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CD36 molecule (Testis cDNA, clone: QtsA-18492, similar to human CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36))

 Q4R6B4_MACFA            Unreviewed;       472 AA.
Q4R6B4;
19-JUL-2005, integrated into UniProtKB/TrEMBL.
19-JUL-2005, sequence version 1.
13-FEB-2019, entry version 48.
SubName: Full=CD36 molecule {ECO:0000313|Ensembl:ENSMFAP00000025488};
SubName: Full=Testis cDNA, clone: QtsA-18492, similar to human CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36) {ECO:0000313|EMBL:BAE01361.1};
Name=CD36 {ECO:0000313|Ensembl:ENSMFAP00000025488};
ORFNames=EGM_12817 {ECO:0000313|EMBL:EHH52385.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|EMBL:BAE01361.1};
[1] {ECO:0000313|EMBL:BAE01361.1}
NUCLEOTIDE SEQUENCE.
PubMed=15944441; DOI=10.1093/molbev/msi187;
Osada N., Hirata M., Tanuma R., Kusuda J., Hida M., Suzuki Y.,
Sugano S., Gojobori T., Shen C.K., Wu C.I., Hashimoto K.;
"Substitution rate and structural divergence of 5'UTR evolution:
comparative analysis between human and cynomolgus monkey cDNAs.";
Mol. Biol. Evol. 22:1976-1982(2005).
[2] {ECO:0000313|EMBL:BAE01361.1}
NUCLEOTIDE SEQUENCE.
International consortium for macaque cDNA sequencing and analysis;
"DNA sequences of macaque genes expressed in brain or testis and its
evolutionary implications.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:EHH52385.1, ECO:0000313|Proteomes:UP000009130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CE-4 {ECO:0000313|EMBL:EHH52385.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[4] {ECO:0000313|Ensembl:ENSMFAP00000025488}
NUCLEOTIDE SEQUENCE.
Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|Ensembl:ENSMFAP00000025488}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- SIMILARITY: Belongs to the CD36 family.
{ECO:0000256|SAAS:SAAS00579224}.
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Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AQIA01047502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AQIA01047503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AB169273; BAE01361.1; -; mRNA.
EMBL; CM001278; EHH52385.1; -; Genomic_DNA.
RefSeq; XP_005550429.1; XM_005550372.2.
RefSeq; XP_005550430.1; XM_005550373.2.
RefSeq; XP_005550431.1; XM_005550374.2.
RefSeq; XP_005550433.1; XM_005550376.2.
RefSeq; XP_005550434.1; XM_005550377.2.
RefSeq; XP_005550435.1; XM_005550378.2.
RefSeq; XP_015303331.1; XM_015447845.1.
RefSeq; XP_015303333.1; XM_015447847.1.
RefSeq; XP_015303334.1; XM_015447848.1.
UniGene; Mfa.8195; -.
SMR; Q4R6B4; -.
Ensembl; ENSMFAT00000033638; ENSMFAP00000025488; ENSMFAG00000044200.
GeneID; 101926577; -.
KEGG; mcf:101926577; -.
CTD; 948; -.
GeneTree; ENSGT00940000153372; -.
HOVERGEN; HBG002754; -.
KO; K06259; -.
OrthoDB; 1106566at2759; -.
Proteomes; UP000009130; Chromosome 3.
GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0008289; F:lipid binding; IEA:Ensembl.
GO; GO:0070892; F:lipoteichoic acid receptor activity; IEA:Ensembl.
GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:Ensembl.
GO; GO:0150025; F:oxidised low-density lipoprotein particle receptor activity; IEA:Ensembl.
GO; GO:0005044; F:scavenger receptor activity; IEA:Ensembl.
GO; GO:0035325; F:Toll-like receptor binding; IEA:Ensembl.
GO; GO:1990000; P:amyloid fibril formation; IEA:Ensembl.
GO; GO:0150094; P:amyloid-beta clearance by cellular catabolic process; IEA:Ensembl.
GO; GO:0043277; P:apoptotic cell clearance; IEA:Ensembl.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
GO; GO:0071726; P:cellular response to diacyl bacterial lipopeptide; IEA:Ensembl.
GO; GO:0071447; P:cellular response to hydroperoxide; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl.
GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0019934; P:cGMP-mediated signaling; IEA:Ensembl.
GO; GO:0070508; P:cholesterol import; IEA:Ensembl.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0050702; P:interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0030299; P:intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0042953; P:lipoprotein transport; IEA:Ensembl.
GO; GO:0044539; P:long-chain fatty acid import into cell; IEA:Ensembl.
GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0055096; P:low-density lipoprotein particle mediated signaling; IEA:Ensembl.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
GO; GO:0150024; P:oxidised low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0006910; P:phagocytosis, recognition; IEA:Ensembl.
GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
GO; GO:2000334; P:positive regulation of blood microparticle formation; IEA:Ensembl.
GO; GO:0010942; P:positive regulation of cell death; IEA:Ensembl.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0010886; P:positive regulation of cholesterol storage; IEA:Ensembl.
GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0098900; P:regulation of action potential; IEA:Ensembl.
GO; GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl.
GO; GO:2000121; P:regulation of removal of superoxide radicals; IEA:Ensembl.
GO; GO:0034121; P:regulation of toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0070543; P:response to linoleic acid; IEA:Ensembl.
GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
GO; GO:0050909; P:sensory perception of taste; IEA:Ensembl.
GO; GO:0034197; P:triglyceride transport; IEA:Ensembl.
InterPro; IPR005428; CD36/SCARB1/SNMP1.
InterPro; IPR033076; CD36_chordates.
InterPro; IPR002159; CD36_fam.
PANTHER; PTHR11923; PTHR11923; 1.
PANTHER; PTHR11923:SF12; PTHR11923:SF12; 1.
Pfam; PF01130; CD36; 1.
PRINTS; PR01610; CD36ANTIGEN.
PRINTS; PR01609; CD36FAMILY.
2: Evidence at transcript level;
Collagen {ECO:0000313|EMBL:BAE01361.1};
Complete proteome {ECO:0000313|Proteomes:UP000009130};
Membrane {ECO:0000256|SAAS:SAAS00106193, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000313|EMBL:BAE01361.1};
Reference proteome {ECO:0000313|Proteomes:UP000009130};
Transmembrane {ECO:0000256|SAAS:SAAS00106193,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00106193,
ECO:0000256|SAM:Phobius}.
TRANSMEM 7 29 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 440 466 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 472 AA; 53041 MW; E26EEF2671CA2581 CRC64;
MGCDRNCGLI TGAVIGAVLA VFGGILMPVG DMLIQKTIKK EVVLEEGTIA FKNWVKTGTE
IYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK ENITQDPKDN TVSFLQPNGA
IFEPSLSVGT EADNFTVLNL AVAAASHIYP NPFVQVVLNS LINKSKSSMF QVRTLRELLW
GYTDPFLSLV PYPVSTRVGM FYPYNNTADG VYKVFNGKDS ISKVAIIDTY KGKRNLSYWE
SYCDMINGTD AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF
ASPVQNPDNH CFCTEKIISK NCTSYGVLDI SKCKEGKPVY ISLPHFLYAS PDVSETIDGL
NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSNKIQ VLKRLKRNYI VPILWLNETG
TIGDEKAKMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM ISYCACRSKT IK


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Pathways :
WP1259: Retinol metabolism
WP1297: Retinol metabolism
WP2316: PPAR signaling pathway
WP805: Retinol metabolism (BiGCaT, NuGO)
WP2272: Pathogenic Escherichia coli infection
WP2328: Allograft rejection
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1017: Type II interferon signaling (IFNG)
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1068: Nuclear Receptors
WP1099: Nuclear receptors in lipid metabolism and toxicity
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1136: Type II interferon signaling (IFNG)
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1183: Toll-like receptor signaling pathway

Related Genes :
[CD36 EGM_12817] CD36 molecule (Testis cDNA, clone: QtsA-18492, similar to human CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36))
[FDC1 CD36_64160] Ferulic acid decarboxylase 1 (EC 4.1.1.102) (Phenacrylate decarboxylase)
[CD36 GP3B GP4] Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36)
[SCARB2 CD36L2 LIMP2 LIMPII] Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36)
[Cd36] Platelet glycoprotein 4 (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36)
[Cd36 Fat] Platelet glycoprotein 4 (Adipocyte membrane protein) (Fatty acid translocase) (Fatty acid transport protein) (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36)
[RAD27 FEN1 CD36_29920] Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1)
[HAM1 Cd36_53590 CD36_53590] Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)
[RBK1 Cd36_11960 CD36_11960] Ribokinase (RK) (EC 2.7.1.15)
[Cd36_71630 CD36_71630] ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)
[CD36 PAS4] Platelet glycoprotein 4 (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36)
[CD36] Platelet glycoprotein 4 (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36)
[PIM1 CD36_29680] Lon protease homolog, mitochondrial (EC 3.4.21.53)
[PAN3 Cd36_54770 CD36_54770] PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)
[PIF1 Cd36_32990 CD36_32990] ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1)
[Cd36_54420 CD36_54420] ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)
[TAH18 Cd36_15780 CD36_15780] NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase)
[PAN2 Cd36_08560 CD36_08560] PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2)
[KEX1 CD36_70870] Pheromone-processing carboxypeptidase KEX1 (EC 3.4.16.6) (Carboxypeptidase D)
[Cd36_50210 CD36_50210] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.21) (EC 2.7.4.24)
[NTG1 Cd36_07730 CD36_07730] Endonuclease III homolog (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[ERG3 CD36_04520] Delta(7)-sterol 5(6)-desaturase (EC 1.14.19.20) (C-5 sterol desaturase) (Ergosterol Delta(5,6) desaturase) (Sterol-C5-desaturase)
[MAP2 CD36_64570] Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M)
[Cd36_30420 CD36_30420] Formate dehydrogenase (FDH) (EC 1.17.1.9) (NAD-dependent formate dehydrogenase)
[Cd36_53500 CD36_53500] Formate dehydrogenase (FDH) (EC 1.17.1.9) (NAD-dependent formate dehydrogenase)
[Cd36_02070 CD36_02070] NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)
[SEC11 CD36_25990] Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) (Signal peptidase I)
[crq CG4280] Protein croquemort (d-CD36)
[EXO5 DEM1 CD36_28710] Exonuclease V, mitochondrial (Exo V) (EC 3.1.-.-) (Defects in morphology protein 1)
[ADI1 Cd36_10410 CD36_10410] 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD)

Bibliography :
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