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Bone morphogenetic protein 4 (BMP-4)

 BMP4_BOVIN              Reviewed;         409 AA.
Q2KJH1;
27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
07-MAR-2006, sequence version 1.
11-DEC-2019, entry version 101.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
Flags: Precursor;
Name=BMP4;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Induces cartilage and bone formation. Acts in concert with
PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary
development and to inhibit hair follicle induction (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homodimer; disulfide-linked. Interacts with SOSTDC1, GREM2,
RGMA, RGMB and RGMC. Interacts with the serine proteases, HTRA1 and
HTRA3.; the interaction with either inhibits BMP4-mediated signaling.
The HTRA protease activity is required for this inhibition. Interacts
with FBN1 (via N-terminal domain) and FBN2.
{ECO:0000250|UniProtKB:P12644, ECO:0000250|UniProtKB:P21275}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000250}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; BC105344; AAI05345.1; -; mRNA.
RefSeq; NP_001039342.1; NM_001045877.1.
RefSeq; XP_005211850.1; XM_005211793.3.
RefSeq; XP_005211851.1; XM_005211794.3.
RefSeq; XP_010807631.1; XM_010809329.2.
RefSeq; XP_010807633.1; XM_010809331.2.
STRING; 9913.ENSBTAP00000004992; -.
PaxDb; Q2KJH1; -.
PRIDE; Q2KJH1; -.
Ensembl; ENSBTAT00000004992; ENSBTAP00000004992; ENSBTAG00000003835.
GeneID; 407216; -.
KEGG; bta:407216; -.
CTD; 652; -.
VGNC; VGNC:26519; BMP4.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00940000159502; -.
HOGENOM; HOG000249478; -.
InParanoid; Q2KJH1; -.
KO; K04662; -.
OMA; GFHHEEH; -.
OrthoDB; 962484at2759; -.
TreeFam; TF351789; -.
Reactome; R-BTA-2129379; Molecules associated with elastic fibres.
Reactome; R-BTA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-BTA-8957275; Post-translational protein phosphorylation.
Proteomes; UP000009136; Chromosome 10.
Bgee; ENSBTAG00000003835; Expressed in 10 organ(s), highest expression level in spleen.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0070700; F:BMP receptor binding; ISS:UniProtKB.
GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0000186; P:activation of MAPKK activity; ISS:UniProtKB.
GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0003130; P:BMP signaling pathway involved in heart induction; ISS:UniProtKB.
GO; GO:0071893; P:BMP signaling pathway involved in nephric duct formation; ISS:UniProtKB.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; ISS:UniProtKB.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; ISS:UniProtKB.
GO; GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; ISS:UniProtKB.
GO; GO:0060433; P:bronchus development; IEA:Ensembl.
GO; GO:0060503; P:bud dilation involved in lung branching; IEA:Ensembl.
GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
GO; GO:0060363; P:cranial suture morphogenesis; IEA:Ensembl.
GO; GO:0035993; P:deltoid tuberosity development; ISS:UniProtKB.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003197; P:endocardial cushion development; IEA:Ensembl.
GO; GO:0001958; P:endochondral ossification; ISS:UniProtKB.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0007281; P:germ cell development; IEA:Ensembl.
GO; GO:0072104; P:glomerular capillary formation; ISS:UniProtKB.
GO; GO:0072015; P:glomerular visceral epithelial cell development; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl.
GO; GO:0048392; P:intermediate mesodermal cell differentiation; ISS:UniProtKB.
GO; GO:0001822; P:kidney development; ISS:UniProtKB.
GO; GO:0060235; P:lens induction in camera-type eye; IEA:Ensembl.
GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
GO; GO:0060592; P:mammary gland formation; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Ensembl.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Ensembl.
GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; ISS:UniProtKB.
GO; GO:0007500; P:mesodermal cell fate determination; IEA:Ensembl.
GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
GO; GO:0072205; P:metanephric collecting duct development; ISS:UniProtKB.
GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0072097; P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; ISS:UniProtKB.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
GO; GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; ISS:UniProtKB.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; ISS:UniProtKB.
GO; GO:0090194; P:negative regulation of glomerulus development; ISS:UniProtKB.
GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; ISS:UniProtKB.
GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; ISS:UniProtKB.
GO; GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:0045839; P:negative regulation of mitotic nuclear division; ISS:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0042326; P:negative regulation of phosphorylation; ISS:UniProtKB.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0045843; P:negative regulation of striated muscle tissue development; IEA:Ensembl.
GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0050918; P:positive chemotaxis; ISS:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
GO; GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; ISS:UniProtKB.
GO; GO:0055020; P:positive regulation of cardiac muscle fiber development; ISS:UniProtKB.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:BHF-UCL.
GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:UniProtKB.
GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0045606; P:positive regulation of epidermal cell differentiation; ISS:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:BHF-UCL.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0090184; P:positive regulation of kidney development; ISS:UniProtKB.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISS:UniProtKB.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
GO; GO:0061155; P:pulmonary artery endothelial tube morphogenesis; ISS:UniProtKB.
GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0010453; P:regulation of cell fate commitment; ISS:UniProtKB.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0042306; P:regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
GO; GO:0003139; P:secondary heart field specification; ISS:UniProtKB.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
GO; GO:0048745; P:smooth muscle tissue development; ISS:UniProtKB.
GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
GO; GO:0072101; P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; ISS:UniProtKB.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; ISS:UniProtKB.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0035990; P:tendon cell differentiation; ISS:UniProtKB.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
GO; GO:0003323; P:type B pancreatic cell development; ISS:UniProtKB.
GO; GO:0072192; P:ureter epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; ISS:UniProtKB.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
Developmental protein; Differentiation; Disulfide bond;
Extracellular matrix; Glycoprotein; Growth factor; Osteogenesis;
Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1..24
/evidence="ECO:0000255"
PROPEP 25..293
/evidence="ECO:0000250"
/id="PRO_0000244401"
CHAIN 294..409
/note="Bone morphogenetic protein 4"
/id="PRO_0000244402"
MOD_RES 91
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P12644"
CARBOHYD 144
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 209
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 351
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 366
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 309..374
/evidence="ECO:0000250"
DISULFID 338..406
/evidence="ECO:0000250"
DISULFID 342..408
/evidence="ECO:0000250"
DISULFID 373
/note="Interchain"
/evidence="ECO:0000250"
SEQUENCE 409 AA; 46626 MW; 5450B9A831D4EE0C CRC64;
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQI QGIGLEYPER PASRANTVRS
FHHEEHLENI PGTSENSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWDQGFHRIN
IYEVMKPPAE VVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT
HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHALTRRRR AKRSPKHHPQ
RARKKNKNCR RHSLYVDFSD VGWNDWIVAP PGYQAFYCHG DCPFPLADHL NSTNHAIVQT
LVNSVNSSIP KACCVPTELS AISMLYLDEY DKVVLKNYQE MVVEGCGCR


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Pathways :
WP1713: Two-component system
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP1049: G Protein Signaling Pathways
WP525: Mitochondrial Unfolded-Protein Response
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1665: Limonene and pinene degradation
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1616: ABC transporters
WP2199: Seed Development
WP1685: Peptidoglycan biosynthesis
WP1692: Protein export
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP1657: Glycerolipid metabolism
WP2324: AGE/RAGE pathway
WP1700: Selenoamino acid metabolism
WP1371: G Protein Signaling Pathways
WP1888: Post-translational protein modification
WP1663: Homologous recombination
WP35: G Protein Signaling Pathways

Related Genes :
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[GDF6 BMP13 GDF16] Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-)
[GDF10 BMP3B] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[ZMYND11 BRAM1 BS69] Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
[Hjv Hfe2 Rgmc] Hemojuvelin (Hemochromatosis type 2 protein homolog) (Hemojuvelin BMP coreceptor) (RGM domain family member C)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[GREM1 CKTSF1B1 DAND2 DRM PIG2] Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[bmp3] Bone morphogenetic protein 3 (BMP-3) (xBMP-3)
[gdf10 bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (xBMP-3B)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[BMP15] Bone morphogenetic protein 15 (BMP-15)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Nanog Ecat4 Enk] Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
[spoIVA spoVP BSU22800] Stage IV sporulation protein A (EC 3.6.1.3) (Coat morphogenetic protein SpoIVA)
[GATA4] Transcription factor GATA-4 (GATA-binding factor 4)

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