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Bone morphogenetic protein 4 (BMP-4)

 BMP4_XENLA              Reviewed;         401 AA.
P30885;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
12-AUG-2020, entry version 95.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
Flags: Precursor;
Name=bmp4; Synonyms=dvr-4;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=1510675; DOI=10.1016/s0006-291x(05)81574-8;
Nishimatsu S., Suzuki A., Shoda A., Murakami K., Ueno N.;
"Genes for bone morphogenetic proteins are differentially transcribed in
early amphibian embryos.";
Biochem. Biophys. Res. Commun. 186:1487-1495(1992).
[2]
FUNCTION.
PubMed=1425343;
Jones C.M., Lyons K.M., Lapan P.M., Wright C.V., Hogan B.L.;
"DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in
Xenopus mesoderm induction.";
Development 115:639-647(1992).
[3]
INTERACTION WITH TWSG1 AND CHRD.
PubMed=10866189; DOI=10.1038/35015500;
Oelgeschlager M., Larrain J., Geissert D., De Robertis E.M.;
"The evolutionarily conserved BMP-binding protein Twisted gastrulation
promotes BMP signalling.";
Nature 405:757-763(2000).
[4]
INTERACTION WITH DERRIERE.
PubMed=12070085;
Eimon P.M., Harland R.M.;
"Effects of heterodimerization and proteolytic processing on Derriere and
Nodal activity: implications for mesoderm induction in Xenopus.";
Development 129:3089-3103(2002).
-!- FUNCTION: Posterior-ventralizing factor in Xenopus mesoderm induction.
Induces posteroventral mesoderm and counteracts dorsalizing signals
such as activin. {ECO:0000269|PubMed:1425343,
ECO:0000269|PubMed:1510675}.
-!- SUBUNIT: Homodimer; disulfide-linked (By similarity). Forms
heterodimers with the TGF-beta family member derriere. Part of a
complex consisting of twsg1 and chrd. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expressed at a low level maternally with expression levels increasing
rapidly after stage 9. Expression is maintained throughout development
and in a range of adult tissues including the ovary and testis.
{ECO:0000269|PubMed:1510675}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; X63426; CAA45020.1; -; mRNA.
PIR; JH0689; JH0689.
RefSeq; NP_001095263.1; NM_001101793.1.
GeneID; 399322; -.
KEGG; xla:399322; -.
CTD; 399322; -.
Xenbase; XB-GENE-6254046; bmp4.S.
KO; K04662; -.
OMA; RIMRGAC; -.
OrthoDB; 962484at2759; -.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
Developmental protein; Differentiation; Disulfide bond;
Extracellular matrix; Glycoprotein; Growth factor; Osteogenesis; Secreted;
Signal.
SIGNAL 1..19
/evidence="ECO:0000255"
PROPEP 20..287
/evidence="ECO:0000250"
/id="PRO_0000033864"
CHAIN 288..401
/note="Bone morphogenetic protein 4"
/id="PRO_0000033865"
CARBOHYD 141
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 204
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 238
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 343
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 358
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 301..366
/evidence="ECO:0000250"
DISULFID 330..398
/evidence="ECO:0000250"
DISULFID 334..400
/evidence="ECO:0000250"
DISULFID 365
/note="Interchain"
/evidence="ECO:0000250"
SEQUENCE 401 AA; 45988 MW; 3580DEC4B9890047 CRC64;
MIPGNRMLMV ILLSQVLLGG TNYASLIPDT GKKKVAADIQ GGGRRSPQSN ELLRDFEVTL
LQMFGLRKRP QPSKDVVVPA YMRDLYRLQS AEEEDELHDI SMEYPETPTS RANTVRSFHH
EEHLENLPGT EENGNFRFVF NLSSIPENEV ISSAELRLYR EQIDHGPAWD EGFHRINIYE
VMKPITANGH MINRLLDTRV IHHNVTQWES FDVSPAIMRW TLDKQINHGL AIEVIHLNQT
KTYQGKHVRI SRSLLPQKDA DWSQMRPLLI TFSHDGRGHA LTRRSKRSPK QQRPRKKNKH
CRRHSLYVDF SDVGWNDWIV APPGYQAFYC HGDCPFPLAD HLNSTNHAIV QTLVNSVNSS
IPKACCVPTE LSAISMLYLD EYDKVVLKNY QEMVVEGCGC R


Related products :

Catalog number Product name Quantity
200-001 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 5
200-002 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 25
102-PA106S BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-PA106 BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 200
101-M233 BMP-2 Anti-Human Host: Mouse bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-P03A BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
U0014h CLIA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA kit BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0013h ELISA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
U0013h CLIA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013h ELISA kit BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013m ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014m ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0013r CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0014m ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0014m CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
E0014r ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0013m ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014r ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0013m CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
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024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg
Pathways :
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1616: ABC transporters
WP2199: Seed Development
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP1692: Protein export
WP1700: Selenoamino acid metabolism
WP1657: Glycerolipid metabolism
WP2324: AGE/RAGE pathway
WP1663: Homologous recombination
WP35: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1888: Post-translational protein modification

Related Genes :
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[GDF6 BMP13 GDF16] Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
[bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[GDF10 BMP3B] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[ZMYND11 BRAM1 BS69] Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
[Hjv Hfe2 Rgmc] Hemojuvelin (Hemochromatosis type 2 protein homolog) (Hemojuvelin BMP coreceptor) (RGM domain family member C)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[GREM1 CKTSF1B1 DAND2 DRM PIG2] Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)
[bmp3] Bone morphogenetic protein 3 (BMP-3) (xBMP-3)
[gdf10 bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (xBMP-3B)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[spoIVA spoVP BSU22800] Stage IV sporulation protein A (EC 3.6.1.-) (Coat morphogenetic protein SpoIVA)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Nanog Ecat4 Enk] Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
[GATA4] Transcription factor GATA-4 (GATA-binding factor 4)
[] Endonuclease V (EC 3.2.2.17) (DNA-(apurinic or apyrimidinic site) lyase) (AP lyase) (EC 4.2.99.18) (T4 pyrimidine dimer glycosylase) (T4-Pdg)

Bibliography :
[32960356] The differentiation effect of bone morphogenetic protein (BMP) on human amniotic epithelial stem cells to express ectodermal lineage markers.
[32736254] Sequential growth factor releasing double cryogel system for enhanced bone regeneration.
[32596370] Effect of the Abnormal Expression of BMP-4 in the Blood of Diabetic Patients on the Osteogenic Differentiation Potential of Alveolar BMSCs and the Rescue Effect of Metformin: A Bioinformatics-Based Study.
[32582651] Investigate the Odontogenic Differentiation and Dentin-Pulp Tissue Regeneration Potential of Neural Crest Cells.
[32572061] Derivation of oocyte-like cells from putative embryonic stem cells and parthenogenetically activated into blastocysts in goat.
[32525771] Icariin accelerate fracture healing via activation of WNT1/β-catenin osteogenic signaling pathway.
[32461130] Continuous psychosocial stress stimulates BMP signaling in dorsal hippocampus concomitant with anxiety-like behavior associated with differential modulation of cell proliferation and neurogenesis.
[32450526] Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells.
[32322728] Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4.
[32138551] Differentiation of neonate mouse spermatogonial stem cells on three-dimensional agar/polyvinyl alcohol nanofiber scaffold.