GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

CRK like proto-oncogene, adaptor protein

 K7EUR8_PONAB            Unreviewed;       251 AA.
K7EUR8;
09-JAN-2013, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 1.
17-JUN-2020, entry version 45.
SubName: Full=CRK like proto-oncogene, adaptor protein {ECO:0000313|Ensembl:ENSPPYP00000024295};
Name=CRKL {ECO:0000313|Ensembl:ENSPPYP00000024295};
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pongo.
NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000024295, ECO:0000313|Proteomes:UP000001595};
[1] {ECO:0000313|Ensembl:ENSPPYP00000024295, ECO:0000313|Proteomes:UP000001595}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Wilson R.K., Mardis E.;
"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPPYP00000024295}
IDENTIFICATION.
Ensembl;
Submitted (NOV-2012) to UniProtKB.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; ABGA01166454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01166463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9601.ENSPPYP00000024295; -.
Ensembl; ENSPPYT00000033557; ENSPPYP00000024295; ENSPPYG00000029862.
eggNOG; KOG4792; Eukaryota.
eggNOG; ENOG4110574; LUCA.
GeneTree; ENSGT00820000127055; -.
HOGENOM; CLU_060542_0_1_1; -.
InParanoid; K7EUR8; -.
OMA; SWYMGPV; -.
TreeFam; TF321436; -.
Proteomes; UP000001595; Chromosome 22.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0098890; C:extrinsic component of postsynaptic membrane; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
GO; GO:0098761; P:cellular response to interleukin-7; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0098749; P:cerebellar neuron development; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0035685; P:helper T cell diapedesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0060465; P:pharynx development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:1903977; P:positive regulation of glial cell migration; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
GO; GO:1904393; P:regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd11758; SH3_CRK_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035457; CRK_SH3_N.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 1.
SUPFAM; SSF50044; SSF50044; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000001595};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}.
DOMAIN 14..102
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
DOMAIN 123..183
/note="SH3"
/evidence="ECO:0000259|PROSITE:PS50002"
REGION 183..236
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 251 AA; 27882 MW; FC1F158E7EDEE92C CRC64;
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT
AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA
KAIQKKSTLC L


Related products :

Catalog number Product name Quantity
EIAAB14724 Feline sarcoma_Fujinami avian sarcoma oncogene homolog,FES,FPS,Homo sapiens,Human,p93c-fes,Proto-oncogene c-Fes,Proto-oncogene c-Fps,Tyrosine-protein kinase Fes_Fps
EIAAB05536 Casitas B-lineage lymphoma proto-oncogene,CBL,CBL2,E3 ubiquitin-protein ligase CBL,Homo sapiens,Human,Proto-oncogene c-Cbl,RING finger protein 55,RNF55,Signal transduction protein CBL
EIAAB05537 Casitas B-lineage lymphoma proto-oncogene,Cbl,E3 ubiquitin-protein ligase CBL,Mouse,Mus musculus,Proto-oncogene c-Cbl,Signal transduction protein CBL
EIAAB33701 cRaf,Homo sapiens,Human,Proto-oncogene c-RAF,RAF,RAF proto-oncogene serine_threonine-protein kinase,RAF1,Raf-1
EIAAB25166 Mos,Mouse,Mus musculus,Oocyte maturation factor mos,Proto-oncogene c-Mos,Proto-oncogene serine_threonine-protein kinase mos
EIAAB39852 Homo sapiens,Human,p60-Src,pp60c-src,Proto-oncogene c-Src,Proto-oncogene tyrosine-protein kinase Src,SRC,SRC1
EIAAB25170 Mos,Oocyte maturation factor mos,Proto-oncogene c-Mos,Proto-oncogene serine_threonine-protein kinase mos,Rat,Rattus norvegicus
EIAAB25167 Homo sapiens,Human,MOS,Oocyte maturation factor mos,Proto-oncogene c-Mos,Proto-oncogene serine_threonine-protein kinase mos
EIAAB25168 MOS,Oocyte maturation factor mos,Pig,Proto-oncogene c-Mos,Proto-oncogene serine_threonine-protein kinase mos,Sus scrofa
EIAAB35721 Homo sapiens,Human,Proto-oncogene c-Ros-1,Proto-oncogene tyrosine-protein kinase ROS,ROS1
EIAAB33700 Bos taurus,Bovine,cRaf,Proto-oncogene c-RAF,RAF proto-oncogene serine_threonine-protein kinase,RAF1,Raf-1
EIAAB33699 cRaf,Proto-oncogene c-RAF,Raf,RAF proto-oncogene serine_threonine-protein kinase,Raf1,Raf-1,Rat,Rattus norvegicus
EIAAB39851 Mouse,Mus musculus,Neuronal proto-oncogene tyrosine-protein kinase Src,p60-Src,pp60c-src,Proto-oncogene c-Src,Src
U1290m CLIA Mouse,Mus musculus,Myc,Myc proto-oncogene protein,Proto-oncogene c-Myc,Transcription factor p64 96T
E1290m ELISA Mouse,Mus musculus,Myc,Myc proto-oncogene protein,Proto-oncogene c-Myc,Transcription factor p64 96T
E1290r ELISA Myc,Myc proto-oncogene protein,Proto-oncogene c-Myc,Rat,Rattus norvegicus,Transcription factor p64 96T
E1290b ELISA kit Bos taurus,Bovine,MYC,Myc proto-oncogene protein,Proto-oncogene c-Myc,Transcription factor p64 96T
EIAAB35722 Mouse,Mus musculus,Proto-oncogene c-Ros-1,Proto-oncogene tyrosine-protein kinase ROS,Ros1,Ros-1
E1290m ELISA kit Mouse,Mus musculus,Myc,Myc proto-oncogene protein,Proto-oncogene c-Myc,Transcription factor p64 96T
U1290r CLIA Myc,Myc proto-oncogene protein,Proto-oncogene c-Myc,Rat,Rattus norvegicus,Transcription factor p64 96T
E1290b ELISA Bos taurus,Bovine,MYC,Myc proto-oncogene protein,Proto-oncogene c-Myc,Transcription factor p64 96T
U1290b CLIA Bos taurus,Bovine,MYC,Myc proto-oncogene protein,Proto-oncogene c-Myc,Transcription factor p64 96T
EIAAB39850 p60-Src,pp60c-src,Proto-oncogene c-Src,Proto-oncogene tyrosine-protein kinase Src,Rat,Rattus norvegicus,Src
EIAAB34305 Mouse,Mus musculus,Proto-oncogene c-Ret,Proto-oncogene tyrosine-protein kinase receptor Ret,Ret
E1290r ELISA kit Myc,Myc proto-oncogene protein,Proto-oncogene c-Myc,Rat,Rattus norvegicus,Transcription factor p64 96T
Pathways :
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP163: Cytoplasmic Ribosomal Proteins
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP288: NLR proteins

Related Genes :

Bibliography :
[31527084] Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
[31318326] The Crk adapter protein is essential for embryogenesis, where it regulates multiple actin-dependent morphogenic events.
[31311869] PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.
[31133010] CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
[29618525] Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection.
[29563135] Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma.
[29167336] Insight into the Roles of E3 Ubiquitin Ligase c-Cbl, ESCRT Machinery, and Host Cell Signaling in Kaposi's Sarcoma-Associated Herpesvirus Entry and Trafficking.
[29025973] Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2.
[28887306] The long noncoding RNA links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma.
[28882999] miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells.