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Bone morphogenetic protein 4 (BMP-4)

 BMP4_CHICK              Reviewed;         405 AA.
Q90752;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
11-DEC-2019, entry version 119.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
Flags: Precursor;
Name=BMP4; Synonyms=BMP-4;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=White leghorn;
PubMed=8119128;
Francis P.H., Richardson M.K., Brickell P.M., Tickle C.;
"Bone morphogenetic proteins and a signalling pathway that controls
patterning in the developing chick limb.";
Development 120:209-218(1994).
[2]
FUNCTION.
PubMed=9927590;
Pizette S., Niswander L.;
"BMPs negatively regulate structure and function of the limb apical
ectodermal ridge.";
Development 126:883-894(1999).
[3]
IDENTIFICATION IN A COMPLEX WITH CHRD AND TSKU.
PubMed=15363410; DOI=10.1016/j.devcel.2004.08.014;
Ohta K., Lupo G., Kuriyama S., Keynes R., Holt C.E., Harris W.A.,
Tanaka H., Ohnuma S.;
"Tsukushi functions as an organizer inducer by inhibition of BMP activity
in cooperation with chordin.";
Dev. Cell 7:347-358(2004).
[4]
INTERACTION WITH TSKU.
PubMed=16943268; DOI=10.1242/dev.02579;
Ohta K., Kuriyama S., Okafuji T., Gejima R., Ohnuma S., Tanaka H.;
"Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node
formation in the chick embryo.";
Development 133:3777-3786(2006).
-!- FUNCTION: Negatively regulates the structure and function of the limb
apical ectodermal ridge. {ECO:0000269|PubMed:9927590}.
-!- SUBUNIT: Homodimer; disulfide-linked. Part of a complex consisting of
TWSG1 and CHRD (By similarity). Forms a ternary complex with
chordin/CHRD and TSKU (PubMed:15363410, PubMed:16943268).
{ECO:0000250|UniProtKB:P12644, ECO:0000269|PubMed:15363410,
ECO:0000269|PubMed:16943268}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; X75915; CAA53514.1; -; mRNA.
PIR; I50608; I50608.
STRING; 9031.ENSGALP00000020289; -.
PaxDb; Q90752; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
HOGENOM; HOG000249478; -.
InParanoid; Q90752; -.
OrthoDB; 962484at2759; -.
PhylomeDB; Q90752; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0070700; F:BMP receptor binding; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0071729; P:beak morphogenesis; IMP:AgBase.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0008283; P:cell population proliferation; IMP:AgBase.
GO; GO:0060197; P:cloacal septation; IEP:UniProtKB.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:AgBase.
GO; GO:0048392; P:intermediate mesodermal cell differentiation; NAS:AgBase.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEP:UniProtKB.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEP:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; NAS:AgBase.
GO; GO:0072179; P:nephric duct formation; IMP:AgBase.
GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
GO; GO:0009951; P:polarity specification of dorsal/ventral axis; NAS:AgBase.
GO; GO:0045606; P:positive regulation of epidermal cell differentiation; ISS:UniProtKB.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:2000872; P:positive regulation of progesterone secretion; TAS:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:AgBase.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0010453; P:regulation of cell fate commitment; ISS:UniProtKB.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:2000290; P:regulation of myotome development; NAS:AgBase.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
GO; GO:0060675; P:ureteric bud morphogenesis; IEP:UniProtKB.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
Growth factor; Osteogenesis; Reference proteome; Secreted; Signal.
SIGNAL 1..19
/evidence="ECO:0000255"
PROPEP 20..291
/evidence="ECO:0000250"
/id="PRO_0000033852"
CHAIN 292..405
/note="Bone morphogenetic protein 4"
/id="PRO_0000033853"
CARBOHYD 144
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 208
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 347
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 362
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 305..370
/evidence="ECO:0000250"
DISULFID 334..402
/evidence="ECO:0000250"
DISULFID 338..404
/evidence="ECO:0000250"
DISULFID 369
/note="Interchain"
/evidence="ECO:0000250"
SEQUENCE 405 AA; 46057 MW; 544302DBA0A40F81 CRC64;
MIPGNRMLMV ILLCQVLLGG TNHASLIPET GRKKVAELQG QAGSGRRSAQ SHELLRGFET
TLLQMFGLRR RPQPSKSAVI PSYMLDLYRL QSGEEEERSL QEISLQYPER SASRANTVRS
FHHEEHLESV PGPSEAPRIR FVFNLSSVPD NEVISSEELR LYREQVEEPS AAWERGFHRI
NIYEVMKPLS ERSQAITRLL DTRLVHHNVT RWETFDVSPA VIRWTKDKQP NHGLVIEVTH
LHQAQTHQGK HVRISRSLPQ GHGGDWAQLR PLLVTFGHDG RGHALTRRAR RSPKHHGSRK
NKKNCRRHAL YVDFSDVGWN DWIVAPPGYQ AFYCHGDCPF PLADHLNSTN HAIVQTLVNS
VNSSIPKACC VPTELSAISM LYLDEYDKVV LKNYQEMVVE GCGCR


Related products :

Catalog number Product name Quantity
200-001 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 5
200-002 BMP-2 Human Host: E. coli bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 25
102-PA106S BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-PA106 BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 200
101-M233 BMP-2 Anti-Human Host: Mouse bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
102-P03A BMP-2 Anti-Human Host: Rabbit bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 100
U0014h CLIA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA kit BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0014h ELISA BMP2B,BMP-2B,BMP4,BMP-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,DVR4,Homo sapiens,Human 96T
E0013h ELISA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
U0013h CLIA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013h ELISA kit BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013m ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014m ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0013r CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0014m ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0014m CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
E0014r ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0013m ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014r ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0013m CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
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024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg
Pathways :
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1616: ABC transporters
WP2199: Seed Development
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP1692: Protein export
WP1700: Selenoamino acid metabolism
WP1657: Glycerolipid metabolism
WP2324: AGE/RAGE pathway
WP35: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1888: Post-translational protein modification
WP1663: Homologous recombination

Related Genes :
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[GDF6 BMP13 GDF16] Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-)
[GDF10 BMP3B] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[ZMYND11 BRAM1 BS69] Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
[Hjv Hfe2 Rgmc] Hemojuvelin (Hemochromatosis type 2 protein homolog) (Hemojuvelin BMP coreceptor) (RGM domain family member C)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[GREM1 CKTSF1B1 DAND2 DRM PIG2] Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[bmp3] Bone morphogenetic protein 3 (BMP-3) (xBMP-3)
[gdf10 bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (xBMP-3B)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
[SMAD4 DPC4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
[Smad4 Dpc4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
[BMP15] Bone morphogenetic protein 15 (BMP-15)
[SMAD4 MADH4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Smad4 Madh4] Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4)
[Nanog Ecat4 Enk] Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
[spoIVA spoVP BSU22800] Stage IV sporulation protein A (EC 3.6.1.3) (Coat morphogenetic protein SpoIVA)
[GATA4] Transcription factor GATA-4 (GATA-binding factor 4)

Bibliography :
[31900800] Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary.
[31675487] Transcriptomic features of trophoblast lineage cells derived from human induced pluripotent stem cells treated with BMP 4.
[31531741] Inhibition of bone morphogenetic protein signaling reduces viability, growth and migratory potential of non-small cell lung carcinoma cells.
[31452178] Effects of Different Therapeutic Radiation Doses on the Development of Neural Tube Defects in Chick Embryos and the Correlation with Bone Morphogenetic Protein 4 and 7 Expression Levels.
[31418391] [Influence of BMP4 on Regulation of Cell Cycle and Apoptosis of Hematopoietic Stem Cells/Progenitor Cells and Its Mechanism in Chemotherapy-Induced Myelosuppression].
[31394504] Crosstalk of BMP-4 and RA signaling pathways on Pomc gene regulation in corticotrophs.
[31345353] Strontium stimulates alkaline phosphatase and bone morphogenetic protein-4 expression in rat chondrocytes cultured in vitro.
[31284378] CCN3 Facilitates Runx2 and Osterix Expression by Inhibiting miR-608 through PI3K/Akt Signaling in Osteoblasts.
[31258657] Expression of BMP-4 and Smad1 in patients with Hirschsprung disease and its clinical significance.
[31120854] Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling.