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CD166 antigen (Activated leukocyte cell adhesion molecule) (SB-10 antigen) (CD antigen CD166) (Fragment)

 CD166_CANLF             Reviewed;         521 AA.
O46634;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-NOV-2018, entry version 89.
RecName: Full=CD166 antigen;
AltName: Full=Activated leukocyte cell adhesion molecule;
AltName: Full=SB-10 antigen {ECO:0000303|PubMed:9556065};
AltName: CD_antigen=CD166;
Flags: Fragment;
Name=ALCAM;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mesenchymal cell;
PubMed=9556065; DOI=10.1359/jbmr.1998.13.4.655;
Bruder S.P., Ricalton N.S., Boynton R.E., Connolly T.J., Jaiswal N.,
Zaia J., Barry F.P.;
"Mesenchymal stem cell surface antigen SB-10 corresponds to activated
leukocyte cell adhesion molecule and is involved in osteogenic
differentiation.";
J. Bone Miner. Res. 13:655-663(1998).
-!- FUNCTION: Cell adhesion molecule that mediates both heterotypic
cell-cell contacts via its interaction with CD6, as well as
homotypic cell-cell contacts. Promotes T-cell activation and
proliferation via its interactions with CD6 (By similarity).
Contributes to the formation and maturation of the immunological
synapse via its interactions with CD6 (By similarity). Mediates
homotypic interactions with cells that express ALCAM. Mediates
attachment of dendritic cells onto endothelial cells via homotypic
interaction. Inhibits endothelial cell migration and promotes
endothelial tube formation via homotypic interactions. Required
for normal organization of the lymph vessel network. Required for
normal hematopoietic stem cell engraftment in the bone marrow.
Plays a role in hematopoiesis; required for normal numbers of
hematopoietic stem cells in bone marrow. Promotes in vitro
osteoblast proliferation and differentiation (By similarity).
Promotes neurite extension, axon growth and axon guidance; axons
grow preferentially on surfaces that contain ALCAM (By
similarity). Mediates outgrowth and pathfinding for retinal
ganglion cell axons (By similarity).
{ECO:0000250|UniProtKB:P42292, ECO:0000250|UniProtKB:Q13740,
ECO:0000250|UniProtKB:Q61490}.
-!- SUBUNIT: Homodimer. Interacts (via extracellular domain) with CD6
(via extracellular domain). Homodimerization and interaction with
CD6 involve the same region and cannot occur simultaneously. The
affinity for CD6 is much higher than the affinity for self-
association. Interacts (via glycosylated extracellular domain)
with LGALS1 and LGALS3. Interaction with LGALS1 or LGALS3 inhibits
interaction with CD6. {ECO:0000250|UniProtKB:Q13740}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:Q61490}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:Q61490}. Cell projection, axon
{ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite
{ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological
synapse, i.e, at the contact zone between antigen-presenting
dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3
complex at the immunological synapse.
{ECO:0000250|UniProtKB:Q13740}.
-!- DOMAIN: The CD6 binding site is located in the N-terminal Ig-like
domain. {ECO:0000250|UniProtKB:Q13740}.
-!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q13740}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; Y13242; CAA73694.1; -; mRNA.
UniGene; Cfa.3742; -.
ProteinModelPortal; O46634; -.
SMR; O46634; -.
STRING; 9615.ENSCAFP00000014280; -.
PaxDb; O46634; -.
eggNOG; ENOG410IFQ2; Eukaryota.
eggNOG; ENOG410ZWU9; LUCA.
HOGENOM; HOG000070101; -.
HOVERGEN; HBG050847; -.
InParanoid; O46634; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0030424; C:axon; ISS:UniProtKB.
GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
GO; GO:0001772; C:immunological synapse; ISS:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0048846; P:axon extension involved in axon guidance; ISS:UniProtKB.
GO; GO:0007155; P:cell adhesion; ISS:UniProtKB.
GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:UniProtKB.
GO; GO:1990138; P:neuron projection extension; ISS:UniProtKB.
GO; GO:0031290; P:retinal ganglion cell axon guidance; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR039810; CD166_antigen.
InterPro; IPR013162; CD80_C2-set.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
PANTHER; PTHR11973:SF2; PTHR11973:SF2; 1.
Pfam; PF08205; C2-set_2; 1.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 4.
PROSITE; PS50835; IG_LIKE; 4.
2: Evidence at transcript level;
Adaptive immunity; Cell adhesion; Cell membrane; Cell projection;
Complete proteome; Disulfide bond; Glycoprotein; Immunity;
Immunoglobulin domain; Membrane; Reference proteome; Repeat;
Transmembrane; Transmembrane helix.
CHAIN <1 521 CD166 antigen.
/FTId=PRO_0000072677.
TOPO_DOM <1 465 Extracellular. {ECO:0000255}.
TRANSMEM 466 487 Helical. {ECO:0000255}.
TOPO_DOM 488 521 Cytoplasmic. {ECO:0000255}.
DOMAIN 63 172 Ig-like V-type 2.
DOMAIN 183 266 Ig-like C2-type 1.
DOMAIN 271 347 Ig-like C2-type 2.
DOMAIN 354 439 Ig-like C2-type 3.
CARBOHYD 33 33 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 105 105 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 244 244 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 299 299 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 395 395 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 418 418 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 437 437 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 95 158 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 208 251 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 292 330 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 373 423 {ECO:0000255|PROSITE-ProRule:PRU00114}.
NON_TER 1 1
SEQUENCE 521 AA; 58107 MW; A3616E9A2429E7B6 CRC64;
GSPVFIAFRS STKKSVQYDD VPEYEDRLSL SENYTLSISN ARISDEKRFV CMLVTEDNVF
EAPTIVKVFK QPSKPEIVSK APFLETEQLK KLGDCISKDS YPDGNITWYR NGKVLQPLEG
VVVLIFKKQM DPVTQLYTMT SSLEYKATKA DIQMQFTCSV TYYGPSGQKT VQSEQAIFDI
YYPTEQVTIQ VLPSKTAIKE GDIITLKCLG NGNPPPEEFL FYLPGQPEGI RSSNTYTLTD
VRRNATGDYK CSLIDKKSMI ASTAITVHYL DLSLNPSGEV TKQIGDALPV SCTISASRNA
TVVWMKDNIR LRSSPSFSSL QYQDAGNYVC ETALQEVEGL KKRESLTLIV EGKPQIKMTK
KTDPSGLSKT IICHVEGFPK PAIQWTITGS GSVINQTEES PYINGRYYST IINSPEENVT
LTCTAENQLE RTVNSLNVSA ISIPEHDEAD EISDENREQV NHRATLIVGI VLRLLHGALV
AGVVYWLYVK KSKTASKHVN KDLGNLEENK KLEQNNHRTE A


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Pathways :
WP2328: Allograft rejection
WP1424: Globo Sphingolipid Metabolism
WP1069: Integrin-mediated cell adhesion
WP1185: Integrin-mediated cell adhesion
WP1386: Integrin-mediated cell adhesion
WP185: Integrin-mediated cell adhesion
WP6: Integrin-mediated cell adhesion
WP74: Integrin-mediated cell adhesion
WP832: Integrin-mediated cell adhesion
WP951: Integrin-mediated cell adhesion
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1043: Calcium Regulation in the Cardiac Cell
WP1078: G1 to S cell cycle control
WP1083: Cell cycle
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1159: Calcium Regulation in the Cardiac Cell
WP1195: G1 to S cell cycle control
WP1200: Cell cycle
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1365: Calcium Regulation in the Cardiac Cell
WP1393: Cell cycle
WP1411: Cell Division: First embryonic mitosis

Related Genes :
[ALCAM MEMD] CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN) (Protein DM-GRASP) (CD antigen CD166)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166)
[ALCAM] CD166 antigen (Activated leukocyte cell adhesion molecule) (SB-10 antigen) (CD antigen CD166) (Fragment)
[ALCAM] CD166 antigen (Activated leukocyte cell adhesion molecule) (SB-10 antigen) (CD antigen CD166) (Fragment)
[ALCAM] CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
[psbA] Photosystem II protein D1 (PSII D1 protein) (EC 1.10.3.9) (Photosystem II Q(B) protein)
[CD6] T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]
[Cd6] T-cell differentiation antigen CD6 (CD antigen CD6)
[ITGAL CD11A] Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
[SELL LNHR LYAM1] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
[EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1] Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
[Sell Lnhr Ly-22 Ly22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[Sell Lnhr Ly-22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[SELE ELAM1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Sele Elam-1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[CEACAM1 BGP BGP1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
[CD69 CLEC2C] Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)
[BCAM LU MSK19] Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)
[Selp Grmp] P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
[SELP GMRP GRMP] P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
[Selp] P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Ptprc Ly-5] Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (Lymphocyte antigen 5) (Ly-5) (T200) (CD antigen CD45)
[SELE] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Ceacam1] Carcinoembryonic antigen-related cell adhesion molecule 1 (ATP-dependent taurocolate-carrier protein) (Cell-CAM 105) (C-CAM 105) (Ecto-ATPase) (GP110) (pp120) (CD antigen CD66a)
[HLA-F HLA-5.4 HLAF] HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)
[Ly9 Ly-9] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)

Bibliography :
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