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CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5)

 G1MX04_MELGA            Unreviewed;       272 AA.
G1MX04;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
17-JUN-2020, entry version 61.
RecName: Full=CD40 ligand {ECO:0000256|PIRNR:PIRNR016527};
Short=CD40-L {ECO:0000256|PIRNR:PIRNR016527};
AltName: Full=Tumor necrosis factor ligand superfamily member 5 {ECO:0000256|PIRNR:PIRNR016527};
Name=CD40LG {ECO:0000313|Ensembl:ENSMGAP00000003333};
Meleagris gallopavo (Wild turkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
Meleagridinae; Meleagris.
NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000003333, ECO:0000313|Proteomes:UP000001645};
[1] {ECO:0000313|Ensembl:ENSMGAP00000003333, ECO:0000313|Proteomes:UP000001645}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
Zhang Y., Reed K.M.;
"Multi-platform next-generation sequencing of the domestic turkey
(Meleagris gallopavo): genome assembly and analysis.";
PLoS Biol. 8:E1000475-E1000475(2010).
[2] {ECO:0000313|Ensembl:ENSMGAP00000003333}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- FUNCTION: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates
T-cell proliferation and cytokine production. Involved in
immunoglobulin class switching. {ECO:0000256|PIRNR:PIRNR016527}.
-!- FUNCTION: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and
ITGAV:ITGB3; both integrins and the CD40 receptor are required for
activation of CD40-CD40LG signaling, which have cell-type dependent
effects, such as B-cell activation, NF-kappa-B signaling and anti-
apoptotic signaling. {ECO:0000256|PIRNR:PIRNR016527}.
-!- SUBUNIT: Homotrimer. {ECO:0000256|PIRNR:PIRNR016527}.
-!- SIMILARITY: Belongs to the tumor necrosis factor family.
{ECO:0000256|PIRNR:PIRNR016527, ECO:0000256|SAAS:SAAS00758062}.
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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RefSeq; XP_010713512.1; XM_010715210.2.
Ensembl; ENSMGAT00000004033; ENSMGAP00000003333; ENSMGAG00000003619.
GeneID; 100546658; -.
KEGG; mgp:100546658; -.
CTD; 959; -.
eggNOG; ENOG410IVYF; Eukaryota.
eggNOG; ENOG4111TET; LUCA.
GeneTree; ENSGT00970000193396; -.
HOGENOM; CLU_093203_0_0_1; -.
InParanoid; G1MX04; -.
KO; K03161; -.
OMA; MKMDKME; -.
OrthoDB; 1146113at2759; -.
TreeFam; TF332169; -.
Proteomes; UP000001645; Chromosome 9.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005174; F:CD40 receptor binding; IEA:UniProtKB-UniRule.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
GO; GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl.
GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
GO; GO:0042100; P:B cell proliferation; IEA:UniProtKB-UniRule.
GO; GO:0023035; P:CD40 signaling pathway; IEA:Ensembl.
GO; GO:0048305; P:immunoglobulin secretion; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0045190; P:isotype switching; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030168; P:platelet activation; IEA:UniProtKB-UniRule.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0051023; P:regulation of immunoglobulin secretion; IEA:Ensembl.
CDD; cd00184; TNF; 1.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR003263; CD40L.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
PANTHER; PTHR11471:SF5; PTHR11471:SF5; 1.
Pfam; PF00229; TNF; 1.
PIRSF; PIRSF016527; TNF_5; 1.
PRINTS; PR01702; CD40LIGAND.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
3: Inferred from homology;
Cytokine {ECO:0000256|PIRNR:PIRNR016527, ECO:0000256|SAAS:SAAS00562264};
Disulfide bond {ECO:0000256|PIRSR:PIRSR016527-2};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000001645};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 20..46
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 137..272
/note="TNF_2"
/evidence="ECO:0000259|PROSITE:PS50049"
REGION 109..128
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SITE 110..111
/note="Cleavage"
/evidence="ECO:0000256|PIRSR:PIRSR016527-1"
DISULFID 190..229
/evidence="ECO:0000256|PIRSR:PIRSR016527-2"
SEQUENCE 272 AA; 30845 MW; 4C052B416BDC8BAD CRC64;
MNEAYSSAAP RPMSSTSPST MKMFMCFLAV FMVVQTIGTV LFCLYLHMKM DKMEEVLSLN
EDYIFLRKVQ KCQTEEGQKS TLLDCEKVLK GFQDLQCKDR TASEELPKFE MHRGHEHPHL
KSRNETSVAE EKRQPIATHL AGVKSSRAVR VLEWKTTSYA PTSSLISYHE GKLKVEKAGL
YYIYAQVSFC TKAAASAPFT LYIYLYLPME EDRLLMKGLD THSTSTALCE LQSIREGGVF
ELRQGDMVFV NVTDSTLVNA NPGNTYFGMF KL


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Pathways :
WP1032: NLR proteins
WP1322: IL-6 Signaling Pathway
WP161: Small Ligand GPCRs
WP971: Small Ligand GPCRs
WP1067: Toll-like receptor signaling pathway
WP40: Inflammatory Response Pathway
WP1156: Inflammatory Response Pathway
WP458: Inflammatory Response Pathway
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP750: IL-6 Signaling Pathway
WP1271: Toll-like receptor signaling pathway
WP829: Toll-like receptor signaling pathway
WP2328: Allograft rejection
WP1317: Small Ligand GPCRs
WP920: Inflammatory Response Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP949: Toll-like receptor signaling pathway
WP387: IL-6 signaling Pathway
WP1094: IL-6 Signaling Pathway
WP453: Inflammatory Response Pathway
WP1825: GPCR ligand binding
WP1183: Toll-like receptor signaling pathway
WP75: Toll-like receptor signaling pathway
WP1256: NLR proteins
WP247: Small Ligand GPCRs

Related Genes :
[CD40LG CD40L TNFSF5 TRAP] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[Cd40lg Cd40l Tnfsf5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[Cd40lg Cd40l Tnfsf5] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40 TNFRSF5] Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[TRAF3 CAP1 CRAF1] TNF receptor-associated factor 3 (EC 2.3.2.27) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
[Traf3 Craf1 Trafamn] TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (RING-type E3 ubiquitin transferase TRAF3) (TRAFAMN)
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF14 HVEML LIGHT UNQ391/PRO726] Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
[Faslg Apt1Lg1 Cd95l Fasl Tnfsf6] Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
[TNFSF11 OPGL RANKL TRANCE] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[Tnfsf11 Opgl Rankl Trance] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738] Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF4 TXGP1] Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252)
[TNFSF18 AITRL GITRL TL6 UNQ149/PRO175] Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)
[LTB TNFC TNFSF3] Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3)
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

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[30529036] A tetrameric form of CD40 ligand with potent biological activities in both mouse and human primary B cells.
[30503823] Impact of activated invariant natural killer T cells on the expansion of regulatory T cell precursors in murine thymocytes in vitro.
[29558818] Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation.
[29374968] Fibrinolytic Deficit and Platelet Activation in Atrial Fibrillation and Their Postablation Modulation.
[29040064] Strong impact on plasma protein profiles by precentrifugation delay but not by repeated freeze-thaw cycles, as analyzed using multiplex proximity extension assays.
[27702550] Modulation of cytotoxic responses by targeting CD160 prolongs skin graft survival across major histocompatibility class I barrier.
[24694719] Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.