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Bone genetic protein 4 (Bone morphogenetic protein 4)

 O57574_DANRE            Unreviewed;       400 AA.
O57574;
01-JUN-1998, integrated into UniProtKB/TrEMBL.
01-JUN-1998, sequence version 1.
11-DEC-2019, entry version 141.
SubName: Full=Bone genetic protein 4 {ECO:0000313|EMBL:BAA24407.1};
SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|EMBL:AAC13302.1};
Name=bmp4 {ECO:0000313|EMBL:AAH78423.1,
ECO:0000313|ZFIN:ZDB-GENE-980528-2059};
Synonyms=BMP4 {ECO:0000313|EMBL:AAC13302.1},
zBMP-4 {ECO:0000313|EMBL:BAA24407.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:BAA24407.1};
[1] {ECO:0000313|EMBL:AAC13302.1}
NUCLEOTIDE SEQUENCE.
PubMed=9303442; DOI=10.1089/dna.1997.16.1003;
Hwang S.P., Tsou M.F., Lin Y.C., Liu C.H.;
"The zebrafish BMP4 gene: sequence analysis and expression pattern during
embryonic development.";
DNA Cell Biol. 16:1003-1011(1997).
[2] {ECO:0000313|EMBL:BAA24407.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Whole embryo {ECO:0000313|EMBL:BAA24407.1};
PubMed=9076679; DOI=10.1016/S0925-4773(96)00625-9;
Nikaido M., Tada M., Saji T., Ueno N.;
"Conservation of BMP signaling in zebrafish mesoderm patterning.";
Mech. Dev. 61:75-88(1997).
[3] {ECO:0000313|EMBL:AAC13302.1}
NUCLEOTIDE SEQUENCE.
Hwang S.P., Tsou M.F., Lin Y.C., Liu C.H.;
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:AAH78423.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Singapore local strain {ECO:0000313|EMBL:AAH78423.1};
TISSUE=Embryo {ECO:0000313|EMBL:AAH78423.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:AJF23295.1}
NUCLEOTIDE SEQUENCE.
PubMed=26341094;
Marques C.L., Fernandez I., Viegas M.N., Cox C.J., Martel P., Rosa J.,
Cancela M.L., Laize V.;
"Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16:
molecular and evolutionary perspectives.";
Cell. Mol. Life Sci. 0:0-0(2015).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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EMBL; AF056336; AAC13302.1; -; Genomic_DNA.
EMBL; BC078423; AAH78423.1; -; mRNA.
EMBL; KM820425; AJF23295.1; -; mRNA.
EMBL; D49972; BAA24407.1; -; mRNA.
RefSeq; NP_571417.1; NM_131342.2.
GeneID; 30612; -.
KEGG; dre:30612; -.
CTD; 652; -.
ZFIN; ZDB-GENE-980528-2059; bmp4.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
KO; K04662; -.
OrthoDB; 962484at2759; -.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IMP:ZFIN.
GO; GO:0003303; P:BMP signaling pathway involved in heart jogging; IMP:ZFIN.
GO; GO:0060803; P:BMP signaling pathway involved in mesodermal cell fate specification; IMP:ZFIN.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0045165; P:cell fate commitment; IGI:ZFIN.
GO; GO:0035844; P:cloaca development; IMP:ZFIN.
GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
GO; GO:0071910; P:determination of liver left/right asymmetry; IMP:ZFIN.
GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IMP:ZFIN.
GO; GO:0048264; P:determination of ventral identity; IDA:ZFIN.
GO; GO:0048565; P:digestive tract development; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0035125; P:embryonic anal fin morphogenesis; IMP:ZFIN.
GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
GO; GO:0007507; P:heart development; IEP:ZFIN.
GO; GO:0003146; P:heart jogging; IGI:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0001707; P:mesoderm formation; IMP:ZFIN.
GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IGI:ZFIN.
GO; GO:0060034; P:notochord cell differentiation; IMP:ZFIN.
GO; GO:0030903; P:notochord development; IMP:ZFIN.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IDA:ZFIN.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:ZFIN.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
GO; GO:0048793; P:pronephros development; IMP:ZFIN.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085}; Secreted {ECO:0000256|SAAS:SAAS00473502};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..24
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 25..400
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5010132959"
DOMAIN 284..400
/note="TGF_BETA_2"
/evidence="ECO:0000259|PROSITE:PS51362"
REGION 276..297
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 280..297
/note="Basic"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 400 AA; 45758 MW; E175AE41D18C2171 CRC64;
MIPGNRMLMV ILLCQVLLGE SSYASLIPEE GKKKASALHL AQSHELLRDF EATLLHMFGL
QRRPRPSHSA VVPQYLLDLY RLQSGELEEA GAQHVSFDYP ERSTSRANTV RGFHHEEHLE
ELQSDGSQET PLRFVFNLSS IPEDELISTA ELRVYRQQID DAFSDPDQTG DHGLHRINIY
EVLKAPREGQ LITQLLDTRL VRHNTSKWES FDVSPAVLRW TQEKRSNHGL AVEVVQMKRN
PVQKGRHVRV SRSVHPLPDE EWDQLRPLLV TFGHDGKSHP LTRRAKRSPK QRGRKRNRNC
RRHALYVDFS DVGWNDWIVA PPGYQAYYCH GECPFPLADH LNSTNHAIVQ TLVNSVNTNI
PKACCVPTEL SAISMLYLDE TDRVVLKNYQ EMVVEGCGCR


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E0014r ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0014m CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
E0013m ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
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024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg
Pathways :
WP2324: AGE/RAGE pathway
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP1659: Glycine, serine and threonine metabolism
WP1665: Limonene and pinene degradation
WP35: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP1675: Nitrogen metabolism
WP731: Sterol regulatory element binding protein related
WP1685: Peptidoglycan biosynthesis
WP1616: ABC transporters
WP211: BMP signaling pathway
WP1644: DNA replication
WP2218: sGC
WP1692: Protein export
WP1700: Selenoamino acid metabolism
WP1657: Glycerolipid metabolism
WP232: G Protein Signaling Pathways
WP1663: Homologous recombination
WP346: Protein Modifications
WP1371: G Protein Signaling Pathways
WP1888: Post-translational protein modification
WP1502: Mitochondrial biogenesis

Related Genes :
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[GDF6 BMP13 GDF16] Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[ZMYND11 BRAM1 BS69] Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
[bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-)
[MX] Interferon-induced GTP-binding protein Mx (Interferon-inducible Mx protein)
[GDF10 BMP3B] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[ELANE ELA2] Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)
[IBSP BNSP] Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
[ALPL] Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)
[SPP1 BNSP OPN PSEC0156] Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)
[BGN SLRR1A] Biglycan (Bone/cartilage proteoglycan I) (PG-S1)
[BST2] Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)
[Bst2] Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (CD antigen CD317)
[DCN SLRR1B] Decorin (Bone proteoglycan II) (PG-S2) (PG40)
[Bst2 Damp1] Bone marrow stromal antigen 2 (BST-2) (Protein DAMP-1) (CD antigen CD317)
[Bst2] Bone marrow stromal antigen 2 (BST-2) (Luminal membrane-associated protein GREG) (CD antigen CD317)
[DCN] Decorin (Bone proteoglycan II) (PG-S2)
[BGN] Biglycan (Bone/cartilage proteoglycan I) (Leucine-rich PG I) (PG-S1)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[PSMB4 PROS26] Proteasome subunit beta type-4 (EC 3.4.25.1) (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)

Bibliography :
[32047514] Genome-Wide Association Analysis Reveals Key Genes Responsible for Egg Production of Lion Head Goose.
[31863652] Cardiac Differentiation of Adipose Tissue-Derived Stem Cells Is Driven by BMP4 and bFGF but Counteracted by 5-Azacytidine and Valproic Acid.
[31847260] The Morphology of Cross-Beaks and Gene Expression in Huiyang Bearded Chickens.
[31721366] Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent.
[31681860] Lens epithelial cells-induced pluripotent stem cells as a model to study epithelial-mesenchymal transition during posterior capsular opacification.
[31452178] Effects of Different Therapeutic Radiation Doses on the Development of Neural Tube Defects in Chick Embryos and the Correlation with Bone Morphogenetic Protein 4 and 7 Expression Levels.
[31179571] Genome-wide association study identifies energy metabolism genes for resistance to ketosis in Chinese Holstein cattle.
[31177178] and Polymorphisms as Potential Biomarkers of Non-small Cell Lung Cancer in a Polish Population.
[31128441] BMP4 mutations in tooth agenesis and low bone mass.
[31017898] Use of PTC124 for nonsense suppression therapy targeting BMP4 nonsense variants in vitro and the bmp4st72 allele in zebrafish.