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C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]

 CXCL2_HUMAN             Reviewed;         107 AA.
P19875; Q6FGD6; Q9UPB8;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 1.
16-OCT-2019, entry version 184.
RecName: Full=C-X-C motif chemokine 2;
AltName: Full=Growth-regulated protein beta;
Short=Gro-beta;
AltName: Full=Macrophage inflammatory protein 2-alpha;
Short=MIP2-alpha;
Contains:
RecName: Full=GRO-beta(5-73);
AltName: Full=GRO-beta-T;
AltName: Full=Hematopoietic synergistic factor;
Short=HSF;
AltName: Full=SB-251353;
Flags: Precursor;
Name=CXCL2; Synonyms=GRO2, GROB, MIP2A, SCYB2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Histiocytic lymphoma;
PubMed=2201751; DOI=10.1084/jem.172.3.911;
Tekamp-Olson P., Gallegos C., Bauer D., McClain J., Sherry B.,
Fabre M., van Deventer S., Cerami A.;
"Cloning and characterization of cDNAs for murine macrophage
inflammatory protein 2 and its human homologues.";
J. Exp. Med. 172:911-919(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2078213; DOI=10.1128/mcb.10.10.5596;
Iida N., Grotendorst G.R.;
"Cloning and sequencing of a new gro transcript from activated human
monocytes: expression in leukocytes and wound tissue.";
Mol. Cell. Biol. 10:5596-5599(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2217207; DOI=10.1073/pnas.87.19.7732;
Haskill S., Peace A., Morris J., Sporn S.A., Anisowicz A., Lee S.W.,
Smith T., Martin G., Ralph P., Sager R.;
"Identification of three related human GRO genes encoding cytokine
functions.";
Proc. Natl. Acad. Sci. U.S.A. 87:7732-7736(1990).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 35-107.
Jang J.S., Kim B.E.;
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 56-107.
PubMed=2341726;
Sporn S.A., Eierman D.F., Johnson C.E., Morris J., Martin G.,
Ladner M., Haskill S.;
"Monocyte adherence results in selective induction of novel genes
sharing homology with mediators of inflammation and tissue repair.";
J. Immunol. 144:4434-4441(1990).
[9]
PROTEIN SEQUENCE OF 39-56, IDENTIFICATION OF GRO-BETA(5-73) BY MASS
SPECTROMETRY, PROTEOLYTIC PROCESSING OF N-TERMINUS, AND FUNCTION.
PubMed=10725737; DOI=10.4049/jimmunol.164.7.3774;
King A.G., Johanson K., Frey C.L., DeMarsh P.L., White J.R.,
McDevitt P., McNulty D., Balcarek J., Jonak Z.L., Bhatnagar P.K.,
Pelus L.M.;
"Identification of unique truncated KC/GRO beta chemokines with potent
hematopoietic and anti-infective activities.";
J. Immunol. 164:3774-3782(2000).
[10]
STRUCTURE BY NMR OF 39-107.
PubMed=10600366; DOI=10.1006/jmbi.1999.3333;
Qian Y.Q., Johanson K.O., McDevitt P.;
"Nuclear magnetic resonance solution structure of truncated human
GRObeta [5-73] and its structural comparison with CXC chemokine family
members GROalpha and IL-8.";
J. Mol. Biol. 294:1065-1072(1999).
-!- FUNCTION: Produced by activated monocytes and neutrophils and
expressed at sites of inflammation. Hematoregulatory chemokine,
which, in vitro, suppresses hematopoietic progenitor cell
proliferation. GRO-beta(5-73) shows a highly enhanced
hematopoietic activity. {ECO:0000269|PubMed:10725737}.
-!- INTERACTION:
P13501:CCL5; NbExp=2; IntAct=EBI-2114901, EBI-2848366;
P48061:CXCL12; NbExp=2; IntAct=EBI-2114901, EBI-3913254;
P27487:DPP4; NbExp=2; IntAct=EBI-2114901, EBI-2871277;
P02776:PF4; NbExp=3; IntAct=EBI-2114901, EBI-2565740;
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The N-terminal processed form GRO-beta(5-73) is produced by
proteolytic cleavage after secretion from bone marrow stromal
cells. {ECO:0000269|PubMed:10725737}.
-!- PHARMACEUTICAL: GRO-beta(5-73) is available under the name
Garnocestim as immunomodulator. It is used prior to hematopoietic
transplantation for peripheral blood stem cell mobilization and
reduction of incidence, duration, and/or severity of chemotherapy
induced cytopenias.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=CXCL2 entry;
URL="https://en.wikipedia.org/wiki/CXCL2";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; X53799; CAA37808.1; -; mRNA.
EMBL; M36820; AAA63183.1; -; mRNA.
EMBL; M57731; AAA63182.1; -; mRNA.
EMBL; CR542171; CAG46968.1; -; mRNA.
EMBL; CH471057; EAX05700.1; -; Genomic_DNA.
EMBL; BC015753; AAH15753.1; -; mRNA.
EMBL; AF043340; AAC03540.1; -; mRNA.
CCDS; CCDS34008.1; -.
PIR; JH0281; JH0281.
RefSeq; NP_002080.1; NM_002089.3.
PDB; 1QNK; NMR; -; A/B=39-107.
PDB; 5OB5; X-ray; 1.65 A; A=40-102.
PDBsum; 1QNK; -.
PDBsum; 5OB5; -.
SMR; P19875; -.
BioGrid; 109177; 6.
DIP; DIP-5908N; -.
IntAct; P19875; 17.
MINT; P19875; -.
STRING; 9606.ENSP00000427279; -.
BindingDB; P19875; -.
ChEMBL; CHEMBL3286076; -.
BioMuta; CXCL2; -.
DMDM; 127085; -.
MassIVE; P19875; -.
MaxQB; P19875; -.
PaxDb; P19875; -.
PeptideAtlas; P19875; -.
PRIDE; P19875; -.
ProteomicsDB; 53697; -.
DNASU; 2920; -.
Ensembl; ENST00000508487; ENSP00000427279; ENSG00000081041.
GeneID; 2920; -.
KEGG; hsa:2920; -.
UCSC; uc003hhm.5; human.
CTD; 2920; -.
DisGeNET; 2920; -.
GeneCards; CXCL2; -.
HGNC; HGNC:4603; CXCL2.
MIM; 139110; gene.
neXtProt; NX_P19875; -.
OpenTargets; ENSG00000081041; -.
PharmGKB; PA35051; -.
eggNOG; ENOG410J3WE; Eukaryota.
eggNOG; ENOG410ZT1C; LUCA.
GeneTree; ENSGT00940000163986; -.
HOGENOM; HOG000220915; -.
InParanoid; P19875; -.
KO; K05505; -.
OMA; LHCRCIQ; -.
OrthoDB; 1618797at2759; -.
PhylomeDB; P19875; -.
TreeFam; TF333433; -.
Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-6783783; Interleukin-10 signaling.
ChiTaRS; CXCL2; human.
EvolutionaryTrace; P19875; -.
GenomeRNAi; 2920; -.
Pharos; P19875; -.
PMAP-CutDB; P19875; -.
PRO; PR:P19875; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000081041; Expressed in 207 organ(s), highest expression level in epithelium of mammary gland.
ExpressionAtlas; P19875; baseline and differential.
Genevisible; P19875; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB.
GO; GO:0030595; P:leukocyte chemotaxis; IBA:GO_Central.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0002237; P:response to molecule of bacterial origin; IDA:BHF-UCL.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
PANTHER; PTHR10179; PTHR10179; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
3D-structure; Chemotaxis; Complete proteome; Cytokine;
Direct protein sequencing; Disulfide bond; Inflammatory response;
Pharmaceutical; Reference proteome; Secreted; Signal.
SIGNAL 1 34
CHAIN 35 107 C-X-C motif chemokine 2.
/FTId=PRO_0000005063.
CHAIN 39 107 GRO-beta(5-73).
/FTId=PRO_0000005064.
DISULFID 43 69
DISULFID 45 85
STRAND 49 51 {ECO:0000244|PDB:1QNK}.
HELIX 54 56 {ECO:0000244|PDB:5OB5}.
STRAND 57 63 {ECO:0000244|PDB:5OB5}.
STRAND 69 71 {ECO:0000244|PDB:5OB5}.
STRAND 73 78 {ECO:0000244|PDB:5OB5}.
STRAND 83 86 {ECO:0000244|PDB:5OB5}.
HELIX 91 101 {ECO:0000244|PDB:5OB5}.
SEQUENCE 107 AA; 11389 MW; 740F277E928571BA CRC64;
MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ GIHLKNIQSV
KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM LKNGKSN


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Pathways :
WP210: Cytoplasmic Ribosomal Proteins
WP1566: Citrate cycle (TCA cycle)
WP215: noncanonical wnt pathway
WP244: Alpha 6 Beta 4 signaling pathway
WP1571: EBV LMP1 signaling
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP262: EBV LMP1 signaling
WP1225: estrogen signalling
WP1434: Osteopontin Signaling
WP433: tRNA Synthetases
WP219: Cytoplasmic tRNA Synthetases
WP32: Translation Factors
WP537: Translation Factors
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP566: canonical wnt - zebrafish
WP2218: sGC
WP1224: EBV LMP1 signaling
WP1835: Interferon alpha/beta signaling
WP406: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP809: TGF-beta Receptor Signaling Pathway
WP113: TGF Beta Signaling Pathway
WP143: Fatty Acid Beta Oxidation
WP505: TGF Beta Signaling Pathway
WP148: Fatty Acid Beta Oxidation 2

Related Genes :
[CXCL2 GRO2 GROB MIP2A SCYB2] C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
[Cxcl1 Gro Gro1 Mgsa Scyb1] Growth-regulated alpha protein (C-X-C motif chemokine 1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Cleaved into: KC(5-72) (Hematopoietic synergistic factor) (HSF) (KC-T)]
[Cxcl2 Cinc3 Mip-2 Mip2 Scyb2] C-X-C motif chemokine 2 (Cytokine-induced neutrophil chemoattractant 3) (CINC-3) (Macrophage inflammatory protein 2) (MIP2)
[Cxcl2 Mip-2 Mip2 Scyb2] C-X-C motif chemokine 2 (Macrophage inflammatory protein 2) (MIP2)
[CCL20 LARC MIP3A SCYA20] C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)]
[PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1] Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[CCL3 G0S19-1 MIP1A SCYA3] C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
[CCL4L1 CCL4L LAG1 SCYA4L1; CCL4L2 CCL4L SCYA4L2] C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)
[CXCL12 SDF1 SDF1A SDF1B] Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)]
[CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18] C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]
[CXCL14 MIP2G NJAC SCYB14 PSEC0212 UNQ240/PRO273] C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14)
[MST1 D3F15S2 DNF15S2 HGFL] Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]
[Mst1r Ron Stk] Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (Stem cell-derived tyrosine kinase) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
[CCL3L1 D17S1718 G0S19-2 SCYA3L1; CCL3L3] C-C motif chemokine 3-like 1 (G0/G1 switch regulatory protein 19-2) (LD78-beta(1-70)) (PAT 464.2) (Small-inducible cytokine A3-like 1) (Tonsillar lymphocyte LD78 beta protein) [Cleaved into: LD78-beta(3-70); LD78-beta(5-70)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Ccr1 Cmkbr1] C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
[Ccl21a Scya21 Scya21a] C-C motif chemokine 21a (6Ckine) (Beta-chemokine exodus-2) (Small-inducible cytokine A21a) (Thymus-derived chemotactic agent 4) (TCA4)
[CCR1 CMKBR1 CMKR1 SCYAR1] C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
[MIF GLIF MMIF] Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)
[Ccl2 Je Mcp1 Scya2] C-C motif chemokine 2 (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Platelet-derived growth factor-inducible protein JE) (Small-inducible cytokine A2)
[MST1R PTK8 RON] Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
[CCL15 MIP5 NCC3 SCYA15] C-C motif chemokine 15 (Chemokine CC-2) (HCC-2) (Leukotactin-1) (LKN-1) (MIP-1 delta) (Macrophage inflammatory protein 5) (MIP-5) (Mrp-2b) (NCC-3) (Small-inducible cytokine A15) [Cleaved into: CCL15(22-92); CCL15(25-92); CCL15(29-92)]
[CXCL11 ITAC SCYB11 SCYB9B] C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)
[APP A4 AD1] Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[Ptk2b Fak2 Pyk2 Raftk] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[gag-pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27, alternate cleaved 1; Capsid protein p27, alternate cleaved 2; Spacer peptide (SP) (p3); Nucleocapsid protein p12; Protease p15 (EC 3.4.23.-); Reverse transcriptase, beta-subunit (RT-beta); Reverse transcriptase, alpha-subunit (RT-alpha) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (pp32); p4]
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Cxcl10 Crg2 Ifi10 Inp10 Scyb10] C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (C7) (Interferon-gamma induced protein CRG-2) (Small-inducible cytokine B10)

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