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COMPASS component SPP1 (Complex proteins associated with SET1 protein SPP1) (Set1C component SPP1) (Suppressor of PRP protein 1)

 SPP1_YEAST              Reviewed;         353 AA.
Q03012; D6W3N0;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
17-JUN-2020, entry version 160.
RecName: Full=COMPASS component SPP1;
AltName: Full=Complex proteins associated with SET1 protein SPP1;
AltName: Full=Set1C component SPP1;
AltName: Full=Suppressor of PRP protein 1;
Name=SPP1; Synonyms=CPS40, SAF41; OrderedLocusNames=YPL138C;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169875;
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
Vo D.H., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
Nature 387:103-105(1997).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
G3 (Bethesda) 4:389-398(2014).
[3]
FUNCTION, AND SUBUNIT.
PubMed=11742990; DOI=10.1093/emboj/20.24.7137;
Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M.,
Aasland R., Stewart A.F.;
"The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and
methylates histone 3 lysine 4.";
EMBO J. 20:7137-7148(2001).
[4]
FUNCTION.
PubMed=11805083; DOI=10.1074/jbc.c200023200;
Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J.,
Johnston M., Shilatifard A.;
"COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric
silencing of gene expression.";
J. Biol. Chem. 277:10753-10755(2002).
[5]
SUBUNIT.
PubMed=11687631; DOI=10.1073/pnas.231473398;
Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P.,
Johnston M., Greenblatt J.F., Shilatifard A.;
"COMPASS: a complex of proteins associated with a trithorax-related SET
domain protein.";
Proc. Natl. Acad. Sci. U.S.A. 98:12902-12907(2001).
[6]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides insights
into evolution.";
Science 325:1682-1686(2009).
-!- FUNCTION: The COMPASS (Set1C) complex specifically mono-, di- and
trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays
a role in telomere length maintenance and transcription elongation
regulation. {ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11805083}.
-!- SUBUNIT: Component of the COMPASS (Set1C) complex which consists of
SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and
SWD3(1). {ECO:0000269|PubMed:11687631, ECO:0000269|PubMed:11742990}.
-!- INTERACTION:
Q03012; P21651: REC107; NbExp=3; IntAct=EBI-32540, EBI-10742;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- MISCELLANEOUS: Present with 1680 molecules/cell in log phase SD medium.
{ECO:0000269|PubMed:14562106}.
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EMBL; U43703; AAB68222.1; -; Genomic_DNA.
EMBL; BK006949; DAA11296.1; -; Genomic_DNA.
PIR; S69047; S69047.
RefSeq; NP_015187.1; NM_001183952.1.
PDB; 6BX3; EM; 4.30 A; F=117-353.
PDB; 6J2P; X-ray; 2.85 A; A/B/C/D=1-124.
PDB; 6VEN; EM; 3.37 A; R=2-353.
PDBsum; 6BX3; -.
PDBsum; 6J2P; -.
PDBsum; 6VEN; -.
SMR; Q03012; -.
BioGRID; 36044; 148.
ComplexPortal; CPX-1039; COMPASS complex.
DIP; DIP-2946N; -.
IntAct; Q03012; 12.
MINT; Q03012; -.
STRING; 4932.YPL138C; -.
iPTMnet; Q03012; -.
MaxQB; Q03012; -.
PaxDb; Q03012; -.
PRIDE; Q03012; -.
EnsemblFungi; YPL138C_mRNA; YPL138C; YPL138C.
GeneID; 855965; -.
KEGG; sce:YPL138C; -.
EuPathDB; FungiDB:YPL138C; -.
SGD; S000006059; SPP1.
HOGENOM; CLU_045707_0_0_1; -.
InParanoid; Q03012; -.
KO; K14960; -.
OMA; WCPPYSS; -.
BioCyc; YEAST:G3O-34036-MONOMER; -.
PRO; PR:Q03012; -.
Proteomes; UP000002311; Chromosome XVI.
RNAct; Q03012; protein.
GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
GO; GO:0005829; C:cytosol; IDA:SGD.
GO; GO:0005634; C:nucleus; IDA:SGD.
GO; GO:0048188; C:Set1C/COMPASS complex; IPI:SGD.
GO; GO:0003682; F:chromatin binding; IDA:SGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0035064; F:methylated histone binding; IDA:SGD.
GO; GO:0006348; P:chromatin silencing at telomere; IMP:SGD.
GO; GO:0051568; P:histone H3-K4 methylation; IDA:SGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
GO; GO:1903341; P:regulation of meiotic DNA double-strand break formation; IMP:SGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:SGD.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR037869; Spp1/CFP1.
InterPro; IPR019786; Zinc_finger_PHD-type_CS.
InterPro; IPR011011; Znf_FYVE_PHD.
InterPro; IPR001965; Znf_PHD.
InterPro; IPR019787; Znf_PHD-finger.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
PANTHER; PTHR46174; PTHR46174; 2.
Pfam; PF00628; PHD; 1.
SMART; SM00249; PHD; 1.
SUPFAM; SSF57903; SSF57903; 1.
PROSITE; PS01359; ZF_PHD_1; 1.
PROSITE; PS50016; ZF_PHD_2; 1.
1: Evidence at protein level;
3D-structure; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
Zinc; Zinc-finger.
CHAIN 1..353
/note="COMPASS component SPP1"
/id="PRO_0000059338"
ZN_FING 22..72
/note="PHD-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
COMPBIAS 246..251
/note="Poly-Lys"
MOD_RES 87
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:19779198"
TURN 25..28
/evidence="ECO:0000244|PDB:6J2P"
STRAND 36..38
/evidence="ECO:0000244|PDB:6J2P"
STRAND 40..43
/evidence="ECO:0000244|PDB:6J2P"
STRAND 45..47
/evidence="ECO:0000244|PDB:6J2P"
HELIX 48..51
/evidence="ECO:0000244|PDB:6J2P"
HELIX 55..57
/evidence="ECO:0000244|PDB:6J2P"
STRAND 61..63
/evidence="ECO:0000244|PDB:6J2P"
HELIX 67..70
/evidence="ECO:0000244|PDB:6J2P"
STRAND 73..76
/evidence="ECO:0000244|PDB:6J2P"
STRAND 98..101
/evidence="ECO:0000244|PDB:6J2P"
STRAND 111..114
/evidence="ECO:0000244|PDB:6J2P"
HELIX 115..117
/evidence="ECO:0000244|PDB:6J2P"
HELIX 203..240
/evidence="ECO:0000244|PDB:6VEN"
STRAND 266..268
/evidence="ECO:0000244|PDB:6VEN"
HELIX 279..282
/evidence="ECO:0000244|PDB:6VEN"
STRAND 291..293
/evidence="ECO:0000244|PDB:6VEN"
STRAND 298..300
/evidence="ECO:0000244|PDB:6VEN"
TURN 307..310
/evidence="ECO:0000244|PDB:6VEN"
HELIX 311..348
/evidence="ECO:0000244|PDB:6VEN"
SEQUENCE 353 AA; 41468 MW; F4B8DFE0CB358CA4 CRC64;
MSLPQWCPPH STLKRNPTTG EDVYCICKRP DYGELMVGCD GCDDWFHFTC LHIPEQFKDL
VFSFYCPYCQ AGITGKNKDA IINGEGSLPK TLWKRKCRIS DCYKPCLQDS KYCSEEHGRE
FVNDIWSRLK TDEDRAVVKK MVEQTGHIDK FKKFGQLDFI DNNIVVKTDD EKEIFDQIVV
RDMTLKTLED DLQEVQEISL PLFKKKLELL EVYLGWLDNV YTEMRKLDDD AASHVECGKE
DSKGTKRKKK KNSSRSRARK NICGYCSTYE RIPCSVEEFV RDFGSNEEAT KIHEVCTKWK
CNRHLDWVST NQEQYLQQID SLESMQERLQ HLIQARKKQL NIQYYEEILR RGL


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Pathways :
WP1713: Two-component system
WP1624: Bacterial secretion system
WP1692: Protein export
WP560: TGF Beta Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP1270: Endochondral Ossification
WP75: Toll-like receptor signaling pathway
WP1065: Endochondral Ossification
WP2272: Pathogenic Escherichia coli infection
WP829: Toll-like receptor signaling pathway
WP1164: TGF Beta Signaling Pathway
WP1183: Toll-like receptor signaling pathway
WP930: TGF Beta Signaling Pathway
WP949: Toll-like receptor signaling pathway
WP1309: Toll-like receptor signaling pathway
WP113: TGF Beta Signaling Pathway
WP1370: TGF Beta Signaling Pathway
WP230: TGF Beta Signaling Pathway
WP85: Focal Adhesion
WP1181: Endochondral Ossification
WP1434: Osteopontin Signaling
WP1048: TGF Beta Signaling Pathway
WP947: Endochondral Ossification
WP1271: Toll-like receptor signaling pathway
WP210: Cytoplasmic Ribosomal Proteins

Related Genes :
[ash2 SPBC13G1.08c] Set1 complex component ash2 (Set1C component ash2) (COMPASS component ash2) (Complex proteins associated with set1 protein ash2) (Lid2 complex component ash2) (Lid2C component ash2)
[SPP1 BNSP OPN PSEC0156] Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)
[SGPP1 SPP1] Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1)
[Sgpp1 Spp1 Spph1] Sphingosine-1-phosphate phosphatase 1 (SPP) (SPPase1) (mSPP1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1)
[Sgpp1] Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1)
[SETD1A KIAA0339 KMT2F SET1 SET1A] Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.354) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
[ASH2L ASH2L1] Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
[ash2 CG6677] Set1/Ash2 histone methyltransferase complex subunit ASH2 (Absent, small, or homeotic discs protein 2)
[Ash2l] Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
[CXXC1 CFP1 CGBP PCCX1 PHF18] CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
[Cxxc1 Cgbp Pccx1] CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
[1] Terminase small subunit (G1P) (Terminase, small subunit gp1)
[SETD1B KIAA1076 KMT2G SET1B] Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.354) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
[yueB BSU31860] ESX secretion system protein YueB (Bacteriophage SPP1 adsorption protein YueB) (Bacteriophage SPP1 receptor protein YueB)
[SUDS3 SAP45 SDS3] Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)
[SCL1 PRC2 PRS2 YGL011C] Proteasome subunit alpha type-1 (EC 3.4.25.1) (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
[Setd1b Kiaa1076 Set1b] Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.354) (SET domain-containing protein 1B)
[HCFC1 HCF1 HFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[set-1 18F11.100 NCU01206] Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.354) (COMPASS component set-1) (SET domain-containing protein 1)
[cytb] Cytochrome b
[FAM20C DMP4] Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)
[HCFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[Wdr5 Big Big3] WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) (WD repeat-containing protein BIG-3)
[RBBP5 RBQ3] Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
[WDR5 BIG3] WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
[CLF ICU1 PIF1 PIF2 SDG1 SET1 At2g23380 F26B6.3] Histone-lysine N-methyltransferase CLF (EC 2.1.1.-) (Polycomb group protein CURLY LEAF) (Protein INCURVATA 1) (Protein SET DOMAIN GROUP 1) (Protein photoperiod insensitive flowering)
[Ifitm3] Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)
[Hcfc1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[WDR5A At3g49660 T16K5.10] COMPASS-like H3K4 histone methylase component WDR5A (AtWDR5A)
[Wdr5] WD repeat-containing protein 5

Bibliography :