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Calcitonin (Calcitonin gene-related peptide 1 alpha-CGRP preproprotein)

 G5BUD9_HETGA            Unreviewed;       140 AA.
G5BUD9;
14-DEC-2011, integrated into UniProtKB/TrEMBL.
14-DEC-2011, sequence version 1.
16-JAN-2019, entry version 28.
SubName: Full=Calcitonin gene-related peptide 1 alpha-CGRP preproprotein {ECO:0000313|EMBL:JAO00852.1};
Name=CALCA {ECO:0000313|EMBL:JAO00852.1};
ORFNames=GW7_21359 {ECO:0000313|EMBL:EHB12900.1};
Heterocephalus glaber (Naked mole rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Bathyergidae; Heterocephalus.
NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB12900.1, ECO:0000313|Proteomes:UP000006813};
[1] {ECO:0000313|EMBL:EHB12900.1, ECO:0000313|Proteomes:UP000006813}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21993625; DOI=10.1038/nature10533;
Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
"Genome sequencing reveals insights into physiology and longevity of
the naked mole rat.";
Nature 479:223-227(2011).
[2] {ECO:0000313|EMBL:JAO00852.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Thyroid {ECO:0000313|EMBL:JAO00852.1};
Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
Platzer M., Szafranski K.;
"FRAMA: From RNA-seq data to annotated mRNA assemblies.";
Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
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EMBL; JH171914; EHB12900.1; -; Genomic_DNA.
EMBL; GEBF01002781; JAO00852.1; -; Transcribed_RNA.
RefSeq; XP_004851529.1; XM_004851472.1.
Ensembl; ENSHGLT00000010388; ENSHGLP00000010274; ENSHGLG00000007371.
Ensembl; ENSHGLT00100004368; ENSHGLP00100004301; ENSHGLG00100003261.
GeneID; 101725159; -.
KEGG; hgl:101725159; -.
CTD; 796; -.
InParanoid; G5BUD9; -.
KO; K12332; -.
OrthoDB; 1454612at2759; -.
Proteomes; UP000006813; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0043195; C:terminal bouton; IEA:Ensembl.
GO; GO:0031716; F:calcitonin receptor binding; IEA:Ensembl.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0007190; P:activation of adenylate cyclase activity; IEA:Ensembl.
GO; GO:0032147; P:activation of protein kinase activity; IEA:Ensembl.
GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; IEA:Ensembl.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
GO; GO:0007631; P:feeding behavior; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0002548; P:monocyte chemotaxis; IEA:Ensembl.
GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl.
GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
GO; GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:Ensembl.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IEA:Ensembl.
GO; GO:0009408; P:response to heat; IEA:Ensembl.
GO; GO:0048265; P:response to pain; IEA:Ensembl.
InterPro; IPR021118; Calcitonin.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00270; CALCITONINA.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000006813};
Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50,
ECO:0000256|SAAS:SAAS00897123};
Reference proteome {ECO:0000313|Proteomes:UP000006813};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 25 {ECO:0000256|SAM:SignalP}.
CHAIN 26 140 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5007660987.
DOMAIN 82 119 CALCITONIN. {ECO:0000259|SMART:SM00113}.
DISULFID 84 90 {ECO:0000256|PIRSR:PIRSR621116-50}.
SEQUENCE 140 AA; 15424 MW; 7B56ABACE6D346EF CRC64;
MGFQKFSPFL ALSILVLYLS SNLHAVPFRQ DLESSPVLVE LGEEEARLLL AALVQDYLQM
KASELEQDQE TEGSSLDSPR SKRCGNLSTC MLGTYTQDLN KFHTFPQTAI GVGAPGKKRD
MASDLETNHH PLVGMPQDAN


Related products :

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E0472r ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
U0472r CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
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E0472h ELISA kit Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
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E0472h ELISA Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
U0472c CLIA Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
E0472c ELISA Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
E0472c ELISA kit Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
U0876h CLIA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876h ELISA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876h ELISA kit Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876r ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
E0876m ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
E0876r ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
E0876m ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
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015-21 Calcitonin Gene Related Peptide (CGRP) Alpha [Cys (Et)2_7](Human) _ 200ug 200 µg
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Pathways :
WP1963: The effect of Glucocorticoids on target gene expression
WP2199: Seed Development
WP1001: Peptide GPCRs
WP1003: Ovarian Infertility Genes
WP1012: IL-7 Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1031: IL-3 Signaling Pathway
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1052: Id Signaling Pathway
WP1055: IL-4 signaling Pathway
WP1117: Peptide GPCRs
WP1120: Ovarian Infertility Genes
WP1131: IL-7 Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1150: IL-3 Signaling Pathway
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1168: Id Signaling Pathway
WP1171: IL-4 signaling Pathway
WP118: IL-7 Signaling Pathway
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1263: Mitochondrial Gene Expression
WP1301: Mitochondrial Gene Expression
WP131: Peptide GPCRs

Related Genes :
[CALCA CALC1] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calcrl Crlr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCB CALC2] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[Calcrl Cgrpr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCA CALC CCALCI] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCA CALC] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calcb] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[] Skin calcitonin gene-related peptide (S-CGRP)
[Calcb] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[CALCB] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[] Calcitonin-1
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[S100A12] Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
[Iapp] Islet amyloid polypeptide (Amylin) (Diabetes-associated peptide) (DAP)
[Atk TK] Tachykinins (AmTRP) (Tachykinin-related peptide) [Cleaved into: APTGHQEMQ-amide (AmTRP1) (Tachykinin-related peptide 1) (TRP1); ALMGFQGVR-amide (AmTRP2) (Tachykinin-related peptide 2) (TRP2); Brain peptide NSIINDVKNELFPEDIN; APMGFQGMR-amide 1 (AmTRP3) (Tachykinin-related peptide 3-1) (TRP3-1); Brain peptide ASFDDEYY; APMGFQGMR-amide 2 (AmTRP3) (Tachykinin-related peptide 3-2) (TRP3-2); Brain peptide SLEEILDEIK; Brain peptide SLEEILDEI; Brain peptide EILDEI; TTRFQDSRSKDVYLIDYPEDY-amide (AmTAP1) (Tachykinin-associated peptide 1); Brain peptide VLSMDGYQNILDKKDELLGEWE; Brain peptide APMGFYGT; APMGFYGTR-amide (AmTRP4) (Tachykinin-related peptide 4) (TRP4); Brain peptide IILDALEELD; Brain peptide ILDALEELD; Brain peptide GVMDFQIGLQ; ARMGFHGMR-amide (AmTRP5) (Tachykinin-related peptide 5) (TRP5); SPFRYLGAR-amide (AmTRP6) (Tachykinin-related peptide 6) (TRP6); NPRWEFRGKFVGVR-amide (AmTRP7) (Tachykinin-related peptide 7) (TRP7)]
[VIP] VIP peptides [Cleaved into: Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] (Fragment)
[] PBAN-type neuropeptides (Pheromone/pyrokinin biosynthesis-activating neuropeptide) [Cleaved into: Diapause hormone (DH); PBAN precursor-related peptide 1 (PBAN-PP-1); PBAN precursor-related peptide 2 (PBAN-PP-2); Alpha-subesophageal ganglion neuropeptide (Alpha-SG neuropeptide) (Alpha-SGNP); Beta-subesophageal ganglion neuropeptide (Beta-SG neuropeptide) (Beta-SGNP) (Pyrokinin-1); Pheromone biosynthesis-activating neuropeptide (Agi-PBAN) (Pyrokinin-2); Gamma-subesophageal ganglion neuropeptide (Gamma-SG neuropeptide) (Gamma-SGNP) (Pyrokinin-3); PBAN precursor-related peptide 3 (PBAN-PP-3)]
[VIP] VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
[] Calcitonin gene-related peptide (CGRP)
[Tk CG14734] Tachykinins (dTk) [Cleaved into: Tachykinin-related peptide 1 (TK-1) (dTK-1) (APTSSFIGMR-amide); Tachykinin-associated peptide 1 (TAP1) (DEEHDTSEGNWLGSGPDPLDYADEEADSSYAEN-amide); Tachykinin-related peptide 2 (TK-2) (dTK-2) (APLAFVGLR-amide); Tachykinin-associated peptide 2 (TAP2) (FIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAV-amide); Tachykinin-related peptide 3 (TK-3) (dTK-3) (APTGFTGMR-amide); Tachykinin-associated peptide 3 (TAP3) (Brain peptide PALLAGDDDAEADEATELQQ); Tachykinin-related peptide 4 (TK-4) (dTK-4) (APVNSFVGMR-amide); Tachykinin-associated peptide 4 (TAP4) (Brain peptide DVSHQHY); Tachykinin-associated peptide 5 (TAP5) (AALSDSYDLRGKQQRFADFNSKFVAVR-amide); Tachykinin-associated peptide 6 (TAP6) (Brain peptide SDLEGNGVGIGDDHEQALVHPWLYLWGE); Tachykinin-related peptide 5 (TK-5) (dTK-5) (APNGFLGMR-amide)]
[MR1] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
[NEDD9 CASL CASS2] Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
[Mr1 Mr1a] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)

Bibliography :
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