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CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Protein FISP-12)

 CCN2_MOUSE              Reviewed;         348 AA.
P29268; G5E830; Q922U0;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 3.
16-OCT-2019, entry version 167.
RecName: Full=CCN family member 2;
AltName: Full=Cellular communication network factor 2;
AltName: Full=Connective tissue growth factor;
AltName: Full=Hypertrophic chondrocyte-specific protein 24;
AltName: Full=Protein FISP-12;
Flags: Precursor;
Name=Ccn2 {ECO:0000312|MGI:MGI:95537};
Synonyms=betaIG-M2 {ECO:0000303|PubMed:2029337}, Ctgf,
Fisp-12 {ECO:0000303|PubMed:1888698},
Fisp12 {ECO:0000303|PubMed:10082563}, Hcs24;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=1888698;
Ryseck R.-P., Macdonald-Bravo H., Mattei M.-G., Bravo R.;
"Structure, mapping, and expression of fisp-12, a growth factor-
inducible gene encoding a secreted cysteine-rich protein.";
Cell Growth Differ. 2:225-233(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2029337; DOI=10.1089/dna.1991.10.293;
Brunner A., Chinn J., Neubauer M.G., Purchio A.F.;
"Identification of a gene family regulated by transforming growth
factor-beta.";
DNA Cell Biol. 10:293-300(1991).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=9184077; DOI=10.1006/excr.1997.3548;
Kireeva M.L., Latinkic B.V., Kolesnikova T.V., Chen C.-C., Yang G.P.,
Abler A.S., Lau L.F.;
"Cyr61 and Fisp12 are both ECM-associated signaling molecules:
activities, metabolism, and localization during development.";
Exp. Cell Res. 233:63-77(1997).
[7]
FUNCTION.
PubMed=10082563; DOI=10.1128/mcb.19.4.2958;
Babic A.M., Chen C.-C., Lau L.F.;
"Fisp12/mouse connective tissue growth factor mediates endothelial
cell adhesion and migration through integrin alphavbeta3, promotes
endothelial cell survival, and induces angiogenesis in vivo.";
Mol. Cell. Biol. 19:2958-2966(1999).
-!- FUNCTION: Major connective tissue mitoattractant secreted by
vascular endothelial cells. Promotes proliferation and
differentiation of chondrocytes (By similarity). Mediates
heparin- and divalent cation-dependent cell adhesion in many cell
types including fibroblasts, myofibroblasts, endothelial and
epithelial cells (By similarity). Enhances fibroblast growth
factor-induced DNA synthesis (By similarity).
{ECO:0000250|UniProtKB:P29279, ECO:0000269|PubMed:10082563,
ECO:0000269|PubMed:9184077}.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000269|PubMed:9184077}. Secreted
{ECO:0000269|PubMed:9184077}.
-!- TISSUE SPECIFICITY: Testis, spleen, kidney, lung, heart, and brain
(lowest level in testis and highest in lung).
-!- INDUCTION: By growth factors.
-!- SIMILARITY: Belongs to the CCN family. {ECO:0000305}.
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EMBL; M70641; AAA37627.1; -; Genomic_DNA.
EMBL; M70642; AAA37628.1; -; mRNA.
EMBL; M80263; AAA73135.1; -; mRNA.
EMBL; AC099695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466540; EDL04783.1; -; Genomic_DNA.
EMBL; BC006783; AAH06783.1; -; mRNA.
CCDS; CCDS23751.1; -.
PIR; A40578; A40578.
RefSeq; NP_034347.2; NM_010217.2.
SMR; P29268; -.
IntAct; P29268; 1.
STRING; 10090.ENSMUSP00000020171; -.
PhosphoSitePlus; P29268; -.
CPTAC; non-CPTAC-3782; -.
MaxQB; P29268; -.
PaxDb; P29268; -.
PeptideAtlas; P29268; -.
PRIDE; P29268; -.
ABCD; P29268; -.
Ensembl; ENSMUST00000020171; ENSMUSP00000020171; ENSMUSG00000019997.
GeneID; 14219; -.
KEGG; mmu:14219; -.
UCSC; uc011xbr.1; mouse.
CTD; 1490; -.
MGI; MGI:95537; Ccn2.
eggNOG; ENOG410IH0W; Eukaryota.
eggNOG; ENOG4111F77; LUCA.
GeneTree; ENSGT00940000155019; -.
HOGENOM; HOG000231462; -.
InParanoid; P29268; -.
KO; K06827; -.
OMA; KEQTAVG; -.
OrthoDB; 999958at2759; -.
TreeFam; TF326070; -.
ChiTaRS; Ccn2; mouse.
PRO; PR:P29268; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000019997; Expressed in 350 organ(s), highest expression level in decidua.
ExpressionAtlas; P29268; baseline and differential.
Genevisible; P29268; MM.
GO; GO:0005938; C:cell cortex; ISO:MGI.
GO; GO:0005801; C:cis-Golgi network; ISO:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0031012; C:extracellular matrix; IDA:MGI.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0001968; F:fibronectin binding; ISO:MGI.
GO; GO:0008083; F:growth factor activity; ISO:MGI.
GO; GO:0008201; F:heparin binding; IDA:MGI.
GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
GO; GO:0005178; F:integrin binding; IDA:MGI.
GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IDA:MGI.
GO; GO:0001502; P:cartilage condensation; IDA:MGI.
GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IDA:MGI.
GO; GO:0016477; P:cell migration; IDA:MGI.
GO; GO:0007160; P:cell-matrix adhesion; IDA:MGI.
GO; GO:0035988; P:chondrocyte proliferation; IMP:MGI.
GO; GO:0061448; P:connective tissue development; IMP:MGI.
GO; GO:0060401; P:cytosolic calcium ion transport; ISO:MGI.
GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0070278; P:extracellular matrix constituent secretion; ISO:MGI.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IDA:MGI.
GO; GO:0007229; P:integrin-mediated signaling pathway; IDA:MGI.
GO; GO:0035556; P:intracellular signal transduction; ISO:MGI.
GO; GO:0030324; P:lung development; IMP:MGI.
GO; GO:0060548; P:negative regulation of cell death; ISO:MGI.
GO; GO:0010629; P:negative regulation of gene expression; IMP:MGI.
GO; GO:0001503; P:ossification; IMP:MGI.
GO; GO:0060452; P:positive regulation of cardiac muscle contraction; ISO:MGI.
GO; GO:0050867; P:positive regulation of cell activation; ISO:MGI.
GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
GO; GO:0045597; P:positive regulation of cell differentiation; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISO:MGI.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
GO; GO:0070318; P:positive regulation of G0 to G1 transition; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
GO; GO:0051496; P:positive regulation of stress fiber assembly; ISO:MGI.
GO; GO:0072593; P:reactive oxygen species metabolic process; IDA:MGI.
GO; GO:0032330; P:regulation of chondrocyte differentiation; IMP:MGI.
GO; GO:0043200; P:response to amino acid; IEA:Ensembl.
GO; GO:0034059; P:response to anoxia; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0070542; P:response to fatty acid; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0051385; P:response to mineralocorticoid; IEA:Ensembl.
GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO; GO:0001894; P:tissue homeostasis; IMP:MGI.
Gene3D; 2.20.100.10; -; 1.
InterPro; IPR006207; Cys_knot_C.
InterPro; IPR006208; Glyco_hormone_CN.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR000867; IGFBP-like.
InterPro; IPR012395; IGFBP_CNN.
InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
InterPro; IPR000884; TSP1_rpt.
InterPro; IPR036383; TSP1_rpt_sf.
InterPro; IPR001007; VWF_dom.
Pfam; PF00007; Cys_knot; 1.
Pfam; PF00219; IGFBP; 1.
Pfam; PF00090; TSP_1; 1.
Pfam; PF00093; VWC; 1.
PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
SMART; SM00041; CT; 1.
SMART; SM00121; IB; 1.
SMART; SM00209; TSP1; 1.
SMART; SM00214; VWC; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF82895; SSF82895; 1.
PROSITE; PS01185; CTCK_1; 1.
PROSITE; PS01225; CTCK_2; 1.
PROSITE; PS00222; IGFBP_N_1; 1.
PROSITE; PS51323; IGFBP_N_2; 1.
PROSITE; PS50092; TSP1; 1.
PROSITE; PS01208; VWFC_1; 1.
PROSITE; PS50184; VWFC_2; 1.
2: Evidence at transcript level;
Cell adhesion; Complete proteome; Disulfide bond; DNA synthesis;
Extracellular matrix; Heparin-binding; Reference proteome; Secreted;
Signal.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 348 CCN family member 2.
/FTId=PRO_0000014403.
DOMAIN 26 97 IGFBP N-terminal. {ECO:0000255|PROSITE-
ProRule:PRU00653}.
DOMAIN 100 166 VWFC. {ECO:0000255|PROSITE-
ProRule:PRU00220}.
DOMAIN 197 242 TSP type-1. {ECO:0000255|PROSITE-
ProRule:PRU00210}.
DOMAIN 255 329 CTCK. {ECO:0000255|PROSITE-
ProRule:PRU00039}.
REGION 246 348 Heparin-binding.
{ECO:0000250|UniProtKB:P29279}.
DISULFID 255 292 {ECO:0000250}.
DISULFID 272 306 {ECO:0000250}.
DISULFID 283 322 {ECO:0000250}.
DISULFID 286 324 {ECO:0000250}.
DISULFID 291 328 {ECO:0000250}.
CONFLICT 24 24 M -> T (in Ref. 1; AAA37627/AAA37628, 2;
AAA73135 and 5; AAH06783). {ECO:0000305}.
CONFLICT 161 161 E -> K (in Ref. 1; AAA37627/AAA37628).
{ECO:0000305}.
SEQUENCE 348 AA; 37824 MW; 9BD99E6D0BEFC7BC CRC64;
MLASVAGPIS LALVLLALCT RPAMGQDCSA QCQCAAEAAP HCPAGVSLVL DGCGCCRVCA
KQLGELCTER DPCDPHKGLF CDFGSPANRK IGVCTAKDGA PCVFGGSVYR SGESFQSSCK
YQCTCLDGAV GCVPLCSMDV RLPSPDCPFP RRVKLPGKCC EEWVCDEPKD RTAVGPALAA
YRLEDTFGPD PTMMRANCLV QTTEWSACSK TCGMGISTRV TNDNTFCRLE KQSRLCMVRP
CEADLEENIK KGKKCIRTPK IAKPVKFELS GCTSVKTYRA KFCGVCTDGR CCTPHRTTTL
PVEFKCPDGE IMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA


Related products :

Catalog number Product name Quantity
U0010m CLIA CCN family member 2,Ccn2,Connective tissue growth factor,Ctgf,Fisp12,Fisp-12,Hcs24,Hypertrophic chondrocyte-specific protein 24,Mouse,Mus musculus,Protein FISP-12 96T
E0010m ELISA CCN family member 2,Ccn2,Connective tissue growth factor,Ctgf,Fisp12,Fisp-12,Hcs24,Hypertrophic chondrocyte-specific protein 24,Mouse,Mus musculus,Protein FISP-12 96T
E0010m ELISA kit CCN family member 2,Ccn2,Connective tissue growth factor,Ctgf,Fisp12,Fisp-12,Hcs24,Hypertrophic chondrocyte-specific protein 24,Mouse,Mus musculus,Protein FISP-12 96T
E0010h ELISA CCN family member 2,CCN2,Connective tissue growth factor,CTGF,HCS24,Homo sapiens,Human,Hypertrophic chondrocyte-specific protein 24,IBP-8,IGF-binding protein 8,IGFBP8,IGFBP-8,Insulin-like growth 96T
U0010h CLIA CCN family member 2,CCN2,Connective tissue growth factor,CTGF,HCS24,Homo sapiens,Human,Hypertrophic chondrocyte-specific protein 24,IBP-8,IGF-binding protein 8,IGFBP8,IGFBP-8,Insulin-like growth 96T
E0010h ELISA kit CCN family member 2,CCN2,Connective tissue growth factor,CTGF,HCS24,Homo sapiens,Human,Hypertrophic chondrocyte-specific protein 24,IBP-8,IGF-binding protein 8,IGFBP8,IGFBP-8,Insulin-like g 96T
10-663-45262 Connective tissue Growth Factor (CTGF) Human - Hypertrophic chondrocyte-specific protein 24 N_A 0.002 mg
10-663-45262 Connective tissue Growth Factor (CTGF) Human - Hypertrophic chondrocyte-specific protein 24 N_A 0.01 mg
10-663-45262 Connective tissue Growth Factor (CTGF) Human - Hypertrophic chondrocyte-specific protein 24 N_A 1 mg
U2153h CLIA kit CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1- 96T
E2153h ELISA kit CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1 96T
U2153h CLIA CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1-induc 96T
E2153h ELISA CCN family member 5,CCN5,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGFL,CTGF-L,Homo sapiens,Human,UNQ228_PRO261,WISP2,WISP-2,WNT1-indu 96T
U0010r CLIA CCN family member 2,Ccn2,Connective tissue growth factor,Connective tissue growth-related protein,Ctgf,Rat,Rattus norvegicus 96T
E0010r ELISA CCN family member 2,Ccn2,Connective tissue growth factor,Connective tissue growth-related protein,Ctgf,Rat,Rattus norvegicus 96T
E0010r ELISA kit CCN family member 2,Ccn2,Connective tissue growth factor,Connective tissue growth-related protein,Ctgf,Rat,Rattus norvegicus 96T
U2153r CLIA kit CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153r ELISA CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153r ELISA kit CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 96T
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E2153m ELISA kit CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
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U2153m CLIA kit CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E0010p ELISA CCN family member 2,CCN2,Connective tissue growth factor,CTGF,Pig,Sus scrofa 96T
Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1909: Signal regulatory protein (SIRP) family interactions
WP1694: Pyrimidine metabolism
WP1654: gamma-Hexachlorocyclohexane degradation
WP1983: Splicing factor NOVA regulated synpatic proteins
WP1661: Glyoxylate and dicarboxylate metabolism
WP211: BMP signaling pathway
WP1714: Tyrosine metabolism
WP346: Protein Modifications
WP1165: G Protein Signaling Pathways
WP1672: Mismatch repair
WP2203: TSLP Signaling Pathway
WP1493: Carbon assimilation C4 pathway
WP2272: Pathogenic Escherichia coli infection

Related Genes :
[CCN2 CTGF HCS24 IGFBP8] CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)
[CCN3 IGFBP9 NOV NOVH] CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
[Ccn3 Nov] CCN family member 3 (Cellular communication network factor 3) (Nephroblastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
[Ccn3 Nov] CCN family member 3 (Cellular communication network factor 3) (Nephroblastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
[PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1] Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
[Ccn6 Wisp3] Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3)
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Gas2 Gas-2] Growth arrest-specific protein 2 (GAS-2)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[IGF2BP1 CRDBP VICKZ1 ZBP1] Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
[Igf2bp1 Vickz1] Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p39); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16) (p35)]
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p39); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16) (p35)]
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p39); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16) (p35)]
[Celf1 Brunol2 Cugbp Cugbp1] CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Brain protein F41) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Deadenylation factor EDEN-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2)
[GN EMB30 GBF3 MIZ2 VAN7 At1g13980 F16A14.20 F7A19.7] ARF guanine-nucleotide exchange factor GNOM (Pattern formation protein EMB30) (Protein EMBRYO DEFECTIVE 30) (Protein MIZU-KUSSEI2) (Protein VASCULAR NETWORK 7)
[SMARCA4 BAF190A BRG1 SNF2B SNF2L4] Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[IGF2BP3 IMP3 KOC1 VICKZ3] Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[IGF2BP2 IMP2 VICKZ2] Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Klk1b3 Klk-3 Klk3 Ngfg] Kallikrein 1-related peptidase b3 (EC 3.4.21.35) (7S nerve growth factor gamma chain) (Gamma-NGF) (Glandular kallikrein K3) (mGK-3) (Tissue kallikrein-3) [Cleaved into: Nerve growth factor gamma chain 1; Nerve growth factor gamma chain 2]
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[FGFR3 JTK4] Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
[POSTN OSF2] Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)

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