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Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)

 CALCB_HUMAN             Reviewed;         127 AA.
P10092; A8K573; D3DQX4; Q569I0; Q9UCN9;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
13-FEB-2019, entry version 163.
RecName: Full=Calcitonin gene-related peptide 2;
AltName: Full=Beta-type CGRP;
Short=Beta-CGRP;
AltName: Full=Calcitonin gene-related peptide II;
Short=CGRP-II;
Flags: Precursor;
Name=CALCB; Synonyms=CALC2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3492393; DOI=10.1016/0014-5793(86)81091-2;
Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Visser A.,
Lips C.J.M., Jansz H.S.;
"Structure and expression of the human calcitonin/CGRP genes.";
FEBS Lett. 209:97-103(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 56-127.
PubMed=2985435; DOI=10.1016/0014-5793(85)80820-6;
Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Lips C.J.M.,
Jansz H.S.;
"A second human calcitonin/CGRP gene.";
FEBS Lett. 183:403-407(1985).
[6]
PROTEIN SEQUENCE OF 82-108.
PubMed=3492492;
Petermann J.B., Born W., Chang J.Y., Fischer J.A.;
"Identification in the human central nervous system, pituitary, and
thyroid of a novel calcitonin gene-related peptide, and partial amino
acid sequence in the spinal cord.";
J. Biol. Chem. 262:542-545(1987).
[7]
PROTEIN SEQUENCE OF 82-86 AND 104-118, AMIDATION AT PHE-118, AND
DISULFIDE BOND.
TISSUE=Spinal cord;
PubMed=2322288; DOI=10.1016/0006-291X(90)90621-S;
Wimalawansa S.J., Morris H.R., Etienne A., Blench I., Panico M.,
McIntyre I.;
"Isolation, purification and characterization of beta-hCGRP from human
spinal cord.";
Biochem. Biophys. Res. Commun. 167:993-1000(1990).
[8]
PROTEIN SEQUENCE OF 82-104.
TISSUE=Pheochromocytoma;
PubMed=1318039; DOI=10.1016/S0006-291X(05)80966-0;
Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.;
"Isolation and characterization of peptides which act on rat
platelets, from a pheochromocytoma.";
Biochem. Biophys. Res. Commun. 185:134-141(1992).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; X04855; CAC05295.1; -; Genomic_DNA.
EMBL; X04857; CAC05295.1; JOINED; Genomic_DNA.
EMBL; X04861; CAC05295.1; JOINED; Genomic_DNA.
EMBL; AK291188; BAF83877.1; -; mRNA.
EMBL; CH471064; EAW68466.1; -; Genomic_DNA.
EMBL; CH471064; EAW68467.1; -; Genomic_DNA.
EMBL; BC092468; AAH92468.1; -; mRNA.
EMBL; X02404; CAA26249.1; -; mRNA.
CCDS; CCDS7820.1; -.
PIR; A25864; A25864.
PIR; I37232; I37232.
RefSeq; NP_000719.1; NM_000728.3.
UniGene; Hs.534305; -.
ProteinModelPortal; P10092; -.
SMR; P10092; -.
BioGrid; 107248; 4.
IntAct; P10092; 1.
STRING; 9606.ENSP00000346017; -.
ChEMBL; CHEMBL3832947; -.
DrugBank; DB05760; MK-0974.
iPTMnet; P10092; -.
PhosphoSitePlus; P10092; -.
BioMuta; CALCB; -.
DMDM; 115487; -.
PaxDb; P10092; -.
PeptideAtlas; P10092; -.
PRIDE; P10092; -.
ProteomicsDB; 52565; -.
Ensembl; ENST00000324229; ENSP00000346017; ENSG00000175868.
Ensembl; ENST00000533448; ENSP00000433490; ENSG00000175868.
GeneID; 797; -.
KEGG; hsa:797; -.
UCSC; uc001mlx.2; human.
CTD; 797; -.
DisGeNET; 797; -.
EuPathDB; HostDB:ENSG00000175868.13; -.
GeneCards; CALCB; -.
HGNC; HGNC:1438; CALCB.
HPA; HPA059886; -.
MIM; 114160; gene.
neXtProt; NX_P10092; -.
OpenTargets; ENSG00000175868; -.
PharmGKB; PA26030; -.
eggNOG; ENOG410IYZP; Eukaryota.
eggNOG; ENOG410YIU3; LUCA.
GeneTree; ENSGT00940000156267; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
InParanoid; P10092; -.
OrthoDB; 1547206at2759; -.
PhylomeDB; P10092; -.
TreeFam; TF333069; -.
Reactome; R-HSA-418555; G alpha (s) signalling events.
Reactome; R-HSA-419812; Calcitonin-like ligand receptors.
ChiTaRS; CALCB; human.
GenomeRNAi; 797; -.
PMAP-CutDB; P10092; -.
PRO; PR:P10092; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000175868; Expressed in 70 organ(s), highest expression level in dorsal root ganglion.
ExpressionAtlas; P10092; baseline and differential.
Genevisible; P10092; HS.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
GO; GO:0005184; F:neuropeptide hormone activity; TAS:ProtInc.
GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006874; P:cellular calcium ion homeostasis; TAS:ProtInc.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Hormone;
Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 79
/FTId=PRO_0000004086.
PEPTIDE 82 118 Calcitonin gene-related peptide 2.
/FTId=PRO_0000004087.
PROPEP 124 127
/FTId=PRO_0000004088.
MOD_RES 118 118 Phenylalanine amide.
{ECO:0000269|PubMed:2322288}.
DISULFID 83 88 {ECO:0000269|PubMed:2322288}.
CONFLICT 73 73 G -> S (in Ref. 5; CAA26249).
{ECO:0000305}.
SEQUENCE 127 AA; 13706 MW; B0A71A063CD5ACE7 CRC64;
MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM
KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR
RRRDLQA


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Pathways :
WP2197: Endothelin
WP2272: Pathogenic Escherichia coli infection
WP1001: Peptide GPCRs
WP1012: IL-7 Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1031: IL-3 Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP105: Fatty Acid Beta Oxidation 2
WP1052: Id Signaling Pathway
WP1055: IL-4 signaling Pathway
WP1058: Senescence and Autophagy
WP1061: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1117: Peptide GPCRs
WP113: TGF Beta Signaling Pathway
WP1131: IL-7 Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1150: IL-3 Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP1168: Id Signaling Pathway
WP1171: IL-4 signaling Pathway
WP1177: Fatty Acid Beta Oxidation

Related Genes :
[CALCA CALC1] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCB CALC2] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcrl Crlr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcrl Cgrpr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCA CALC CCALCI] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcb] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[Calcb] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[CALCA CALC] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCB] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[] Skin calcitonin gene-related peptide (S-CGRP)
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[S100A12] Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
[] PBAN-type neuropeptides (Pheromone/pyrokinin biosynthesis-activating neuropeptide) [Cleaved into: Diapause hormone (DH); PBAN precursor-related peptide 1 (PBAN-PP-1); PBAN precursor-related peptide 2 (PBAN-PP-2); Alpha-subesophageal ganglion neuropeptide (Alpha-SG neuropeptide) (Alpha-SGNP); Beta-subesophageal ganglion neuropeptide (Beta-SG neuropeptide) (Beta-SGNP) (Pyrokinin-1); Pheromone biosynthesis-activating neuropeptide (Agi-PBAN) (Pyrokinin-2); Gamma-subesophageal ganglion neuropeptide (Gamma-SG neuropeptide) (Gamma-SGNP) (Pyrokinin-3); PBAN precursor-related peptide 3 (PBAN-PP-3)]
[Atk TK] Tachykinins (AmTRP) (Tachykinin-related peptide) [Cleaved into: APTGHQEMQ-amide (AmTRP1) (Tachykinin-related peptide 1) (TRP1); ALMGFQGVR-amide (AmTRP2) (Tachykinin-related peptide 2) (TRP2); Brain peptide NSIINDVKNELFPEDIN; APMGFQGMR-amide 1 (AmTRP3) (Tachykinin-related peptide 3-1) (TRP3-1); Brain peptide ASFDDEYY; APMGFQGMR-amide 2 (AmTRP3) (Tachykinin-related peptide 3-2) (TRP3-2); Brain peptide SLEEILDEIK; Brain peptide SLEEILDEI; Brain peptide EILDEI; TTRFQDSRSKDVYLIDYPEDY-amide (AmTAP1) (Tachykinin-associated peptide 1); Brain peptide VLSMDGYQNILDKKDELLGEWE; Brain peptide APMGFYGT; APMGFYGTR-amide (AmTRP4) (Tachykinin-related peptide 4) (TRP4); Brain peptide IILDALEELD; Brain peptide ILDALEELD; Brain peptide GVMDFQIGLQ; ARMGFHGMR-amide (AmTRP5) (Tachykinin-related peptide 5) (TRP5); SPFRYLGAR-amide (AmTRP6) (Tachykinin-related peptide 6) (TRP6); NPRWEFRGKFVGVR-amide (AmTRP7) (Tachykinin-related peptide 7) (TRP7)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[CALCA CALC] Calcitonin gene-related peptide (CGRP)
[Tk CG14734] Tachykinins (dTk) [Cleaved into: Tachykinin-related peptide 1 (TK-1) (dTK-1) (APTSSFIGMR-amide); Tachykinin-associated peptide 1 (TAP1) (DEEHDTSEGNWLGSGPDPLDYADEEADSSYAEN-amide); Tachykinin-related peptide 2 (TK-2) (dTK-2) (APLAFVGLR-amide); Tachykinin-associated peptide 2 (TAP2) (FIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAV-amide); Tachykinin-related peptide 3 (TK-3) (dTK-3) (APTGFTGMR-amide); Tachykinin-associated peptide 3 (TAP3) (Brain peptide PALLAGDDDAEADEATELQQ); Tachykinin-related peptide 4 (TK-4) (dTK-4) (APVNSFVGMR-amide); Tachykinin-associated peptide 4 (TAP4) (Brain peptide DVSHQHY); Tachykinin-associated peptide 5 (TAP5) (AALSDSYDLRGKQQRFADFNSKFVAVR-amide); Tachykinin-associated peptide 6 (TAP6) (Brain peptide SDLEGNGVGIGDDHEQALVHPWLYLWGE); Tachykinin-related peptide 5 (TK-5) (dTK-5) (APNGFLGMR-amide)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Mr1 Mr1a] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
[TMPO LAP2] Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]
[HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
[Stradb Als2cr2 Papk Syradb] STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase) (Pseudokinase ALS2CR2)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[STRADB ALS2CR2 ILPIP PRO1038] STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2)

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