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Bcl-2-related ovarian killer protein

 BOK_RAT                 Reviewed;         213 AA.
Q792S6; O88857;
04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
29-SEP-2021, entry version 122.
RecName: Full=Bcl-2-related ovarian killer protein {ECO:0000303|PubMed:9356461};
Name=Bok {ECO:0000312|RGD:70984};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
FUNCTION.
STRAIN=Sprague-Dawley; TISSUE=Ovary;
PubMed=9356461; DOI=10.1073/pnas.94.23.12401;
Hsu S.Y., Kaipia A., McGee E., Lomeli M., Hsueh A.J.W.;
"Bok is a pro-apoptotic Bcl-2 protein with restricted expression in
reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-
2 family members.";
Proc. Natl. Acad. Sci. U.S.A. 94:12401-12406(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, PROTEIN
HETERODIMERIZATION, SUBUNIT, AND MUTAGENESIS OF 71-LEU--LEU-74;
75-GLY--GLU-77 AND GLY-75.
PubMed=9804769; DOI=10.1074/jbc.273.46.30139;
Hsu S.Y., Hsueh A.J.;
"A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain
induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins
in vitro.";
J. Biol. Chem. 273:30139-30146(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Apoptosis regulator that functions through different
apoptotic signaling pathways (PubMed:9356461, PubMed:9804769). Plays a
roles as pro-apoptotic protein that positively regulates intrinsic
apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and
BAK1-independent manner (By similarity). In response to endoplasmic
reticulum stress promotes mitochondrial apoptosis through downstream
BAX/BAK1 activation and positive regulation of PERK-mediated unfolded
protein response (By similarity). Activates apoptosis independently of
heterodimerization with survival-promoting BCL2 and BCL2L1 through
induction of mitochondrial outer membrane permeabilization, in a
BAX- and BAK1-independent manner, in response to inhibition of ERAD-
proteasome degradation system, resulting in cytochrome c release (By
similarity). In response to DNA damage, mediates intrinsic apoptotic
process in a TP53-dependent manner. Plays a role in granulosa cell
apoptosis by CASP3 activation (By similarity). Plays a roles as anti-
apoptotic protein during neuronal apoptotic process, by negatively
regulating poly ADP-ribose polymerase-dependent cell death through
regulation of neuronal calcium homeostasis and mitochondrial
bioenergetics in response to NMDA excitation (By similarity). In
addition to its role in apoptosis, may regulate trophoblast cell
proliferation during the early stages of placental development, by
acting on G1/S transition through regulation of CCNE1 expression. May
also play a role as an inducer of autophagy by disrupting interaction
between MCL1 and BECN1 (By similarity). {ECO:0000250|UniProtKB:O35425,
ECO:0000250|UniProtKB:Q9UMX3, ECO:0000269|PubMed:9356461,
ECO:0000269|PubMed:9804769}.
-!- FUNCTION: [Isoform 2]: positively regulates apoptotic process in an
heterodimerization-independent manner with antiapoptotic Bcl-2
proteins. {ECO:0000269|PubMed:9804769}.
-!- SUBUNIT: Isoform 1: Honomer; positively regulates apoptotic process.
Homodimer (By similarity). Heterodimer (PubMed:9804769). Oligomer;
promoted by apoptotic stimuli and BH3-only proteins; mediates
constitutive activation. Interacts (via BH4 domain) with ITPR1;
enhances BOK expression and stabilization; limits apoptosis and
prevents ubiquitination and then degradation; protects ITPR1 from
proteolysis by CASP3 during apoptosis. Interacts with ITPR2 AND ITPR3;
binds most strongly to ITPR2, and barely to ITPR3; regulates their
expression (By similarity). Interacts with XPO1; translocates to the
cytoplasm. Interacts with BNIP3; promotes oligomerization (By
similarity). Isoform 2: Does not heterodimerize with antiapoptotic Bcl-
2 proteins (PubMed:9804769). {ECO:0000250|UniProtKB:O35425,
ECO:0000250|UniProtKB:Q9UMX3, ECO:0000269|PubMed:9804769}.
-!- SUBCELLULAR LOCATION: Mitochondrion membrane
{ECO:0000250|UniProtKB:O35425}; Single-pass membrane protein
{ECO:0000250|UniProtKB:O35425}. Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:Q9UMX3}; Single-pass membrane protein
{ECO:0000250|UniProtKB:O35425}. Mitochondrion inner membrane
{ECO:0000250|UniProtKB:Q9UMX3}. Cytoplasm
{ECO:0000250|UniProtKB:Q9UMX3}. Nucleus {ECO:0000250|UniProtKB:Q9UMX3}.
Mitochondrion {ECO:0000250|UniProtKB:Q9UMX3}. Endoplasmic reticulum
{ECO:0000250|UniProtKB:Q9UMX3}. Mitochondrion outer membrane
{ECO:0000250|UniProtKB:Q9UMX3}. Early endosome membrane
{ECO:0000250|UniProtKB:O35425}. Recycling endosome membrane
{ECO:0000250|UniProtKB:O35425}. Nucleus outer membrane
{ECO:0000250|UniProtKB:O35425}. Golgi apparatus, cis-Golgi network
membrane {ECO:0000250|UniProtKB:O35425}. Golgi apparatus, trans-Golgi
network membrane {ECO:0000250|UniProtKB:O35425}. Membrane
{ECO:0000250|UniProtKB:Q9UMX3}. Note=Nuclear and cytoplasmic
compartments in the early stages of apoptosis and during apoptosis it
associates with mitochondria. In healthy cells, associates loosely with
the membrane in a hit-and-run mode. The insertion and accumulation on
membranes is enhanced through the activity of death signals, resulting
in the integration of the membrane-bound protein into the membrane (By
similarity). The transmembrane domain controls subcellular
localization; constitutes a tail-anchor. Localizes in early and late
endosome upon blocking of apoptosis. Must localize to the mitochondria
to induce mitochondrial outer membrane permeabilization and apoptosis
(By similarity). {ECO:0000250|UniProtKB:O35425,
ECO:0000250|UniProtKB:Q9UMX3}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Bok-L {ECO:0000303|PubMed:9804769};
IsoId=Q792S6-1; Sequence=Displayed;
Name=2; Synonyms=Bok-S {ECO:0000303|PubMed:9804769};
IsoId=Q792S6-2; Sequence=VSP_012447;
-!- TISSUE SPECIFICITY: Expressed in ovary, testis and uterus.
{ECO:0000269|PubMed:9356461}.
-!- DOMAIN: BH4 domain mediates interaction with ITPR1.
{ECO:0000250|UniProtKB:O35425}.
-!- PTM: Ubiquitinated by AMFR/gp78 E3 ubiquitin ligase complex; mediates
degradation by ubiquitin-proteasome pathway in a VCP/p97-dependent
manner; prevents from proapoptotic activity; promotes degradation of
newly synthesized proteins that are not ITPR1 associated.
{ECO:0000250|UniProtKB:O35425}.
-!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; AF027954; AAB87418.1; -; mRNA.
EMBL; AF051093; AAC61928.1; -; mRNA.
EMBL; BC078871; AAH78871.1; -; mRNA.
RefSeq; NP_059008.1; NM_017312.2. [Q792S6-1]
RefSeq; XP_017451805.1; XM_017596316.1. [Q792S6-1]
SMR; Q792S6; -.
STRING; 10116.ENSRNOP00000024693; -.
PhosphoSitePlus; Q792S6; -.
PaxDb; Q792S6; -.
Ensembl; ENSRNOT00000024526; ENSRNOP00000024526; ENSRNOG00000018214. [Q792S6-2]
Ensembl; ENSRNOT00000024695; ENSRNOP00000024693; ENSRNOG00000018214. [Q792S6-1]
GeneID; 29884; -.
KEGG; rno:29884; -.
UCSC; RGD:70984; rat. [Q792S6-1]
CTD; 666; -.
RGD; 70984; Bok.
eggNOG; KOG4728; Eukaryota.
GeneTree; ENSGT01020000230347; -.
HOGENOM; CLU_114994_0_0_1; -.
InParanoid; Q792S6; -.
OMA; MVHAIVD; -.
OrthoDB; 1278637at2759; -.
PhylomeDB; Q792S6; -.
TreeFam; TF315834; -.
PRO; PR:Q792S6; -.
Proteomes; UP000002494; Chromosome 9.
Bgee; ENSRNOG00000018214; Expressed in brain and 21 other tissues.
Genevisible; Q792S6; RN.
GO; GO:0033106; C:cis-Golgi network membrane; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
GO; GO:0032588; C:trans-Golgi network membrane; ISS:UniProtKB.
GO; GO:0051400; F:BH domain binding; IPI:RGD.
GO; GO:0046983; F:protein dimerization activity; IPI:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IDA:UniProtKB.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; ISS:UniProtKB.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; ISO:RGD.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
GO; GO:0008584; P:male gonad development; IEP:RGD.
GO; GO:0051902; P:negative regulation of mitochondrial depolarization; ISO:RGD.
GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISO:RGD.
GO; GO:0060546; P:negative regulation of necroptotic process; ISO:RGD.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
GO; GO:0051402; P:neuron apoptotic process; ISO:RGD.
GO; GO:0048709; P:oligodendrocyte differentiation; IEP:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO; GO:1902237; P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; ISS:UniProtKB.
GO; GO:1900119; P:positive regulation of execution phase of apoptosis; ISS:UniProtKB.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; ISS:UniProtKB.
GO; GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
GO; GO:1903899; P:positive regulation of PERK-mediated unfolded protein response; ISS:UniProtKB.
GO; GO:0051259; P:protein complex oligomerization; ISS:UniProtKB.
GO; GO:0010506; P:regulation of autophagy; ISO:RGD.
GO; GO:1901382; P:regulation of chorionic trophoblast cell proliferation; ISS:UniProtKB.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:RGD.
GO; GO:1904708; P:regulation of granulosa cell apoptotic process; ISS:UniProtKB.
GO; GO:0001836; P:release of cytochrome c from mitochondria; ISO:RGD.
CDD; cd06845; Bcl-2_like; 1.
Gene3D; 1.10.437.10; -; 1.
InterPro; IPR036834; Bcl-2-like_sf.
InterPro; IPR026298; Bcl-2_fam.
InterPro; IPR002475; Bcl2-like.
InterPro; IPR026309; BOK.
PANTHER; PTHR11256; PTHR11256; 1.
PANTHER; PTHR11256:SF48; PTHR11256:SF48; 1.
Pfam; PF00452; Bcl-2; 1.
PRINTS; PR01862; BCL2FAMILY.
SMART; SM00337; BCL; 1.
SUPFAM; SSF56854; SSF56854; 1.
PROSITE; PS50062; BCL2_FAMILY; 1.
1: Evidence at protein level;
Alternative splicing; Apoptosis; Cytoplasm; Endoplasmic reticulum;
Endosome; Golgi apparatus; Isopeptide bond; Membrane; Mitochondrion;
Mitochondrion inner membrane; Mitochondrion outer membrane; Nucleus;
Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
Ubl conjugation.
CHAIN 1..213
/note="Bcl-2-related ovarian killer protein"
/id="PRO_0000143088"
TRANSMEM 190..210
/note="Helical"
/evidence="ECO:0000255"
REGION 15..45
/note="Interactions with ITPR1"
/evidence="ECO:0000250|UniProtKB:O35425"
REGION 71..79
/note="Nuclear export signal"
/evidence="ECO:0000250|UniProtKB:Q9UMX3"
MOTIF 32..44
/note="BH4"
MOTIF 67..83
/note="BH3"
MOTIF 113..132
/note="BH1"
MOTIF 165..179
/note="BH2"
MOD_RES 7
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:O35425"
CROSSLNK 25
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:O35425"
CROSSLNK 32
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:O35425"
CROSSLNK 160
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:O35425"
CROSSLNK 177
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:O35425"
VAR_SEQ 75..117
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:9356461"
/id="VSP_012447"
MUTAGEN 71..74
/note="LLRL->GGGG: Retains proapoptotic activity. Does not
heterodimerizes."
/evidence="ECO:0000269|PubMed:9804769"
MUTAGEN 75..77
/note="GDE->AAA: Retains proapoptotic activity."
/evidence="ECO:0000269|PubMed:9804769"
MUTAGEN 75
/note="G->A: Retains proapoptotic activity."
/evidence="ECO:0000269|PubMed:9804769"
SEQUENCE 213 AA; 23456 MW; F8755C45CB05D626 CRC64;
MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERASPAP
GGRLAEVCTV LLRLGDELEQ IRPSVYRNVA RQLHIPLQSE PVVTDAFLAV AGHIFSAGIT
WGKVVSLYSV AAGLAVDCVR QAQPAMVHAL VDCLGEFVRK TLATWLRRRG GWTDVLKCVV
STDPGFRSHW LVATLCSFGR FLKAAFFLLL PER


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Pathways :
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection
WP731: Sterol regulatory element binding protein related
WP1003: Ovarian Infertility Genes
WP1690: Propanoate metabolism
WP73: G Protein Signaling Pathways
WP834: Cytoplasmic Ribosomal Proteins
WP1625: Base excision repair
WP210: Cytoplasmic Ribosomal Proteins
WP1782: APC/C-mediated degradation of cell cycle proteins
WP1654: gamma-Hexachlorocyclohexane degradation
WP2203: TSLP Signaling Pathway
WP1853: Metabolism of proteins
WP1165: G Protein Signaling Pathways
WP1694: Pyrimidine metabolism
WP813: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1714: Tyrosine metabolism
WP1929: Thrombin signalling through proteinase activated receptors (PARs)
WP1661: Glyoxylate and dicarboxylate metabolism
WP2292: Chemokine signaling pathway
WP1902: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
WP1672: Mismatch repair
WP2371: Parkinsons Disease Pathway
WP20: Cytoplasmic Ribosomal Proteins

Related Genes :
[Bok Mtd] Bcl-2-related ovarian killer protein (Apoptosis activator Mtd) (Protein matador)
[BOK BCL2L9] Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)
[Bok] Bcl-2-related ovarian killer protein
[Bcl2l11 Bim Bod] Bcl-2-like protein 11 (Bcl2-L-11) (Bcl-2-related ovarian death protein) (Bcl2-interacting mediator of cell death)
[BAK1 BAK BCL2L7 CDN1] Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)
[BIK NBK] Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4)
[Bak1 Bak] Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)
[BOK BCL2L9 BOKL hCG_33052] BCL2-related ovarian killer, isoform CRA_a (Bcl-2-related ovarian killer protein isoform 1)
[Bak1 Bak rCG_60911] BAK protein (BCL2-antagonist/killer 1) (BCL2-antagonist/killer 1, isoform CRA_b) (Bak1 protein)
[Debcl Bcl-2 bcl-2 Bcl2 BG1 BOK Bok Bok(Debcl) Borg1 borg1 buffy CG12397 DBok Dbok dBOK dBok dbok dBORG-1 dBorg-1 dBorg01 dBorg1 dborg1 dBrog-1 debc1 DEBCL debcl debok Dmel\CG33134 DROB-1 Drob-1 dRob-1 drob-1 CG33134 Dmel_CG33134] BG1 (Bcl-2 ortholog dBorg-1) (Death executioner Bcl-2) (Drob-1) (IP01389p) (Proapoptotic Bcl-2 homolog DEBCL)
[BOK] Bcl-2-related ovarian killer protein
[BCL2A1 BCL2L5 BFL1 GRS HBPA1] Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS)
[MCL1 BCL2L3] Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
[Mcl1] Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1)
[Bik Biklk Blk Nbk] Bcl-2-interacting killer (Apoptosis inducer NBK) (Bik-like killer protein)
[Bcl2l1 Bcl2l Bclx] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[bokb bok zgc:64041] Bcl-2-related ovarian killer protein homolog B (zBok2)
[Bcl2a1 A1 Bcl2a1a Bfl1] Bcl-2-related protein A1 (A1-A) (Hemopoietic-specific early response protein) (Protein BFL-1)
[BCL2L1 BCL2L BCLX] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[BCL2L1 BCL-X BCLX] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[boka bok zgc:100979] Bcl-2-related ovarian killer protein homolog A (zBok1)
[Bcl9l B9l] B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (BCL9-related beta-catenin-binding protein) (Protein BCL9-2)
[NCR2 LY95] Natural cytotoxicity triggering receptor 2 (Lymphocyte antigen 95 homolog) (NK cell-activating receptor) (Natural killer cell p44-related protein) (NK-p44) (NKp44) (CD antigen CD336)
[MUC16 CA125] Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125)
[TSHZ2 C20orf17 TSH2 ZNF218] Teashirt homolog 2 (Ovarian cancer-related protein 10-2) (OVC10-2) (Zinc finger protein 218)
[BCL2] Apoptosis regulator Bcl-2
[BAK1] BCL2 antagonist/killer 1
[BOK] Bcl-2-related ovarian killer protein
[BAK1] BCL2-antagonist/killer 1 (Bcl-2 homologous antagonist/killer transcript variant 1)
[BOK] Bcl-2-related ovarian killer protein

Bibliography :
[34136494] Identification of the Bok Interactome Using Proximity Labeling.
[34001648] CEBPA-AS1 Knockdown Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Neuron Cell Damage by the MicroRNA 24-3p/BOK Axis.
[33807047] Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.
[33773141] Bok binds to a largely disordered loop in the coupling domain of type 1 inositol 1,4,5-trisphosphate receptor.
[33553610] BOK-MCL1 transmembrane interactions: a challenging target for cancer therapy.
[33216728] Protective effect of DLX6-AS1 silencing against cerebral ischemia/reperfusion induced impairments.
[33043006] The Multifaceted Roles of the BCL-2 Family Member BOK.
[31899307] SpBOK inhibits WSSV infection by regulating the apoptotic pathway in mud crab (Scylla paramamosain).
[30976095] Bok regulates mitochondrial fusion and morphology.
[30471638] Negative Regulation of BOK Expression by Recruitment of TRIM28 to Regulatory Elements in Its 3' Untranslated Region.