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Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)

 BCAR1_MOUSE             Reviewed;         874 AA.
Q61140; Q60869; Q6PFF9;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
13-FEB-2019, entry version 177.
RecName: Full=Breast cancer anti-estrogen resistance protein 1;
AltName: Full=CRK-associated substrate;
AltName: Full=p130cas;
Name=Bcar1; Synonyms=Cas, Crkas;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CAS-A AND CAS-B), AND INTERACTION
WITH PTK2/FAK1.
TISSUE=Embryo;
PubMed=7479864; DOI=10.1073/pnas.92.23.10678;
Polte T.R., Hanks S.K.;
"Interaction between focal adhesion kinase and Crk-associated tyrosine
kinase substrate p130Cas.";
Proc. Natl. Acad. Sci. U.S.A. 92:10678-10682(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Placenta;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH BCAR3.
PubMed=10438950;
Cai D., Clayton L.K., Smolyar A., Lerner A.;
"AND-34, a novel p130Cas-binding thymic stromal cell protein regulated
by adhesion and inflammatory cytokines.";
J. Immunol. 163:2104-2112(1999).
[5]
INTERACTION WITH NPHP1.
PubMed=10739664; DOI=10.1006/excr.2000.4822;
Donaldson J.C., Dempsey P.J., Reddy S., Bouton A.H., Coffey R.J.,
Hanks S.K.;
"Crk-associated substrate p130(Cas) interacts with nephrocystin and
both proteins localize to cell-cell contacts of polarized epithelial
cells.";
Exp. Cell Res. 256:168-178(2000).
[6]
INTERACTION WITH BCAR3.
PubMed=10896938; DOI=10.1074/jbc.M003074200;
Gotoh T., Cai D., Tian X., Feig L.A., Lerner A.;
"p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-
Ras guanine nucleotide exchange factor.";
J. Biol. Chem. 275:30118-30123(2000).
[7]
INTERACTION WITH SH2D3C.
PubMed=10692442; DOI=10.1074/jbc.275.9.6404;
Sakakibara A., Hattori S.;
"Chat, a Cas/HEF1-associated adaptor protein that integrates multiple
signaling pathways.";
J. Biol. Chem. 275:6404-6410(2000).
[8]
INTERACTION WITH SH2D3C.
TISSUE=Spleen;
PubMed=12486027; DOI=10.1074/jbc.M207942200;
Sakakibara A., Hattori S., Nakamura S., Katagiri T.;
"A novel hematopoietic adaptor protein, Chat-H, positively regulates T
cell receptor-mediated interleukin-2 production by Jurkat cells.";
J. Biol. Chem. 278:6012-6017(2003).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-132; TYR-366; TYR-376
AND TYR-414, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=15592455; DOI=10.1038/nbt1046;
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
Zha X.-M., Polakiewicz R.D., Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer
cells.";
Nat. Biotechnol. 23:94-101(2005).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-253, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
"Large scale localization of protein phosphorylation by use of
electron capture dissociation mass spectrometry.";
Mol. Cell. Proteomics 8:904-912(2009).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-238, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Heart, Lung, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Docking protein which plays a central coordinating role
for tyrosine kinase-based signaling related to cell adhesion.
Implicated in induction of cell migration (By similarity). Has
been shown to be essential in cardiovascular development during
embryogenesis. {ECO:0000250}.
-!- SUBUNIT: Forms complexes in vivo with PTK2/FAK1, adapter protein
CRKL and LYN kinase. Can heterodimerize with NEDD9. Interacts with
activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1 (By
similarity). Part of a collagen stimulated complex involved in
cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas (By
similarity). Interacts with BCAR3, the interaction regulates
adhesion-dependent serine phosphorylation. Interacts with NPHP1,
PTK2B/PYK2 and SH2D3C. {ECO:0000250, ECO:0000269|PubMed:10438950,
ECO:0000269|PubMed:10692442, ECO:0000269|PubMed:10739664,
ECO:0000269|PubMed:10896938, ECO:0000269|PubMed:12486027,
ECO:0000269|PubMed:7479864}.
-!- INTERACTION:
Q9QY53:Nphp1; NbExp=2; IntAct=EBI-77088, EBI-77230;
P34152:Ptk2; NbExp=3; IntAct=EBI-77088, EBI-77070;
P18031:PTPN1 (xeno); NbExp=5; IntAct=EBI-77088, EBI-968788;
Q9QWI6:Srcin1; NbExp=2; IntAct=EBI-77088, EBI-775592;
-!- SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}.
Cytoplasm {ECO:0000250}. Note=Unphosphorylated form localizes in
the cytoplasm and can move to the membrane upon tyrosine
phosphorylation. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Cas-B;
IsoId=Q61140-1; Sequence=Displayed;
Name=Cas-A;
IsoId=Q61140-2; Sequence=VSP_004134;
-!- DOMAIN: Contains a central domain (substrate domain) containing
multiple potential SH2-binding sites and a C-terminal domain
containing a divergent helix-loop-helix (HLH) motif. The SH2-
binding sites putatively bind CRK, NCK and ABL SH2 domains. The
HLH motif is absolutely required for the induction of pseudohyphal
growth in yeast and mediates heterodimerization with NEDD9.
-!- DOMAIN: A serine-rich region promotes activation of the serum
response element (SRE). {ECO:0000250}.
-!- DOMAIN: The SH3 domain is necessary for the localization of the
protein to focal adhesions and interacts with one proline-rich
region of PTK2/FAK1.
-!- PTM: PTK2/FAK1 activation mediates phosphorylation at the YDYVHL
motif; phosphorylation is most likely catalyzed by SRC family
members. SRC-family kinases are recruited to the phosphorylated
sites and can phosphorylate other tyrosine residues. Tyrosine
phosphorylation is triggered by integrin mediated adhesion of
cells to the extracellular matrix (By similarity). {ECO:0000250}.
-!- PTM: Dephosphorylated by PTPN14 at Tyr-132. {ECO:0000250}.
-!- SIMILARITY: Belongs to the CAS family. {ECO:0000305}.
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EMBL; U48853; AAA93381.1; -; mRNA.
EMBL; U28151; AAA93248.1; -; mRNA.
EMBL; AK145863; BAE26705.1; -; mRNA.
EMBL; BC057578; AAH57578.1; -; mRNA.
CCDS; CCDS52675.1; -. [Q61140-1]
CCDS; CCDS85616.1; -. [Q61140-2]
RefSeq; NP_001185768.1; NM_001198839.1. [Q61140-2]
RefSeq; NP_034084.2; NM_009954.3. [Q61140-1]
UniGene; Mm.3758; -.
PDB; 5W93; X-ray; 2.00 A; A/B/C=738-874.
PDBsum; 5W93; -.
ProteinModelPortal; Q61140; -.
SMR; Q61140; -.
BioGrid; 198886; 8.
CORUM; Q61140; -.
IntAct; Q61140; 14.
MINT; Q61140; -.
STRING; 10090.ENSMUSP00000129584; -.
iPTMnet; Q61140; -.
PhosphoSitePlus; Q61140; -.
PaxDb; Q61140; -.
PRIDE; Q61140; -.
Ensembl; ENSMUST00000166232; ENSMUSP00000129584; ENSMUSG00000031955. [Q61140-1]
Ensembl; ENSMUST00000212349; ENSMUSP00000148364; ENSMUSG00000031955. [Q61140-2]
GeneID; 12927; -.
KEGG; mmu:12927; -.
UCSC; uc009nmt.2; mouse. [Q61140-2]
UCSC; uc009nmu.2; mouse. [Q61140-1]
CTD; 9564; -.
MGI; MGI:108091; Bcar1.
eggNOG; ENOG410IEDD; Eukaryota.
eggNOG; ENOG410ZSUM; LUCA.
GeneTree; ENSGT00940000154002; -.
HOGENOM; HOG000261698; -.
HOVERGEN; HBG004354; -.
InParanoid; Q61140; -.
KO; K05726; -.
OMA; TVEHNQP; -.
OrthoDB; 1086228at2759; -.
TreeFam; TF328782; -.
Reactome; R-MMU-186763; Downstream signal transduction.
Reactome; R-MMU-372708; p130Cas linkage to MAPK signaling for integrins.
Reactome; R-MMU-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-MMU-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
PRO; PR:Q61140; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000031955; Expressed in 282 organ(s), highest expression level in heart.
Genevisible; Q61140; MM.
GO; GO:0015629; C:actin cytoskeleton; IDA:MGI.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005925; C:focal adhesion; IDA:MGI.
GO; GO:0030027; C:lamellipodium; IDA:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0001726; C:ruffle; ISS:UniProtKB.
GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO; GO:0030036; P:actin cytoskeleton organization; ISO:MGI.
GO; GO:0007015; P:actin filament organization; ISS:UniProtKB.
GO; GO:0090527; P:actin filament reorganization; IBA:GO_Central.
GO; GO:0050851; P:antigen receptor-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0060326; P:cell chemotaxis; ISO:MGI.
GO; GO:0016477; P:cell migration; IDA:MGI.
GO; GO:1990859; P:cellular response to endothelin; ISO:MGI.
GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; ISO:MGI.
GO; GO:0071732; P:cellular response to nitric oxide; ISO:MGI.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; ISO:MGI.
GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:1900025; P:negative regulation of substrate adhesion-dependent cell spreading; ISO:MGI.
GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; ISS:UniProtKB.
GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:MGI.
GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; ISO:MGI.
CDD; cd12001; SH3_BCAR1; 1.
Gene3D; 1.20.120.830; -; 1.
InterPro; IPR028848; BCAR1.
InterPro; IPR035745; BCAR1_SH3.
InterPro; IPR021901; CAS_C.
InterPro; IPR037362; CAS_fam.
InterPro; IPR014928; Serine_rich_dom.
InterPro; IPR038319; Serine_rich_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR10654; PTHR10654; 1.
PANTHER; PTHR10654:SF15; PTHR10654:SF15; 1.
Pfam; PF12026; CAS_C; 1.
Pfam; PF08824; Serine_rich; 1.
Pfam; PF00018; SH3_1; 1.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00326; SH3; 1.
SUPFAM; SSF50044; SSF50044; 1.
PROSITE; PS50002; SH3; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Alternative splicing; Cell adhesion;
Cell junction; Complete proteome; Cytoplasm; Phosphoprotein;
Reference proteome; SH3 domain; SH3-binding.
CHAIN 1 874 Breast cancer anti-estrogen resistance
protein 1.
/FTId=PRO_0000064855.
DOMAIN 3 65 SH3. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
REGION 119 420 Substrate for kinases. {ECO:0000250}.
REGION 750 800 Divergent helix-loop-helix motif.
MOTIF 639 647 SH3-binding. {ECO:0000255}.
COMPBIAS 74 87 Pro-rich.
COMPBIAS 426 618 Ser-rich.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P56945}.
MOD_RES 132 132 Phosphotyrosine.
{ECO:0000244|PubMed:15592455}.
MOD_RES 143 143 Phosphoserine.
{ECO:0000250|UniProtKB:P56945}.
MOD_RES 238 238 Phosphotyrosine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 253 253 Phosphotyrosine.
{ECO:0000244|PubMed:19131326}.
MOD_RES 273 273 Phosphothreonine.
{ECO:0000250|UniProtKB:P56945}.
MOD_RES 296 296 Phosphoserine.
{ECO:0000250|UniProtKB:P56945}.
MOD_RES 366 366 Phosphotyrosine.
{ECO:0000244|PubMed:15592455}.
MOD_RES 376 376 Phosphotyrosine.
{ECO:0000244|PubMed:15592455}.
MOD_RES 414 414 Phosphotyrosine.
{ECO:0000244|PubMed:15592455}.
MOD_RES 432 432 Phosphoserine.
{ECO:0000250|UniProtKB:P56945}.
MOD_RES 441 441 Phosphoserine.
{ECO:0000250|UniProtKB:P56945}.
MOD_RES 643 643 Phosphoserine.
{ECO:0000250|UniProtKB:P56945}.
VAR_SEQ 1 4 MTVP -> MKYL (in isoform Cas-A).
{ECO:0000303|PubMed:7479864}.
/FTId=VSP_004134.
CONFLICT 72 72 V -> A (in Ref. 1; AAA93381/AAA93248).
{ECO:0000305}.
HELIX 742 774 {ECO:0000244|PDB:5W93}.
HELIX 779 806 {ECO:0000244|PDB:5W93}.
HELIX 810 839 {ECO:0000244|PDB:5W93}.
HELIX 844 872 {ECO:0000244|PDB:5W93}.
SEQUENCE 874 AA; 94285 MW; 81E56BC7AD87B095 CRC64;
MTVPNVLAKA LYDNVAESPD ELSFRKGDIM TVLERDTQGL DGWWLCSLHG RQGIVPGNRL
KILVGMYDKK PVGPGPGPPA TPPQPQPSLP QGVHAPVPPA SQYSPMLPTA YQPQSDNVYL
VPTPSKTQQG LYQAPGPNPQ FQSPPAKQTS TFSKQTPHHS FPSPATDLYQ VPPGPGSPAQ
DIYQVPPSAG IGHDIYQVPP SLDTRGWEGT KPPAKVVVPT RVGQGYVYEA AQTEQDEYDT
PRHLLAPGPQ DIYDVPPVRG LLPNQYGQEV YDTPPMAVKG PNGRDPLLDV YDVPPSVEKG
LLSSSHHSVY DVPPSVSKDV PDGPLLREET YDVPPAFAKP KPFDPTRHPL ILAAPPPDSP
AAEDVYDVPP PAPDLYDVPP GLRRPGPGTL YDVPRERVLP PEVADGSVVD DGVYAVPPPA
EREAPTDGKR LSASSTGSTR SSQSASSLEV VVPGREPLEL EVAVESLARL QQGVSTTVAH
LLDLVGSASG PGGWRGTSEP QEPPAQDLKA AVAAVHGAVH ELLEFARGAV SNATHTSDRT
LHAKLSRQLQ KMEDVYQTLV VHGQVLDSGR GSPGFTPEDL DRLVACSRAV PEDAKQLASF
LHGNASLLFR RTKAPGPGPE GSSSLHPNPT DKASSIQSRP LPSPPKFTSQ DSPDGQYENS
EGGWMEDYDY VHLQGKEEFE KTQKELLERG NIMRQGKGQL ELQQLKQFER LEQEVSRPID
HDLANWTPAQ PLVPGRTGGL GPSDRQLLLF YLEQCEANLT TLTDAVDAFF TAVATNQPPK
IFVAHSKFVI LSAHKLVFIG DTLSRQAKAA DVRSQVTHYS NLLCDLLRGI VATTKAAALQ
YPSPSAAQDM VDRVKELGHS TQQFRRVLGQ LAAA


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Pathways :
WP1984: Integrated Breast Cancer Pathway
WP2199: Seed Development
WP1049: G Protein Signaling Pathways
WP1053: Estrogen metabolism
WP1077: cytochrome P450
WP1104: estrogen signalling
WP1165: G Protein Signaling Pathways
WP1169: Estrogen metabolism
WP1194: cytochrome P450
WP1202: estrogen signalling
WP1219: cytochrome P450
WP1225: estrogen signalling
WP1244: estrogen signalling
WP1264: Estrogen metabolism
WP1274: cytochrome P450
WP1279: estrogen signalling
WP1302: Estrogen metabolism
WP1330: estrogen signalling
WP1371: G Protein Signaling Pathways
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WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)

Related Genes :
[SRCIN1 KIAA1684 P140] SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)
[Srcin1 Kiaa1684 P140] SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)
[Srcin1 P140 Snip] SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)
[NEDD9 CASL CASS2] Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
[TNK2 ACK1] Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
[PTK2 FAK FAK1] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[Nedd9 Casl] Enhancer of filamentation 1 (mEF1) (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[INPPL1 SHIP2] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
[CDC42] Cell division control protein 42 homolog (G25K GTP-binding protein)
[Ptk2 Fadk Fak Fak1 Kiaa4203] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[BRCA1 RNF53] Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
[FN1 FN] Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
[ABCG2 ABCP BCRP BCRP1 MXR] ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)
[PTPRH SAP1] Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
[Tnk2 Ack1] Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2)
[TNK2 ACK1 ACK2] Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Activated CDC42 kinase 2) (Tyrosine kinase non-receptor protein 2)
[Tnk2 Ack1] Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
[PTK2B FAK2 PYK2 RAFTK] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[MUC1 PUM] Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
[Inppl1 Ship2] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (AblSH3-binding protein) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
[Inppl1 Ship2] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
[PTK2 FAK FAK1] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (p41/p43FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[CD2AP] CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
[Src] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[VWF F8VWF] von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]
[Brca1] Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BRCA1)
[Src] Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[GPER1 CEPR CMKRL2 DRY12 GPER GPR30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)

Bibliography :
[29304771] High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer.
[26247733] Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.
[21469768] Breast cancer anti-estrogen resistance protein 1 (BCAR1/p130cas) in pulmonary disease tissue and serum.
[15671247] AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.
[15277346] Development of an ELISA for measurement of BCAR1 protein in human breast cancer tissue.
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