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Calmodulin-2

 CALM2_MOUSE             Reviewed;         149 AA.
P0DP27; P02593; P62204; P70667; P99014; Q3TEH7; Q3THK5; Q3U6Z5; Q3U7C7;
Q498A3; Q61379; Q61380; Q8BNC9; Q91VQ9; Q9D6G4;
10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
10-MAY-2017, sequence version 1.
29-SEP-2021, entry version 33.
RecName: Full=Calmodulin-2 {ECO:0000250|UniProtKB:P0DP24};
Name=Calm2 {ECO:0000312|MGI:MGI:103250}; Synonyms=Cam2, CamC;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=2551780; DOI=10.1016/0378-1119(89)90259-x;
Danchin A., Sezer O., Glaser P., Chalon P., Caput D.;
"Cloning and expression of mouse-brain calmodulin as an activator of
Bordetella pertussis adenylate cyclase in Escherichia coli.";
Gene 80:145-149(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CAST/EiJ; TISSUE=Brain;
PubMed=16670015; DOI=10.1186/1471-2164-7-102;
Farber C.R., Corva P.M., Medrano J.F.;
"Genome-wide isolation of growth and obesity QTL using mouse speed congenic
strains.";
BMC Genomics 7:102-102(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, DBA/2J, and NOD;
TISSUE=Amnion, Bone marrow, Colon, Hippocampus, Kidney, Liver, Lung,
Mammary gland, Ovary, Placenta, Stomach, Testis, Thymus, and Tongue;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=129, C57BL/6J, and Czech II;
TISSUE=Brain, Mammary tumor, Placenta, and Spinal ganglion;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-131.
PubMed=7828884; DOI=10.1016/0378-1119(94)90665-3;
Skinner T.L., Kerns R.T., Bender P.K.;
"Three different calmodulin-encoding cDNAs isolated by a modified 5'-RACE
using degenerate oligodeoxyribonucleotides.";
Gene 151:247-251(1994).
[6]
PROTEIN SEQUENCE OF 2-14, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
ALA-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=C57BL/6J; TISSUE=Liver;
Bienvenut W.V.;
Submitted (JUL-2005) to UniProtKB.
[7]
PROTEIN SEQUENCE OF 15-31; 79-87 AND 92-107, AND IDENTIFICATION BY MASS
SPECTROMETRY.
STRAIN=C57BL/6J; TISSUE=Brain, and Hippocampus;
Lubec G., Klug S., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[8]
INTERACTION WITH RYR1 AND RYR2.
PubMed=18650434; DOI=10.1074/jbc.m804432200;
Wright N.T., Prosser B.L., Varney K.M., Zimmer D.B., Schneider M.F.,
Weber D.J.;
"S100A1 and calmodulin compete for the same binding site on ryanodine
receptor.";
J. Biol. Chem. 283:26676-26683(2008).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-100, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-100 AND SER-102, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[11]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-22, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
[12]
INTERACTION WITH IQCF1.
PubMed=25380116; DOI=10.1111/andr.296;
Fang P., Xu W., Li D., Zhao X., Dai J., Wang Z., Yan X., Qin M., Zhang Y.,
Xu C., Wang L., Qiao Z.;
"A novel acrosomal protein, IQCF1, involved in sperm capacitation and the
acrosome reaction.";
Andrology 3:332-344(2015).
[13]
INTERACTION WITH SYT7.
PubMed=24569478; DOI=10.7554/elife.01524;
Liu H., Bai H., Hui E., Yang L., Evans C.S., Wang Z., Kwon S.E.,
Chapman E.R.;
"Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle
replenishment.";
Elife 3:E01524-E01524(2014).
-!- FUNCTION: Calmodulin mediates the control of a large number of enzymes,
ion channels, aquaporins and other proteins through calcium-binding.
Among the enzymes to be stimulated by the calmodulin-calcium complex
are a number of protein kinases and phosphatases. Together with CCP110
and centrin, is involved in a genetic pathway that regulates the
centrosome cycle and progression through cytokinesis. Mediates calcium-
dependent inactivation of CACNA1C. Positively regulates calcium-
activated potassium channel activity of KCNN2.
{ECO:0000250|UniProtKB:P62158}.
-!- SUBUNIT: Interacts with CEP97, CCP110, MYO1C, TTN/titin and SRY.
Interacts with MYO10. Interacts with RRAD (By similarity). Interacts
with USP6; the interaction is calcium dependent (By similarity).
Interacts with CDK5RAP2. Interacts with SCN5A (By similarity).
Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the
interaction with the cytoplasmic domains from two MIP subunits promotes
MIP water channel closure. Interacts with ORAI1; this may play a role
in the regulation of ORAI1-mediated calcium transport (By similarity).
Interacts with RYR1 (PubMed:18650434). Interacts with MYO5A (By
similarity). Interacts with IQCF1 (PubMed:25380116). Interacts with
SYT7 (PubMed:24569478). Interacts with CEACAM1 (via cytoplasmic
domain); this interaction is in a calcium dependent manner and reduces
homophilic cell adhesion through dissociation of dimer (By similarity).
Interacts with RYR2; regulates RYR2 calcium-release channel activity
(PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium-
binding (By similarity). Interacts with the heterotetrameric KCNQ2 and
KCNQ3 channel; the interaction is calcium-independent, constitutive and
participates in the proper assembly of a functional heterotetrameric M
channel (By similarity). {ECO:0000250|UniProtKB:P0DP24,
ECO:0000250|UniProtKB:P0DP26, ECO:0000250|UniProtKB:P62161,
ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:24569478,
ECO:0000269|PubMed:25380116}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Cytoplasm,
cytoskeleton, spindle pole. Note=Distributed throughout the cell during
interphase, but during mitosis becomes dramatically localized to the
spindle poles and the spindle microtubules. {ECO:0000250}.
-!- PTM: Ubiquitination results in a strongly decreased activity.
{ECO:0000250}.
-!- PTM: Phosphorylation results in a decreased activity. {ECO:0000250}.
-!- MISCELLANEOUS: This protein has four functional calcium-binding sites.
{ECO:0000250|UniProtKB:P0DP24}.
-!- SIMILARITY: Belongs to the calmodulin family. {ECO:0000305}.
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EMBL; M27844; AAA37365.1; -; Genomic_DNA.
EMBL; AY902353; AAY21063.1; -; Genomic_DNA.
EMBL; AK012247; BAB28116.1; -; mRNA.
EMBL; AK012564; BAB28319.1; -; mRNA.
EMBL; AK013068; BAB28631.1; -; mRNA.
EMBL; AK152303; BAE31109.1; -; mRNA.
EMBL; AK160636; BAE35930.1; -; mRNA.
EMBL; AK161268; BAE36280.1; -; mRNA.
EMBL; AK161984; BAE36667.1; -; mRNA.
EMBL; AK168741; BAE40582.1; -; mRNA.
EMBL; BC010730; AAH10730.1; -; mRNA.
EMBL; BC021347; AAH21347.1; -; mRNA.
EMBL; BC051444; AAH51444.1; -; mRNA.
EMBL; BC100301; AAI00302.1; -; mRNA.
EMBL; L31642; AAA65934.1; -; mRNA.
CCDS; CCDS37716.1; -.
RefSeq; NP_031615.1; NM_007589.5.
RefSeq; NP_031616.1; NM_007590.3.
RefSeq; NP_033920.1; NM_009790.5.
SMR; P0DP27; -.
iPTMnet; P0DP27; -.
jPOST; P0DP27; -.
ProteomicsDB; 265327; -.
Antibodypedia; 39411; 181 antibodies.
Antibodypedia; 4344; 534 antibodies.
Antibodypedia; 53945; 69 antibodies.
DNASU; 12313; -.
Ensembl; ENSMUST00000019514; ENSMUSP00000019514; ENSMUSG00000019370.
Ensembl; ENSMUST00000040440; ENSMUSP00000048857; ENSMUSG00000036438.
Ensembl; ENSMUST00000110082; ENSMUSP00000105709; ENSMUSG00000001175.
GeneID; 12313; -.
GeneID; 12314; -.
GeneID; 12315; -.
KEGG; mmu:12313; -.
KEGG; mmu:12314; -.
KEGG; mmu:12315; -.
CTD; 801; -.
CTD; 805; -.
CTD; 808; -.
MGI; MGI:103250; Calm2.
VEuPathDB; HostDB:ENSMUSG00000001175; -.
VEuPathDB; HostDB:ENSMUSG00000019370; -.
VEuPathDB; HostDB:ENSMUSG00000036438; -.
OMA; DEMIREP; -.
OrthoDB; 1386217at2759; -.
BioGRID-ORCS; 12313; 4 hits in 65 CRISPR screens.
BioGRID-ORCS; 12314; 1 hit in 60 CRISPR screens.
BioGRID-ORCS; 12315; 1 hit in 63 CRISPR screens.
ChiTaRS; Calm2; mouse.
PRO; PR:P0DP27; -.
Proteomes; UP000000589; Chromosome 12.
Proteomes; UP000000589; Chromosome 17.
Proteomes; UP000000589; Chromosome 7.
RNAct; P0DP27; protein.
ExpressionAtlas; P0DP27; baseline and differential.
GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
GO; GO:1902494; C:catalytic complex; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0030426; C:growth cone; ISO:MGI.
GO; GO:0016020; C:membrane; IDA:ARUK-UCL.
GO; GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
GO; GO:0043209; C:myelin sheath; IDA:CAFA.
GO; GO:0043005; C:neuron projection; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0030017; C:sarcomere; IEA:Ensembl.
GO; GO:0005876; C:spindle microtubule; IEA:Ensembl.
GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
GO; GO:0031982; C:vesicle; IDA:ARUK-UCL.
GO; GO:0008076; C:voltage-gated potassium channel complex; IGI:MGI.
GO; GO:0010856; F:adenylate cyclase activator activity; IEA:Ensembl.
GO; GO:0008179; F:adenylate cyclase binding; ISO:MGI.
GO; GO:0019855; F:calcium channel inhibitor activity; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO; GO:0048306; F:calcium-dependent protein binding; IPI:ARUK-UCL.
GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl.
GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
GO; GO:0031997; F:N-terminal myristoylation domain binding; IEA:Ensembl.
GO; GO:0050998; F:nitric-oxide synthase binding; ISO:MGI.
GO; GO:0030235; F:nitric-oxide synthase regulator activity; ISO:MGI.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; ISO:MGI.
GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0047485; F:protein N-terminus binding; ISO:MGI.
GO; GO:0072542; F:protein phosphatase activator activity; IEA:Ensembl.
GO; GO:0031432; F:titin binding; IEA:Ensembl.
GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
GO; GO:0031800; F:type 3 metabotropic glutamate receptor binding; ISO:MGI.
GO; GO:0007190; P:activation of adenylate cyclase activity; IEA:Ensembl.
GO; GO:0016240; P:autophagosome membrane docking; IEA:Ensembl.
GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
GO; GO:0090151; P:establishment of protein localization to mitochondrial membrane; IEA:Ensembl.
GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:MGI.
GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:Ensembl.
GO; GO:1905913; P:negative regulation of calcium ion export across plasma membrane; IDA:ARUK-UCL.
GO; GO:1901020; P:negative regulation of calcium ion transmembrane transporter activity; IDA:ARUK-UCL.
GO; GO:1901842; P:negative regulation of high voltage-gated calcium channel activity; IEA:Ensembl.
GO; GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; ISS:UniProtKB.
GO; GO:0051343; P:positive regulation of cyclic-nucleotide phosphodiesterase activity; IEA:Ensembl.
GO; GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Ensembl.
GO; GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IEA:Ensembl.
GO; GO:0060316; P:positive regulation of ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
GO; GO:0050848; P:regulation of calcium-mediated signaling; IGI:ARUK-UCL.
GO; GO:0098901; P:regulation of cardiac muscle cell action potential; IEA:Ensembl.
GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
GO; GO:0010880; P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
GO; GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
GO; GO:1900242; P:regulation of synaptic vesicle endocytosis; IEA:Ensembl.
GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
CDD; cd00051; EFh; 2.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
Pfam; PF13499; EF-hand_7; 2.
SMART; SM00054; EFh; 4.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 4.
PROSITE; PS50222; EF_HAND_2; 4.
1: Evidence at protein level;
Acetylation; Calcium; Cytoplasm; Cytoskeleton; Direct protein sequencing;
Isopeptide bond; Metal-binding; Methylation; Phosphoprotein;
Reference proteome; Repeat; Ubl conjugation.
INIT_MET 1
/note="Removed"
/evidence="ECO:0000269|Ref.6"
CHAIN 2..149
/note="Calmodulin-2"
/id="PRO_0000439936"
DOMAIN 8..43
/note="EF-hand 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
DOMAIN 44..79
/note="EF-hand 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
DOMAIN 81..116
/note="EF-hand 3"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
DOMAIN 117..149
/note="EF-hand 4"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
CA_BIND 21..32
/note="1"
CA_BIND 57..68
/note="2"
CA_BIND 94..105
/note="3"
CA_BIND 130..141
/note="4"
REGION 77..149
/note="Necessary and sufficient for interaction with PCP4"
/evidence="ECO:0000250|UniProtKB:P0DP24"
MOD_RES 2
/note="N-acetylalanine"
/evidence="ECO:0000269|Ref.6"
MOD_RES 22
/note="N6-acetyllysine; alternate"
/evidence="ECO:0007744|PubMed:23806337"
MOD_RES 45
/note="Phosphothreonine; by CaMK4"
/evidence="ECO:0000250|UniProtKB:P0DP30"
MOD_RES 82
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P0DP24"
MOD_RES 95
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:P0DP24"
MOD_RES 100
/note="Phosphotyrosine"
/evidence="ECO:0007744|PubMed:18034455,
ECO:0007744|PubMed:21183079"
MOD_RES 102
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 111
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P0DP24"
MOD_RES 116
/note="N6,N6,N6-trimethyllysine; alternate"
/evidence="ECO:0000250|UniProtKB:P0DP24"
MOD_RES 116
/note="N6-methyllysine; alternate"
/evidence="ECO:0000250|UniProtKB:P0DP24"
MOD_RES 139
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P0DP24"
CROSSLNK 22
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2); alternate"
/evidence="ECO:0000250|UniProtKB:P0DP24"
CROSSLNK 22
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin); alternate"
/evidence="ECO:0000250|UniProtKB:P62157"
SEQUENCE 149 AA; 16838 MW; 6B4BC3FCDE10727B CRC64;
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE
EVDEMIREAD IDGDGQVNYE EFVQMMTAK


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orb80987 Human Calmodulin protein Calmodulin Human Recombinant full length protein expressed in E.coli, having Molecular Weight of approximately 16 kDa, the Accession number is NP_001734. For research use only 10
1740-2384 NATIVE BOVINE CALMODULIN, Product Type Purified Protein, Specificity CALMODULIN, Target Species Bovine, Host N_A, Format Purified, Isotypes , Applications E, Clone 1 mg
SCH-1740-2384 NATIVE BOVINE CALMODULIN, Product Type Purified Protein, Specificity CALMODULIN, Target Species Bovine, Host N_A, Format Purified, Isotypes , Applications E, Clone 1 mg
108334-68-5 Syntide 2 calmodulin-dependent protein Syntide 2 calmodulin-d 1g
73298-54-1 Calmodulin Calmodulin 1g
AS09 486 Antibody: Ca2+-ATPase | calmodulin-stimulated calcium-ATPase, Immunogen: KLH-conjugated synthetic peptide derived from Brassica oleracea calmodulin-stimulated calcium-ATPase P93067, Host: rabbit, poly 100
MCA5125Z MOUSE ANTI HUMAN CALMODULIN Azide free, Product Type Monoclonal Antibody, Specificity CALMODULIN, Target Species Human, Host Mouse, Format Azide Free, Isotypes IgG1, Applications IF, Clone 3F4 0.1 mg
EIAAB05237 Calmodulin-regulated spectrin-associated protein 1-like protein 1,Calmodulin-regulated spectrin-associated protein 2,CAMSAP1L1,CAMSAP2,Homo sapiens,Human,KIAA1078
EIAAB05236 Calmodulin-regulated spectrin-associated protein 1-like protein 1,Calmodulin-regulated spectrin-associated protein 2,Camsap1l1,Camsap2,Kiaa1078,Mouse,Mus musculus
orb70537 Calmodulin Dependent Protein Kinase 2-g (345-358) peptide This is Calmodulin Dependent Protein Kinase 2-g (345-358) peptide. For research use only. 1 mg
orb71484 Calmodulin-Dependent Protein Kinase 2 (281-309) peptide This is Calmodulin-Dependent Protein Kinase 2 (281-309) peptide. For research use only. 1 mg
orb70539 Calmodulin-Dependent Protein Kinase 2 (281-289) peptide This is Calmodulin-Dependent Protein Kinase 2 (281-289) peptide. For research use only. 1 mg
orb71485 Calmodulin-Dependent Protein Kinase 2 (290-309) peptide This is Calmodulin-Dependent Protein Kinase 2 (290-309) peptide. For research use only. 1 mg
Pathways :
WP2075: Alzheimers Disease
WP164: Glutathione metabolism
WP1389: Monoamine GPCRs
WP1382: Delta-Notch Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP580: Dauer formation
WP1545: miRNAs involved in DDR
WP1373: GPCRs, Class C Metabotropic glutamate, pheromone
WP270: Tryptophan metabolism
WP1379: Diurnally regulated genes with circadian orthologs
WP1321: Myometrial Relaxation and Contraction Pathways
WP537: Translation Factors
WP1329: Alpha6-Beta4 Integrin Signaling Pathway
WP394: RNA interference and miRNA
WP79: Tryptophan metabolism
WP1380: Regulation of Actin Cytoskeleton
WP104: Alanine and aspartate metabolism
WP1355: One Carbon Metabolism
WP426: Urea cycle and metabolism of amino groups
WP1039: Glutathione metabolism
WP1365: Calcium Regulation in the Cardiac Cell
WP1642: D-Arginine and D-ornithine metabolism
WP1323: EGFR1 Signaling Pathway
WP1362: Homologous recombination
WP1385: Nuclear Receptors

Related Genes :
[Calm2 Cam2 CamC] Calmodulin-2
[cmk-1 K07A9.2] Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI)
[fem-2 T19C3.8] Protein phosphatase fem-2 (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Feminization of XX and XO animals protein 2) (Sex-determining protein fem-2)
[ckk-1 C05H8.1] Calcium/calmodulin-dependent protein kinase kinase (CaM-KK) (CaM-kinase kinase) (EC 2.7.11.17)
[Eef2k] Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)
[unc-43 K11E8.1] Calcium/calmodulin-dependent protein kinase type II (CaM kinase II) (EC 2.7.11.17) (Uncoordinated protein 43)
[tax-6 cna-1 C02F4.2] Serine/threonine-protein phosphatase 2B catalytic subunit (EC 3.1.3.16) (Abnormal chemotaxis protein 6) (Calmodulin-dependent calcineurin subunit A)
[Camkk2] Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
[CAMKK2 CAMKKB KIAA0787] Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
[Camkk2 Kiaa0787] Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
[CAMTA3 CMTA3 SARD3 SR1 At2g22300 T26C19.4] Calmodulin-binding transcription activator 3 (AtCAMTA3) (Ethylene-induced calmodulin-binding protein 1) (EICBP1) (Ethylene-induced calmodulin-binding protein a) (EICBP.a) (Protein SAR-DEFICIENT 3) (Signal-responsive protein 1) (AtSR1)
[CAMTA2 CMTA2 SR4 At5g64220 MSJ1.6] Calmodulin-binding transcription activator 2 (AtCAMTA2) (AtER66) (Ethylene-induced calmodulin-binding protein c) (EICBP.c) (Signal-responsive protein 4) (AtSR4)
[CAMTA1 CMTA1 SR2 At5g09410 T5E8.210] Calmodulin-binding transcription activator 1 (AtCAMTA1) (Ethylene-induced calmodulin-binding protein b) (EICBP.b) (Signal-responsive protein 2) (AtSR2)
[CRK1 CaMK3 CBK3 At2g41140 T3K9.9] CDPK-related kinase 1 (AtCRK1) (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase 3) (Calmodulin-binding protein kinase 3) (AtCBK3) (CaM-binding protein kinase 3)
[CML24 TCH2 At5g37770 K22F20.1] Calcium-binding protein CML24 (Calmodulin-like protein 24) (Touch-induced calmodulin-related protein 2)
[Camk2n1] Calcium/calmodulin-dependent protein kinase II inhibitor 1 (calcium/calmodulin-dependent protein kinase II inhibitor alpha) (CaM-KIINalpha) (CaMKIINalpha)
[Camkk1] Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)
[Camkk1 Camkk] Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)
[CAMKK1 CAMKKA] Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)
[cmkA AN2412] Calcium/calmodulin-dependent protein kinase cmkA (CMPK) (EC 2.7.11.17) (Multifunctional calcium/calmodulin-dependent protein kinase) (ACMPK) (CaMK)
[Calm1 Calm Cam Cam1] Calmodulin-1
[cmd-1 T21H3.3] Calmodulin (CaM)
[CAMRLK MEE62 At5g45800 MRA19.24] Calmodulin-binding receptor kinase CaMRLK (EC 2.7.11.1) (Calmodulin-binding receptor-like kinase) (AtCaMRLK) (Protein MATERNAL EFFECT EMBRYO ARREST 62)
[Calm3 Cam3 Camc] Calmodulin-3
[CAMK1 Os03g0366200 LOC_Os03g25070] Calcium/calmodulin-dependent serine/threonine-protein kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-binding serine/threonine-protein kinase) (CaM-binding protein kinase) (OsCBK)
[CAMSAP2 CAMSAP1L1 KIAA1078] Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)
[Camsap2 Camsap1l1 Kiaa1078] Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)
[CAM GSPATT00015825001] Calmodulin (CaM)
[calA camA DDB_G0279407] Calmodulin (CaM)
[CAMK2B CAM2 CAMK2 CAMKB] Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)

Bibliography :
[34604066] Calmodulin 2 Facilitates Angiogenesis and Metastasis of Gastric Cancer STAT3/HIF-1A/VEGF-A Mediated Macrophage Polarization.
[33951696] Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis.
[33788723] Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression.
[33173240] HLA-J, a Non-Pseudogene as a New Prognostic Marker for Therapy Response and Survival in Breast Cancer.
[32724216] Identification of the novel bacterial blight resistance gene Xa46(t) by mapping and expression analysis of the rice mutant H120.
[31628181] Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses.
[31602204] Smoking alters the evolutionary trajectory of non-small cell lung cancer.
[31429119] lncRNA GAS5 regulates myocardial infarction by targeting the miR-525-5p/CALM2 axis.
[30713075] Dynamic Interactions of Plant CNGC Subunits and Calmodulins Drive Oscillatory Ca Channel Activities.
[27881195] The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers.