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Calcium and integrin-binding family member 2

 CIB2_RAT                Reviewed;         187 AA.
Q568Z7;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
10-MAY-2005, sequence version 1.
08-MAY-2019, entry version 95.
RecName: Full=Calcium and integrin-binding family member 2;
Name=Cib2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Calcium-binding protein critical for proper
photoreceptor cell maintenance and function. Plays a role in
intracellular calcium homeostasis by decreasing ATP-induced
calcium release. May be involved in the mechanotransduction
process. {ECO:0000250, ECO:0000250|UniProtKB:O75838}.
-!- SUBUNIT: Homodimer. Interacts with WHRN and MYO7A. Interacts with
ITGA2B (via C-terminus cytoplasmic tail region) and ITGA7 (via C-
terminus cytoplasmic tail region); the interactions are
stabilized/increased in a calcium and magnesium-dependent manner.
{ECO:0000250|UniProtKB:O75838}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z309}.
Cell projection, stereocilium {ECO:0000250|UniProtKB:O75838}.
Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9Z309}. Cell
projection, cilium, photoreceptor outer segment
{ECO:0000250|UniProtKB:Q9Z309}. Cell membrane, sarcolemma
{ECO:0000250|UniProtKB:Q9Z309}. Note=Colocalized with ITGA7 at the
myotendinous junctions (MTJ) and at the neuromuscular junctions
(NMJ). Localizes in the cuticular plate along and at the tip of
the stereocilia of vestibular sensory hair cells.
{ECO:0000250|UniProtKB:O75838, ECO:0000250|UniProtKB:Q9Z309}.
-!- MISCELLANEOUS: The binding of either calcium or magnesium
significantly increases the structural stability of the protein in
comparison to apo-CIB (calcium- and magnesium-free form).
{ECO:0000250|UniProtKB:O75838}.
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EMBL; BC092630; AAH92630.1; -; mRNA.
RefSeq; NP_001015010.1; NM_001015010.1.
SMR; Q568Z7; -.
STRING; 10116.ENSRNOP00000013623; -.
PaxDb; Q568Z7; -.
PRIDE; Q568Z7; -.
Ensembl; ENSRNOT00000078571; ENSRNOP00000071683; ENSRNOG00000059834.
GeneID; 300719; -.
KEGG; rno:300719; -.
UCSC; RGD:1308718; rat.
CTD; 10518; -.
RGD; 1308718; Cib2.
eggNOG; KOG0038; Eukaryota.
eggNOG; COG5126; LUCA.
GeneTree; ENSGT00940000157327; -.
HOGENOM; HOG000233019; -.
InParanoid; Q568Z7; -.
OMA; APNIVPM; -.
OrthoDB; 1271942at2759; -.
PhylomeDB; Q568Z7; -.
TreeFam; TF313865; -.
PRO; PR:Q568Z7; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000059834; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue.
Genevisible; Q568Z7; RN.
GO; GO:0032437; C:cuticular plate; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005927; C:muscle tendon junction; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
GO; GO:0001750; C:photoreceptor outer segment; ISS:UniProtKB.
GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO; GO:0032420; C:stereocilium; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0055074; P:calcium ion homeostasis; ISS:UniProtKB.
GO; GO:0071318; P:cellular response to ATP; ISS:UniProtKB.
GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
CDD; cd00051; EFh; 1.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
Pfam; PF13499; EF-hand_7; 1.
SMART; SM00054; EFh; 3.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 2.
PROSITE; PS50222; EF_HAND_2; 3.
2: Evidence at transcript level;
Calcium; Cell membrane; Cell projection; Complete proteome; Cytoplasm;
Magnesium; Membrane; Metal-binding; Reference proteome; Repeat.
CHAIN 1 187 Calcium and integrin-binding family
member 2.
/FTId=PRO_0000289289.
DOMAIN 66 101 EF-hand 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 103 138 EF-hand 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 144 179 EF-hand 3. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 116 127 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 157 168 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
SEQUENCE 187 AA; 21672 MW; B97050DCBC0A6E0D CRC64;
MGNKQTIFTE EQLDNYQDCT FFNKKDILKL HARFYELAPN LVPMDYRKSP IVHVPMSLII
QMPELRENPF KERIVEAFSE DGEGNLTFND FVDMFSVLCE SAPRELKANY AFKIYDFNTD
NFICKEDLEL TLARLTKSEL DEDEVVLVCD KVIEEADLDG DGKLGFADFE DMIAKAPDFL
STFHIRI


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Catalog number Product name Quantity
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GWB-6EFFE7 Calcium and integrin binding family member 2 (CIB2), Antibody
CIB4 CIB2 Gene calcium and integrin binding family member 2
CIDEA CIB4 Gene calcium and integrin binding family member 4
CSB-EL005427RA Rat Calcium and integrin-binding family member 2(CIB2) ELISA kit 96T
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CIB2_HUMAN ELISA Kit FOR Calcium and integrin-binding family member 2; organism: Human; gene name: CIB2 96T
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Pathways :
WP1365: Calcium Regulation in the Cardiac Cell
WP1329: Alpha6-Beta4 Integrin Signaling Pathway
WP1386: Integrin-mediated cell adhesion
WP1126: Tryptophan metabolism
WP497: Urea cycle and metabolism of amino groups
WP951: Integrin-mediated cell adhesion
WP1799: Costimulation by the CD28 family
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP246: TNF-alpha NF-kB Signaling Pathway
WP1832: Integrin alphaIIb beta3 signaling
WP240: Alanine and aspartate metabolism
WP1344: Wnt Signaling Pathway and Pluripotency
WP1043: Calcium Regulation in the Cardiac Cell
WP326: Calcium Regulation in the Cardiac Cell
WP164: Glutathione metabolism
WP1159: Calcium Regulation in the Cardiac Cell
WP488: Alpha6-Beta4 Integrin Signaling Pathway
WP1373: GPCRs, Class C Metabotropic glutamate, pheromone
WP185: Integrin-mediated cell adhesion
WP1323: EGFR1 Signaling Pathway
WP572: EGFR1 Signaling Pathway
WP1909: Signal regulatory protein (SIRP) family interactions
WP1378: Senescence and Autophagy
WP2226: Cell engulfment
WP590: Cardiovascular Signaling

Related Genes :

Bibliography :
[30174586] Preferential Binding of Mg Over Ca to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J.
[29337188] Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells.
[29255404] Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice.
[29125118] Research Advances of Calcium-and Integrin-binding Protein 1 in Tumors.
[28729416] CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1.
[28051089] Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.
[26473954] Correction: A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family.
[26426422] A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family.
[25038933] Overexpression of the PLAP-1 gene inhibits the differentiation of BMSCs into osteoblast-like cells.
[23503467] A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.