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Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)

 BMP4_HUMAN              Reviewed;         408 AA.
P12644; Q9UM80;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
12-AUG-2020, entry version 218.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
AltName: Full=Bone morphogenetic protein 2B;
Short=BMP-2B;
Flags: Precursor;
Name=BMP4; Synonyms=BMP2B, DVR4;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3201241; DOI=10.1126/science.3201241;
Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J.,
Kriz R.W., Hewick R.M., Wang E.A.;
"Novel regulators of bone formation: molecular clones and activities.";
Science 242:1528-1534(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-152.
PubMed=9701626; DOI=10.1007/s002239900518;
Shore E.M., Xu M., Shah P.B., Janoff H.B., Hahn G.V., Deardorff M.A.,
Sovinsky L., Spinner N.B., Zasloff M.A., Wozney J.M., Kaplan F.S.;
"The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure
and transcriptional regulation.";
Calcif. Tissue Int. 63:221-229(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-152.
TISSUE=Duodenum;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 7-408.
TISSUE=Placenta;
PubMed=7579580; DOI=10.3109/10425179509030980;
Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S.;
"Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human
placental cDNA library.";
DNA Seq. 5:273-275(1995).
[5]
INTERACTION WITH SOSTDC1.
PubMed=15020244; DOI=10.1016/j.bbrc.2004.02.075;
Yanagita M., Oka M., Watabe T., Iguchi H., Niida A., Takahashi S.,
Akiyama T., Miyazono K., Yanagisawa M., Sakurai T.;
"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in
the kidney.";
Biochem. Biophys. Res. Commun. 316:490-500(2004).
[6]
INTERACTION WITH FBN1 AND FBN2.
PubMed=18339631; DOI=10.1074/jbc.m707820200;
Sengle G., Charbonneau N.L., Ono R.N., Sasaki T., Alvarez J., Keene D.R.,
Baechinger H.P., Sakai L.Y.;
"Targeting of bone morphogenetic protein growth factor complexes to
fibrillin.";
J. Biol. Chem. 283:13874-13888(2008).
[7]
PHOSPHORYLATION AT SER-91.
PubMed=26091039; DOI=10.1016/j.cell.2015.05.028;
Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J.,
Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N.,
Pinna L.A., Pagliarini D.J., Dixon J.E.;
"A single kinase generates the majority of the secreted phosphoproteome.";
Cell 161:1619-1632(2015).
[8]
VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367.
PubMed=12404109; DOI=10.1038/sj.ejhg.5200875;
Felder B., Stegmann K., Schultealbert A., Geller F., Strehl E., Ermert A.,
Koch M.C.;
"Evaluation of BMP4 and its specific inhibitor NOG as candidates in human
neural tube defects (NTDs).";
Eur. J. Hum. Genet. 10:753-756(2002).
[9]
VARIANT MCOPS6 GLY-93.
PubMed=18252212; DOI=10.1016/j.ajhg.2007.09.023;
Bakrania P., Efthymiou M., Klein J.C., Salt A., Bunyan D.J., Wyatt A.,
Ponting C.P., Martin A., Williams S., Lindley V., Gilmore J., Restori M.,
Robson A.G., Neveu M.M., Holder G.E., Collin J.R.O., Robinson D.O.,
Farndon P., Johansen-Berg H., Gerrelli D., Ragge N.K.;
"Mutations in BMP4 cause eye, brain, and digit developmental anomalies:
overlap between the BMP4 and hedgehog signaling pathways.";
Am. J. Hum. Genet. 82d:304-319(2008).
[10]
VARIANTS CYS-91; SER-116 AND LYS-150.
PubMed=18305125; DOI=10.1681/asn.2006111282;
Weber S., Taylor J.C., Winyard P., Baker K.F., Sullivan-Brown J.,
Schild R., Knueppel T., Zurowska A.M., Caldas-Alfonso A., Litwin M.,
Emre S., Ghiggeri G.M., Bakkaloglu A., Mehls O., Antignac C., Schaefer F.,
Burdine R.D.;
"SIX2 and BMP4 mutations associate with anomalous kidney development.";
J. Am. Soc. Nephrol. 19:891-903(2008).
[11]
VARIANTS OFC11 CYS-91; GLN-162; HIS-287 AND VAL-346, AND VARIANTS ALA-102;
ALA-152 AND ALA-168.
PubMed=19249007; DOI=10.1016/j.ajhg.2009.02.002;
Suzuki S., Marazita M.L., Cooper M.E., Miwa N., Hing A., Jugessur A.,
Natsume N., Shimozato K., Ohbayashi N., Suzuki Y., Niimi T., Minami K.,
Yamamoto M., Altannamar T.J., Erkhembaatar T., Furukawa H.,
Daack-Hirsch S., L'heureux J., Brandon C.A., Weinberg S.M., Neiswanger K.,
Deleyiannis F.W., de Salamanca J.E., Vieira A.R., Lidral A.C., Martin J.F.,
Murray J.C.;
"Mutations in BMP4 are associated with subepithelial, microform, and overt
cleft lip.";
Am. J. Hum. Genet. 84:406-411(2009).
-!- FUNCTION: Induces cartilage and bone formation. Also acts in mesoderm
induction, tooth development, limb formation and fracture repair. Acts
in concert with PTHLH/PTHRP to stimulate ductal outgrowth during
embryonic mammary development and to inhibit hair follicle induction
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts with
GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with
the serine proteases, HTRA1 and HTRA3; the interaction with either
inhibits BMP4-mediated signaling. The HTRA protease activity is
required for this inhibition (By similarity). Interacts with SOSTDC1.
Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).
{ECO:0000250|UniProtKB:P21275, ECO:0000269|PubMed:15020244,
ECO:0000269|PubMed:18339631}.
-!- INTERACTION:
P12644; P36894: BMPR1A; NbExp=2; IntAct=EBI-1998134, EBI-1029237;
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix.
-!- TISSUE SPECIFICITY: Expressed in the lung and lower levels seen in the
kidney. Present also in normal and neoplastic prostate tissues, and
prostate cancer cell lines.
-!- DISEASE: Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932]: A disease
characterized by microphthalmia/anophthalmia associated with facial,
genital, skeletal, neurologic and endocrine anomalies. Microphthalmia
is a disorder of eye formation, ranging from small size of a single eye
to complete bilateral absence of ocular tissues (anophthalmia). In many
cases, microphthalmia/anophthalmia occurs in association with syndromes
that include non-ocular abnormalities. {ECO:0000269|PubMed:18252212}.
Note=The disease is caused by mutations affecting the gene represented
in this entry.
-!- DISEASE: Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625]: A birth
defect consisting of cleft lips with or without cleft palate. Cleft
lips are associated with cleft palate in two-third of cases. A cleft
lip can occur on one or both sides and range in severity from a simple
notch in the upper lip to a complete opening in the lip extending into
the floor of the nostril and involving the upper gum.
{ECO:0000269|PubMed:19249007}. Note=The disease is caused by mutations
affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=Bone morphogenetic protein 4 entry;
URL="https://en.wikipedia.org/wiki/Bone_morphogenetic_protein_4";
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/BMP4ID811ch14q22.html";
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EMBL; M22490; AAA51835.1; -; mRNA.
EMBL; U43842; AAC72278.1; -; Genomic_DNA.
EMBL; BC020546; AAH20546.1; -; mRNA.
EMBL; D30751; BAA06410.1; -; mRNA.
CCDS; CCDS9715.1; -.
PIR; C37278; BMHU4.
RefSeq; NP_001193.2; NM_001202.5.
RefSeq; NP_001334843.1; NM_001347914.1.
RefSeq; NP_001334845.1; NM_001347916.1.
RefSeq; NP_570911.2; NM_130850.4.
RefSeq; NP_570912.2; NM_130851.3.
BioGRID; 107120; 93.
CORUM; P12644; -.
DIP; DIP-5795N; -.
ELM; P12644; -.
IntAct; P12644; 19.
MINT; P12644; -.
STRING; 9606.ENSP00000245451; -.
BindingDB; P12644; -.
ChEMBL; CHEMBL5350; -.
DrugBank; DB01373; Calcium.
GlyGen; P12644; 4 sites.
iPTMnet; P12644; -.
PhosphoSitePlus; P12644; -.
BioMuta; BMP4; -.
DMDM; 115073; -.
jPOST; P12644; -.
MassIVE; P12644; -.
PaxDb; P12644; -.
PeptideAtlas; P12644; -.
PRIDE; P12644; -.
ProteomicsDB; 52861; -.
Antibodypedia; 3485; 814 antibodies.
DNASU; 652; -.
Ensembl; ENST00000245451; ENSP00000245451; ENSG00000125378.
Ensembl; ENST00000417573; ENSP00000394165; ENSG00000125378.
Ensembl; ENST00000558984; ENSP00000454134; ENSG00000125378.
Ensembl; ENST00000559087; ENSP00000453485; ENSG00000125378.
GeneID; 652; -.
KEGG; hsa:652; -.
CTD; 652; -.
DisGeNET; 652; -.
EuPathDB; HostDB:ENSG00000125378.15; -.
GeneCards; BMP4; -.
GeneReviews; BMP4; -.
HGNC; HGNC:1071; BMP4.
HPA; ENSG00000125378; Tissue enhanced (retina).
MalaCards; BMP4; -.
MIM; 112262; gene.
MIM; 600625; phenotype.
MIM; 607932; phenotype.
neXtProt; NX_P12644; -.
OpenTargets; ENSG00000125378; -.
Orphanet; 199306; Cleft lip/palate.
Orphanet; 139471; Microphthalmia with brain and digit anomalies.
Orphanet; 93100; Renal agenesis, unilateral.
PharmGKB; PA25381; -.
eggNOG; KOG3900; Eukaryota.
GeneTree; ENSGT00940000159502; -.
HOGENOM; CLU_020515_4_2_1; -.
InParanoid; P12644; -.
KO; K04662; -.
OMA; REKQPNH; -.
OrthoDB; 962484at2759; -.
PhylomeDB; P12644; -.
TreeFam; TF351789; -.
PathwayCommons; P12644; -.
Reactome; R-HSA-2129379; Molecules associated with elastic fibres.
Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-HSA-8957275; Post-translational protein phosphorylation.
SignaLink; P12644; -.
SIGNOR; P12644; -.
BioGRID-ORCS; 652; 6 hits in 873 CRISPR screens.
ChiTaRS; BMP4; human.
GeneWiki; Bone_morphogenetic_protein_4; -.
GenomeRNAi; 652; -.
Pharos; P12644; Tchem.
PRO; PR:P12644; -.
Proteomes; UP000005640; Chromosome 14.
RNAct; P12644; protein.
Bgee; ENSG00000125378; Expressed in pigmented layer of retina and 159 other tissues.
ExpressionAtlas; P12644; baseline and differential.
Genevisible; P12644; HS.
GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO; GO:0070700; F:BMP receptor binding; IDA:MGI.
GO; GO:0042056; F:chemoattractant activity; IDA:UniProtKB.
GO; GO:0039706; F:co-receptor binding; IPI:BHF-UCL.
GO; GO:0005125; F:cytokine activity; IDA:MGI.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0000186; P:activation of MAPKK activity; IDA:UniProtKB.
GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; ISS:BHF-UCL.
GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IDA:BHF-UCL.
GO; GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; ISS:BHF-UCL.
GO; GO:0003130; P:BMP signaling pathway involved in heart induction; IMP:BHF-UCL.
GO; GO:0071893; P:BMP signaling pathway involved in nephric duct formation; IDA:UniProtKB.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; ISS:UniProtKB.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; ISS:UniProtKB.
GO; GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IDA:UniProtKB.
GO; GO:0060433; P:bronchus development; IDA:MGI.
GO; GO:0060503; P:bud dilation involved in lung branching; IDA:MGI.
GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0003279; P:cardiac septum development; TAS:BHF-UCL.
GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO; GO:0071773; P:cellular response to BMP stimulus; IMP:BHF-UCL.
GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; IDA:UniProtKB.
GO; GO:0060976; P:coronary vasculature development; ISS:BHF-UCL.
GO; GO:0060363; P:cranial suture morphogenesis; IEA:Ensembl.
GO; GO:0035993; P:deltoid tuberosity development; ISS:UniProtKB.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003197; P:endocardial cushion development; ISS:BHF-UCL.
GO; GO:0001958; P:endochondral ossification; ISS:UniProtKB.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IDA:MGI.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IDA:MGI.
GO; GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0007281; P:germ cell development; IEA:Ensembl.
GO; GO:0072104; P:glomerular capillary formation; ISS:UniProtKB.
GO; GO:0072015; P:glomerular visceral epithelial cell development; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IDA:UniProtKB.
GO; GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl.
GO; GO:0048392; P:intermediate mesodermal cell differentiation; IDA:UniProtKB.
GO; GO:0001822; P:kidney development; IMP:UniProtKB.
GO; GO:0060235; P:lens induction in camera-type eye; IEA:Ensembl.
GO; GO:0048286; P:lung alveolus development; IDA:MGI.
GO; GO:0060425; P:lung morphogenesis; IDA:MGI.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IMP:BHF-UCL.
GO; GO:0030225; P:macrophage differentiation; IDA:DFLAT.
GO; GO:0060592; P:mammary gland formation; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; ISS:BHF-UCL.
GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Ensembl.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Ensembl.
GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IDA:UniProtKB.
GO; GO:0007500; P:mesodermal cell fate determination; IEA:Ensembl.
GO; GO:0001823; P:mesonephros development; IEP:UniProtKB.
GO; GO:0072205; P:metanephric collecting duct development; ISS:UniProtKB.
GO; GO:0030224; P:monocyte differentiation; IDA:DFLAT.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
GO; GO:0072097; P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; IDA:UniProtKB.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; IDA:HGNC-UCL.
GO; GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:MGI.
GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; IMP:BHF-UCL.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISS:BHF-UCL.
GO; GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
GO; GO:0090194; P:negative regulation of glomerulus development; IDA:UniProtKB.
GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; IMP:BHF-UCL.
GO; GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.
GO; GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; IDA:UniProtKB.
GO; GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; IDA:UniProtKB.
GO; GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; IDA:UniProtKB.
GO; GO:0045839; P:negative regulation of mitotic nuclear division; IDA:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IDA:MGI.
GO; GO:0042326; P:negative regulation of phosphorylation; IDA:UniProtKB.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0045843; P:negative regulation of striated muscle tissue development; IDA:MGI.
GO; GO:0033085; P:negative regulation of T cell differentiation in thymus; IMP:BHF-UCL.
GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; IMP:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0042476; P:odontogenesis; IGI:UniProtKB.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IDA:BHF-UCL.
GO; GO:0003148; P:outflow tract septum morphogenesis; ISS:BHF-UCL.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; ISS:BHF-UCL.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
GO; GO:0030501; P:positive regulation of bone mineralization; IDA:UniProtKB.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; ISS:UniProtKB.
GO; GO:0055020; P:positive regulation of cardiac muscle fiber development; IMP:BHF-UCL.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061036; P:positive regulation of cartilage development; IDA:MGI.
GO; GO:0010942; P:positive regulation of cell death; IDA:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:BHF-UCL.
GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; ISS:BHF-UCL.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:BHF-UCL.
GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IDA:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:UniProtKB.
GO; GO:0045606; P:positive regulation of epidermal cell differentiation; IDA:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:BHF-UCL.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IDA:BHF-UCL.
GO; GO:0090184; P:positive regulation of kidney development; IDA:UniProtKB.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045778; P:positive regulation of ossification; IDA:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:BHF-UCL.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; IDA:BHF-UCL.
GO; GO:0032092; P:positive regulation of protein binding; IDA:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI.
GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IDA:BHF-UCL.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0009791; P:post-embryonic development; IDA:MGI.
GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
GO; GO:0034504; P:protein localization to nucleus; IDA:UniProtKB.
GO; GO:0061155; P:pulmonary artery endothelial tube morphogenesis; IDA:UniProtKB.
GO; GO:0003184; P:pulmonary valve morphogenesis; ISS:BHF-UCL.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0010453; P:regulation of cell fate commitment; IDA:UniProtKB.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
GO; GO:0042306; P:regulation of protein import into nucleus; IDA:MGI.
GO; GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
GO; GO:0003139; P:secondary heart field specification; IMP:BHF-UCL.
GO; GO:0060395; P:SMAD protein signal transduction; IDA:UniProtKB.
GO; GO:0048745; P:smooth muscle tissue development; IEP:UniProtKB.
GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
GO; GO:0072101; P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; IDA:UniProtKB.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; IMP:UniProtKB.
GO; GO:0021537; P:telencephalon development; IDA:MGI.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0035990; P:tendon cell differentiation; ISS:UniProtKB.
GO; GO:0060438; P:trachea development; IDA:MGI.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
GO; GO:0003323; P:type B pancreatic cell development; IDA:BHF-UCL.
GO; GO:0072192; P:ureter epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; ISS:UniProtKB.
GO; GO:0001657; P:ureteric bud development; IDA:MGI.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
Developmental protein; Differentiation; Disease mutation; Disulfide bond;
Extracellular matrix; Glycoprotein; Growth factor; Microphthalmia;
Osteogenesis; Phosphoprotein; Polymorphism; Reference proteome; Secreted;
Signal.
SIGNAL 1..19
/evidence="ECO:0000255"
PROPEP 20..292
/id="PRO_0000033856"
CHAIN 293..408
/note="Bone morphogenetic protein 4"
/id="PRO_0000033857"
MOD_RES 91
/note="Phosphoserine; by FAM20C"
/evidence="ECO:0000269|PubMed:26091039"
CARBOHYD 143
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 208
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 350
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 365
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 308..373
/evidence="ECO:0000250"
DISULFID 337..405
/evidence="ECO:0000250"
DISULFID 341..407
/evidence="ECO:0000250"
DISULFID 372
/note="Interchain"
/evidence="ECO:0000250"
VARIANT 91
/note="S -> C (in OFC11; also found in renal hypodysplasia
patients; dbSNP:rs121912767)"
/evidence="ECO:0000269|PubMed:12404109,
ECO:0000269|PubMed:18305125, ECO:0000269|PubMed:19249007"
/id="VAR_043531"
VARIANT 93
/note="E -> G (in MCOPS6; dbSNP:rs121912765)"
/evidence="ECO:0000269|PubMed:18252212"
/id="VAR_043532"
VARIANT 102
/note="T -> A (in dbSNP:rs202159001)"
/evidence="ECO:0000269|PubMed:19249007"
/id="VAR_058314"
VARIANT 116
/note="T -> S (in a renal hypodysplasia patient;
dbSNP:rs750427266)"
/evidence="ECO:0000269|PubMed:18305125"
/id="VAR_043533"
VARIANT 150
/note="N -> K (in a renal hypodysplasia patient;
dbSNP:rs767216159)"
/evidence="ECO:0000269|PubMed:18305125"
/id="VAR_043534"
VARIANT 152
/note="V -> A (in dbSNP:rs17563)"
/evidence="ECO:0000269|PubMed:12404109,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:19249007,
ECO:0000269|PubMed:9701626"
/id="VAR_016174"
VARIANT 162
/note="R -> Q (in OFC11; dbSNP:rs770493925)"
/evidence="ECO:0000269|PubMed:19249007"
/id="VAR_058315"
VARIANT 168
/note="G -> A"
/evidence="ECO:0000269|PubMed:19249007"
/id="VAR_058316"
VARIANT 225
/note="T -> A (in dbSNP:rs144556455)"
/evidence="ECO:0000269|PubMed:12404109"
/id="VAR_043535"
VARIANT 226
/note="R -> W (in dbSNP:rs140590144)"
/evidence="ECO:0000269|PubMed:12404109"
/id="VAR_043536"
VARIANT 287
/note="R -> H (in OFC11; dbSNP:rs121912768)"
/evidence="ECO:0000269|PubMed:19249007"
/id="VAR_058317"
VARIANT 346
/note="A -> V (in OFC11; dbSNP:rs121912766)"
/evidence="ECO:0000269|PubMed:19249007"
/id="VAR_058318"
VARIANT 367
/note="S -> T (in dbSNP:rs1320581580)"
/evidence="ECO:0000269|PubMed:12404109"
/id="VAR_043537"
SEQUENCE 408 AA; 46555 MW; 79B01179DBB98204 CRC64;
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR


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024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg
Pathways :
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1616: ABC transporters
WP2199: Seed Development
WP1685: Peptidoglycan biosynthesis
WP1692: Protein export
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP1657: Glycerolipid metabolism
WP2324: AGE/RAGE pathway
WP1700: Selenoamino acid metabolism
WP1888: Post-translational protein modification
WP1663: Homologous recombination
WP35: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways

Related Genes :
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[GDF6 BMP13 GDF16] Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
[bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[GDF10 BMP3B] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7] Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.354) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
[ZMYND11 BRAM1 BS69] Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[ACVR2B] Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
[Sh3pxd2b Fad49 Tks4] SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Acvr2b] Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)

Bibliography :
[8358941] Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma.