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CRK like proto-oncogene, adaptor protein

 A0A2K6TEM2_SAIBB        Unreviewed;       303 AA.
A0A2K6TEM2;
28-MAR-2018, integrated into UniProtKB/TrEMBL.
28-MAR-2018, sequence version 1.
17-JUN-2020, entry version 14.
SubName: Full=CRK like proto-oncogene, adaptor protein {ECO:0000313|Ensembl:ENSSBOP00000018094};
Name=CRKL {ECO:0000313|Ensembl:ENSSBOP00000018094};
Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
Saimiriinae; Saimiri.
NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000018094, ECO:0000313|Proteomes:UP000233220};
[1] {ECO:0000313|Ensembl:ENSSBOP00000018094, ECO:0000313|Proteomes:UP000233220}
NUCLEOTIDE SEQUENCE.
Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
"The Draft Genome of Saimiri boliviensis.";
Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSBOP00000018094}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
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RefSeq; XP_003942698.1; XM_003942649.2.
Ensembl; ENSSBOT00000034909; ENSSBOP00000018094; ENSSBOG00000025677.
GeneID; 101051048; -.
KEGG; sbq:101051048; -.
CTD; 1399; -.
GeneTree; ENSGT00820000127055; -.
KO; K04438; -.
OMA; SWYMGPV; -.
OrthoDB; 1414461at2759; -.
Proteomes; UP000233220; Whole Genome Shotgun Assembly.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0098890; C:extrinsic component of postsynaptic membrane; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
GO; GO:0098761; P:cellular response to interleukin-7; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0098749; P:cerebellar neuron development; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0035685; P:helper T cell diapedesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0060465; P:pharynx development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:1903977; P:positive regulation of glial cell migration; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
GO; GO:1904393; P:regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd11759; SH3_CRK_C; 1.
CDD; cd11758; SH3_CRK_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035458; CRK_SH3_C.
InterPro; IPR035457; CRK_SH3_N.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
Pfam; PF07653; SH3_2; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000233220};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}.
DOMAIN 14..102
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
DOMAIN 123..183
/note="SH3"
/evidence="ECO:0000259|PROSITE:PS50002"
DOMAIN 235..296
/note="SH3"
/evidence="ECO:0000259|PROSITE:PS50002"
REGION 184..203
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 303 AA; 33764 MW; 3CE95D5725A66CC1 CRC64;
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPSLPT
AEENLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPIPAVS GSPGAAITPL PSTQNGPVFA
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD
ENE


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WP1049: G Protein Signaling Pathways
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WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP288: NLR proteins

Related Genes :

Bibliography :
[31527084] Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
[31318326] The Crk adapter protein is essential for embryogenesis, where it regulates multiple actin-dependent morphogenic events.
[31311869] PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.
[31133010] CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
[29618525] Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection.
[29563135] Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma.
[29167336] Insight into the Roles of E3 Ubiquitin Ligase c-Cbl, ESCRT Machinery, and Host Cell Signaling in Kaposi's Sarcoma-Associated Herpesvirus Entry and Trafficking.
[29025973] Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2.
[28887306] The long noncoding RNA links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma.
[28882999] miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells.