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Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)

 BMP4_RAT                Reviewed;         408 AA.
Q06826;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
12-AUG-2020, entry version 140.
RecName: Full=Bone morphogenetic protein 4;
Short=BMP-4;
AltName: Full=Bone morphogenetic protein 2B;
Short=BMP-2B;
Flags: Precursor;
Name=Bmp4; Synonyms=Bmp-4, Dvr-4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8373807; DOI=10.1016/0167-4781(93)90200-w;
Chen D., Feng J.Q., Feng M., Harris M.A., Mundy G.R., Harris S.E.;
"Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat
calvarial cell.";
Biochim. Biophys. Acta 1174:289-292(1993).
-!- FUNCTION: Induces cartilage and bone formation. Acts in concert with
PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary
development and to inhibit hair follicle induction (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homodimer; disulfide-linked. Interacts with SOSTDC1, GREM2,
RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD.
Interacts with the serine proteases, HTRA1 and HTRA3; the interaction
with either inhibits BMP4-mediated signaling. The HTRA protease
activity is required for this inhibition. Interacts with FBN1 (via N-
terminal domain) and FBN2. {ECO:0000250|UniProtKB:P12644,
ECO:0000250|UniProtKB:P21275}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; Z22607; CAA80329.1; -; mRNA.
PIR; S38343; S38343.
STRING; 10116.ENSRNOP00000012957; -.
GlyGen; Q06826; 4 sites.
PhosphoSitePlus; Q06826; -.
PaxDb; Q06826; -.
PRIDE; Q06826; -.
UCSC; RGD:2213; rat.
RGD; 2213; Bmp4.
eggNOG; KOG3900; Eukaryota.
InParanoid; Q06826; -.
PhylomeDB; Q06826; -.
Reactome; R-RNO-2129379; Molecules associated with elastic fibres.
Reactome; R-RNO-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-RNO-8957275; Post-translational protein phosphorylation.
PRO; PR:Q06826; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005576; C:extracellular region; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0031982; C:vesicle; IDA:RGD.
GO; GO:0070700; F:BMP receptor binding; ISS:UniProtKB.
GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
GO; GO:0039706; F:co-receptor binding; ISO:RGD.
GO; GO:0005125; F:cytokine activity; ISO:RGD.
GO; GO:0008083; F:growth factor activity; IDA:RGD.
GO; GO:0008201; F:heparin binding; ISO:RGD.
GO; GO:0042802; F:identical protein binding; IPI:RGD.
GO; GO:0000186; P:activation of MAPKK activity; ISS:UniProtKB.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISO:RGD.
GO; GO:0060033; P:anatomical structure regression; IEP:RGD.
GO; GO:0001525; P:angiogenesis; ISO:RGD.
GO; GO:0009948; P:anterior/posterior axis specification; ISO:RGD.
GO; GO:0003180; P:aortic valve morphogenesis; ISO:RGD.
GO; GO:0001568; P:blood vessel development; ISO:RGD.
GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; ISO:RGD.
GO; GO:0003130; P:BMP signaling pathway involved in heart induction; ISS:UniProtKB.
GO; GO:0071893; P:BMP signaling pathway involved in nephric duct formation; ISS:UniProtKB.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; ISS:UniProtKB.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; ISS:UniProtKB.
GO; GO:0060348; P:bone development; ISO:RGD.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0060442; P:branching involved in prostate gland morphogenesis; ISO:RGD.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; ISS:UniProtKB.
GO; GO:0060433; P:bronchus development; ISO:RGD.
GO; GO:0060503; P:bud dilation involved in lung branching; ISO:RGD.
GO; GO:0060449; P:bud elongation involved in lung branching; ISO:RGD.
GO; GO:0043010; P:camera-type eye development; ISO:RGD.
GO; GO:0048593; P:camera-type eye morphogenesis; ISO:RGD.
GO; GO:0055007; P:cardiac muscle cell differentiation; ISO:RGD.
GO; GO:0045165; P:cell fate commitment; ISO:RGD.
GO; GO:0008283; P:cell population proliferation; NAS:RGD.
GO; GO:0071773; P:cellular response to BMP stimulus; IEP:RGD.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IDA:UniProtKB.
GO; GO:0071363; P:cellular response to growth factor stimulus; ISO:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
GO; GO:0034599; P:cellular response to oxidative stress; IDA:RGD.
GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:RGD.
GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
GO; GO:0060197; P:cloacal septation; ISO:RGD.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0060976; P:coronary vasculature development; ISO:RGD.
GO; GO:0060363; P:cranial suture morphogenesis; ISO:RGD.
GO; GO:0035993; P:deltoid tuberosity development; ISS:UniProtKB.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; ISO:RGD.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISO:RGD.
GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
GO; GO:0048598; P:embryonic morphogenesis; ISO:RGD.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISO:RGD.
GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
GO; GO:0003197; P:endocardial cushion development; ISO:RGD.
GO; GO:0001958; P:endochondral ossification; ISS:UniProtKB.
GO; GO:0007492; P:endoderm development; ISO:RGD.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; ISO:RGD.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEP:RGD.
GO; GO:0060684; P:epithelial-mesenchymal cell signaling; ISO:RGD.
GO; GO:0060429; P:epithelium development; ISO:RGD.
GO; GO:0030218; P:erythrocyte differentiation; ISO:RGD.
GO; GO:0030900; P:forebrain development; ISO:RGD.
GO; GO:0007281; P:germ cell development; ISO:RGD.
GO; GO:0072104; P:glomerular capillary formation; ISS:UniProtKB.
GO; GO:0072015; P:glomerular visceral epithelial cell development; ISO:RGD.
GO; GO:0007507; P:heart development; ISO:RGD.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0060113; P:inner ear receptor cell differentiation; ISO:RGD.
GO; GO:0048392; P:intermediate mesodermal cell differentiation; ISS:UniProtKB.
GO; GO:0001822; P:kidney development; ISS:UniProtKB.
GO; GO:0060235; P:lens induction in camera-type eye; ISO:RGD.
GO; GO:0048286; P:lung alveolus development; ISO:RGD.
GO; GO:0030324; P:lung development; ISO:RGD.
GO; GO:0060462; P:lung lobe development; IEP:RGD.
GO; GO:0060425; P:lung morphogenesis; ISO:RGD.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0030225; P:macrophage differentiation; ISO:RGD.
GO; GO:0060592; P:mammary gland formation; ISO:RGD.
GO; GO:0003149; P:membranous septum morphogenesis; ISO:RGD.
GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; ISO:RGD.
GO; GO:2001012; P:mesenchymal cell differentiation involved in renal system development; ISO:RGD.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; ISO:RGD.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; ISO:RGD.
GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; ISS:UniProtKB.
GO; GO:0007498; P:mesoderm development; NAS:RGD.
GO; GO:0001707; P:mesoderm formation; ISO:RGD.
GO; GO:0048333; P:mesodermal cell differentiation; ISO:RGD.
GO; GO:0007500; P:mesodermal cell fate determination; ISO:RGD.
GO; GO:0001823; P:mesonephros development; ISS:UniProtKB.
GO; GO:0072205; P:metanephric collecting duct development; ISS:UniProtKB.
GO; GO:0001656; P:metanephros development; ISO:RGD.
GO; GO:0030224; P:monocyte differentiation; ISO:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0072097; P:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; ISS:UniProtKB.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
GO; GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; ISS:UniProtKB.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; ISO:RGD.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
GO; GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; ISS:UniProtKB.
GO; GO:0090194; P:negative regulation of glomerulus development; ISS:UniProtKB.
GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; ISS:UniProtKB.
GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0072200; P:negative regulation of mesenchymal cell proliferation involved in ureter development; ISS:UniProtKB.
GO; GO:2000007; P:negative regulation of metanephric comma-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:2000005; P:negative regulation of metanephric S-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:0045839; P:negative regulation of mitotic nuclear division; ISS:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; ISO:RGD.
GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:RGD.
GO; GO:0042326; P:negative regulation of phosphorylation; ISS:UniProtKB.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; ISO:RGD.
GO; GO:0060686; P:negative regulation of prostatic bud formation; ISO:RGD.
GO; GO:0045843; P:negative regulation of striated muscle tissue development; ISO:RGD.
GO; GO:0033085; P:negative regulation of T cell differentiation in thymus; ISO:RGD.
GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0001843; P:neural tube closure; ISO:RGD.
GO; GO:0048663; P:neuron fate commitment; ISO:RGD.
GO; GO:0042476; P:odontogenesis; IEP:RGD.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; ISO:RGD.
GO; GO:0001759; P:organ induction; ISO:RGD.
GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
GO; GO:0003151; P:outflow tract morphogenesis; ISO:RGD.
GO; GO:0003148; P:outflow tract septum morphogenesis; ISO:RGD.
GO; GO:0001541; P:ovarian follicle development; IMP:RGD.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; ISO:RGD.
GO; GO:0021983; P:pituitary gland development; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
GO; GO:0030501; P:positive regulation of bone mineralization; IDA:RGD.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; ISS:UniProtKB.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; IMP:RGD.
GO; GO:0055020; P:positive regulation of cardiac muscle fiber development; ISS:UniProtKB.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; ISO:RGD.
GO; GO:0061036; P:positive regulation of cartilage development; ISO:RGD.
GO; GO:0010942; P:positive regulation of cell death; ISO:RGD.
GO; GO:0045597; P:positive regulation of cell differentiation; ISO:RGD.
GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; ISO:RGD.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:UniProtKB.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IMP:RGD.
GO; GO:0045603; P:positive regulation of endothelial cell differentiation; ISO:RGD.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0045606; P:positive regulation of epidermal cell differentiation; ISS:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:BHF-UCL.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:RGD.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0070368; P:positive regulation of hepatocyte differentiation; IMP:RGD.
GO; GO:0090184; P:positive regulation of kidney development; ISS:UniProtKB.
GO; GO:1902462; P:positive regulation of mesenchymal stem cell proliferation; IMP:RGD.
GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:RGD.
GO; GO:0010976; P:positive regulation of neuron projection development; IDA:RGD.
GO; GO:0045778; P:positive regulation of ossification; IDA:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:RGD.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; ISO:RGD.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; ISO:RGD.
GO; GO:0032092; P:positive regulation of protein binding; ISO:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISS:UniProtKB.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:1901341; P:positive regulation of store-operated calcium channel activity; IMP:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0009791; P:post-embryonic development; ISO:RGD.
GO; GO:0060512; P:prostate gland morphogenesis; ISO:RGD.
GO; GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
GO; GO:0061155; P:pulmonary artery endothelial tube morphogenesis; ISS:UniProtKB.
GO; GO:0003184; P:pulmonary valve morphogenesis; ISO:RGD.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; ISO:RGD.
GO; GO:0061035; P:regulation of cartilage development; ISO:RGD.
GO; GO:0045595; P:regulation of cell differentiation; IDA:RGD.
GO; GO:0010453; P:regulation of cell fate commitment; ISS:UniProtKB.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IDA:RGD.
GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
GO; GO:0060688; P:regulation of morphogenesis of a branching structure; ISO:RGD.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; ISO:RGD.
GO; GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0042306; P:regulation of protein import into nucleus; ISO:RGD.
GO; GO:0051150; P:regulation of smooth muscle cell differentiation; ISO:RGD.
GO; GO:0048660; P:regulation of smooth muscle cell proliferation; ISO:RGD.
GO; GO:0003014; P:renal system process; ISO:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
GO; GO:0071731; P:response to nitric oxide; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0032526; P:response to retinoic acid; IEP:RGD.
GO; GO:0033574; P:response to testosterone; IEP:RGD.
GO; GO:0060041; P:retina development in camera-type eye; IEP:RGD.
GO; GO:0003139; P:secondary heart field specification; ISS:UniProtKB.
GO; GO:0001501; P:skeletal system development; ISO:RGD.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
GO; GO:0051145; P:smooth muscle cell differentiation; ISO:RGD.
GO; GO:0048745; P:smooth muscle tissue development; ISS:UniProtKB.
GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
GO; GO:0010159; P:specification of animal organ position; ISO:RGD.
GO; GO:0072101; P:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; ISS:UniProtKB.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; ISS:UniProtKB.
GO; GO:0021537; P:telencephalon development; ISO:RGD.
GO; GO:0021978; P:telencephalon regionalization; ISO:RGD.
GO; GO:0035990; P:tendon cell differentiation; ISS:UniProtKB.
GO; GO:0009888; P:tissue development; ISO:RGD.
GO; GO:0043587; P:tongue morphogenesis; IEP:RGD.
GO; GO:0060438; P:trachea development; ISO:RGD.
GO; GO:0060440; P:trachea formation; ISO:RGD.
GO; GO:0003323; P:type B pancreatic cell development; ISS:UniProtKB.
GO; GO:0072192; P:ureter epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; ISS:UniProtKB.
GO; GO:0001657; P:ureteric bud development; ISO:RGD.
GO; GO:0001944; P:vasculature development; ISO:RGD.
GO; GO:0042060; P:wound healing; IEP:RGD.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
Developmental protein; Differentiation; Disulfide bond;
Extracellular matrix; Glycoprotein; Growth factor; Osteogenesis;
Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1..19
/evidence="ECO:0000255"
PROPEP 20..292
/id="PRO_0000033862"
CHAIN 293..408
/note="Bone morphogenetic protein 4"
/id="PRO_0000033863"
MOD_RES 91
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P12644"
CARBOHYD 144
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 209
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 350
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 365
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 308..373
/evidence="ECO:0000250"
DISULFID 337..405
/evidence="ECO:0000250"
DISULFID 341..407
/evidence="ECO:0000250"
DISULFID 372
/note="Interchain"
/evidence="ECO:0000250"
SEQUENCE 408 AA; 46541 MW; 61E92B4B8D5624F3 CRC64;
MIPGNRMLMV VLLCQVLLGG ATDASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS
FHHEEHLENI PGTSESSAFR FFFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN
IYEVMKPPAE MVPGHLITRL LDTRLVRHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT
HLHQTRTHQG QHVRISRSLP QGSGNWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR


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E0013h ELISA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
U0013h CLIA BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013h ELISA kit BMP2,BMP-2,BMP2A,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Homo sapiens,Human 96T
E0013m ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014m ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0013r CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
U0014r CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0014m ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
U0014m CLIA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Mouse,Mus musculus 96T
E0014r ELISA kit BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
E0013m ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0014r ELISA BMP-2B,Bmp4,BMP-4,Bmp-4,Bone morphogenetic protein 2B,Bone morphogenetic protein 4,Dvr-4,Rat,Rattus norvegicus 96T
U0013m CLIA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Mouse,Mus musculus 96T
E0013r ELISA Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
E0013r ELISA kit Bmp2,BMP-2,Bmp-2,BMP-2A,Bone morphogenetic protein 2,Bone morphogenetic protein 2A,Rat,Rattus norvegicus 96T
024-15071 Bone Morphogenetic Protein 13 (BMP 13), Human, recombinant Source Human bone morphogenetic protein 13 cDNA expressed in E.coli Appearance Lyophilized form with no additives (Sterile_filtered) Molecul 10ìg
Pathways :
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1616: ABC transporters
WP2199: Seed Development
WP1685: Peptidoglycan biosynthesis
WP1692: Protein export
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP1657: Glycerolipid metabolism
WP2324: AGE/RAGE pathway
WP1700: Selenoamino acid metabolism
WP1888: Post-translational protein modification
WP1663: Homologous recombination
WP35: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways

Related Genes :
[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[BMP2 BMP2A] Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
[Bmp8b] Bone morphogenetic protein 8B (BMP-8B)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[GDF6 BMP13 GDF16] Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
[bmp1] Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-)
[Gdf10 Bmp3b] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[GDF10 BMP3B] Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7] Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.354) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
[ZMYND11 BRAM1 BS69] Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[ACVR2B] Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
[Sh3pxd2b Fad49 Tks4] SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Acvr2b] Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)

Bibliography :
[8358941] Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma.