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CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]

 CD40L_FELCA             Reviewed;         260 AA.
O97605;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
17-JUN-2020, entry version 129.
RecName: Full=CD40 ligand;
Short=CD40-L;
AltName: Full=Tumor necrosis factor ligand superfamily member 5;
AltName: CD_antigen=CD154;
Contains:
RecName: Full=CD40 ligand, membrane form;
Contains:
RecName: Full=CD40 ligand, soluble form {ECO:0000250|UniProtKB:P29965};
Short=sCD40L {ECO:0000250|UniProtKB:P29965};
Name=CD40LG; Synonyms=CD40L, TNFSF5;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Thymus;
Hosie M.J., Willett B.J.;
"Adjuvant properties of feline CD154 (CD40 ligand).";
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Cytokine that acts as a ligand to CD40/TNFRSF5 (By
similarity). Costimulates T-cell proliferation and cytokine production
(By similarity). Its cross-linking on T-cells generates a costimulatory
signal which enhances the production of IL4 and IL10 in conjunction
with the TCR/CD3 ligation and CD28 costimulation (By similarity).
Induces the activation of NF-kappa-B (By similarity). Induces the
activation of kinases MAPK8 and PAK2 in T-cells (By similarity).
Mediates B-cell proliferation in the absence of co-stimulus as well as
IgE production in the presence of IL4 (By similarity). Involved in
immunoglobulin class switching (By similarity).
{ECO:0000250|UniProtKB:P27548, ECO:0000250|UniProtKB:P29965}.
-!- FUNCTION: [CD40 ligand, soluble form]: Acts as a ligand for integrins,
specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40
receptor are required for activation of CD40-CD40LG signaling, which
have cell-type dependent effects, such as B-cell activation, NF-kappa-B
signaling and anti-apoptotic signaling. {ECO:0000250|UniProtKB:P29965}.
-!- SUBUNIT: Homotrimer (By similarity). Interacts with CD28 (By
similarity). CD40 ligand, soluble form: Exists as either a monomer or a
homotrimer (By similarity). Forms a ternary complex between CD40 and
integrins for CD40-CD40LG signaling (By similarity).
{ECO:0000250|UniProtKB:P29965}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P29965};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:P29965}.
Cell surface {ECO:0000250|UniProtKB:P29965}.
-!- SUBCELLULAR LOCATION: [CD40 ligand, soluble form]: Secreted
{ECO:0000250|UniProtKB:P29965}. Note=Release of soluble CD40L from
platelets is partially regulated by GP IIb/IIIa, actin polymerization,
and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
{ECO:0000250|UniProtKB:P29965}.
-!- PTM: The soluble form derives from the membrane form by proteolytic
processing. {ECO:0000250|UniProtKB:P29965}.
-!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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EMBL; AF079105; AAD02954.1; -; mRNA.
RefSeq; NP_001009298.1; NM_001009298.1.
STRING; 9685.ENSFCAP00000003839; -.
Ensembl; ENSFCAT00000043435; ENSFCAP00000033038; ENSFCAG00000039949.
GeneID; 493850; -.
KEGG; fca:493850; -.
CTD; 959; -.
eggNOG; ENOG410IVYF; Eukaryota.
eggNOG; ENOG4111TET; LUCA.
GeneTree; ENSGT00970000193396; -.
HOGENOM; CLU_093203_0_0_1; -.
InParanoid; O97605; -.
KO; K03161; -.
OMA; MKMDKME; -.
OrthoDB; 1146113at2759; -.
Proteomes; UP000011712; Chromosome X.
Bgee; ENSFCAG00000004168; Expressed in liver.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005174; F:CD40 receptor binding; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
GO; GO:0007257; P:activation of JUN kinase activity; ISS:UniProtKB.
GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
GO; GO:0042100; P:B cell proliferation; ISS:UniProtKB.
GO; GO:0023035; P:CD40 signaling pathway; IEA:Ensembl.
GO; GO:0048305; P:immunoglobulin secretion; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0045190; P:isotype switching; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030168; P:platelet activation; ISS:UniProtKB.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0032733; P:positive regulation of interleukin-10 production; ISS:UniProtKB.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:0051023; P:regulation of immunoglobulin secretion; IEA:Ensembl.
CDD; cd00184; TNF; 1.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR003263; CD40L.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
PANTHER; PTHR11471:SF5; PTHR11471:SF5; 1.
Pfam; PF00229; TNF; 1.
PIRSF; PIRSF016527; TNF_5; 1.
PRINTS; PR01702; CD40LIGAND.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
2: Evidence at transcript level;
Cell membrane; Cytokine; Disulfide bond; Glycoprotein; Membrane;
Reference proteome; Secreted; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1..260
/note="CD40 ligand, membrane form"
/id="PRO_0000034482"
CHAIN 112..260
/note="CD40 ligand, soluble form"
/evidence="ECO:0000250|UniProtKB:P29965"
/id="PRO_0000034483"
TOPO_DOM 1..22
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 23..46
/note="Helical; Signal-anchor for type II membrane protein"
/evidence="ECO:0000255"
TOPO_DOM 47..260
/note="Extracellular"
/evidence="ECO:0000255"
SITE 111..112
/note="Cleavage"
/evidence="ECO:0000250"
CARBOHYD 239
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 177..217
/evidence="ECO:0000255"
SEQUENCE 260 AA; 28727 MW; 349FA0391FB7B932 CRC64;
MIETYSQTAP RSVAPGPPVS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL DKIEDERNLY
EDFVFMKTLQ KCNKGEGALS LLNCEEIKSR FEAFLKEIML NKETKKEKNV AMQKGDQDPR
VAAHVISEAS SSTASVLQWA PKGYYTISSN LVTLENGKQL AVKRQGLYYI YAQVTFCSNR
EASSQAPFIA SLCLHSPSGS ERVLLRAANA RSSSKPCGQQ SIHLGGVFEL HPGASVFVNV
TDPSQVSHGT GFTSFGLLKL


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Catalog number Product name Quantity
20-783-71229 RAT ANTI HUMAN CD154 - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 0.2 mg
20-783-70607 HAMSTER ANTI MOUSE CD154 - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 0.1 mg
20-783-70608 HAMSTER ANTI MOUSE CD154 RPE - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 100 TESTS
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20-783-71230 RAT ANTI HUMAN CD154 FITC - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 0.1 mg
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20-783-71309 MOUSE ANTI HUMAN CD154 FITC - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 100 TESTS
20-783-71308 MOUSE ANTI HUMAN CD154 Biotin - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 100 TESTS
20-783-70606 HAMSTER ANTI MOUSE CD154 FITC - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 0.5 mg
20-783-70605 HAMSTER ANTI MOUSE CD154 FITC - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 0.1 mg
20-783-71231 RAT ANTI HUMAN CD154 Azide Free - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 1 mg
20-783-70609 HAMSTER ANTI MOUSE CD154 Azide Free - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 1 mg
20-783-71310 MOUSE ANTI HUMAN CD154 Azide Free - CD40 LIGAND; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD154 antigen Monoclonal 0.1 mg
10-663-45114 Soluble CD40 (CD154) Ligand_TRAP Human - CD40-L; Tumor necrosis factor ligand superfamily member 5; TNF-related activation protein; TRAP; T cell antigen Gp39; CD154 antigen N_A 1 mg
10-663-45114 Soluble CD40 (CD154) Ligand_TRAP Human - CD40-L; Tumor necrosis factor ligand superfamily member 5; TNF-related activation protein; TRAP; T cell antigen Gp39; CD154 antigen N_A 0.01 mg
10-663-45114 Soluble CD40 (CD154) Ligand_TRAP Human - CD40-L; Tumor necrosis factor ligand superfamily member 5; TNF-related activation protein; TRAP; T cell antigen Gp39; CD154 antigen N_A 0.05 mg
U0119p CLIA CD40 ligand,CD40L,CD40-L,CD40LG,Pig,Sus scrofa,TNFSF5,Tumor necrosis factor ligand superfamily member 5 96T
E0119p ELISA kit CD40 ligand,CD40L,CD40-L,CD40LG,Pig,Sus scrofa,TNFSF5,Tumor necrosis factor ligand superfamily member 5 96T
E0119p ELISA CD40 ligand,CD40L,CD40-L,CD40LG,Pig,Sus scrofa,TNFSF5,Tumor necrosis factor ligand superfamily member 5 96T
E0119b ELISA Bos taurus,Bovine,CD40 ligand,CD40L,CD40-L,CD40LG,TNFSF5,Tumor necrosis factor ligand superfamily member 5 96T
U0119r CLIA CD40 ligand,Cd40l,CD40-L,Cd40lg,Rat,Rattus norvegicus,Tnfsf5,Tumor necrosis factor ligand superfamily member 5 96T
E0119b ELISA kit Bos taurus,Bovine,CD40 ligand,CD40L,CD40-L,CD40LG,TNFSF5,Tumor necrosis factor ligand superfamily member 5 96T
E0119r ELISA CD40 ligand,Cd40l,CD40-L,Cd40lg,Rat,Rattus norvegicus,Tnfsf5,Tumor necrosis factor ligand superfamily member 5 96T
U0119b CLIA Bos taurus,Bovine,CD40 ligand,CD40L,CD40-L,CD40LG,TNFSF5,Tumor necrosis factor ligand superfamily member 5 96T
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Pathways :
WP2328: Allograft rejection
WP247: Small Ligand GPCRs
WP1032: NLR proteins
WP858: IL-6 Signaling Pathway
WP1322: IL-6 Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP353: Small Ligand GPCRs
WP1067: Toll-like receptor signaling pathway
WP1825: GPCR ligand binding
WP1156: Inflammatory Response Pathway
WP976: IL-6 Signaling Pathway
WP161: Small Ligand GPCRs
WP746: Small Ligand GPCRs
WP1271: Toll-like receptor signaling pathway
WP799: NLR proteins
WP853: Small Ligand GPCRs
WP1317: Small Ligand GPCRs
WP2355: Corticotropin-releasing hormone
WP1094: IL-6 Signaling Pathway
WP971: Small Ligand GPCRs
WP40: Inflammatory Response Pathway
WP458: Inflammatory Response Pathway
WP1183: Toll-like receptor signaling pathway
WP1256: NLR proteins
WP750: IL-6 Signaling Pathway

Related Genes :
[CD40LG CD40L TNFSF5 TRAP] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[Cd40lg Cd40l Tnfsf5] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[Cd40lg Cd40l Tnfsf5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5] CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40 TNFRSF5] Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
[TRAF3 CAP1 CRAF1] TNF receptor-associated factor 3 (EC 2.3.2.27) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
[Traf3 Craf1 Trafamn] TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (RING-type E3 ubiquitin transferase TRAF3) (TRAFAMN)
[Faslg Apt1Lg1 Cd95l Fasl Tnfsf6] Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF14 HVEML LIGHT UNQ391/PRO726] Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
[Tnfsf11 Opgl Rankl Trance] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[TNFSF11 OPGL RANKL TRANCE] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738] Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

Bibliography :
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