GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

BMP4

 O13107_DANRE            Unreviewed;       400 AA.
O13107;
01-JUL-1997, integrated into UniProtKB/TrEMBL.
01-JUL-1997, sequence version 1.
11-DEC-2019, entry version 103.
SubName: Full=BMP4 {ECO:0000313|EMBL:AAC60285.1};
Name=bmp4 {ECO:0000313|ZFIN:ZDB-GENE-980528-2059};
Synonyms=BMP4 {ECO:0000313|EMBL:AAC60285.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAC60285.1};
[1] {ECO:0000313|EMBL:AAC60285.1}
NUCLEOTIDE SEQUENCE.
PubMed=9370264; DOI=10.1016/S0378-1119(97)00292-8;
Martinez-Barbera J.P., Toresson H., Da Rocha S., Krauss S.;
"Cloning and expression of three members of the zebrafish Bmp family:
Bmp2a, Bmp2b and Bmp4.";
Gene 198:53-59(1997).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; U82231; AAC60285.1; -; mRNA.
ZFIN; ZDB-GENE-980528-2059; bmp4.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
HOGENOM; HOG000249478; -.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IMP:ZFIN.
GO; GO:0003303; P:BMP signaling pathway involved in heart jogging; IMP:ZFIN.
GO; GO:0060803; P:BMP signaling pathway involved in mesodermal cell fate specification; IMP:ZFIN.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0045165; P:cell fate commitment; IGI:ZFIN.
GO; GO:0035844; P:cloaca development; IMP:ZFIN.
GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
GO; GO:0071910; P:determination of liver left/right asymmetry; IMP:ZFIN.
GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IMP:ZFIN.
GO; GO:0048264; P:determination of ventral identity; IDA:ZFIN.
GO; GO:0048565; P:digestive tract development; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0035125; P:embryonic anal fin morphogenesis; IMP:ZFIN.
GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
GO; GO:0007507; P:heart development; IEP:ZFIN.
GO; GO:0003146; P:heart jogging; IGI:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0001707; P:mesoderm formation; IMP:ZFIN.
GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IGI:ZFIN.
GO; GO:0060034; P:notochord cell differentiation; IMP:ZFIN.
GO; GO:0030903; P:notochord development; IMP:ZFIN.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IDA:ZFIN.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:ZFIN.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
GO; GO:0048793; P:pronephros development; IMP:ZFIN.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085}; Secreted {ECO:0000256|SAAS:SAAS00473502};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..24
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 25..400
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5004157118"
DOMAIN 284..400
/note="TGF_BETA_2"
/evidence="ECO:0000259|PROSITE:PS51362"
REGION 276..297
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 280..297
/note="Basic"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 400 AA; 45758 MW; 427D1DB8FE12D025 CRC64;
MIPGNRMLMV ILLCQVLLGE SSYASLIPEE GKKKASALHL AQSHELLRDF EATLLHMFGL
QRRPRPSHSA VVPQYLLDLY RLQSGELEEA GAQHVSFDYP ERSTSRASTV RGFHHEEHLE
ELQSDGSQET PLRFVFNLSS IPEDELISTA DVRIYRQQID DAFSDPDQTG DHGLHRINIY
EVLKAPREGQ LITQLLDTRL VRPNTSKWES FDVSPAVLRW TQEKRSNHGL AVEVVQMKRN
PVQKGRHARV SRSVHPLPNE EWDHVRPLLV TFGHDGKSHP LTRRAKRSPK QRGRKRNRNC
RRHALYVDFS DVGWNDWIVA PPGYQAYYCH GECPFPLADH LNSTNHAIVQ TLVNSVNTNI
PKWCCVPTEL SAISMLYLDE TDRVVLKNYQ EMVVEGCGCR


Related products :

Catalog number Product name Quantity
A0424 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 100ug
A0425 BMP4 Polyclonal Antibody, Reactivity: H, Gene ID: 652, Synonyms: BMP4 100ug
A1565 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 100ug
A0424 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 200ug
A1565 BMP4 Polyclonal Antibody, Reactivity: H M R, Gene ID: 652, Synonyms: BMP4 200ug
A0425 BMP4 Polyclonal Antibody, Reactivity: H, Gene ID: 652, Synonyms: BMP4 200ug
DL-BMP4-Hu Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-Mu Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-b Bovine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-Rb Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-g Caprine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-P Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-CH Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-c Canine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
DL-BMP4-g Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
A1565 BMP4 Primary Antibody, BMP4, Species: Human Recombinant Protein Source: Rabbit Polyclonal 50ug
  P-5006-BMP4-96  QuantiSir Specific Gene Knockdown Quantification Kit For Cell Cycle Regulation _ BMP4 (96 assays)
A0424 BMP4 Primary Antibody, BMP4, Species: Human Recombinant Protein Source: Rabbit Polyclonal 100ug
A0425 BMP4 Primary Antibody, BMP4, Species: Human Synthetic peptide Source: Rabbit Polyclonal 100ug
P-5006-BMP4-96 QuantiSir Specific Gene Knockdown Quantification Kit For Cell Cycle Regulation _ BMP4 96 assays 96 assays
P-5006-BMP4-96 QuantiSir Specific Gene Knockdown Quantification Kit For Cell Cycle Regulation - BMP4 (96 assays)
PC-BMP4 Rabbit BMP4 Antibody Positive Control 5 Applications
DL-BMP4-Ra Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit 96T
P-BMP4 Rabbit BMP4 Antibody Blocking Peptide 250
LF-PA40150 anti-BMP4, Rabbit polyclonal to BMP4, Isotype IgG, Host Rabbit 50 ug
Pathways :
WP1048: TGF Beta Signaling Pathway
WP2406: Cardiac Progenitor Differentiation
WP505: TGF Beta Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP152: FGF signaling pathway
WP761: Adipogenesis
WP930: TGF Beta Signaling Pathway
WP2064: Neural Crest Differentiation
WP211: BMP signaling pathway
WP236: Adipogenesis
WP447: Adipogenesis
WP113: TGF Beta Signaling Pathway
WP1370: TGF Beta Signaling Pathway
WP566: canonical wnt - zebrafish
WP869: Adipogenesis
WP1591: Heart Development
WP2074: Neural Crest Differentiation
WP230: TGF Beta Signaling Pathway
WP339: ESC Pluripotency Pathways
WP1105: Adipogenesis
WP1331: Adipogenesis
WP560: TGF Beta Signaling Pathway
WP812: TGF Beta Signaling Pathway
WP155: Adipogenesis
WP987: Adipogenesis

Related Genes :
[Bmp4 Bmp-4 Dvr-4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[Bmp4 Bmp-4 Dvr-4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[BMP4] Bone morphogenetic protein 4 (BMP-4)
[BMP4 BMP-4] Bone morphogenetic protein 4 (BMP-4)
[BMP4] Bone morphogenetic protein 4 (BMP-4) (sBmp4)
[BMP4] Bone morphogenetic protein 4 (BMP-4)
[BMP4 BMP-4] Bone morphogenetic protein 4 (BMP-4)
[BMP4 CK820_G0002472] BMP4 isoform 1 (BMP4 isoform 2) (BMP4 isoform 3) (BMP4 isoform 4) (Bone morphogenetic protein 4)
[bmp4 BMP4 zBMP-4] Bone genetic protein 4 (Bone morphogenetic protein 4)
[bmp4 BMP4] BMP4
[Bmp4 rCG_61245] Bmp4 protein (Bone morphogenetic protein 4) (Bone morphogenetic protein 4, isoform CRA_a)
[Bmp4] TGF_BETA_2 domain-containing protein
[Bmpr1a Acvrlk3 Bmpr] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMP4] TGF_BETA_2 domain-containing protein
[BMP4] Bone morphogenetic protein 4
[bmp4] Bone morphogenetic protein 4
[bmp4] Bone morphogenetic protein-4 (Fragment)
[BMP4] Bone morphogenetic protein 4
[BMP4 hCG_20967] Bone morphogenetic protein 4 (Bone morphogenetic protein 4, isoform CRA_a) (Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human)) (Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human))
[BMP4] Bone morphogenetic protein 4
[BMP4 CR201_G0009625] BMP4 isoform 1 (BMP4 isoform 2) (BMP4 isoform 3) (BMP4 isoform 4) (Bone morphogenetic protein 4)
[bmp4 dvr-4] Bone morphogenetic protein 4 (BMP-4)
[BMP4 Bmp4] Bone morphogenetic protein 4
[bmp4 BMP4] Bone morphogenetic protein 4
[BMP4] Bone morphogenetic protein 4
[BMP4] Bone morphogenetic protein 4
[Bmp4] bone morphogenetic protein 4
[Bmp4] bone morphogenetic protein 4
[CgPICR_017346 H671_1g3115] BMP4 (Bone morphogenetic protein 4)

Bibliography :
[32061928] HOXD3, a novel link between BMP9 and TGFβ1 signaling.
[32048992] Derivation of trophoblast stem cells from naïve human pluripotent stem cells.
[32047514] Genome-Wide Association Analysis Reveals Key Genes Responsible for Egg Production of Lion Head Goose.
[32042865] Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells (MSCs).
[32032551] Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum-Free Media.
[32029225] BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice.
[32028267] Correction for: Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes.
[32021879] CRISPR-Cpf1 Activation of Endogenous Gene for Osteogenic Differentiation of Umbilical-Cord-Derived Mesenchymal Stem Cells.
[32011747] DNA methylation of GJA1, BMP2 and BMP4 in a human cementoblast cell line induced by lipopolysaccharide.
[32003519] Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells.