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Bone morphogenetic protein 4 (Bone morphogenetic protein 4, isoform CRA_a) (Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human)) (Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human))

 Q53XC5_HUMAN            Unreviewed;       408 AA.
Q53XC5;
24-MAY-2005, integrated into UniProtKB/TrEMBL.
24-MAY-2005, sequence version 1.
11-DEC-2019, entry version 128.
SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|EMBL:ACB21039.1};
SubName: Full=Bone morphogenetic protein 4, isoform CRA_a {ECO:0000313|EMBL:EAW80628.1};
SubName: Full=Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human) {ECO:0000313|EMBL:CAD61876.1};
SubName: Full=Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human) {ECO:0000313|EMBL:CAD61909.1};
Name=BMP4 {ECO:0000313|EMBL:ACB21039.1};
ORFNames=hCG_20967 {ECO:0000313|EMBL:EAW80628.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:CAD61909.1};
[1] {ECO:0000313|EMBL:EAW80628.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P.,
Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.,
Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J.,
Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J.,
McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C.,
Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M.,
Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C.,
Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K.,
Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P.,
Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y.,
Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N.,
Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B.,
Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J.,
Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W.,
Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S.,
Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T.,
Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I.,
Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L.,
Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L.,
Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C.,
Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C.,
Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D.,
McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B.,
Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S.,
Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S.,
Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R.,
Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B.,
Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S.,
Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S.,
Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J.,
Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M.,
Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S.,
Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M.,
Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J.,
Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J.,
Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N.,
Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:CAD61909.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Neuroblastoma {ECO:0000313|EMBL:CAD61876.1}, and
Placenta {ECO:0000313|EMBL:CAD61909.1};
Li W.B., Gruber C., Jessee J., Polayes D.;
"Full-length cDNA libraries and normalization.";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:CAD61909.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Neuroblastoma {ECO:0000313|EMBL:CAD61876.1}, and
Placenta {ECO:0000313|EMBL:CAD61909.1};
Genoscope;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:EAW80628.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:ACB21039.1}
NUCLEOTIDE SEQUENCE.
Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N.,
Rajkumar N., Willa H.T., Stanaway I.B., Nguyen C.P., Gildersleeve H.,
Johnson E.J., Swanson J.E., McFarland I., Park C., Nickerson D.A.;
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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EMBL; EU518936; ACB21039.1; -; Genomic_DNA.
EMBL; BX161385; CAD61876.1; -; mRNA.
EMBL; BX161438; CAD61909.1; -; mRNA.
EMBL; CH471061; EAW80628.1; -; Genomic_DNA.
EMBL; CH471061; EAW80629.1; -; Genomic_DNA.
EMBL; CH471061; EAW80630.1; -; Genomic_DNA.
EMBL; CH471061; EAW80631.1; -; Genomic_DNA.
RefSeq; NP_001193.2; NM_001202.5.
RefSeq; NP_001334843.1; NM_001347914.1.
RefSeq; NP_001334845.1; NM_001347916.1.
RefSeq; NP_570911.2; NM_130850.4.
RefSeq; NP_570912.2; NM_130851.3.
DNASU; 652; -.
GeneID; 652; -.
KEGG; hsa:652; -.
UCSC; uc001xal.6; human.
CTD; 652; -.
EuPathDB; HostDB:ENSG00000125378.15; -.
PharmGKB; PA25381; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
KO; K04662; -.
OMA; GFHHEEH; -.
OrthoDB; 962484at2759; -.
ChiTaRS; BMP4; human.
GenomeRNAi; 652; -.
Bgee; ENSG00000125378; Expressed in 144 organ(s), highest expression level in pigmented layer of retina.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; IEA:Ensembl.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; IEA:Ensembl.
GO; GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
GO; GO:0060363; P:cranial suture morphogenesis; IEA:Ensembl.
GO; GO:0035993; P:deltoid tuberosity development; IEA:Ensembl.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003197; P:endocardial cushion development; IEA:Ensembl.
GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0007281; P:germ cell development; IEA:Ensembl.
GO; GO:0072104; P:glomerular capillary formation; IEA:Ensembl.
GO; GO:0072015; P:glomerular visceral epithelial cell development; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO; GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl.
GO; GO:0060235; P:lens induction in camera-type eye; IEA:Ensembl.
GO; GO:0060592; P:mammary gland formation; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Ensembl.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Ensembl.
GO; GO:0007500; P:mesodermal cell fate determination; IEA:Ensembl.
GO; GO:0072205; P:metanephric collecting duct development; IEA:Ensembl.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001759; P:organ induction; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; IEA:Ensembl.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045778; P:positive regulation of ossification; IEA:Ensembl.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0048660; P:regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0035990; P:tendon cell differentiation; IEA:Ensembl.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
GO; GO:0072192; P:ureter epithelial cell differentiation; IEA:Ensembl.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085}; Secreted {ECO:0000256|SAAS:SAAS00473502};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..24
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 25..408
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5014309520"
DOMAIN 286..408
/note="TGF_BETA_2"
/evidence="ECO:0000259|PROSITE:PS51362"
REGION 283..307
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 408 AA; 46555 MW; 79B01179DBB98204 CRC64;
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR


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WP1700: Selenoamino acid metabolism
WP1657: Glycerolipid metabolism
WP2292: Chemokine signaling pathway
WP1663: Homologous recombination
WP2371: Parkinsons Disease Pathway
WP1888: Post-translational protein modification
WP1939: Unfolded Protein Response
WP1673: Naphthalene and anthracene degradation
WP1502: Mitochondrial biogenesis
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[BMP4 BMP2B DVR4] Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
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[BMPR1B] Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
[BMP7 OP1] Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
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[BMP15 GDF9B] Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B)
[RHOA ARH12 ARHA RHO12] Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
[ELANE ELA2] Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)
[SMAD1 BSP1 MADH1 MADR1] Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
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[RHOB ARH6 ARHB] Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
[RHOC ARH9 ARHC] Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
[SPP1 BNSP OPN PSEC0156] Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)
[ITGB1 FNRB MDF2 MSK12] Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
[NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2] Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)
[TCIRG1 ATP6N1C ATP6V0A3] V-type proton ATPase 116 kDa subunit a isoform 3 (V-ATPase 116 kDa isoform a3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)
[AKAP13 BRX HT31 LBC] A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)
[CCNDBP1 DIP1 GCIP HHM] Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid)
[TSC22D1 KIAA1994 TGFB1I4 TSC22 hucep-2] TSC22 domain family protein 1 (Cerebral protein 2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)
[BST2] Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)
[DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4] DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
[CTNNB1 CTNNB OK/SW-cl.35 PRO2286] Catenin beta-1 (Beta-catenin)
[DCN SLRR1B] Decorin (Bone proteoglycan II) (PG-S2) (PG40)
[HELLS PASG SMARCA6 Nbla10143] Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
[IGF2 PP1446] Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
[ALPL] Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)

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