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Casein kinase II subunit alpha (CK II) (EC 2 7 11 1)

 CSK21_XENLA             Reviewed;         392 AA.
P28020;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
31-JAN-2002, sequence version 2.
17-JUN-2020, entry version 104.
RecName: Full=Casein kinase II subunit alpha;
Short=CK II;
EC=2.7.11.1 {ECO:0000250|UniProtKB:P68400};
Name=csnk2a1;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Oocyte;
PubMed=1544409; DOI=10.1016/0014-5793(92)80556-v;
Jedlicki A., Hinrichs M.V., Allende C., Allende J.E.;
"The cDNAs coding for the alpha- and beta-subunits of Xenopus laevis casein
kinase II.";
FEBS Lett. 297:280-284(1992).
[2]
SEQUENCE REVISION TO C-TERMINUS.
Allende J.E.;
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalytic subunit of a constitutively active
serine/threonine-protein kinase complex that phosphorylates a large
number of substrates containing acidic residues C-terminal to the
phosphorylated serine or threonine. Regulates numerous cellular
processes, such as cell cycle progression, apoptosis and transcription,
as well as viral infection. May act as a regulatory node which
integrates and coordinates numerous signals leading to an appropriate
cellular response. During mitosis, functions as a component of the
p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains
cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Can
also negatively regulate apoptosis. Phosphorylates the caspases CASP9
and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects
CASP9 from cleavage and activation by CASP8, and inhibits the
dimerization of CASP2 and activation of CASP8 (By similarity). Plays an
important role in the circadian clock function by phosphorylating
ARNTL/BMAL1 (By similarity). {ECO:0000250|UniProtKB:P19139,
ECO:0000250|UniProtKB:P68400}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
Evidence={ECO:0000250|UniProtKB:P68400};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990;
Evidence={ECO:0000250|UniProtKB:P68400};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P68400};
-!- SUBUNIT: Tetramer composed of an alpha chain, an alpha' and two beta
chains.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P68400}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
kinase family. CK2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
---------------------------------------------------------------------------
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EMBL; X62375; CAA44238.2; -; mRNA.
PIR; S20404; S20404.
SMR; P28020; -.
PRIDE; P28020; -.
Xenbase; XB-GENE-959755; csnk2a1.
BRENDA; 2.7.11.1; 6725.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISS:UniProtKB.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
ATP-binding; Kinase; Nucleotide-binding; Nucleus;
Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.
CHAIN 1..392
/note="Casein kinase II subunit alpha"
/id="PRO_0000085894"
DOMAIN 39..324
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 45..53
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
ACT_SITE 156
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 68
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SEQUENCE 392 AA; 45187 MW; 94189BAE50770CF9 CRC64;
MSGPVPSRAR VYTDVNTHRP RDYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT
NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD
FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE
FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD
QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF
LDKLLRYDHQ TRLTAREAMD HPYFYPIVKD QSRMGGSNMP SGSSTPVSSA SMMSGISTVP
TPSALGSLAG SPVISATNTL GTPVAAAAGA TQ


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Pathways :
WP32: Translation Factors
WP1655: Geraniol degradation
WP1614: 1- and 2-Methylnaphthalene degradation
WP1566: Citrate cycle (TCA cycle)
WP2292: Chemokine signaling pathway
WP1003: Ovarian Infertility Genes
WP1701: Starch and sucrose metabolism
WP457: TNF-alpha NF-kB Signaling Pathway
WP1584: Type II diabetes mellitus
WP622: Long-Day Flowering Time Pathway
WP1619: Amino sugar and nucleotide sugar metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1718: Vitamin B6 metabolism
WP1225: estrogen signalling
WP1844: MAP kinase cascade
WP885: Ovarian Infertility Genes
WP1644: DNA replication
WP246: TNF-alpha NF-kB Signaling Pathway
WP1663: Homologous recombination
WP263: Ovarian Infertility Genes
WP1434: Osteopontin Signaling
WP1963: The effect of Glucocorticoids on target gene expression
WP1531: Vitamin D synthesis
WP215: noncanonical wnt pathway

Related Genes :
[CSNK2A1 CK2A1] Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
[CSNK2A2 CK2A2] Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)
[CSNK2A3 CSNK2A1P] Casein kinase II subunit alpha 3 (CK II alpha 3) (EC 2.7.11.1) (Casein kinase II alpha 1 polypeptide pseudogene)
[cka1 orb5 SPAC23C11.11] Casein kinase II subunit alpha (CK II subunit alpha) (EC 2.7.11.1)
[Csnk2a1] Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
[Csnk2a1 Ckiia] Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
[CSNK2A1 CK2A1] Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
[Csnk2a2] Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)
[cka ck-1b 5C2.270 NCU03124] Casein kinase II subunit alpha (CK II subunit alpha) (EC 2.7.11.1)
[hchA A8C65_13880 A9R57_25255 AMK83_16550 AWB10_10580 AWG90_013200 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI693_17820 CI694_25210 CIG45_02340 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D4628_09465 D6T98_10515 D6X36_17295 D9D20_21030 D9D43_06110 D9G29_20785 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 D9J58_04360 D9S45_22925 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLU50_17670 DLW88_16170 DLY44_04800 DND16_20085 DNR35_16895 DQE83_22775 DQP61_11280 DTL43_21780 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K55_17625 E4K61_03800 E5P22_21380 E5S46_06650 EA213_19000 EA225_13320 EAX79_27320 EC95NR1_00961 ED648_25045 EG796_17135 EHD79_18540 EI028_00085 ELT20_21515 ELV08_24970 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC019_03873 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 F7F11_20115 F7F18_11615 F7F29_22635 FNJ83_13175 FQ915_04255 FQR64_09390 FQZ46_21375 FWK02_18105 FZ043_14730 GIY13_02485 GNZ00_15670 GNZ02_11235 GNZ03_00440 GP712_09450 GQE64_12165 GQL64_10635 GQM17_02800 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMA87_25350 BMT91_24760 BON76_21885 BvCmsC61A_00149 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C7B08_25495 C9Z39_20510 CR538_10415 D3Y67_22910 D4023_08350 D9G42_11130 D9I97_22010 D9J11_25195 D9J52_16665 DJ503_24045 DLX40_18195 DM267_05215 DN627_18690 DP258_02540 DQE91_25240 EC3234A_36c00010 EC382_21100 ECTO6_01955 EHH55_07135 FORC82_1921 FV293_07100 GHR40_13690 GKE15_01795 GKE22_01795 GKE24_01795 GKE26_01795 GKE29_19015 GKE31_01795 GKE39_01795 GKE46_01795 GKE58_00235 GKE60_01795 GKE64_01795 GKE77_01800 GKE87_19180 GKE93_04790 GKF00_12775 GKF03_06100 GKF74_23075 GKF86_23585 GKF89_24720 GKG12_21690 GP700_02420 GP720_02430 GP727_01495 GP912_03195 NCTC12650_02300 NCTC8500_02249 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[CkIalpha CKI CG2028] Casein kinase I isoform alpha (CKI-alpha) (DmCK1) (EC 2.7.11.1)
[CSNK2A1] Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
[CSNK1D HCKID] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[nnrD nnrE BHS81_24940 BMA87_06210 BON75_25135 BUE81_24185 BW690_00535 C5P01_11605 C9114_00800 C9141_20385 C9160_20005 C9201_17640 C9Z03_11025 C9Z39_09990 CF006_04810 CG692_00180 CI641_014360 CI693_12780 COD46_22200 CWS33_03515 D2185_07770 D3821_07085 D3O91_01535 D3Y67_00680 D4011_02210 D4638_06395 D6W00_07670 D6X63_00505 D7W70_13040 D8Y65_09515 D9D20_08295 D9D44_05795 D9G29_02235 D9H68_15720 D9H94_06330 D9I18_04405 D9J11_13510 D9J52_05810 D9J63_13405 DAH30_09295 DAH34_17710 DAH37_06235 DEN89_23315 DEO04_15015 DK132_00975 DL292_04305 DL326_12595 DLU82_19955 DM973_03315 DMC44_08050 DMY83_06260 DNW42_15620 DOY22_05310 DOY61_22135 DQE91_09055 DT034_15395 E0I42_01095 E2119_06500 E5P22_06605 E5S42_20000 EA213_12050 EAI42_08035 EAI42_19730 EAI46_08330 ED307_02425 EEP23_07485 EH186_16255 EI021_09655 EI041_04975 EIZ86_02830 EL75_3998 EL79_4176 EL80_4091 ELT20_09170 EPT01_09990 EXX24_09350 EXX78_19455 F1E13_09470 F1E19_03510 FQ022_21765 FQR64_20885 FRV13_14670 FV293_00830 GHR40_02625 GKF89_03420 GNZ03_04915 GP654_08840 GP689_08305 GQE30_17865 GQE34_01730 GQE51_12505 GQE64_09140 GQL64_02225 GRW80_01300 RK56_012375] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[HD16 CKI EL1 Os03g0793500 LOC_Os03g57940 OsJ_12923 OSJNBb0060J21.12] Casein kinase 1-like protein HD16 (EC 2.7.11.1) (Os03g0793500 protein) (Protein EARLY FLOWERING 1) (Protein HEADING DATE 16)
[FAM20C DMP4] Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)
[CKB2 YOR039W OR26.32] Casein kinase II subunit beta' (CK II beta')
[Csnk1d Hckid] Casein kinase I isoform delta (CKI-delta) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[hchA AM465_15370 AWF59_019055 AZZ83_004235 B9N33_26475 BFD68_20845 C7B02_06890 C9Z28_17130 CCZ14_26645 CCZ17_22700 CRJUMX01_1140054 CRT43_11430 CUB99_23505 D3C88_02905 D3P02_16265 D9D33_15385 D9D94_15735 D9E49_19020 D9I20_10460 D9J46_03345 DJ487_18960 DJ492_13470 DL251_00505 DL979_00380 DMC44_18755 DMZ50_24495 DNR41_00375 DS966_16070 DU333_03260 DW236_02290 E0L04_20335 EA159_21345 EA167_21075 EA189_00370 EA191_21560 EA198_02280 EA200_00370 EA203_21510 EA222_02305 EA232_20265 EA233_11705 EA242_17410 EA245_13290 EA429_05770 EA435_21775 EA834_21700 ECTO124_02024 EGT48_04930 ELT23_21030 ELT33_08025 ELT34_19745 ELU82_24705 ELU96_05025 ELV13_26065 ELX79_15035 ELX83_25640 ELY23_20490 ELY24_19085 ELY50_24510 EPS76_06485 EPS91_17475 EPS94_00505 ERS085406_02591 EWK56_00075 ExPECSC065_02714 EYX99_25670 FNJ67_10775 FV295_16190 GFU40_00360 GFU45_09680 GFU47_04835 GJ638_18410 GKE92_23545 GKF28_00040 GKF34_00055 GKF47_00040 GKG08_13460 GKG09_11990 GKG11_12245 GKG22_12830 GKG29_13740 GQE47_24120 GQN33_12435 GQS26_09145 NCTC10766_03778 NCTC7928_05955 NCTC8450_02317 NCTC9007_02951 NCTC9075_02834 SY51_11150 U12A_02105 U14A_02105] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[Csnk1d Hckid] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[CSNK1D HCKID] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[CSNK1D HCKID] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[CSNK1E] Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
[hmpA hmp A6V01_10200 A8C65_03855 A9R57_17040 ACN002_2592 ACN68_11055 ACN81_26320 ACU57_10360 ACU90_01485 AM270_07210 AM464_04560 AML07_10430 APZ14_05505 AUQ13_13215 AUS26_21665 AW106_11070 AWB10_06910 BANRA_01097 BANRA_03418 BANRA_04525 BB545_05760 BHS81_15570 BHS87_14445 BJJ90_06510 BK292_20760 BK296_24730 BMA87_03660 BMT91_09730 BN17_18391 BOH76_09290 BON63_10755 BON69_13990 BON71_13675 BON75_17540 BUE81_08005 BvCms12BK_01774 BvCms2454_04468 BvCmsHHP001_04806 BvCmsHHP019_04806 BvCmsHHP056_01828 BvCmsKSP026_04305 BvCmsNSP072_00267 BvCmsOUP014_02948 BvCmsSIP019_03821 BvCmsSIP044_05092 BVL39_14050 BW690_11150 BZL31_13550 C2U48_21325 C5N07_10115 C5P01_05560 C7235_06805 C9098_02900 C9114_06110 C9141_01855 C9160_04920 C9201_01350 C9306_06605 C9E25_16695 C9Z03_13455 C9Z37_03155 C9Z39_18350 C9Z89_02035 CF006_16010 CI641_005655 CI693_09205 CI694_19335 CIG45_08585 CJU64_15040 CMR93_17935 CO706_10650 COD30_01045 COD46_11500 CRM83_27495 CWS33_10010 D2184_18725 D2185_06690 D3821_11445 D3O91_03570 D3Y67_23905 D4638_14775 D5H35_00985 D6004_00980 D6W00_02395 D7W70_06755 D9610_05050 D9C99_14310 D9D44_02510 D9E19_04690 D9F87_12905 D9G29_09320 D9G69_17680 D9H68_00985 D9I18_09865 D9I97_07905 D9J11_04290 D9J44_00060 D9J63_02360 D9K48_25840 D9S45_04285 D9Z28_05540 DAH18_00220 DAH32_12610 DAH34_18605 DAH37_19275 DEN89_09990 DEO04_07795 DIV22_11300 DJ503_18890 DK132_08375 DL292_04635 DL326_03510 DL479_01320 DL530_01200 DL545_07245 DL800_19195 DLU67_05700 DLU82_05745 DLW60_01510 DLY41_10965 DLY44_09805 DM155_03210 DM267_09015 DM296_18085 DM382_04695 DM973_01355 DN808_02505 DNC98_15250 DNI21_11200 DNX19_14815 DOY61_05325 DP265_12450 DP277_03620 DQE91_09215 DQF36_02795 DQF71_00500 DQF72_12760 DS143_00500 DT034_06375 DTL43_01910 DVB38_05460 DXT69_13075 DXT71_19935 E0I42_02095 E0K84_11045 E2119_10050 E2127_03890 E2128_10370 E2129_06190 E2134_09855 E2135_00930 E2855_03303 E2863_03210 E4K60_01585 E4K61_07850 E5P22_05385 E5P28_04540 E5S47_00200 EA213_03875 EAI42_06330 EAM59_02405 EAN70_01040 EB476_05175 EBA46_07820 EBM08_03540 EC1094V2_1116 EC3234A_44c01590 EC95NR1_01777 ECTO6_01279 ED307_10115 ED600_07770 EEP23_02350 EG599_00985 EG808_01365 EH186_03630 EH412_02350 EHH55_21860 EHJ36_02425 EI021_12090 EI028_07810 EI032_05735 EI041_00200 EIZ86_09040 EIZ93_07130 EKI52_21980 ELT20_16535 ELV08_03290 ELY05_02130 EPT01_18845 ERS085365_01518 ERS085374_00038 ERS085416_03760 ERS139211_00868 ERS150873_01392 ERS150876_00857 EXX71_04790 EXX78_07615 EYD11_06210 EYY78_04395 F1E19_02170 F7F00_00975 F7F23_03720 F7F26_02345 FORC82_1263 FQ022_12130 FQR64_06320 FRV13_24300 FV293_03855 FWK02_18305 FZ043_18225 GHR40_10735 GII67_02720 GKF74_16560 GKF86_17785 GKF89_05425 GKG12_07770 GP654_15220 GP666_02550 GP689_11980 GP935_11615 GP946_10005 GP950_14040 GQE22_07390 GQE34_03495 GQE42_05370 GQE64_06950 GQE93_09845 GQM06_13725 GQM09_02790 GQM17_07930 GRW42_07130 GRW80_05725 HmCms184_00603 HmCmsJML079_04829 HW43_17160 NCTC10963_01285 NCTC11022_02631 NCTC11181_03552 NCTC12650_01586 NCTC13148_02382 NCTC8500_01411 NCTC8960_04037 NCTC8985_06124 NCTC9036_01390 NCTC9058_00631 NCTC9062_01812 NCTC9073_04581 NCTC9706_04593 NCTC9962_00729 PGD_00684 PU06_05410 RG28_09110 RK56_022045 SAMEA3472043_01058 SAMEA3472044_03009 SAMEA3472070_00042 SAMEA3472080_01630 SAMEA3484427_00463 SAMEA3484429_00572 SAMEA3752553_02327 SAMEA3752557_00946 SAMEA3753097_02775 SK85_02808 WQ89_05840] Flavohemoprotein (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) (EC 1.14.12.17)
[Csnk1e] Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[TK UL23] Thymidine kinase (EC 2.7.1.21)
[UL97] Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 protein)

Bibliography :
[32254052] Crystal structure of Arabidopsis thaliana casein kinase 2 α1.
[32103024] Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1.
[31779225] Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.
[31583500] Protein kinase CK2 is involved in zinc homeostasis in breast and prostate cancer cells.
[31268746] Protein kinase CK2 subunits exert specific and coordinated functions in skeletal muscle differentiation and fusogenic activity.
[31091289] Activity of CK2α protein kinase is required for efficient replication of some HPV types.
[30883733] TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target.
[30834696] A proteomics analysis of CK2β C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit.
[30689946] 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action.
[30607803] Up-Regulation of the Alpha Prime Subunit of Protein Kinase CK2 as a Marker of Fast Proliferation in GL261 Cultured Cells.