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Bestrophin homolog

 H3DS98_PRIPA            Unreviewed;       151 AA.
H3DS98;
18-APR-2012, integrated into UniProtKB/TrEMBL.
18-APR-2012, sequence version 1.
16-JAN-2019, entry version 27.
RecName: Full=Bestrophin homolog {ECO:0000256|RuleBase:RU363126};
Name=WBGene00089833 {ECO:0000313|EnsemblMetazoa:PPA00279};
Pristionchus pacificus (Parasitic nematode).
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Diplogasteromorpha; Diplogasteroidea; Neodiplogasteridae;
Pristionchus.
NCBI_TaxID=54126 {ECO:0000313|EnsemblMetazoa:PPA00279, ECO:0000313|Proteomes:UP000005239};
[1] {ECO:0000313|EnsemblMetazoa:PPA00279, ECO:0000313|Proteomes:UP000005239}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA00279,
ECO:0000313|Proteomes:UP000005239};
PubMed=18806794; DOI=10.1038/ng.227;
Dieterich C., Clifton S.W., Schuster L.N., Chinwalla A.,
Delehaunty K., Dinkelacker I., Fulton L., Fulton R., Godfrey J.,
Minx P., Mitreva M., Roeseler W., Tian H., Witte H., Yang S.P.,
Wilson R.K., Sommer R.J.;
"The Pristionchus pacificus genome provides a unique perspective on
nematode lifestyle and parasitism.";
Nat. Genet. 40:1193-1198(2008).
[2] {ECO:0000313|EnsemblMetazoa:PPA00279}
IDENTIFICATION.
STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA00279};
EnsemblMetazoa;
Submitted (JUN-2015) to UniProtKB.
-!- FUNCTION: Forms chloride channels.
{ECO:0000256|RuleBase:RU363126}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000256|RuleBase:RU363126}; Multi-pass membrane protein
{ECO:0000256|RuleBase:RU363126}.
-!- SIMILARITY: Belongs to the bestrophin family.
{ECO:0000256|RuleBase:RU363126}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|RuleBase:RU363126}.
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EnsemblMetazoa; PPA00279; PPA00279; PPA00279.
eggNOG; KOG3547; Eukaryota.
eggNOG; ENOG410XS3J; LUCA.
InParanoid; H3DS98; -.
OMA; MRYIMAN; -.
Proteomes; UP000005239; Unassembled WGS sequence.
GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
InterPro; IPR033041; Best1.
InterPro; IPR000615; Bestrophin.
InterPro; IPR021134; Bestrophin/UPF0187.
PANTHER; PTHR10736; PTHR10736; 1.
PANTHER; PTHR10736:SF4; PTHR10736:SF4; 1.
Pfam; PF01062; Bestrophin; 1.
3: Inferred from homology;
Cell membrane {ECO:0000256|RuleBase:RU363126};
Chloride {ECO:0000256|RuleBase:RU363126};
Chloride channel {ECO:0000256|RuleBase:RU363126};
Complete proteome {ECO:0000313|Proteomes:UP000005239};
Ion channel {ECO:0000256|RuleBase:RU363126};
Ion transport {ECO:0000256|RuleBase:RU363126};
Membrane {ECO:0000256|RuleBase:RU363126};
Reference proteome {ECO:0000313|Proteomes:UP000005239};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|RuleBase:RU363126};
Transmembrane helix {ECO:0000256|RuleBase:RU363126};
Transport {ECO:0000256|RuleBase:RU363126}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 151 Bestrophin homolog.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003583629.
TRANSMEM 30 53 Helical. {ECO:0000256|RuleBase:RU363126}.
SEQUENCE 151 AA; 17912 MW; 25EE5CAE8EAD6DD0 CRC64;
MTSFLALFYL IMTIYRWGLS EEYQKQLEKV ALYCREFTLT IPITFVMGFY VTFVAGRWWQ
QYMNIPWPDR IALQVSAYVS GADERGRLMR RALVRYANLL AIFTFQSTST VIKRRFPTID
HLLEAGLLTE EEKRTIENIH SPQGTWFRMS F


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1036: Homologous recombination
WP1097: Non-homologous end joining
WP1153: Homologous recombination
WP1201: Non-homologous end joining
WP1205: Homologous recombination
WP1208: Non-homologous end joining
WP1216: Homologous recombination
WP1222: Non-homologous end joining
WP1234: Homologous recombination
WP1242: Non-homologous end joining
WP1258: Homologous recombination
WP1277: Non-homologous end joining
WP1296: Homologous recombination
WP1324: Non-homologous end joining
WP1362: Homologous recombination
WP1570: Non-homologous end joining
WP1576: Homologous recombination
WP1663: Homologous recombination
WP1676: Non-homologous end-joining
WP186: Homologous recombination
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP32: Translation Factors
WP438: Non-homologous end joining
WP739: Non-homologous end joining

Related Genes :
[BEST1 VMD2] Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2)
[Best1 anon-WO0118547.380 best Dbest dBest1 dbest1 dmBest1 Dmel\CG6264 CG6264 Dmel_CG6264] Bestrophin homolog
[myrf-1 pqn-47 F59B10.1] Myelin regulatory factor homolog 1 (EC 3.4.-.-) (Polyglutamine-repeat protein 47) [Cleaved into: Myelin regulatory factor homolog 1, N-terminal; Myelin regulatory factor homolog 1, C-terminal]
[myrf-2 F21A10.2] Myelin regulatory factor homolog 2 (EC 3.4.-.-) [Cleaved into: Myelin regulatory factor homolog 2, N-terminal; Myelin regulatory factor homolog 2, C-terminal]
[SLIT2 SLIL3] Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]
[Slit2] Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]
[SMAD7 MADH7 MADH8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
[Smad7 Madh7 Madh8] Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7)
[SMAD2 MADH2 MADR2] Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[SMAD3 MADH3] Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
[Best1 anon-WO0118547.380 best Dbest dBest1 dbest1 dmBest1 Dmel\CG6264 CG6264 Dmel_CG6264] Bestrophin homolog
[] Basic phospholipase A2 homolog bothropstoxin-1 (svPLA2 homolog) (BOJU-I) (Bothropstoxin I) (BthTx-I) (BtxtxI) (Myotoxic phospholipase A2-like) (Phospholipase A2 homolog 1)
[XPD UVH6 At1g03190 F15K9.20] General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (ERCC2 homolog) (RAD3 homolog) (UV hypersensitive protein 6) (AtUVH6) (XPD homolog) (AtXPD)
[Smad2 Madh2 Madr2] Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2) (SMAD family member 2) (SMAD 2) (Smad2)
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[MRE11 HNGS1 MRE11A] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[Best1 Bmd1 Vmd2] Bestrophin-1 (Vitelliform macular dystrophy protein 2 homolog)
[trap1 DDB_G0276947] TNF receptor-associated protein 1 homolog, mitochondrial (TNFR-associated protein 1 homolog) (Trap1 homolog)
[DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4] DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
[Cln5] Ceroid-lipofuscinosis neuronal protein 5 homolog (Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form]
[YFH1 YDL120W] Frataxin homolog, mitochondrial (EC 1.16.3.1) [Cleaved into: Frataxin homolog intermediate form]
[best-15 R13.3] Bestrophin homolog 15 (Bestrophin-1) (ceBest1)
[Best2 Vmd2l1] Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1)
[PRMT5 HRMT1L5 IBP72 JBP1 SKB1] Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
[LLGL1 DLG4 HUGL HUGL1] Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)
[him-6 T04A11.6] Bloom syndrome protein homolog (EC 3.6.4.12) (High incidence of males protein 6) (RecQ helicase homolog)
[SMAD9 MADH6 MADH9 SMAD8] Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)
[SMAD5 MADH5] Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)

Bibliography :
[30477598] Exploring the homolog of a novel proinflammatory microfilarial sheath protein (MfP) of Wuchereria bancrofti in the adult-stage bovine filarial parasite Setaria cervi.
[25324390] Structure and selectivity in bestrophin ion channels.
[11747204] Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity.