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CD177 molecule

 E2RFK4_CANLF            Unreviewed;       394 AA.
E2RFK4;
30-NOV-2010, integrated into UniProtKB/TrEMBL.
30-NOV-2010, sequence version 1.
16-JAN-2019, entry version 36.
SubName: Full=CD177 molecule {ECO:0000313|Ensembl:ENSCAFP00000007099};
Name=CD177 {ECO:0000313|VGNC:VGNC:38934};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000007099, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000007099, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000007099,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000007099}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000007099};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AAEX03000909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
SMR; E2RFK4; -.
STRING; 9615.ENSCAFP00000007099; -.
PaxDb; E2RFK4; -.
PRIDE; E2RFK4; -.
Ensembl; ENSCAFT00000007665; ENSCAFP00000007099; ENSCAFG00000004765.
VGNC; VGNC:38934; CD177.
eggNOG; ENOG410J207; Eukaryota.
eggNOG; ENOG4111D7X; LUCA.
GeneTree; ENSGT00530000063351; -.
InParanoid; E2RFK4; -.
OMA; GQVCQET; -.
TreeFam; TF337286; -.
Reactome; R-CFA-202733; Cell surface interactions at the vascular wall.
Reactome; R-CFA-6798695; Neutrophil degranulation.
Proteomes; UP000002254; Chromosome 1.
Bgee; ENSCAFG00000004765; Expressed in 3 organ(s), highest expression level in liver.
InterPro; IPR016054; LY6_UPA_recep-like.
Pfam; PF00021; UPAR_LY6; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002254};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 21 {ECO:0000256|SAM:SignalP}.
CHAIN 22 394 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003163507.
DOMAIN 133 202 UPAR/Ly6. {ECO:0000259|Pfam:PF00021}.
DOMAIN 325 393 UPAR/Ly6. {ECO:0000259|Pfam:PF00021}.
SEQUENCE 394 AA; 42094 MW; DF098B10537D4CBC CRC64;
MSPALQLAFL GMTLMLSRVQ ALTCQSGTHN SLRDVLELPL EWTAGQESCE DGWGCQDTLI
LIENGPQVNV VISKGCTAAA DQDVLIREHR SGPGLSILSY THVCREKDNC NSLSTTLPLW
SLPSTTGPGS LRCPVCLSTE DCESATELAC PAGSTHCYRG AVWIRGGNIF QILRVQGCMS
QPGCDLLNGT QEIGSIKVSE DCRPNAPFSD LSRGIMLHSH QHLSQTPIKW TPNNYELCNI
GEVCQETLLL IDVGHKSIIV GSKGCSKGRT QDAPTITIHS APPGVLVASY AHFCSSNRCN
RASSTSVLLN SLPHSAAPAP GDLQCPVCLQ IFGSCPENPE KVTCPSGTTH CYSGYITLRE
GGIYSALDIQ GCMTQGSSSL LNHARTIGVF SVME


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1F-314-T025 Mouse Monoclonal to CD177 Antigen CD177 Isotype IgG1 Antigen CD177 Isotype IgG1 25 tests
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1A-314-T100 Mouse Monoclonal to CD177 Antigen CD177 Isotype IgG1 Antigen CD177 Isotype IgG1 100 tests

Kits Elisa; taq POLYMERASE

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Pathways :
WP1932: Transmembrane transport of small molecules
WP1937: Transport of vitamins, nucleosides, and related molecules
WP1963: The effect of Glucocorticoids on target gene expression
WP2328: Allograft rejection

Related Genes :
[CD177 NB1 PRV1 UNQ595/PRO1181] CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)
[Cd177] CD177 antigen (CD antigen CD177)
[PECAM1] Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
[ITGB2 CD18 MFI7] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[PRTN3 MBN] Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
[Pecam1 Pecam Pecam-1] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)
[Pecam1 Pecam] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)
[PECAM1] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)
[Itgb2] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[Itgam] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (CD antigen CD11b)
[Prtn3] Myeloblastin (EC 3.4.21.76) (Proteinase 3) (PR-3)
[KCNIP3 CSEN DREAM KCHIP3] Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)
[ITGB2 CD18] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[ITGB2 CD18] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[ITGB2 CD18] Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
[PECAM1] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)
[ITGAM] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (CD antigen CD11b) (Fragment)
[F11R JAM1 JCAM UNQ264/PRO301] Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)
[Chl1 Call] Neural cell adhesion molecule L1-like protein (Cell adhesion molecule with homology to L1CAM) (Chl1-like protein) (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]
[JAM2 C21orf43 VEJAM UNQ219/PRO245] Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)
[Nrcam] Neuronal cell adhesion molecule (Nr-CAM) (Ankyrin-binding cell adhesion molecule NrCAM) (Neuronal surface protein Bravo) (rBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)
[Cadm1 Igsf4 Necl2 Ra175 Syncam SynCam1 Tslc1] Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
[CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1] Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
[JAM3 UNQ859/PRO1868] Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)]
[CRTAM] Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355)
[CADM3 IGSF4B NECL1 SYNCAM3 TSLL1 UNQ225/PRO258] Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1)
[Jam3] Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)]
[Ceacam2 Bgp2] Carcinoembryonic antigen-related cell adhesion molecule 2 (CEA-related cell adhesion molecule 2) (Biliary glycoprotein 2) (BGP-2)
[Cadm3 Igsf4b Necl1 Syncam3 Tsll1] Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (TSLC1-like protein 1)

Bibliography :
[30697465] Proteomic Profiles in Advanced Age-Related Macular Degeneration Using an Aptamer-Based Proteomic Technology.
[30674924] Genome-wide transcriptome analysis to further understand neutrophil activation and lncRNA transcript profiles in Kawasaki disease.
[30236159] Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA.
[29990379] CD177-mediated nanoparticle targeting of human and mouse neutrophils.
[29637127] Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.
[28807980] CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.
[27568821] Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients.
[25809793] CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1α, CXCR4, Osteopontin and Cathepsin K.
[25359465] Characterization of a novel mouse model with genetic deletion of CD177.
[25221604] Peripheral blood T cells and neutrophils from asthma patients express class-I MHC-restricted T cell-associated molecule.
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