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Bone morphogenetic protein 4 (BMP-4)

 BMP4_RABIT              Reviewed;         409 AA.
O46576;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
12-AUG-2020, entry version 106.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
Flags: Precursor;
Name=BMP4; Synonyms=BMP-4;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white; TISSUE=Ocular ciliary epithelium;
Wan X.L., Sears J., Chen S., Sears M.;
"Cloning and expression of BMP-2/-4 from rabbit ocular ciliary
epithelium.";
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Induces cartilage and bone formation. Acts in concert with
PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary
development and to inhibit hair follicle induction (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homodimer; disulfide-linked. Interacts with SOSTDC1, GREM2,
RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD.
Interacts with the serine proteases, HTRA1 and HTRA3; the interaction
with either inhibits BMP4-mediated signaling. The HTRA protease
activity is required for this inhibition. Interacts with FBN1 (via N-
terminal domain) and FBN2. {ECO:0000250|UniProtKB:P12644,
ECO:0000250|UniProtKB:P21275}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000250}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; AF042497; AAB97467.1; -; mRNA.
STRING; 9986.ENSOCUP00000009545; -.
eggNOG; KOG3900; Eukaryota.
InParanoid; O46576; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0070700; F:BMP receptor binding; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0000186; P:activation of MAPKK activity; ISS:UniProtKB.
GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0003130; P:BMP signaling pathway involved in heart induction; ISS:UniProtKB.
GO; GO:0071893; P:BMP signaling pathway involved in nephric duct formation; ISS:UniProtKB.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; ISS:UniProtKB.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; ISS:UniProtKB.
GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0035993; P:deltoid tuberosity development; ISS:UniProtKB.
GO; GO:0001958; P:endochondral ossification; ISS:UniProtKB.
GO; GO:0072104; P:glomerular capillary formation; ISS:UniProtKB.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0001822; P:kidney development; ISS:UniProtKB.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0072205; P:metanephric collecting duct development; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; ISS:UniProtKB.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; ISS:UniProtKB.
GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; ISS:UniProtKB.
GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; ISS:UniProtKB.
GO; GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:0045839; P:negative regulation of mitotic nuclear division; ISS:UniProtKB.
GO; GO:0042326; P:negative regulation of phosphorylation; ISS:UniProtKB.
GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
GO; GO:0050918; P:positive chemotaxis; ISS:UniProtKB.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; ISS:UniProtKB.
GO; GO:0055020; P:positive regulation of cardiac muscle fiber development; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:BHF-UCL.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:UniProtKB.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0045606; P:positive regulation of epidermal cell differentiation; ISS:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:BHF-UCL.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
GO; GO:0061155; P:pulmonary artery endothelial tube morphogenesis; ISS:UniProtKB.
GO; GO:0010453; P:regulation of cell fate commitment; ISS:UniProtKB.
GO; GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0003139; P:secondary heart field specification; ISS:UniProtKB.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; ISS:UniProtKB.
GO; GO:0035990; P:tendon cell differentiation; ISS:UniProtKB.
GO; GO:0003323; P:type B pancreatic cell development; ISS:UniProtKB.
GO; GO:0072192; P:ureter epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; ISS:UniProtKB.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
Developmental protein; Differentiation; Disulfide bond;
Extracellular matrix; Glycoprotein; Growth factor; Osteogenesis;
Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1..19
/evidence="ECO:0000255"
PROPEP 20..293
/evidence="ECO:0000250"
/id="PRO_0000033860"
CHAIN 294..409
/note="Bone morphogenetic protein 4"
/id="PRO_0000033861"
MOD_RES 91
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P12644"
CARBOHYD 144
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 209
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 351
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 366
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 309..374
/evidence="ECO:0000250"
DISULFID 338..406
/evidence="ECO:0000250"
DISULFID 342..408
/evidence="ECO:0000250"
DISULFID 373
/note="Interchain"
/evidence="ECO:0000250"
SEQUENCE 409 AA; 46641 MW; 35557561447AD625 CRC64;
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRH PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQM PSGGLEYPER PASRANTVRS
FHHEEHLENI PGTSENSAFR FLFNLSSIPE NEAISSAELR LFREQVDQGP DWERGFHRIN
IYEVMKPPAE AVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNHGLAVEVT
HFHHTRTHQG QHVRLSRSLL QGSGDWAQFR PLLVTFGHDG RGHALTRRRR AKRSLKHHPQ
RARKKNKNCR RHALYVDFSD VGWNDWIVAP PGYQAFYCHG DCPFPLADHF NSTNHAIVQT
LVNSVNSSIP KACCVPTELS AISMLYLDEY DKVVLKNYQE MVVEGCGCR


Related products :

Catalog number Product name Quantity
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200-002 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 25
102-PA106S BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
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101-M233 BMP-2 Anti-Human Host: Mouse bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-P03A BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
U0014h CLIA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA kit BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
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E0014m ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0013r CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0014m ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
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024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg
Pathways :
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1616: ABC transporters
WP2199: Seed Development
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP1692: Protein export
WP1700: Selenoamino acid metabolism
WP1657: Glycerolipid metabolism
WP2324: AGE/RAGE pathway
WP1663: Homologous recombination
WP35: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1888: Post-translational protein modification

Related Genes :
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[GDF6 BMP13 GDF16] Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
[bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[GDF10 BMP3B] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[ZMYND11 BRAM1 BS69] Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
[Hjv Hfe2 Rgmc] Hemojuvelin (Hemochromatosis type 2 protein homolog) (Hemojuvelin BMP coreceptor) (RGM domain family member C)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[GREM1 CKTSF1B1 DAND2 DRM PIG2] Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)
[bmp3] Bone morphogenetic protein 3 (BMP-3) (xBMP-3)
[gdf10 bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (xBMP-3B)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[spoIVA spoVP BSU22800] Stage IV sporulation protein A (EC 3.6.1.-) (Coat morphogenetic protein SpoIVA)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Nanog Ecat4 Enk] Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
[GATA4] Transcription factor GATA-4 (GATA-binding factor 4)
[] Endonuclease V (EC 3.2.2.17) (DNA-(apurinic or apyrimidinic site) lyase) (AP lyase) (EC 4.2.99.18) (T4 pyrimidine dimer glycosylase) (T4-Pdg)

Bibliography :
[32960356] The differentiation effect of bone morphogenetic protein (BMP) on human amniotic epithelial stem cells to express ectodermal lineage markers.
[32736254] Sequential growth factor releasing double cryogel system for enhanced bone regeneration.
[32596370] Effect of the Abnormal Expression of BMP-4 in the Blood of Diabetic Patients on the Osteogenic Differentiation Potential of Alveolar BMSCs and the Rescue Effect of Metformin: A Bioinformatics-Based Study.
[32582651] Investigate the Odontogenic Differentiation and Dentin-Pulp Tissue Regeneration Potential of Neural Crest Cells.
[32572061] Derivation of oocyte-like cells from putative embryonic stem cells and parthenogenetically activated into blastocysts in goat.
[32525771] Icariin accelerate fracture healing via activation of WNT1/β-catenin osteogenic signaling pathway.
[32461130] Continuous psychosocial stress stimulates BMP signaling in dorsal hippocampus concomitant with anxiety-like behavior associated with differential modulation of cell proliferation and neurogenesis.
[32450526] Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells.
[32322728] Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4.
[32138551] Differentiation of neonate mouse spermatogonial stem cells on three-dimensional agar/polyvinyl alcohol nanofiber scaffold.