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Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF)

 BATF_BOVIN              Reviewed;         125 AA.
E1BD44;
28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
02-NOV-2010, sequence version 1.
16-JAN-2019, entry version 52.
RecName: Full=Basic leucine zipper transcriptional factor ATF-like;
AltName: Full=B-cell-activating transcription factor;
Short=B-ATF;
Name=BATF;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford;
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
-!- FUNCTION: AP-1 family transcription factor that controls the
differentiation of lineage-specific cells in the immune system:
specifically mediates the differentiation of T-helper 17 cells
(Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells
and class-switch recombination (CSR) in B-cells. Acts via the
formation of a heterodimer with JUNB that recognizes and binds DNA
sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a
complex with IRF4 (or IRF8) in immune cells, leading to
recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-
specific regulatory element, followed by cooperative binding of
BATF and IRF4 (or IRF8) and activation of genes. Controls
differentiation of T-helper cells producing interleukin-17 (Th17
cells) by binding to Th17-associated gene promoters: regulates
expression of the transcription factor RORC itself and RORC target
genes such as IL17 (IL17A or IL17B). Also involved in
differentiation of follicular T-helper cells (TfH) by directing
expression of BCL6 and MAF. In B-cells, involved in class-switch
recombination (CSR) by controlling the expression of both AICDA
and of germline transcripts of the intervening heavy-chain region
and constant heavy-chain region (I(H)-C(H)). Following infection,
can participate in CD8(+) dendritic cell differentiation via
interaction with IRF4 and IRF8 to mediate cooperative gene
activation. Regulates effector CD8(+) T-cell differentiation by
regulating expression of SIRT1. Following DNA damage, part of a
differentiation checkpoint that limits self-renewal of
hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to
differentiation of HSCs, thereby restricting self-renewal of HSCs
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer; mainly heterodimerizes with JUNB. The BATF-
JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP
domain) with IRF4 and IRF8; the interaction is direct. Also forms
heterodimers with JUN and JUND. Also Interacts with IFI35 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=Present in the
nucleus and cytoplasm, but shows increased nuclear translocation
after activation of T-cells. {ECO:0000250}.
-!- PTM: Phosphorylated on serine and threonine residues and at least
one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA
binding activity and transforms it as a negative regulator of AP-1
mediated transcription (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; DAAA02029620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_001193207.1; NM_001206278.1.
UniGene; Bt.9265; -.
SMR; E1BD44; -.
STRING; 9913.ENSBTAP00000035554; -.
PaxDb; E1BD44; -.
PRIDE; E1BD44; -.
Ensembl; ENSBTAT00000035684; ENSBTAP00000035554; ENSBTAG00000025405.
GeneID; 617628; -.
KEGG; bta:617628; -.
CTD; 10538; -.
VGNC; VGNC:26425; BATF.
eggNOG; KOG1414; Eukaryota.
eggNOG; ENOG4111CH5; LUCA.
GeneTree; ENSGT00940000159745; -.
InParanoid; E1BD44; -.
KO; K09034; -.
OMA; DSNDTSY; -.
OrthoDB; 1544557at2759; -.
TreeFam; TF332340; -.
Proteomes; UP000009136; Chromosome 10.
Bgee; ENSBTAG00000025405; Expressed in 7 organ(s), highest expression level in spleen.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0001816; P:cytokine production; ISS:UniProtKB.
GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; ISS:UniProtKB.
GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
GO; GO:0045190; P:isotype switching; ISS:UniProtKB.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0043011; P:myeloid dendritic cell differentiation; ISS:UniProtKB.
GO; GO:0072539; P:T-helper 17 cell differentiation; ISS:UniProtKB.
GO; GO:0072540; P:T-helper 17 cell lineage commitment; ISS:UniProtKB.
GO; GO:0045064; P:T-helper 2 cell differentiation; ISS:UniProtKB.
InterPro; IPR000837; AP-1.
InterPro; IPR029820; BATF.
InterPro; IPR004827; bZIP.
PANTHER; PTHR23351; PTHR23351; 1.
PANTHER; PTHR23351:SF14; PTHR23351:SF14; 1.
Pfam; PF00170; bZIP_1; 1.
PRINTS; PR00042; LEUZIPPRFOS.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
3: Inferred from homology;
Activator; Complete proteome; Cytoplasm; Differentiation; DNA-binding;
Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 125 Basic leucine zipper transcriptional
factor ATF-like.
/FTId=PRO_0000420463.
DOMAIN 26 89 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 28 50 Basic motif.
REGION 54 75 Leucine-zipper.
MOD_RES 43 43 Phosphoserine.
{ECO:0000250|UniProtKB:O35284}.
MOD_RES 48 48 Phosphothreonine.
{ECO:0000250|UniProtKB:O35284}.
SEQUENCE 125 AA; 14079 MW; 0BF32190D0B1786B CRC64;
MPHSSDSSDS SFSRSPPPGK QDSSDDVRKV QRREKNRIAA QKSRQRQTQK ADTLHLESED
LEKQNAALRK EIKQLTEEMK YFTSVLSSHE PLCSVLAPGA PSPPEVVYST HAFHQPHVSS
PRFQP


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1043: Calcium Regulation in the Cardiac Cell
WP1066: Eukaryotic Transcription Initiation
WP1069: Integrin-mediated cell adhesion
WP1078: G1 to S cell cycle control
WP1083: Cell cycle
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1159: Calcium Regulation in the Cardiac Cell

Related Genes :
[BATF] Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF) (SF-HT-activated gene 2 protein) (SFA-2)
[Batf] Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF)
[ATF6] Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]
[ATF2 CREB2 CREBP1] Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (Histone acetyltransferase ATF2) (cAMP response element-binding protein CRE-BP1)
[Atf5 Atfx Nap1] Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5-alpha/beta) (BZIP protein ATF7) (NAP1) (NRIF3-associated protein) (Transcription factor ATFx) (Transcription factor-like protein ODA-10)
[ATF5 ATFX] Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx)
[ATF1] Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)
[ATF7 ATFA] Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)
[ATF3] Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
[Atf5 Atfx] Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx)
[Atf2] Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (MXBP protein) (cAMP response element-binding protein CRE-BP1)
[Atf2] Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (cAMP response element-binding protein CRE-BP1)
[Atf3] Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) (Transcription factor LRG-21)
[BATF] Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF)
[Atf3 Lrf1] Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) (Liver regeneration factor 1) (LRF-1)
[Batf] Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF)
[atf1 gad7 mts1 sss1 SPBC29B5.01] Transcription factor atf1 (Protein sss1) (Transcription factor mts1)
[ATF7IP MCAF MCAF1] Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)
[Atf1] Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (TCR-ATF1)
[Atf3 A3-3 CG11405] Activating transcription factor 3
[Batf3] Basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3)
[CREB3 LZIP] Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]
[Atf7ip Mcaf1] Activating transcription factor 7-interacting protein 1 (ATFa-associated modulator) (mAM) (MBD1-containing chromatin-associated factor 1)
[HBZ] HTLV-1 basic zipper factor (HBZ)
[TCF3 BHLHB21 E2A ITF1] Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
[JUN] Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
[CEBPB TCF5 PP9092] CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
[BLZF1 JEM1] Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor)
[Atf7] Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)
[Cebpb Crp2 Nf-il6 Sfb] CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B)

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