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Bcl-xL-like protein 1 (Bcl2-like 1) (Bcl2l protein)

 Q90Z98_DANRE            Unreviewed;       238 AA.
Q90Z98;
01-DEC-2001, integrated into UniProtKB/TrEMBL.
01-DEC-2001, sequence version 1.
03-JUL-2019, entry version 142.
SubName: Full=BCL2-like 1 {ECO:0000313|Ensembl:ENSDARP00000027919};
SubName: Full=Bcl-XL-like protein 1 {ECO:0000313|EMBL:AAK81706.1, ECO:0000313|EMBL:AAY43152.1};
SubName: Full=Bcl2l protein {ECO:0000313|EMBL:AAH44130.1};
Name=bcl2l1 {ECO:0000313|Ensembl:ENSDARP00000027919,
ECO:0000313|ZFIN:ZDB-GENE-010730-1};
Synonyms=bcl2l {ECO:0000313|ZFIN:ZDB-GENE-010730-1},
blp1 {ECO:0000313|EMBL:AAK81706.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAK81706.1};
[1] {ECO:0000313|EMBL:AAK81706.1}
NUCLEOTIDE SEQUENCE.
PubMed=11406282; DOI=10.1016/S0167-4781(01)00209-3;
Chen M.C., Gong H.Y., Cheng C.Y., Wang J.P., Hong J.R., Wu J.L.;
"Cloning and characterization of zfBLP1, a Bcl-XL homologue from the
zebrafish, Danio rerio.";
Biochim. Biophys. Acta 1519:127-133(2001).
[2] {ECO:0000313|EMBL:AAY43152.1}
NUCLEOTIDE SEQUENCE.
STRAIN=AB {ECO:0000313|EMBL:AAY43152.1};
Takahashi N., Dawid I.B.;
"Splicing isoform of Bcl-XL-like protein 1.";
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:AAI65156.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=AB {ECO:0000313|EMBL:AAH44130.1};
TISSUE=Embryo {ECO:0000313|EMBL:AAH71291.1},
PCR rescue {ECO:0000313|EMBL:AAI65156.1}, and
Whole body {ECO:0000313|EMBL:AAH44130.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSDARP00000027919}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000027919};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[5] {ECO:0000313|Ensembl:ENSDARP00000027919, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000027919,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
-----------------------------------------------------------------------
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EMBL; CR788311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC044130; AAH44130.1; -; mRNA.
EMBL; BC071291; AAH71291.1; -; mRNA.
EMBL; BC165156; AAI65156.1; -; mRNA.
EMBL; AF317837; AAK81706.1; -; mRNA.
EMBL; DQ022560; AAY43152.1; -; mRNA.
RefSeq; NP_571882.1; NM_131807.1.
RefSeq; XP_005162083.1; XM_005162026.3.
STRING; 7955.ENSDARP00000027919; -.
Ensembl; ENSDART00000012507; ENSDARP00000027919; ENSDARG00000008434.
Ensembl; ENSDART00000147617; ENSDARP00000119990; ENSDARG00000008434.
GeneID; 114401; -.
KEGG; dre:114401; -.
CTD; 598; -.
ZFIN; ZDB-GENE-010730-1; bcl2l1.
eggNOG; KOG4728; Eukaryota.
eggNOG; ENOG41123S0; LUCA.
GeneTree; ENSGT00950000182651; -.
HOGENOM; HOG000056452; -.
KO; K04570; -.
OMA; NGSPSWH; -.
OrthoDB; 1218929at2759; -.
TreeFam; TF315834; -.
Reactome; R-DRE-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
Reactome; R-DRE-844455; The NLRP1 inflammasome.
Proteomes; UP000000437; Chromosome 23.
Bgee; ENSDARG00000008434; Expressed in 47 organ(s), highest expression level in testis.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:ZFIN.
GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:ZFIN.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:ZFIN.
GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IDA:ZFIN.
GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
GO; GO:0001894; P:tissue homeostasis; IMP:ZFIN.
InterPro; IPR013279; Apop_reg_BclX.
InterPro; IPR002475; Bcl2-like.
InterPro; IPR020717; Bcl2_BH1_motif_CS.
InterPro; IPR003093; Bcl2_BH4.
InterPro; IPR036834; Blc2-like_sf.
InterPro; IPR026298; Blc2_fam.
PANTHER; PTHR11256; PTHR11256; 1.
PANTHER; PTHR11256:SF12; PTHR11256:SF12; 1.
Pfam; PF00452; Bcl-2; 1.
Pfam; PF02180; BH4; 1.
PRINTS; PR01864; APOPREGBCLX.
PRINTS; PR01862; BCL2FAMILY.
SMART; SM00265; BH4; 1.
SUPFAM; SSF56854; SSF56854; 1.
PROSITE; PS50062; BCL2_FAMILY; 1.
PROSITE; PS01080; BH1; 1.
PROSITE; PS50063; BH4_2; 1.
1: Evidence at protein level;
Apoptosis {ECO:0000256|PROSITE-ProRule:PRU00025};
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Membrane {ECO:0000256|SAM:Phobius};
Proteomics identification {ECO:0000213|PeptideAtlas:Q90Z98};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 216 234 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 5 22 BH4_2. {ECO:0000259|PROSITE:PS50063}.
REGION 56 85 Disordered. {ECO:0000256|MobiDB-
lite:Q90Z98}.
MOTIF 5 22 BH4. {ECO:0000256|PROSITE-
ProRule:PRU00025}.
COMPBIAS 56 84 Polar. {ECO:0000256|MobiDB-lite:Q90Z98}.
SEQUENCE 238 AA; 26253 MW; 6E58394933EEFDDB CRC64;
MSYYNRELVV FFIKYKLSQR NYPCNHIGLT EDTNRTDGAE ENGEGAAGAT TLVNGTMNRT
NASSTGTPPQ SPASSPQRQT NGSGGLDAVK EALRDSANEF ELRYSRAFND LSSQLHITPA
TAYQSFESVM DEVFRDGVNW GRIVGLFAFG GALCVECVEK EMSPLVGRIA EWMTVYLDNH
IQPWIQSQGG WERFAEIFGK DAAAESRKSQ ESFKKWLFAG MTLLTGVVVG GLIAQKRL


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[BAD BBC6 BCL2L8] Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
[BCL2L1 BCL2L BCLX] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[Bcl2l1 Bcl2l Bclx] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[Bcl2l1 Bclx Blc2l] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
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[Bcl2l11 Bim] Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)
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[BAX BCL2L4] Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
[BCL2A1 BCL2L5 BFL1 GRS HBPA1] Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS)
[BCL2L13 MIL1 CD003] Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1)
[BOK BCL2L9] Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)
[BCL2L2 BCLW KIAA0271] Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)
[BCL2L10 BCLB] Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)
[BCL2L1 BCLX BLC2L] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[Bad Bbc6] Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
[BECN1 GT197] Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
[BCL2] Apoptosis regulator Bcl-2
[Bcl2 Bcl-2] Apoptosis regulator Bcl-2
[Bad] Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
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[Becn1] Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
[Becn1] Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
[Bcl2 Bcl-2] Apoptosis regulator Bcl-2
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Bibliography :
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