GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]

 CFLAR_MOUSE             Reviewed;         481 AA.
O35732; D3Z0W6; O35707; O35733;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
25-OCT-2017, sequence version 3.
10-APR-2019, entry version 173.
RecName: Full=CASP8 and FADD-like apoptosis regulator;
AltName: Full=Caspase homolog;
Short=CASH;
AltName: Full=Caspase-eight-related protein;
Short=Casper;
AltName: Full=Caspase-like apoptosis regulatory protein;
Short=CLARP;
AltName: Full=Cellular FLICE-like inhibitory protein;
Short=c-FLIP;
AltName: Full=FADD-like antiapoptotic molecule 1;
Short=FLAME-1;
AltName: Full=Inhibitor of FLICE;
Short=I-FLICE;
AltName: Full=MACH-related inducer of toxicity;
Short=MRIT;
AltName: Full=Usurpin;
Contains:
RecName: Full=CASP8 and FADD-like apoptosis regulator subunit p43;
Contains:
RecName: Full=CASP8 and FADD-like apoptosis regulator subunit p12;
Flags: Precursor;
Name=Cflar; Synonyms=Cash;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Liver, and Skin fibroblast;
PubMed=9289491; DOI=10.1074/jbc.272.32.19641;
Goltsev Y.V., Kovalenko A.V., Arnold E., Varfolomeev E.E.,
Brodianskii V.M., Wallach D.;
"CASH, a novel caspase homologue with death effector domains.";
J. Biol. Chem. 272:19641-19644(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Heart;
PubMed=9217161; DOI=10.1038/40657;
Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V.,
Bodmer J.-L., Schroeter M., Burns K., Mattmann C., Rimoldi D.,
French L.E., Tschopp J.;
"Inhibition of death receptor signals by cellular FLIP.";
Nature 388:190-195(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
FUNCTION.
PubMed=10894163; DOI=10.1016/S1074-7613(00)80214-9;
Yeh W.-C., Itie A., Elia A.J., Ng M., Shu H.-B., Wakeham A.,
Mirtsos C., Suzuki N., Bonnard M., Goeddel D.V., Mak T.W.;
"Requirement for Casper (c-FLIP) in regulation of death receptor-
induced apoptosis and embryonic development.";
Immunity 12:633-642(2000).
[5]
FUNCTION.
PubMed=10602037;
DOI=10.1002/1521-4141(200001)30:1<155::AID-IMMU155>3.0.CO;2-X;
Wang J., Lobito A.A., Shen F., Hornung F., Winoto A., Lenardo M.J.;
"Inhibition of Fas-mediated apoptosis by the B cell antigen receptor
through c-FLIP.";
Eur. J. Immunol. 30:155-163(2000).
-!- FUNCTION: Apoptosis regulator protein which may function as a
crucial link between cell survival and cell death pathways in
mammalian cells. Acts as an inhibitor of TNFRSF6 mediated
apoptosis. A proteolytic fragment (p43) is likely retained in the
death-inducing signaling complex (DISC) thereby blocking further
recruitment and processing of caspase-8 at the complex. Full
length and shorter isoforms have been shown either to induce
apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic
(caspase) activity (By similarity). {ECO:0000250,
ECO:0000269|PubMed:10602037, ECO:0000269|PubMed:10894163}.
-!- SUBUNIT: TNFRSF6 stimulation triggers recruitment to the death-
inducing signaling complex (DISC) formed by TNFRSF6, FADD and
caspase-8. A proteolytic fragment (p43) stays associated with the
DISC (By similarity). {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=FLIP-L, CASH alpha;
IsoId=O35732-1; Sequence=Displayed;
Name=2; Synonyms=FLIP-S, CASH beta;
IsoId=O35732-2; Sequence=VSP_000842, VSP_000843;
-!- TISSUE SPECIFICITY: Highly expressed in heart.
-!- DEVELOPMENTAL STAGE: At 9.5 and 10.5 dpc, highly expressed in
developing heart.
-!- INDUCTION: Isoform 1 but not isoform 2 is activated by BCR cross-
linking in primary B-cells.
-!- DOMAIN: The caspase domain lacks the active site residues involved
in catalysis.
-!- PTM: Proteolytically processed; probably by caspase-8. Processing
likely occurs at the DISC and generates subunit p43 and p12 (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; Y14041; CAA74368.1; -; mRNA.
EMBL; Y14042; CAA74369.1; -; mRNA.
EMBL; U97076; AAC53281.1; -; mRNA.
EMBL; AC112968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS14978.1; -. [O35732-1]
CCDS; CCDS35582.1; -. [O35732-2]
RefSeq; NP_001276633.1; NM_001289704.2. [O35732-1]
RefSeq; NP_997536.1; NM_207653.5. [O35732-1]
RefSeq; XP_006495698.1; XM_006495635.3. [O35732-1]
RefSeq; XP_011236722.1; XM_011238420.2. [O35732-1]
RefSeq; XP_011236723.1; XM_011238421.2. [O35732-1]
RefSeq; XP_011236724.1; XM_011238422.1. [O35732-1]
RefSeq; XP_011236725.1; XM_011238423.2. [O35732-1]
RefSeq; XP_017169048.1; XM_017313559.1. [O35732-1]
UniGene; Mm.336848; -.
UniGene; Mm.486313; -.
ProteinModelPortal; O35732; -.
SMR; O35732; -.
BioGrid; 198686; 6.
IntAct; O35732; 2.
STRING; 10090.ENSMUSP00000109952; -.
MEROPS; C14.974; -.
iPTMnet; O35732; -.
PhosphoSitePlus; O35732; -.
PaxDb; O35732; -.
PRIDE; O35732; -.
Ensembl; ENSMUST00000069333; ENSMUSP00000065107; ENSMUSG00000026031. [O35732-1]
Ensembl; ENSMUST00000114309; ENSMUSP00000109948; ENSMUSG00000026031. [O35732-2]
Ensembl; ENSMUST00000114313; ENSMUSP00000109952; ENSMUSG00000026031. [O35732-1]
GeneID; 12633; -.
KEGG; mmu:12633; -.
CTD; 8837; -.
MGI; MGI:1336166; Cflar.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
GeneTree; ENSGT00530000064199; -.
HOGENOM; HOG000069972; -.
HOVERGEN; HBG050918; -.
InParanoid; O35732; -.
KO; K04724; -.
OMA; VYDWNSR; -.
OrthoDB; 939331at2759; -.
Reactome; R-MMU-3371378; Regulation by c-FLIP.
Reactome; R-MMU-5213460; RIPK1-mediated regulated necrosis.
Reactome; R-MMU-5218900; CASP8 activity is inhibited.
Reactome; R-MMU-69416; Dimerization of procaspase-8.
Reactome; R-MMU-75158; TRAIL signaling.
ChiTaRS; Cflar; mouse.
PRO; PR:O35732; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026031; Expressed in 292 organ(s), highest expression level in blood.
ExpressionAtlas; O35732; baseline and differential.
GO; GO:0031265; C:CD95 death-inducing signaling complex; ISO:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0031264; C:death-inducing signaling complex; ISO:MGI.
GO; GO:0045121; C:membrane raft; ISO:MGI.
GO; GO:0097342; C:ripoptosome; ISO:MGI.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0005123; F:death receptor binding; ISO:MGI.
GO; GO:0008047; F:enzyme activator activity; ISO:MGI.
GO; GO:0016504; F:peptidase activator activity; IDA:MGI.
GO; GO:0002020; F:protease binding; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI.
GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
GO; GO:0006915; P:apoptotic process; ISO:MGI.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Ensembl.
GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
GO; GO:0071732; P:cellular response to nitric oxide; ISO:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; ISO:MGI.
GO; GO:1903845; P:negative regulation of cellular response to transforming growth factor beta stimulus; ISO:MGI.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.
GO; GO:1904036; P:negative regulation of epithelial cell apoptotic process; ISO:MGI.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IGI:MGI.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISO:MGI.
GO; GO:1903944; P:negative regulation of hepatocyte apoptotic process; ISO:MGI.
GO; GO:1901740; P:negative regulation of myoblast fusion; IMP:BHF-UCL.
GO; GO:0060546; P:negative regulation of necroptotic process; IGI:MGI.
GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; ISO:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
GO; GO:1903055; P:positive regulation of extracellular matrix organization; ISO:MGI.
GO; GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; ISO:MGI.
GO; GO:2000347; P:positive regulation of hepatocyte proliferation; ISO:MGI.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.
GO; GO:0060544; P:regulation of necroptotic process; ISO:MGI.
GO; GO:0014842; P:regulation of skeletal muscle satellite cell proliferation; IMP:BHF-UCL.
GO; GO:0009617; P:response to bacterium; IEP:MGI.
GO; GO:0033574; P:response to testosterone; ISO:MGI.
GO; GO:0014732; P:skeletal muscle atrophy; IMP:BHF-UCL.
GO; GO:0007519; P:skeletal muscle tissue development; IMP:BHF-UCL.
GO; GO:0043403; P:skeletal muscle tissue regeneration; IMP:BHF-UCL.
GO; GO:0014866; P:skeletal myofibril assembly; IMP:BHF-UCL.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR001875; DED_dom.
InterPro; IPR002398; Pept_C14.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
Pfam; PF01335; DED; 2.
SMART; SM00115; CASc; 1.
SMART; SM00031; DED; 2.
SUPFAM; SSF47986; SSF47986; 2.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS50208; CASPASE_P20; 1.
PROSITE; PS50168; DED; 2.
2: Evidence at transcript level;
Alternative splicing; Apoptosis; Complete proteome;
Reference proteome; Repeat.
CHAIN 1 377 CASP8 and FADD-like apoptosis regulator
subunit p43. {ECO:0000250}.
/FTId=PRO_0000004680.
CHAIN 378 481 CASP8 and FADD-like apoptosis regulator
subunit p12. {ECO:0000250}.
/FTId=PRO_0000004681.
DOMAIN 6 78 DED 1. {ECO:0000255|PROSITE-
ProRule:PRU00065}.
DOMAIN 97 172 DED 2. {ECO:0000255|PROSITE-
ProRule:PRU00065}.
REGION 265 360 Caspase.
COMPBIAS 418 422 Poly-Ser.
VAR_SEQ 205 215 LQNGRSKEPRF -> VSLEPVYGVPA (in isoform
2). {ECO:0000303|PubMed:9289491}.
/FTId=VSP_000842.
VAR_SEQ 216 481 Missing (in isoform 2).
{ECO:0000303|PubMed:9289491}.
/FTId=VSP_000843.
CONFLICT 121 121 T -> TRIT (in Ref. 1; CAA74369/CAA74368).
{ECO:0000305}.
SEQUENCE 481 AA; 54875 MW; 433E07E2E5FA5A05 CRC64;
MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL
AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL
TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS
QGARSNMNTL QASLPKLSIK YNSRLQNGRS KEPRFVEYRD SQRTLVKTSI QESGAFLPPH
IREETYRMQS KPLGICLIID CIGNDTKYLQ ETFTSLGYHI QLFLFPKSHD ITQIVRRYAS
MAQHQDYDSF ACVLVSLGGS QSMMGRDQVH SGFSLDHVKN MFTGDTCPSL RGKPKLFFIQ
NYESLGSQLE DSSLEVDGPS IKNVDSKPLQ PRHCTTHPEA DIFWSLCTAD VSHLEKPSSS
SSVYLQKLSQ QLKQGRRRPL VDLHVELMDK VYAWNSGVSS KEKYSLSLQH TLRKKLILAP
T


Related products :

Catalog number Product name Quantity
18-003-42865 CASP8 and FADD-like apoptosis regulator - Cellular FLICE-like inhibitory protein; c-FLIP; Caspase-eight-related protein; Casper; Caspase-like apoptosis regulatory protein; CLARP; MACH-related inducer 0.1 mg Protein A
18-661-15040 CASP8 and FADD-like apoptosis regulator - Cellular FLICE-like inhibitory protein; c-FLIP; Caspase-eight-related protein; Casper; Caspase-like apoptosis regulatory protein; CLARP; MACH-related inducer 0.1 mg
18-661-15024 CASP8 and FADD-like apoptosis regulator - Cellular FLICE-like inhibitory protein; c-FLIP; Caspase-eight-related protein; Casper; Caspase-like apoptosis regulatory protein; CLARP; MACH-related inducer 0.1 mg
18-661-15026 CASP8 and FADD-like apoptosis regulator - Cellular FLICE-like inhibitory protein; c-FLIP; Caspase-eight-related protein; Casper; Caspase-like apoptosis regulatory protein; CLARP; MACH-related inducer 0.1 mg
EIAAB06986 CASH,Cash,CASP8 and FADD-like apoptosis regulator,Caspase homolog,Caspase-eight-related protein,Caspase-like apoptosis regulatory protein,Casper,Cellular FLICE-like inhibitory protein,Cflar,c-FLIP,CLA
EIAAB06987 CASH,CASH,CASP8 and FADD-like apoptosis regulator,CASP8AP1,Caspase homolog,Caspase-eight-related protein,Caspase-like apoptosis regulatory protein,Casper,Cellular FLICE-like inhibitory protein,CFLAR,c
OBT1187 CFLAR, CASP8 & FADD_like apoptosis regulator, C_FLIP, CASPER, CLARP, MRIT, CASH, I_FLICE, FLAME_1, USURPIN, 55_35kD, Goat anti_Human; WB 100 µg.
EH1762 CASP8 and FADD-like apoptosis regulator Elisa Kit 96T
pro-920 Recombinant Human CASP8 and FADD-Like Apoptosis Regulator 20
pro-920 Recombinant Human CASP8 and FADD-Like Apoptosis Regulator 5
RPR-920 Recombinant Human CASP8 and FADD-Like Apoptosis Regulator 5
pro-920 Recombinant Human CASP8 and FADD-Like Apoptosis Regulator 1mg
E10807h Mouse ELISA Kit FOR CASP8 and FADD-like apoptosis regulator 96T
ant-433 Mouse Anti Human CASP8 and FADD-like apoptosis regulator 20
ant-433 Mouse Anti Human CASP8 and FADD-like apoptosis regulator 100
ant-433 Mouse Anti Human CASP8 and FADD-like apoptosis regulator 5
CFM2 CFLAR Gene CASP8 and FADD-like apoptosis regulator
201-20-1042 CFLAR{CASP8 and FADD-like apoptosis regulator}rabbit.pAb 0.1ml
U2015h CLIA Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,CASP8,CASP-8,Caspase-8,FADD-homologous ICE_ced-3-like protease,FADD-like ICE,FLICE,Homo sapiens,Human,ICE-like apoptotic protease 5,MACH, 96T
E2015h ELISA Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,CASP8,CASP-8,Caspase-8,FADD-homologous ICE_ced-3-like protease,FADD-like ICE,FLICE,Homo sapiens,Human,ICE-like apoptotic protease 5,MACH 96T
ant-433 Mouse Anti Human CASP8 and FADD-like apoptosis regulator CFLAR 100
CSB-EL005282HU Human CASP8 and FADD-like apoptosis regulator(CFLAR) ELISA kit 96T
CSB-EL005282MO Mouse CASP8 and FADD-like apoptosis regulator(CFLAR) ELISA kit 96T
GWB-F0708E Anti- CFLAR (CASP8 and FADD-like apoptosis regulator) Antibody
ant-433 Mouse Anti Human CASP8 and FADD-like apoptosis regulator CFLAR 20

Kits Elisa; taq POLYMERASE

Search in Google:

google

Share this page:
share on twitter rss feedsfacebookgoogle gentaur



Quick order!
Enter catalog number :


Gentaur; yes we can

Pathways :
WP1772: Apoptosis Modulation and Signaling
WP1018: Apoptosis
WP1082: Apoptosis Modulation by HSP70
WP1137: Apoptosis
WP1199: Apoptosis Modulation by HSP70
WP1254: Apoptosis
WP1290: Apoptosis
WP1351: Apoptosis
WP1392: Apoptosis Modulation by HSP70
WP166: Apoptosis Modulation by HSP70
WP2119: Interferon induced apoptosis
WP2272: Pathogenic Escherichia coli infection
WP2428: the quecetin and apoptosis pathway
WP254: Apoptosis
WP384: Apoptosis Modulation by HSP70
WP487: Apoptosis Modulation by HSP70
WP787: Apoptosis
WP843: Apoptosis Modulation by HSP70
WP901: Apoptosis
WP963: Apoptosis Modulation by HSP70
WP1019: FAS pathway and Stress induction of HSP regulation
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1067: Toll-like receptor signaling pathway
WP1138: FAS pathway and Stress induction of HSP regulation
WP1163: TNF-alpha NF-kB Signaling Pathway

Related Genes :
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[Cflar Cash] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[FADD MORT1 GIG3] FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) (Protein FADD)
[PYCARD ASC CARD5 TMS1] Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
[BIRC3 API2 MIHC RNF49] Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
[BIRC2 API1 MIHB RNF48] Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
[Fadd Mort1] FAS-associated death domain protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity) (Protein FADD)
[XIAP API3 BIRC4 IAP3] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[NOL3 ARC NOP] Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30)
[FAS APT1 FAS1 TNFRSF6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[Nol3 Arc] Nucleolar protein 3 (Apoptosis repressor with CARD)
[Birc2] Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (Inhibitor of apoptosis protein 2) (mIAP2) (RING-type E3 ubiquitin transferase BIRC2)
[CFLAR] CASP8 and FADD-like apoptosis regulator [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[Xiap Aipa Api3 Birc4 Miha] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[Fas Apt1 Tnfrsf6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Pycard Asc] Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein)
[Diap2 DIHA Iap2 Ilp CG8293] Death-associated inhibitor of apoptosis 2 (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2)
[DEDD2 FLAME3 PSEC0004] DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)
[Fadd fadd rCG_48606] FAS-associated death domain protein (FAS-associating death domain-containing protein) (Protein FADD)
[FADD] FAS-associated death domain protein (FAS-associating death domain-containing protein) (Protein FADD)
[APP A4 AD1] Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[FAS APT1 TNFRSF6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[RIPK1 RIP RIP1] Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
[Traf2] TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2)
[TRAF2 TRAP3] TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)

Bibliography :