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C-C motif chemokine 24 (Eosinophil chemotactic protein 2) (Eotaxin-2) (Small-inducible cytokine A24)

 CCL24_MOUSE             Reviewed;         119 AA.
Q9JKC0;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
02-JUN-2021, entry version 150.
RecName: Full=C-C motif chemokine 24;
AltName: Full=Eosinophil chemotactic protein 2 {ECO:0000303|PubMed:11067944};
Short=Eotaxin-2 {ECO:0000303|PubMed:11067944};
AltName: Full=Small-inducible cytokine A24;
Flags: Precursor;
Name=Ccl24 {ECO:0000303|Ref.2, ECO:0000312|MGI:MGI:1928953};
Synonyms=Scya24;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
PubMed=11067944; DOI=10.4049/jimmunol.165.10.5839;
Zimmermann N., Hogan S.P., Mishra A., Brandt E.B., Bodette T.R., Pope S.M.,
Finkelman F.D., Rothenberg M.E.;
"Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen
challenge and IL-4 overexpression.";
J. Immunol. 165:5839-5846(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Rossi D., Zlotnik A.;
"Identification of a mouse homolog of CC chemokine CCL24/MPIF-2/Eotaxin-
2.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Thymus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
PubMed=15647285; DOI=10.1074/jbc.M406037200;
Pope S.M., Fulkerson P.C., Blanchard C., Saito Akei H., Nikolaidis N.M.,
Zimmermann N., Molkentin J.D., Rothenberg M.E.;
"Identification of a cooperative mechanism involving interleukin-13 and
eotaxin-2 in experimental allergic lung inflammation.";
J. Biol. Chem. 280:13952-13961(2005).
-!- FUNCTION: Chemotactic for resting T-lymphocytes, and eosinophils
(PubMed:15647285). Has lower chemotactic activity for neutrophils but
none for monocytes and activated lymphocytes. Is a strong suppressor of
colony formation by a multipotential hematopoietic progenitor cell
line. Binds to CCR3 (By similarity). {ECO:0000250|UniProtKB:O00175,
ECO:0000269|PubMed:15647285}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00175}.
-!- TISSUE SPECIFICITY: Highest expression in jejunum and spleen. Lower
levels found in liver and lung. No expression detected in kidney,
thymus, brain or testis. {ECO:0000269|PubMed:11067944}.
-!- INDUCTION: By interleukin-4 and allergen challenge with A.fumigatus
(PubMed:11067944). By interleukin-13 (IL13) (PubMed:15647285).
{ECO:0000269|PubMed:11067944, ECO:0000269|PubMed:15647285}.
-!- DISRUPTION PHENOTYPE: No visible phenotype in normal conditions
(PubMed:15647285). Mice display a normal base-line eosinophil levels in
the hematopoietic tissues and gastrointestinal tract (PubMed:15647285).
However, following intratracheal IL13 administration, mice show a
profound reduction in airway eosinophilia (PubMed:15647285).
{ECO:0000269|PubMed:15647285}.
-!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
{ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; AF281075; AAG32664.1; -; mRNA.
EMBL; AF244367; AAF61736.1; -; mRNA.
EMBL; BC065389; AAH65389.1; -; mRNA.
CCDS; CCDS19742.1; -.
RefSeq; NP_062523.1; NM_019577.4.
RefSeq; XP_006504507.1; XM_006504444.3.
RefSeq; XP_006504508.1; XM_006504445.3.
SMR; Q9JKC0; -.
STRING; 10090.ENSMUSP00000004936; -.
GlyGen; Q9JKC0; 2 sites.
MaxQB; Q9JKC0; -.
PaxDb; Q9JKC0; -.
PRIDE; Q9JKC0; -.
ProteomicsDB; 265612; -.
Antibodypedia; 14858; 505 antibodies.
DNASU; 56221; -.
Ensembl; ENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814.
Ensembl; ENSMUST00000201401; ENSMUSP00000144002; ENSMUSG00000004814.
GeneID; 56221; -.
KEGG; mmu:56221; -.
UCSC; uc008zyn.1; mouse.
CTD; 6369; -.
MGI; MGI:1928953; Ccl24.
eggNOG; ENOG502S6ZP; Eukaryota.
GeneTree; ENSGT01030000234602; -.
HOGENOM; CLU_141716_1_1_1; -.
InParanoid; Q9JKC0; -.
OMA; SASVCPM; -.
OrthoDB; 1575018at2759; -.
PhylomeDB; Q9JKC0; -.
TreeFam; TF334888; -.
BioGRID-ORCS; 56221; 1 hit in 52 CRISPR screens.
PRO; PR:Q9JKC0; -.
Proteomes; UP000000589; Chromosome 5.
RNAct; Q9JKC0; protein.
Bgee; ENSMUSG00000004814; Expressed in liver and 78 other tissues.
Genevisible; Q9JKC0; MM.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0031728; F:CCR3 chemokine receptor binding; ISO:MGI.
GO; GO:0008009; F:chemokine activity; ISO:MGI.
GO; GO:0005125; F:cytokine activity; IDA:MGI.
GO; GO:0048018; F:receptor ligand activity; ISO:MGI.
GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0006935; P:chemotaxis; IDA:MGI.
GO; GO:0007010; P:cytoskeleton organization; ISO:MGI.
GO; GO:0048245; P:eosinophil chemotaxis; ISO:MGI.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0030838; P:positive regulation of actin filament polymerization; ISO:MGI.
GO; GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL.
GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI.
GO; GO:2000418; P:positive regulation of eosinophil migration; IMP:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0043547; P:positive regulation of GTPase activity; ISO:MGI.
GO; GO:0050729; P:positive regulation of inflammatory response; IMP:BHF-UCL.
GO; GO:0008360; P:regulation of cell shape; ISO:MGI.
InterPro; IPR039809; Chemokine_b/g/d.
InterPro; IPR000827; Chemokine_CC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR036048; Interleukin_8-like_sf.
PANTHER; PTHR12015; PTHR12015; 1.
Pfam; PF00048; IL8; 1.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
2: Evidence at transcript level;
Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
Reference proteome; Secreted; Signal.
SIGNAL 1..26
/evidence="ECO:0000255"
CHAIN 27..119
/note="C-C motif chemokine 24"
/id="PRO_0000005233"
REGION 96..119
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
CARBOHYD 54
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 115
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 33..58
/evidence="ECO:0000250|UniProtKB:O00175"
DISULFID 34..74
/evidence="ECO:0000250|UniProtKB:O00175"
SEQUENCE 119 AA; 12871 MW; 1EA921B3F13138A8 CRC64;
MAGSATIVAG LLLLVACACC IFPIDSVTIP SSCCTSFISK KIPENRVVSY QLANGSICPK
AGVIFITKKG HKICTDPKLL WVQRHIQKLD AKKNQPSKGA KAVRTKFAVQ RRRGNSTEV


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Pathways :
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WP971: Small Ligand GPCRs
WP1659: Glycine, serine and threonine metabolism
WP2272: Pathogenic Escherichia coli infection
WP1665: Limonene and pinene degradation
WP2324: AGE/RAGE pathway
WP1493: Carbon assimilation C4 pathway
WP1714: Tyrosine metabolism
WP1566: Citrate cycle (TCA cycle)
WP1909: Signal regulatory protein (SIRP) family interactions
WP1673: Naphthalene and anthracene degradation
WP346: Protein Modifications
WP1678: Nucleotide excision repair
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Related Genes :
[Ccl24 Scya24] C-C motif chemokine 24 (Eosinophil chemotactic protein 2) (Eotaxin-2) (Small-inducible cytokine A24)
[Ccl11 Scya11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[CCL11 SCYA11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[Ccl11 Scya11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[Ccl2 Je Mcp1 Scya2] C-C motif chemokine 2 (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Platelet-derived growth factor-inducible protein JE) (Small-inducible cytokine A2)
[CCL2 MCP1 SCYA2] C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
[CCL2 MCP1 SCYA2] C-C motif chemokine 2 (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Small-inducible cytokine A2)
[Ccl21a Scya21 Scya21a] C-C motif chemokine 21a (6Ckine) (Beta-chemokine exodus-2) (Small-inducible cytokine A21a) (Thymus-derived chemotactic agent 4) (TCA4)
[CCL8 MCP2 SCYA10 SCYA8] C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
[CCL11 SCYA11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[Ccl21b Scya21 Scya21b] C-C motif chemokine 21b (6Ckine) (Beta-chemokine exodus-2) (Small-inducible cytokine A21b) (Thymus-derived chemotactic agent 4) (TCA4)
[Ccl1 Scya1 Tca3] C-C motif chemokine 1 (P500) (SIS-epsilon) (Small-inducible cytokine A1) (T-cell activation protein 3) (TCA-3) (TCA3)
[Ccl2 Je Mcp1 Scya2] C-C motif chemokine 2 (Immediate-early serum-responsive protein JE) (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Small-inducible cytokine A2)
[CCL2 SCYA2] C-C motif chemokine 2 (Acidic seminal fluid protein) (Monocyte chemotactic protein 1A) (MCP-1) (MCP-1A) (Small-inducible cytokine A2)
[CCL2 SCYA2] C-C motif chemokine 2 (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Small-inducible cytokine A2)
[Cxcl10 Crg2 Ifi10 Inp10 Scyb10] C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (C7) (Interferon-gamma induced protein CRG-2) (Small-inducible cytokine B10)
[CCL8 MCP2] C-C motif chemokine 8 (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8)
[Ccl21c Scya21c] C-C motif chemokine 21c (6Ckine) (Beta-chemokine exodus-2) (Small-inducible cytokine A21c) (Thymus-derived chemotactic agent 4) (TCA4)
[CCL8 MCP2 SCYA8] C-C motif chemokine 8 (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8)
[CCL11] Eotaxin (C-C motif chemokine 11) (Small-inducible cytokine A11)
[Ccl8 Mcp2 Scya8] C-C motif chemokine 8 (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8)
[Cxcl5 Scyb5] C-X-C motif chemokine 5 (Cytokine LIX) (Small-inducible cytokine B5) [Cleaved into: GCP-2(1-78); GCP-2(9-78)]
[CCL21 SCYA21 UNQ784/PRO1600] C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21)
[CX3CL1 FKN NTT SCYD1 A-152E5.2] Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
[CCL15 MIP5 NCC3 SCYA15] C-C motif chemokine 15 (Chemokine CC-2) (HCC-2) (Leukotactin-1) (LKN-1) (MIP-1 delta) (Macrophage inflammatory protein 5) (MIP-5) (Mrp-2b) (NCC-3) (Small-inducible cytokine A15) [Cleaved into: CCL15(22-92); CCL15(25-92); CCL15(29-92)]
[Cx3cl1 Cx3c Fkn Scyd1] Fractalkine (FK) (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
[Ccl25 Scya25 Teck] C-C motif chemokine 25 (Chemokine TECK) (Small-inducible cytokine A25) (Thymus-expressed chemokine)
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[Cxcl13 Blc Scyb13] C-X-C motif chemokine 13 (B lymphocyte chemoattractant) (CXC chemokine BLC) (Small-inducible cytokine B13)
[Ccl19 Elc Scya19] C-C motif chemokine 19 (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Small-inducible cytokine A19)

Bibliography :
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