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Bone morphogenetic protein 4 (Bone morphogenetic protein 4, isoform CRA_a) (Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human)) (Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human))

 Q53XC5_HUMAN            Unreviewed;       408 AA.
Q53XC5;
24-MAY-2005, integrated into UniProtKB/TrEMBL.
24-MAY-2005, sequence version 1.
16-JAN-2019, entry version 121.
SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|EMBL:ACB21039.1};
SubName: Full=Bone morphogenetic protein 4, isoform CRA_a {ECO:0000313|EMBL:EAW80628.1};
SubName: Full=Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human) {ECO:0000313|EMBL:CAD61876.1};
SubName: Full=Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human) {ECO:0000313|EMBL:CAD61909.1};
Name=BMP4 {ECO:0000313|EMBL:ACB21039.1};
ORFNames=hCG_20967 {ECO:0000313|EMBL:EAW80628.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:CAD61909.1};
[1] {ECO:0000313|EMBL:EAW80628.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:CAD61909.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Neuroblastoma {ECO:0000313|EMBL:CAD61876.1}, and
Placenta {ECO:0000313|EMBL:CAD61909.1};
Li W.B., Gruber C., Jessee J., Polayes D.;
"Full-length cDNA libraries and normalization.";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:CAD61909.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Neuroblastoma {ECO:0000313|EMBL:CAD61876.1}, and
Placenta {ECO:0000313|EMBL:CAD61909.1};
Genoscope;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:EAW80628.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:ACB21039.1}
NUCLEOTIDE SEQUENCE.
Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N.,
Rajkumar N., Willa H.T., Stanaway I.B., Nguyen C.P., Gildersleeve H.,
Johnson E.J., Swanson J.E., McFarland I., Park C., Nickerson D.A.;
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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EMBL; EU518936; ACB21039.1; -; Genomic_DNA.
EMBL; BX161385; CAD61876.1; -; mRNA.
EMBL; BX161438; CAD61909.1; -; mRNA.
EMBL; CH471061; EAW80628.1; -; Genomic_DNA.
EMBL; CH471061; EAW80629.1; -; Genomic_DNA.
EMBL; CH471061; EAW80630.1; -; Genomic_DNA.
EMBL; CH471061; EAW80631.1; -; Genomic_DNA.
RefSeq; NP_001193.2; NM_001202.5.
RefSeq; NP_001334843.1; NM_001347914.1.
RefSeq; NP_001334845.1; NM_001347916.1.
RefSeq; NP_570911.2; NM_130850.4.
RefSeq; NP_570912.2; NM_130851.3.
UniGene; Hs.68879; -.
DNASU; 652; -.
GeneID; 652; -.
KEGG; hsa:652; -.
UCSC; uc001xal.6; human.
CTD; 652; -.
EuPathDB; HostDB:ENSG00000125378.15; -.
PharmGKB; PA25381; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
HOVERGEN; HBG004860; -.
KO; K04662; -.
OMA; QGFHRIN; -.
OrthoDB; 962484at2759; -.
ChiTaRS; BMP4; human.
GenomeRNAi; 652; -.
Bgee; ENSG00000125378; Expressed in 144 organ(s), highest expression level in pigmented layer of retina.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0061151; P:BMP signaling pathway involved in renal system segmentation; IEA:Ensembl.
GO; GO:0061149; P:BMP signaling pathway involved in ureter morphogenesis; IEA:Ensembl.
GO; GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl.
GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
GO; GO:0060197; P:cloacal septation; IEA:Ensembl.
GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
GO; GO:0060363; P:cranial suture morphogenesis; IEA:Ensembl.
GO; GO:0035993; P:deltoid tuberosity development; IEA:Ensembl.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
GO; GO:0003197; P:endocardial cushion development; IEA:Ensembl.
GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0007281; P:germ cell development; IEA:Ensembl.
GO; GO:0072104; P:glomerular capillary formation; IEA:Ensembl.
GO; GO:0072015; P:glomerular visceral epithelial cell development; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO; GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl.
GO; GO:0060235; P:lens induction in camera-type eye; IEA:Ensembl.
GO; GO:0060592; P:mammary gland formation; IEA:Ensembl.
GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
GO; GO:0072161; P:mesenchymal cell differentiation involved in kidney development; IEA:Ensembl.
GO; GO:0072198; P:mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
GO; GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; IEA:Ensembl.
GO; GO:0007500; P:mesodermal cell fate determination; IEA:Ensembl.
GO; GO:0072205; P:metanephric collecting duct development; IEA:Ensembl.
GO; GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001759; P:organ induction; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0061047; P:positive regulation of branching involved in lung morphogenesis; IEA:Ensembl.
GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:1901964; P:positive regulation of cell proliferation involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045778; P:positive regulation of ossification; IEA:Ensembl.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Ensembl.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0048660; P:regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0035990; P:tendon cell differentiation; IEA:Ensembl.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
GO; GO:0072192; P:ureter epithelial cell differentiation; IEA:Ensembl.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085};
Secreted {ECO:0000256|SAAS:SAAS00516087};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 24 {ECO:0000256|SAM:SignalP}.
CHAIN 25 408 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014309520.
DOMAIN 286 408 TGF_BETA_2.
{ECO:0000259|PROSITE:PS51362}.
SEQUENCE 408 AA; 46555 MW; 79B01179DBB98204 CRC64;
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR


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