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CRK like proto-oncogene, adaptor protein

 F1RKX9_PIG              Unreviewed;       303 AA.
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-MAY-2011, sequence version 1.
17-JUN-2020, entry version 66.
SubName: Full=CRK like proto-oncogene, adaptor protein {ECO:0000313|Ensembl:ENSSSCP00000010768};
Name=CRKL {ECO:0000313|Ensembl:ENSSSCP00000010768,
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010768, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000010768, ECO:0000313|Proteomes:UP000008227}
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010768,
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000010768}
Submitted (MAY-2011) to UniProtKB.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AEMK02000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003133042.1; XM_003132994.3.
STRING; 9823.ENSSSCP00000010768; -.
PaxDb; F1RKX9; -.
PeptideAtlas; F1RKX9; -.
Ensembl; ENSSSCT00000011056; ENSSSCP00000010768; ENSSSCG00000010095.
GeneID; 100525363; -.
KEGG; ssc:100525363; -.
CTD; 1399; -.
eggNOG; KOG4792; Eukaryota.
eggNOG; ENOG4110574; LUCA.
GeneTree; ENSGT00820000127055; -.
HOGENOM; CLU_060542_0_1_1; -.
InParanoid; F1RKX9; -.
KO; K04438; -.
OrthoDB; 1414461at2759; -.
TreeFam; TF321436; -.
Reactome; R-SSC-170968; Frs2-mediated activation.
Reactome; R-SSC-186763; Downstream signal transduction.
Reactome; R-SSC-8875555; MET activates RAP1 and RAC1.
Reactome; R-SSC-8875656; MET receptor recycling.
Reactome; R-SSC-9027284; Erythropoietin activates RAS.
Reactome; R-SSC-912631; Regulation of signaling by CBL.
Proteomes; UP000008227; Chromosome 14.
Bgee; ENSSSCG00000010095; Expressed in kidney and 5 other tissues.
ExpressionAtlas; F1RKX9; baseline and differential.
Genevisible; F1RKX9; SS.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0098890; C:extrinsic component of postsynaptic membrane; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
GO; GO:0098761; P:cellular response to interleukin-7; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0098749; P:cerebellar neuron development; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0035685; P:helper T cell diapedesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0060465; P:pharynx development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:1903977; P:positive regulation of glial cell migration; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
GO; GO:1904393; P:regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd11758; SH3_CRK_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035457; CRK_SH3_N.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
Pfam; PF07653; SH3_2; 1.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
1: Evidence at protein level;
Proteomics identification {ECO:0000213|PeptideAtlas:F1RKX9};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
DOMAIN 14..102
DOMAIN 123..183
DOMAIN 235..296
REGION 186..226
SEQUENCE 303 AA; 33796 MW; 0F7D103E028EBEEA CRC64;

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WP1049: G Protein Signaling Pathways
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WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP288: NLR proteins

Related Genes :

Bibliography :
[31527084] Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
[31318326] The Crk adapter protein is essential for embryogenesis, where it regulates multiple actin-dependent morphogenic events.
[31311869] PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.
[31133010] CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
[29618525] Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection.
[29563135] Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma.
[29167336] Insight into the Roles of E3 Ubiquitin Ligase c-Cbl, ESCRT Machinery, and Host Cell Signaling in Kaposi's Sarcoma-Associated Herpesvirus Entry and Trafficking.
[29025973] Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2.
[28887306] The long noncoding RNA links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma.
[28882999] miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells.