Rabbit polyclonal to BMP4, Isotype IgG, Host Rabbit 50 ug
Pathways :
WP1048: TGF Beta Signaling Pathway
WP2406: Cardiac Progenitor Differentiation
WP505: TGF Beta Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP152: FGF signaling pathway
WP761: Adipogenesis
WP930: TGF Beta Signaling Pathway
WP2064: Neural Crest Differentiation
WP211: BMP signaling pathway
WP236: Adipogenesis
WP113: TGF Beta Signaling Pathway
WP447: Adipogenesis
WP566: canonical wnt - zebrafish
WP1370: TGF Beta Signaling Pathway
WP1591: Heart Development
WP869: Adipogenesis
WP2074: Neural Crest Differentiation
WP230: TGF Beta Signaling Pathway
WP1105: Adipogenesis
WP339: ESC Pluripotency Pathways
WP560: TGF Beta Signaling Pathway
WP1331: Adipogenesis
WP155: Adipogenesis
WP812: TGF Beta Signaling Pathway
WP987: Adipogenesis

Related Genes :
[Bmp4 Bmp-4 Dvr-4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[Bmp4 Bmp-4 Dvr-4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[BMP4] Bone morphogenetic protein 4 (BMP-4)
[BMP4 BMP-4] Bone morphogenetic protein 4 (BMP-4)
[BMP4] Bone morphogenetic protein 4 (BMP-4)
[BMP4] Bone morphogenetic protein 4 (BMP-4) (sBmp4)
[BMP4 BMP-4] Bone morphogenetic protein 4 (BMP-4)
[bmp4 BMP4 zBMP-4] Bone genetic protein 4 (Bone morphogenetic protein 4)
[bmp4 BMP4] BMP4
[Bmp4 rCG_61245] Bmp4 protein (Bone morphogenetic protein 4) (Bone morphogenetic protein 4, isoform CRA_a)
[BMP4 bmp4] Bone morphogenetic protein 4
[Bmp4] TGF_BETA_2 domain-containing protein
[Bmpr1a Acvrlk3 Bmpr] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMP4 hCG_20967] Bone morphogenetic protein 4 (Bone morphogenetic protein 4, isoform CRA_a) (Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human)) (Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human))
[BMP4] Bone morphogenetic protein 4
[BMP4] TGF_BETA_2 domain-containing protein
[BMP4] Bone morphogenetic protein 4
[BMP4] Bone morphogenetic protein 4
[bmp4] Bone morphogenetic protein 4
[bmp4] Bone morphogenetic protein-4 (Fragment)
[bmp4 dvr-4] Bone morphogenetic protein 4 (BMP-4)
[BMP4 Bmp4] Bone morphogenetic protein 4
[BMP4] TGF_BETA_2 domain-containing protein
[Bmp4] bone morphogenetic protein 4
[CgPICR_017346 H671_1g3115] BMP4 (Bone morphogenetic protein 4)
[Bmp4] bone morphogenetic protein 4
[BMP4] Bone morphogenetic protein 4
[BMP4] TGF_BETA_2 domain-containing protein
[BMP4] Bone morphogenetic protein 4

Bibliography :
[32971095] Development, structure, and bioengineering of the human corneal stroma: A review of collagen-based implants.
[32968094] Detection of circulating BMP5 as a risk factor for Barrett's esophagus.
[32960356] The differentiation effect of bone morphogenetic protein (BMP) on human amniotic epithelial stem cells to express ectodermal lineage markers.
[32957295] Teratogenic effects of environmentally relevant concentrations of phenanthrene on the early development of marine medaka (Oryzia melastigma).
[32953277] Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells.
[32933486] Deficiency in Aim2 affects viability and calcification of vascular smooth muscle cells from murine aortas and angiotensin-II induced aortic aneurysms.
[32922265] Physical Activity Protects the Pathological Alterations of Alzheimer's Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways.
[32916121] Androgen Maintains Intestinal Homeostasis by Inhibiting BMP Signaling via Intestinal Stromal Cells.
[32903477] When the Damage Is Done: Injury and Repair in Thymus Function.
[32899497] Insight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling.