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Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)

 CALCA_CANLF             Reviewed;         128 AA.
Q9MYV1;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
16-JAN-2019, entry version 95.
RecName: Full=Calcitonin gene-related peptide 1;
AltName: Full=Alpha-type CGRP;
AltName: Full=Calcitonin gene-related peptide I;
Short=CGRP-I;
Flags: Precursor;
Name=CALCA; Synonyms=CALC, CCALCI;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10967131; DOI=10.1007/s003350010157;
Wende S., Krempler A., Breen M., Brunnberg L., Brenig B.;
"Molecular analysis and chromosomal assignment of the canine CALC-
I/alpha-CGRP gene.";
Mamm. Genome 11:736-740(2000).
[2]
PROTEIN SEQUENCE OF 26-50.
TISSUE=Thyroid;
PubMed=1758974; DOI=10.1016/0167-0115(91)90082-R;
Mol J.A., Kwant M.M., Arnold I.C.J., Hazewinkel H.A.W.;
"Elucidation of the sequence of canine (pro)-calcitonin. A molecular
biological and protein chemical approach.";
Regul. Pept. 35:189-195(1991).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role. It also elevates platelet cAMP (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin-gene related peptide I;
IsoId=Q9MYV1-1; Sequence=Displayed;
Name=Calcitonin;
IsoId=P41547-1; Sequence=External;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; AJ271090; CAB97487.1; -; Genomic_DNA.
RefSeq; NP_001300719.1; NM_001313790.1. [Q9MYV1-1]
RefSeq; NP_001300720.1; NM_001313791.1. [Q9MYV1-1]
UniGene; Cfa.3806; -.
UniGene; Cfa.45595; -.
ProteinModelPortal; Q9MYV1; -.
SMR; Q9MYV1; -.
Ensembl; ENSCAFT00000013581; ENSCAFP00000012566; ENSCAFG00000008562. [Q9MYV1-1]
GeneID; 403946; -.
CTD; 796; -.
GeneTree; ENSGT00940000167380; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
OMA; VKDFVQM; -.
OrthoDB; 1454612at2759; -.
Proteomes; UP000002254; Chromosome 21.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
1: Evidence at protein level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Disulfide bond; Hormone;
Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000269|PubMed:1758974}.
PROPEP 26 80 {ECO:0000250}.
/FTId=PRO_0000004041.
PEPTIDE 83 119 Calcitonin gene-related peptide 1.
/FTId=PRO_0000004042.
PROPEP 125 128 {ECO:0000250}.
/FTId=PRO_0000004043.
MOD_RES 119 119 Phenylalanine amide. {ECO:0000250}.
DISULFID 84 89 {ECO:0000250}.
CONFLICT 45 45 E -> K (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 49 49 L -> N (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 128 AA; 13874 MW; 72331258DB8CB564 CRC64;
MGLWKSSPFL AFSILVLCQA GGLQAAPFRS ALEGLPDPTA LSEKEGRLLL AALVKAYVQR
KNELEQEQEQ ETEGSSITAQ KRSCNTATCV THRLAGLLSR SGGVVKNNFV PTNVGSEAFG
RRRRDLRA


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Related Genes :
[CALCA CALC1] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcrl Crlr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCB CALC2] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[Calcrl Cgrpr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCA CALC CCALCI] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCA CALC] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calcb] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[Calcb] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[] Skin calcitonin gene-related peptide (S-CGRP)
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[CALCB] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[S100A12] Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
[Atk TK] Tachykinins (AmTRP) (Tachykinin-related peptide) [Cleaved into: APTGHQEMQ-amide (AmTRP1) (Tachykinin-related peptide 1) (TRP1); ALMGFQGVR-amide (AmTRP2) (Tachykinin-related peptide 2) (TRP2); Brain peptide NSIINDVKNELFPEDIN; APMGFQGMR-amide 1 (AmTRP3) (Tachykinin-related peptide 3-1) (TRP3-1); Brain peptide ASFDDEYY; APMGFQGMR-amide 2 (AmTRP3) (Tachykinin-related peptide 3-2) (TRP3-2); Brain peptide SLEEILDEIK; Brain peptide SLEEILDEI; Brain peptide EILDEI; TTRFQDSRSKDVYLIDYPEDY-amide (AmTAP1) (Tachykinin-associated peptide 1); Brain peptide VLSMDGYQNILDKKDELLGEWE; Brain peptide APMGFYGT; APMGFYGTR-amide (AmTRP4) (Tachykinin-related peptide 4) (TRP4); Brain peptide IILDALEELD; Brain peptide ILDALEELD; Brain peptide GVMDFQIGLQ; ARMGFHGMR-amide (AmTRP5) (Tachykinin-related peptide 5) (TRP5); SPFRYLGAR-amide (AmTRP6) (Tachykinin-related peptide 6) (TRP6); NPRWEFRGKFVGVR-amide (AmTRP7) (Tachykinin-related peptide 7) (TRP7)]
[Tk CG14734] Tachykinins (dTk) [Cleaved into: Tachykinin-related peptide 1 (TK-1) (dTK-1) (APTSSFIGMR-amide); Tachykinin-associated peptide 1 (TAP1) (DEEHDTSEGNWLGSGPDPLDYADEEADSSYAEN-amide); Tachykinin-related peptide 2 (TK-2) (dTK-2) (APLAFVGLR-amide); Tachykinin-associated peptide 2 (TAP2) (FIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAV-amide); Tachykinin-related peptide 3 (TK-3) (dTK-3) (APTGFTGMR-amide); Tachykinin-associated peptide 3 (TAP3) (Brain peptide PALLAGDDDAEADEATELQQ); Tachykinin-related peptide 4 (TK-4) (dTK-4) (APVNSFVGMR-amide); Tachykinin-associated peptide 4 (TAP4) (Brain peptide DVSHQHY); Tachykinin-associated peptide 5 (TAP5) (AALSDSYDLRGKQQRFADFNSKFVAVR-amide); Tachykinin-associated peptide 6 (TAP6) (Brain peptide SDLEGNGVGIGDDHEQALVHPWLYLWGE); Tachykinin-related peptide 5 (TK-5) (dTK-5) (APNGFLGMR-amide)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[Mr1 Mr1a] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
[MR1] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
[] PBAN-type neuropeptides (Pheromone/pyrokinin biosynthesis-activating neuropeptide) [Cleaved into: Diapause hormone (DH); PBAN precursor-related peptide 1 (PBAN-PP-1); PBAN precursor-related peptide 2 (PBAN-PP-2); Alpha-subesophageal ganglion neuropeptide (Alpha-SG neuropeptide) (Alpha-SGNP); Beta-subesophageal ganglion neuropeptide (Beta-SG neuropeptide) (Beta-SGNP) (Pyrokinin-1); Pheromone biosynthesis-activating neuropeptide (Agi-PBAN) (Pyrokinin-2); Gamma-subesophageal ganglion neuropeptide (Gamma-SG neuropeptide) (Gamma-SGNP) (Pyrokinin-3); PBAN precursor-related peptide 3 (PBAN-PP-3)]
[] Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[TAP1 ABCB2 PSF1 RING4 Y3] Antigen peptide transporter 1 (APT1) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein)
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[Vcsa1 Smr1] SMR1 protein (VCS-alpha 1) [Cleaved into: SMR1-related undecapeptide; SMR1-related hexapeptide; Sialorphin (SMR1-related pentapeptide); Submandibular gland peptide T (SGP-T)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[KCNH2 ERG ERG1 HERG] Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)

Bibliography :
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