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Bone morphogenetic protein 4

 F1QAD6_DANRE            Unreviewed;       400 AA.
F1QAD6;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-MAY-2011, sequence version 1.
26-FEB-2020, entry version 61.
SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|Ensembl:ENSDARP00000069635};
Name=bmp4 {ECO:0000313|Ensembl:ENSDARP00000069635,
ECO:0000313|ZFIN:ZDB-GENE-980528-2059};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000069635, ECO:0000313|Proteomes:UP000000437};
[1] {ECO:0000313|Ensembl:ENSDARP00000069635}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069635};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSDARP00000069635, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069635,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the human
genome.";
Nature 496:498-503(2013).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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EMBL; CR391996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CU012045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 7955.ENSDARP00000069635; -.
PaxDb; F1QAD6; -.
Ensembl; ENSDART00000075150; ENSDARP00000069635; ENSDARG00000019995.
ZFIN; ZDB-GENE-980528-2059; bmp4.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00940000159502; -.
HOGENOM; CLU_020515_4_2_1; -.
InParanoid; F1QAD6; -.
OMA; GFHHEEH; -.
TreeFam; TF351789; -.
Reactome; R-DRE-2129379; Molecules associated with elastic fibres.
Reactome; R-DRE-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-DRE-8957275; Post-translational protein phosphorylation.
Proteomes; UP000000437; Chromosome 17.
Bgee; ENSDARG00000019995; Expressed in atrioventricular canal and 99 other tissues.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IMP:ZFIN.
GO; GO:0003303; P:BMP signaling pathway involved in heart jogging; IMP:ZFIN.
GO; GO:0060803; P:BMP signaling pathway involved in mesodermal cell fate specification; IMP:ZFIN.
GO; GO:0045165; P:cell fate commitment; IGI:ZFIN.
GO; GO:0035844; P:cloaca development; IMP:ZFIN.
GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
GO; GO:0071910; P:determination of liver left/right asymmetry; IMP:ZFIN.
GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IMP:ZFIN.
GO; GO:0048264; P:determination of ventral identity; IDA:ZFIN.
GO; GO:0048565; P:digestive tract development; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0035125; P:embryonic anal fin morphogenesis; IMP:ZFIN.
GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
GO; GO:0007507; P:heart development; IEP:ZFIN.
GO; GO:0003146; P:heart jogging; IGI:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0001707; P:mesoderm formation; IMP:ZFIN.
GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IGI:ZFIN.
GO; GO:0060034; P:notochord cell differentiation; IMP:ZFIN.
GO; GO:0030903; P:notochord development; IMP:ZFIN.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IDA:ZFIN.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:ZFIN.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
GO; GO:0048793; P:pronephros development; IMP:ZFIN.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
3: Inferred from homology;
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
Secreted {ECO:0000256|SAAS:SAAS00473502}; Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..24
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 25..400
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5003272533"
DOMAIN 284..400
/note="TGF_BETA_2"
/evidence="ECO:0000259|PROSITE:PS51362"
REGION 276..297
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 280..297
/note="Basic"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 400 AA; 45788 MW; 24B5A886D04C2EEA CRC64;
MIPGNRMLMV ILLCQVLLGE SSYASLIPEE GKKKASALHL AQSHELLRDF EATLLHMFGL
QRRPRPSHSA VVPQYLLDLY RLQSGELEEA GAQHVSFDYP ERSTSRANTV RGFHHEEHLE
ELQSDSSQET PLRFVFNLSS IPEDELISTA ELRVYRQQID DAFSDPDQTG DHGLHRINIY
EVLKAPREGQ LITQLLDTRL VRHNTSKWES FDVSPAVLRW TQEKRSNHGL AVEVVQMKRN
PVQKGRHVRV SRSVHPLPDE EWDQLRPLLV TFGHDGKSHP LTRRAKRSPK QRGRKRNRNC
RRHALYVDFS DVGWNDWIVA PPGYQAYYCH GECPFPLADH LNSTNHAIVQ TLVNSVNTNI
PKACCVPTEL SAISMLYLDE TDRVVLKNYQ EMVVEGCGCR


Related products :

Catalog number Product name Quantity
200-001 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 5
200-002 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 25
102-PA106S BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-PA106 BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 200
101-M233 BMP-2 Anti-Human Host: Mouse bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-P03A BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
U0014h CLIA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA kit BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0013h ELISA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
U0013h CLIA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013h ELISA kit BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013m ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014m ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0013r CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0014m ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0014m CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
E0014r ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0013m ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014r ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0013m CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0013r ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
E0013r ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP1049: G Protein Signaling Pathways
WP1692: Protein export
WP2353: vitamin B9 (folate) biosynthesis pathway
WP1644: DNA replication
WP1348: Androgen Receptor Signaling Pathway
WP1657: Glycerolipid metabolism
WP2324: AGE/RAGE pathway
WP1371: G Protein Signaling Pathways
WP1700: Selenoamino acid metabolism
WP106: Alanine and aspartate metabolism
WP1888: Post-translational protein modification
WP2087: miRNA regulation of DNA Damage Response
WP1663: Homologous recombination
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP1673: Naphthalene and anthracene degradation
WP346: Protein Modifications
WP1502: Mitochondrial biogenesis
WP1939: Unfolded Protein Response
WP673: ErbB signaling pathway
WP1613: 1,4-Dichlorobenzene degradation
WP211: BMP signaling pathway
WP1678: Nucleotide excision repair
WP525: Mitochondrial Unfolded-Protein Response
WP1690: Propanoate metabolism

Related Genes :
[Bmp4 Bmp-4 Dvr-4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[Bmp4 Bmp-4 Dvr-4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[Bmpr1a] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Bone morphogenetic protein 4 receptor) (CD antigen CD292)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[Bmp2 Bmp-2] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP3 BMP3A] Bone morphogenetic protein 3 (BMP-3) (Bone morphogenetic protein 3A) (BMP-3A) (Osteogenin)
[BMP1 PCOLC] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
[BMP4] Bone morphogenetic protein 4 (BMP-4) (sBmp4)
[BMP4] Bone morphogenetic protein 4 (BMP-4)
[Bmpr1a Acvrlk3 Bmpr] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMP4 BMP-4] Bone morphogenetic protein 4 (BMP-4)
[Bmp2 Bmp-2] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[Bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
[Bmpr2] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (BRK-3) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP4] Bone morphogenetic protein 4 (BMP-4)
[BMP4 BMP-4] Bone morphogenetic protein 4 (BMP-4)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[BMP10] Bone morphogenetic protein 10 (BMP-10)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[GDF2 BMP9] Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[BMP6 VGR] Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)
[BMP5] Bone morphogenetic protein 5 (BMP-5)
[Bmp8a Bmp-8 Bmp8] Bone morphogenetic protein 8A (BMP-8A) (Osteogenic protein 2) (OP-2)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[BMPER KIAA1965] BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2)

Bibliography :
[32220969] Cabozantinib Reverses Renal Cell Carcinoma-Mediated Osteoblast Inhibition in Three-Dimensional Co-culture In Vitro and Reduces Bone Osteolysis In Vivo.
[32211112] Gene-gene interactions between BMP4 and ARHGAP29 among non-syndromic cleft lip only (NSCLO) trios from western Han Chinese population.
[32201555] Ectopic transient overexpression of facilitates BMP4-induced osteogenic transdifferentiation of human umbilical vein endothelial cells.
[32201526] Function of BMP4 in the Formation of Vasculogenic Mimicry in Hepatocellular Carcinoma.
[32154930] Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit.
[32138551] Differentiation of neonate mouse spermatogonial stem cells on three-dimensional agar/polyvinyl alcohol nanofiber scaffold.
[32102285] Bone Morphogenetic Protein 4 Targeting Glioma Stem-Like Cells for Malignant Glioma Treatment: Latest Advances and Implications for Clinical Application.
[32093330] Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist.
[32047514] Genome-Wide Association Analysis Reveals Key Genes Responsible for Egg Production of Lion Head Goose.
[32029225] BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice.