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CULLIN_2 domain-containing protein

 H0YU78_TAEGU            Unreviewed;       776 AA.
H0YU78;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
10-FEB-2021, entry version 71.
RecName: Full=CULLIN_2 domain-containing protein {ECO:0000259|PROSITE:PS50069};
Name=CUL1 {ECO:0000313|Ensembl:ENSTGUP00000001846};
Taeniopygia guttata (Zebra finch) (Poephila guttata).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
Estrildinae; Taeniopygia.
NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000001846, ECO:0000313|Proteomes:UP000007754};
[1] {ECO:0000313|Ensembl:ENSTGUP00000001846, ECO:0000313|Proteomes:UP000007754}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20360741; DOI=10.1038/nature08819;
Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
"The genome of a songbird.";
Nature 464:757-762(2010).
[2] {ECO:0000313|Ensembl:ENSTGUP00000001846}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000256|ARBA:ARBA00004906}.
-!- SIMILARITY: Belongs to the cullin family.
{ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
ECO:0000256|RuleBase:RU003829}.
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RefSeq; XP_002198372.1; XM_002198336.2.
SMR; H0YU78; -.
Ensembl; ENSTGUT00000001864; ENSTGUP00000001846; ENSTGUG00000001790.
GeneTree; ENSGT00940000154774; -.
HOGENOM; CLU_004747_6_1_1; -.
InParanoid; H0YU78; -.
OMA; WLWHLCK; -.
OrthoDB; 1040292at2759; -.
TreeFam; TF101151; -.
UniPathway; UPA00143; -.
Proteomes; UP000007754; Chromosome 2.
GO; GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR016157; Cullin_CS.
InterPro; IPR016158; Cullin_homology.
InterPro; IPR036317; Cullin_homology_sf.
InterPro; IPR001373; Cullin_N.
InterPro; IPR019559; Cullin_neddylation_domain.
InterPro; IPR016159; Cullin_repeat-like_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00888; Cullin; 1.
Pfam; PF10557; Cullin_Nedd8; 1.
SMART; SM00182; CULLIN; 1.
SMART; SM00884; Cullin_Nedd8; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF74788; SSF74788; 1.
SUPFAM; SSF75632; SSF75632; 1.
PROSITE; PS01256; CULLIN_1; 1.
PROSITE; PS50069; CULLIN_2; 1.
3: Inferred from homology;
Coiled coil {ECO:0000256|SAM:Coils};
Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
Reference proteome {ECO:0000313|Proteomes:UP000007754};
Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
DOMAIN 417..644
/note="CULLIN_2"
/evidence="ECO:0000259|PROSITE:PS50069"
COILED 261..281
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 776 AA; 89692 MW; 3E1F8B63C6E498F4 CRC64;
MSSNRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN
QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT
QQWEDYRFSS KVLNGICAYL NRHWVRRECD EGRKGIYEIY SLALVTWRDC LFRPLNKQVT
NAVLKLIEKE RNGETINTRL ISGVVQSYVE LGLNEDDAFA KGPTLTVYKE SFESQFLADT
ERFYTRESTE FLQQNPVTEY MKKAEARLLE EQRRVQVYLH ESTQDELARK CEQVLIEKHL
EIFHTEFQNL LDADKNEDLG RMYNLVSRIQ DGLGELKKLL ETHIHNQGLA AIEKCGEAAL
NDPKMYVQTV LDVHKKYNAL VMSAFNNDAG FVAALDKACG RFINNNAVTK MAQSSSKSPE
LLARYCDSLL KKSSKNPEEA ELEDTLNQVM VVFKYIEDKD VFQKFYAKML AKRLVHQNSA
SDDAEASMIS KLKQACGFEY TSKLQRMFQD IGVSKDLNEQ FKKHLTNSEP LDLDFSIQVL
SSGSWPFQQS CTFALPSELE RSYQRFTAFY ASRHSGRKLT WLYQLSKGEL VTNCFKNRYT
LQASTFQMAI LLQYNTEDAY TVQQLTDSTQ IKMDILAQVL QILLKSKLLV LEDENANVDE
VELKPDTLIK LYLGYKNKKL RVNINVPMKT EQKQEQETTH KNIEEDRKLL IQAAIVRIMK
MRKVLKHQQL LGEVLTQLSS RFKPRVPVIK KCIDILIEKE YLERVDGEKD TYSYLA


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Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP163: Cytoplasmic Ribosomal Proteins
WP1659: Glycine, serine and threonine metabolism
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection

Related Genes :
[cul-2 ccd-3 div-3 ZK520.4] Cullin-2 (CUL-2)
[DCUN1D2 C13orf17 DCUN1L2] DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)
[CAND1 ETA2 HVE At2g02560 T8K22.14] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (AtCAND1) (Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 2) (Protein HEMIVENATA)
[cul-1 lin-19 D2045.6] Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)
[Dcun1d5] DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
[CACUL1 C10orf46 CAC1] CDK2-associated and cullin domain-containing protein 1 (Cdk-associated cullin 1)
[CAND2 KIAA0667 TIP120B] Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2)
[cul-3 Y108G3AL.1] Cullin-3 (CUL-3)
[DCUN1D1 DCN1 DCUN1L1 RP42 SCCRO] DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
[DCUN1D5 SCCRO5] DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
[DCUN1D3 SCCRO3] DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
[Cul3 BG:DS07851.2 br34 CG11861 CG31829 CUL-3 Cul-3 cul-3 CUL3 cul3 Cullin3 dCul-3 dCul3 DMcul-3 Dmel\CG42616 gft guftagu l(2)06430 l(2)35Cd l(2)br34 l35Cd mds CG42616 Dmel_CG42616] Cullin 3, isoform C (Cullin 3, isoform D) (Cullin 3, isoform E) (LD10516p)
[Cul7 Kiaa0076] Cullin-7 (CUL-7) (p185) (p193)
[DCUN1D4 KIAA0276] DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)
[Cul4b mKIAA0695] Cullin-4B (CUL-4B)
[CUL3] CULLIN_2 domain-containing protein
[Dcun1d1 Dcun1l1 Rp42 Tes3] DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Testis-specific protein 3)
[CUL3] CULLIN_2 domain-containing protein
[CUL3] CULLIN_2 domain-containing protein
[CUL2] Cullin-2 (CUL-2)
[dcn-1 H38K22.2] Defective in cullin neddylation protein 1
[CAND1 KIAA0829 TIP120 TIP120A] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
[Cul3 BG:DS07851.2 br34 CG11861 CG31829 CUL-3 Cul-3 cul-3 Cul-3-RF CUL3 cul3 Cullin3 dCul-3 dCul3 DMcul-3 Dmel\CG42616 gft guftagu l(2)06430 l(2)35Cd l(2)br34 l35Cd mds CG42616 Dmel_CG42616] Cullin 3, isoform F (FI19425p1)
[RTT101 CUL8 YJL047C J1166] Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)
[Cand1 Tip120 Tip120a] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
[CUL3] CULLIN_2 domain-containing protein
[CUL3] CULLIN_2 domain-containing protein
[CUL3] CULLIN_2 domain-containing protein
[CUL3] CULLIN_2 domain-containing protein
[CUL3] CULLIN_2 domain-containing protein

Bibliography :
[29991678] CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.
[26735018] An ID2-dependent mechanism for VHL inactivation in cancer.
[19030229] VHL type 2B mutations retain VBC complex form and function.
[18372249] CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.