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C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1 homolog) (Neurolymphatic receptor) (NLR) (CD antigen CD185)

 CXCR5_RAT               Reviewed;         374 AA.
P34997;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 1.
26-FEB-2020, entry version 122.
RecName: Full=C-X-C chemokine receptor type 5;
Short=CXC-R5;
Short=CXCR-5;
AltName: Full=Burkitt lymphoma receptor 1 homolog;
AltName: Full=Neurolymphatic receptor;
Short=NLR;
AltName: CD_antigen=CD185;
Name=Cxcr5; Synonyms=Blr1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Spleen;
PubMed=8386678; DOI=10.1016/0014-5793(93)80102-z;
Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V.;
"Cloning of a novel putative G-protein-coupled receptor (NLR) which is
expressed in neuronal and lymphatic tissue.";
FEBS Lett. 321:173-178(1993).
-!- FUNCTION: Cytokine receptor that binds to B-lymphocyte chemoattractant
(BLC). Involved in B-cell migration into B-cell follicles of spleen and
Peyer patches but not into those of mesenteric or peripheral lymph
nodes (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in neuronal and lymphatic tissue.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; X71463; CAA50582.1; -; Genomic_DNA.
PIR; S32785; S32785.
RefSeq; NP_445755.1; NM_053303.1.
STRING; 10116.ENSRNOP00000016580; -.
PhosphoSitePlus; P34997; -.
PaxDb; P34997; -.
PRIDE; P34997; -.
GeneID; 29363; -.
KEGG; rno:29363; -.
UCSC; RGD:62010; rat.
CTD; 643; -.
RGD; 62010; Cxcr5.
eggNOG; ENOG410IE41; Eukaryota.
eggNOG; ENOG410YWPA; LUCA.
InParanoid; P34997; -.
KO; K04190; -.
OrthoDB; 794531at2759; -.
PhylomeDB; P34997; -.
Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
Reactome; R-RNO-418594; G alpha (i) signalling events.
PRO; PR:P34997; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
GO; GO:0019956; F:chemokine binding; IBA:GO_Central.
GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0030595; P:leukocyte chemotaxis; ISO:RGD.
GO; GO:0048535; P:lymph node development; ISO:RGD.
GO; GO:0032467; P:positive regulation of cytokinesis; ISO:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
InterPro; IPR001053; Chemokine_CXCR5.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00564; CXCCHMKINER5.
PRINTS; PR00237; GPCRRHODOPSN.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
B-cell activation; Cell membrane; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1..374
/note="C-X-C chemokine receptor type 5"
/id="PRO_0000069362"
TOPO_DOM 1..57
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 58..78
/note="Helical; Name=1"
/evidence="ECO:0000255"
TOPO_DOM 79..90
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 91..111
/note="Helical; Name=2"
/evidence="ECO:0000255"
TOPO_DOM 112..126
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 127..147
/note="Helical; Name=3"
/evidence="ECO:0000255"
TOPO_DOM 148..169
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 170..190
/note="Helical; Name=4"
/evidence="ECO:0000255"
TOPO_DOM 191..221
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 222..242
/note="Helical; Name=5"
/evidence="ECO:0000255"
TOPO_DOM 243..261
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 262..282
/note="Helical; Name=6"
/evidence="ECO:0000255"
TOPO_DOM 283..306
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 307..327
/note="Helical; Name=7"
/evidence="ECO:0000255"
TOPO_DOM 328..374
/note="Cytoplasmic"
/evidence="ECO:0000255"
CARBOHYD 28
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 198
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 124..204
/evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SEQUENCE 374 AA; 42013 MW; D87A3AC816207319 CRC64;
MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS FKTIFMPVAY
SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG
TFLCKTVIAL HKINFYCSSL LLACIAVDRY LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF
LFALPELLFA KVVQPHNNES LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY
VGVVHRLLQA QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPGWRKS
SLSESENATS LTTF


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[Cxcr5 Blr1 Gpcr6] C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1 homolog) (CD antigen CD185)
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Bibliography :