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Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)

 CALRL_HUMAN             Reviewed;         461 AA.
Q16602; A8K6G5; A8KAD3; Q53S02; Q53TS5;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
14-APR-2009, sequence version 2.
13-FEB-2019, entry version 171.
RecName: Full=Calcitonin gene-related peptide type 1 receptor;
Short=CGRP type 1 receptor;
AltName: Full=Calcitonin receptor-like receptor;
Flags: Precursor;
Name=CALCRL; Synonyms=CGRPR;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
PubMed=8626685; DOI=10.1074/jbc.271.19.11325;
Aiyar N., Rand K., Elshourbagy N.A., Zeng Z., Adamou J.E.,
Bergsma D.J., Li Y.;
"A cDNA encoding the calcitonin gene-related peptide type 1
receptor.";
J. Biol. Chem. 271:11325-11329(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Cerebellum;
PubMed=7818539; DOI=10.1006/bbrc.1995.1047;
Fluehmann B., Muff R., Hunziker W., Fischer J.A., Born W.;
"A human orphan calcitonin receptor-like structure.";
Biochem. Biophys. Res. Commun. 206:341-347(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
Kopatz S.A., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-8.
TISSUE=Placenta, and Trachea;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[6]
PROTEIN SEQUENCE OF 23-37.
PubMed=15340161; DOI=10.1110/ps.04682504;
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally
verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[7]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 23-133 IN COMPLEX WITH RAMP1
AND ANTAGONIST, SUBUNIT, AND DISULFIDE BONDS.
PubMed=20826335; DOI=10.1016/j.str.2010.05.014;
ter Haar E., Koth C.M., Abdul-Manan N., Swenson L., Coll J.T.,
Lippke J.A., Lepre C.A., Garcia-Guzman M., Moore J.M.;
"Crystal structure of the ectodomain complex of the CGRP receptor, a
class-B GPCR, reveals the site of drug antagonism.";
Structure 18:1083-1093(2010).
[8]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 23-136 IN COMPLEX WITH RAMP2,
FUNCTION, MUTAGENESIS OF TRP-72; PHE-92 AND TRP-121, AND DISULFIDE
BONDS.
PubMed=22102369; DOI=10.1002/pro.2003;
Kusano S., Kukimoto-Niino M., Hino N., Ohsawa N., Okuda K.,
Sakamoto K., Shirouzu M., Shindo T., Yokoyama S.;
"Structural basis for extracellular interactions between calcitonin
receptor-like receptor and receptor activity-modifying protein 2 for
adrenomedullin-specific binding.";
Protein Sci. 21:199-210(2012).
-!- FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP)
together with RAMP1 and receptor for adrenomedullin together with
RAMP3 (By similarity). Receptor for adrenomedullin together with
RAMP2. The activity of this receptor is mediated by G proteins
which activate adenylyl cyclase. {ECO:0000250,
ECO:0000269|PubMed:22102369}.
-!- SUBUNIT: Heterodimer of CALCRL and RAMP3 (By similarity).
Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2. {ECO:0000250,
ECO:0000269|PubMed:20826335, ECO:0000269|PubMed:22102369}.
-!- INTERACTION:
P06881:CALCA; NbExp=2; IntAct=EBI-962878, EBI-962928;
O60894:RAMP1; NbExp=3; IntAct=EBI-962878, EBI-962893;
O60895:RAMP2; NbExp=6; IntAct=EBI-962878, EBI-9009040;
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Predominantly expressed in the lung and heart.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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EMBL; L76380; AAC41994.1; -; mRNA.
EMBL; U17473; AAA62158.1; -; mRNA.
EMBL; AY389506; AAQ91332.1; -; mRNA.
EMBL; AK291630; BAF84319.1; ALT_INIT; mRNA.
EMBL; AK292998; BAF85687.1; -; mRNA.
EMBL; AC007319; AAY14806.1; -; Genomic_DNA.
EMBL; AC074020; AAY14996.1; -; Genomic_DNA.
CCDS; CCDS2293.1; -.
PIR; JC2477; JC2477.
RefSeq; NP_001258680.1; NM_001271751.1.
RefSeq; NP_005786.1; NM_005795.5.
UniGene; Hs.470882; -.
UniGene; Hs.744587; -.
PDB; 3AQF; X-ray; 2.60 A; B=23-136.
PDB; 3N7P; X-ray; 2.80 A; A/B/C/J=23-133.
PDB; 3N7R; X-ray; 2.90 A; A/B=23-133.
PDB; 3N7S; X-ray; 2.10 A; A/B=23-133.
PDB; 4RWF; X-ray; 1.76 A; A=31-116.
PDB; 4RWG; X-ray; 2.44 A; A/B/C=31-114.
PDB; 5V6Y; X-ray; 2.80 A; A/B/C/D=29-144.
PDB; 6D1U; X-ray; 2.05 A; A/B/C=29-144.
PDB; 6E3Y; EM; 3.30 A; R=22-461.
PDBsum; 3AQF; -.
PDBsum; 3N7P; -.
PDBsum; 3N7R; -.
PDBsum; 3N7S; -.
PDBsum; 4RWF; -.
PDBsum; 4RWG; -.
PDBsum; 5V6Y; -.
PDBsum; 6D1U; -.
PDBsum; 6E3Y; -.
ProteinModelPortal; Q16602; -.
SMR; Q16602; -.
BioGrid; 115498; 4.
ComplexPortal; CPX-2189; CGRP receptor complex.
ComplexPortal; CPX-2191; Adrenomedullin receptor AM1 complex.
ComplexPortal; CPX-3148; Adrenomedullin receptor AM2 complex.
CORUM; Q16602; -.
DIP; DIP-37674N; -.
IntAct; Q16602; 4.
STRING; 9606.ENSP00000376177; -.
BindingDB; Q16602; -.
ChEMBL; CHEMBL3798; -.
GuidetoPHARMACOLOGY; 47; -.
TCDB; 9.A.14.4.12; the g-protein-coupled receptor (gpcr) family.
iPTMnet; Q16602; -.
PhosphoSitePlus; Q16602; -.
BioMuta; CALCRL; -.
DMDM; 226693507; -.
EPD; Q16602; -.
jPOST; Q16602; -.
PaxDb; Q16602; -.
PeptideAtlas; Q16602; -.
PRIDE; Q16602; -.
ProteomicsDB; 60942; -.
DNASU; 10203; -.
Ensembl; ENST00000392370; ENSP00000376177; ENSG00000064989.
Ensembl; ENST00000409998; ENSP00000386972; ENSG00000064989.
Ensembl; ENST00000410068; ENSP00000387190; ENSG00000064989.
GeneID; 10203; -.
KEGG; hsa:10203; -.
UCSC; uc002upv.6; human.
CTD; 10203; -.
DisGeNET; 10203; -.
EuPathDB; HostDB:ENSG00000064989.12; -.
GeneCards; CALCRL; -.
HGNC; HGNC:16709; CALCRL.
HPA; HPA008070; -.
HPA; HPA046515; -.
MIM; 114190; gene.
neXtProt; NX_Q16602; -.
PharmGKB; PA26033; -.
eggNOG; KOG4564; Eukaryota.
eggNOG; ENOG410XRS2; LUCA.
HOVERGEN; HBG102129; -.
InParanoid; Q16602; -.
KO; K04577; -.
OrthoDB; 349367at2759; -.
PhylomeDB; Q16602; -.
TreeFam; TF315710; -.
Reactome; R-HSA-418555; G alpha (s) signalling events.
Reactome; R-HSA-419812; Calcitonin-like ligand receptors.
ChiTaRS; CALCRL; human.
EvolutionaryTrace; Q16602; -.
GeneWiki; CALCRL; -.
GenomeRNAi; 10203; -.
PRO; PR:Q16602; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000064989; Expressed in 181 organ(s), highest expression level in lung.
ExpressionAtlas; Q16602; baseline and differential.
Genevisible; Q16602; HS.
GO; GO:1903143; C:adrenomedullin receptor complex; IDA:UniProtKB.
GO; GO:1990406; C:CGRP receptor complex; IDA:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO; GO:0005768; C:endosome; IDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005764; C:lysosome; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:1990409; F:adrenomedullin binding; IPI:UniProtKB.
GO; GO:0001605; F:adrenomedullin receptor activity; IPI:UniProtKB.
GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; IPI:UniProtKB.
GO; GO:0004948; F:calcitonin receptor activity; IEA:InterPro.
GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
GO; GO:0008565; F:protein transporter activity; IDA:UniProtKB.
GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IPI:UniProtKB.
GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IPI:UniProtKB.
GO; GO:0001525; P:angiogenesis; IDA:UniProtKB.
GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IPI:UniProtKB.
GO; GO:0006816; P:calcium ion transport; IDA:UniProtKB.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
GO; GO:0071329; P:cellular response to sucrose stimulus; IDA:UniProtKB.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0015031; P:protein transport; IDA:UniProtKB.
GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
CDD; cd15274; 7tmB1_calcitonin_R; 1.
Gene3D; 4.10.1240.10; -; 1.
InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
InterPro; IPR017981; GPCR_2-like.
InterPro; IPR003289; GPCR_2_CGRP1_rcpt.
InterPro; IPR036445; GPCR_2_extracell_dom_sf.
InterPro; IPR001879; GPCR_2_extracellular_dom.
InterPro; IPR000832; GPCR_2_secretin-like.
InterPro; IPR017983; GPCR_2_secretin-like_CS.
Pfam; PF00002; 7tm_2; 1.
Pfam; PF02793; HRM; 1.
PRINTS; PR01351; CGRPRECEPTOR.
PRINTS; PR01350; CTRFAMILY.
PRINTS; PR00249; GPCRSECRETIN.
SMART; SM00008; HormR; 1.
SUPFAM; SSF111418; SSF111418; 1.
PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome;
Direct protein sequencing; Disulfide bond; G-protein coupled receptor;
Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor;
Reference proteome; Signal; Transducer; Transmembrane;
Transmembrane helix.
SIGNAL 1 22 {ECO:0000269|PubMed:15340161}.
CHAIN 23 461 Calcitonin gene-related peptide type 1
receptor.
/FTId=PRO_0000012811.
TOPO_DOM 23 146 Extracellular. {ECO:0000255}.
TRANSMEM 147 166 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 167 173 Cytoplasmic. {ECO:0000255}.
TRANSMEM 174 193 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 194 213 Extracellular. {ECO:0000255}.
TRANSMEM 214 236 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 237 253 Cytoplasmic. {ECO:0000255}.
TRANSMEM 254 273 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 274 289 Extracellular. {ECO:0000255}.
TRANSMEM 290 313 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 314 336 Cytoplasmic. {ECO:0000255}.
TRANSMEM 337 354 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 355 366 Extracellular. {ECO:0000255}.
TRANSMEM 367 388 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 389 461 Cytoplasmic. {ECO:0000255}.
MOD_RES 420 420 Phosphoserine.
{ECO:0000250|UniProtKB:Q9R1W5}.
MOD_RES 445 445 Phosphoserine.
{ECO:0000250|UniProtKB:Q9R1W5}.
CARBOHYD 66 66 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 118 118 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 123 123 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 48 74
DISULFID 65 105
DISULFID 88 127
VARIANT 8 8 N -> Y (in dbSNP:rs698577).
{ECO:0000269|PubMed:14702039}.
/FTId=VAR_054822.
VARIANT 16 16 F -> L (in dbSNP:rs13391909).
/FTId=VAR_049453.
VARIANT 274 274 R -> I (in dbSNP:rs34010553).
/FTId=VAR_049454.
MUTAGEN 72 72 W->A: Strongly reduced affinity for
adrenomedullin.
{ECO:0000269|PubMed:22102369}.
MUTAGEN 92 92 F->A: Strongly reduced affinity for
adrenomedullin.
{ECO:0000269|PubMed:22102369}.
MUTAGEN 121 121 W->A: Strongly reduced affinity for
adrenomedullin.
{ECO:0000269|PubMed:22102369}.
CONFLICT 144 144 L -> Q (in Ref. 4; BAF84319).
{ECO:0000305}.
STRAND 33 35 {ECO:0000244|PDB:3N7P}.
HELIX 36 54 {ECO:0000244|PDB:4RWF}.
STRAND 60 62 {ECO:0000244|PDB:4RWF}.
STRAND 63 65 {ECO:0000244|PDB:3N7S}.
STRAND 71 75 {ECO:0000244|PDB:5V6Y}.
STRAND 78 87 {ECO:0000244|PDB:4RWF}.
STRAND 90 92 {ECO:0000244|PDB:6D1U}.
STRAND 99 105 {ECO:0000244|PDB:4RWF}.
TURN 115 117 {ECO:0000244|PDB:4RWF}.
TURN 125 128 {ECO:0000244|PDB:4RWF}.
HELIX 130 144 {ECO:0000244|PDB:6D1U}.
HELIX 172 197 {ECO:0000244|PDB:6E3Y}.
TURN 198 200 {ECO:0000244|PDB:6E3Y}.
TURN 203 207 {ECO:0000244|PDB:6E3Y}.
HELIX 210 241 {ECO:0000244|PDB:6E3Y}.
HELIX 254 259 {ECO:0000244|PDB:6E3Y}.
TURN 260 263 {ECO:0000244|PDB:6E3Y}.
HELIX 264 276 {ECO:0000244|PDB:6E3Y}.
HELIX 281 283 {ECO:0000244|PDB:6E3Y}.
STRAND 286 290 {ECO:0000244|PDB:6E3Y}.
HELIX 292 320 {ECO:0000244|PDB:6E3Y}.
HELIX 330 345 {ECO:0000244|PDB:6E3Y}.
HELIX 347 349 {ECO:0000244|PDB:6E3Y}.
STRAND 350 352 {ECO:0000244|PDB:6E3Y}.
HELIX 364 374 {ECO:0000244|PDB:6E3Y}.
HELIX 376 382 {ECO:0000244|PDB:6E3Y}.
TURN 383 386 {ECO:0000244|PDB:6E3Y}.
HELIX 389 398 {ECO:0000244|PDB:6E3Y}.
TURN 399 401 {ECO:0000244|PDB:6E3Y}.
SEQUENCE 461 AA; 52929 MW; AF98E55E5454767C CRC64;
MEKKCTLNFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA
EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT
WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL
FFSFVCNSVV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL
IVVAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI
AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS
YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N


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10-288-22138F Calcitonin gene-related peptide-receptor component protein - CGRP-receptor component protein; CGRP-RCP; CGRPRCP 0.05 mg
10-288-22138F Calcitonin gene-related peptide-receptor component protein - CGRP-receptor component protein; CGRP-RCP; CGRPRCP 0.1 mg
E0472m ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
E0472r ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472r ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472m ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
U0472r CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
U0472m CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
EIAAB35834 Calcitonin gene-related peptide-receptor component protein,CGRPRCP,CGRP-RCP,CGRP-receptor component protein,Crcp,DNA-directed RNA polymerase III subunit RPC9,Rat,Rattus norvegicus,RNA polymerase III s
EIAAB35835 Calcitonin gene-related peptide-receptor component protein,CGRPRCP,CGRP-RCP,CGRP-receptor component protein,Crcp,DNA-directed RNA polymerase III subunit RPC9,Mouse,Mus musculus,RNA polymerase III subu
EIAAB35836 Calcitonin gene-related peptide-receptor component protein,CGRPRCP,CGRP-RCP,CGRP-receptor component protein,CRCP,DNA-directed RNA polymerase III subunit RPC9,Homo sapiens,HsC17,Human,RNA polymerase II
E0876h ELISA kit Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
U0876h CLIA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876h ELISA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876m ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
E0876r ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
U0876r CLIA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T

Kits Elisa; taq POLYMERASE

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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP1025: B Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP1963: The effect of Glucocorticoids on target gene expression
WP2197: Endothelin
WP274: B Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1183: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor

Related Genes :
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcrl Crlr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcrl Cgrpr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCA CALC1] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCB CALC2] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[PTH1R PTHR PTHR1] Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[CALCA CALC CCALCI] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[NTRK1 MTC TRK TRKA] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
[Ackr3 Cmkor1 Cxcr7 Rdc1] Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor RDC1 homolog) (RDC-1)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[OPRM1 MOR1] Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[ACVR1 ACVRLK2] Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
[Rorc Nr1f3 Rorg Thor] Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) (Thymus orphan receptor) (TOR)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Fpr-s1 Fpr2 Fpr3 Fprl1 Lxa4r] Formyl peptide receptor-related sequence 1 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor related sequence 1) (Formyl peptide receptor-like 1) (Lipoxin A4 receptor) (LXA4 receptor) (N-formyl peptide receptor 2) (N-formyl peptide receptor 3)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[RYR1 RYDR] Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[ITPR1 INSP3R1] Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[GPER1 CEPR CMKRL2 DRY12 GPER GPR30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
[ACVR1B ACVRLK4 ALK4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
[Acvr1b Alk4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)

Bibliography :
[30689083] Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
[30680847] Adrenomedullin disulfide bond mimetics uncover structural requirements for AM receptor activation.
[30340421] Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat Ex-Vivo Heart Model.
[30209400] Cryo-EM structure of the active, G-protein complexed, human CGRP receptor.
[30088106] PACAP38 and PAC receptor blockade: a new target for headache?
[29201256] Neuropeptides and ATP signaling in the trigeminal ganglion.
[28417590] Calcitonin gene-related peptide (CGRP): A novel target for Alzheimer's disease.
[28317098] CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1.
[28192258] Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries.
[28116293] Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases.