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Caspase 10

 A0A2U9DQS2_DANRE        Unreviewed;       512 AA.
A0A2U9DQS2;
12-SEP-2018, integrated into UniProtKB/TrEMBL.
12-SEP-2018, sequence version 1.
10-FEB-2021, entry version 12.
SubName: Full=Caspase 10 {ECO:0000313|EMBL:AWP39897.1};
Name=casp10 {ECO:0000313|ZFIN:ZDB-GENE-070608-2};
Synonyms=casp8l2 {ECO:0000313|ZFIN:ZDB-GENE-070608-2};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Danionidae; Danioninae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AWP39897.1};
[1] {ECO:0000313|EMBL:AWP39897.1}
NUCLEOTIDE SEQUENCE.
PubMed=29791492; DOI=10.1371/journal.pone.0197966;
Spead O., Verreet T., Donelson C.J., Poulain F.E.;
"Characterization of the caspase family in zebrafish.";
PLoS ONE 13:E0197966-E0197966(2018).
-!- SIMILARITY: Belongs to the peptidase C14A family.
{ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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EMBL; MG958003; AWP39897.1; -; mRNA.
ZFIN; ZDB-GENE-070608-2; casp10.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IBA:GO_Central.
GO; GO:0035877; F:death effector domain binding; IBA:GO_Central.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR001875; DED_dom.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
Pfam; PF01335; DED; 2.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SMART; SM00031; DED; 2.
SUPFAM; SSF47986; SSF47986; 2.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
PROSITE; PS50168; DED; 2.
2: Evidence at transcript level;
Hydrolase {ECO:0000256|ARBA:ARBA00022807};
Protease {ECO:0000256|ARBA:ARBA00022807};
Repeat {ECO:0000256|ARBA:ARBA00022737};
Thiol protease {ECO:0000256|ARBA:ARBA00022807};
Zymogen {ECO:0000256|ARBA:ARBA00023145}.
DOMAIN 2..80
/note="DED"
/evidence="ECO:0000259|PROSITE:PS50168"
DOMAIN 102..179
/note="DED"
/evidence="ECO:0000259|PROSITE:PS50168"
DOMAIN 271..395
/note="CASPASE_P20"
/evidence="ECO:0000259|PROSITE:PS50208"
DOMAIN 419..508
/note="CASPASE_P10"
/evidence="ECO:0000259|PROSITE:PS50207"
SEQUENCE 512 AA; 57946 MW; 631399FF1954AAE1 CRC64;
MCFQRALLRV QESLSADELQ DLLFLCSDLL CSRDLNTVSS GRQLFTLLQN QDLLSLEDPS
LLIELLSITK RTRLMRSLQS DACMQTSGTA DQPLQQQQRI SRYRQFLYEL SESICDQDLK
NIKFLLMKTL SRKKLEQNLT LLQLFLEMEK EDLLGENNLD VLQRIFADIY PALGRKINQY
KEENLNGVFI AQETEGISSI ADLPSAQTSL SSVEMIDREM DEITLNENAS GFSGDNSQHS
DSVNSGIISE SSEMPQIESS MVEQYEMKGE RRGVCLIINN YDFSACGWLN REGTDIDHDS
LRDVFEWLGF EILTRRDCTG DQILQALMDL STQDHTQADC VVCCILSHGR LNDIIGVDGK
AVPFKELMET LSPFRCSSLY QKPKLFFIQA CRGTQNQRAV FPQTFTEDED VLASDAGVPR
DSIPEMADYL MAMSTVPWYA SYRDKSKGTW FIQSLCDNLR LLVPRGNDLL SILTKVNADV
SKKSDKSGLK KQMPQPEFSL TRTVVFPPPG LP


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Related Genes :
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[CASP14] Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[caspb casp19a caspy2] Caspase b (EC 3.4.22.58) (Caspase 19a) [Cleaved into: Caspase b subunit p20; Caspase b subunit p10]
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP9 MCH6] Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
[CASP1 IL1BC IL1BCE] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[Casp1 Il1bc] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[Casp9 Mch6] Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
[CASP5 ICH3] Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10]
[Casp1 Il1bc Il1bce] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[caspa casp1 caspy] Caspase a (EC 3.4.22.36) [Cleaved into: Caspase a subunit p20; Caspase a subunit p10]
[Casp14] Caspase-14 (CASP-14) (EC 3.4.22.-) (Mini-ICE) (MICE) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[CARD10 CARMA3] Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3)
[RFFL RNF189 RNF34L] E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)
[RNF34] E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)
[CASP4] Caspase-4 (CASP-4) (EC 3.4.22.57) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[CARD19 C9orf89] Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD)
[CASP1 IL1BC] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[CASP1 IL1BC] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[csp-2 Y73B6BL.7] Putative inactive caspase B [Cleaved into: Putative inactive caspase B subunit p31; Putative inactive caspase B subunit p17; Putative inactive caspase subunit p14]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Dronc Nc CG8091] Caspase Dronc (EC 3.4.22.-) (NEDD2-like caspase) [Cleaved into: Caspase Nc subunit 1; Caspase Nc subunit 2]
[CASP1 IL1BC] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]

Bibliography :
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[32986201] Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line.
[32904118] Smokeless tobacco induced biophysical and biochemical alterations in the plasma, erythrocytes, and platelets of panmasala users: Subsequent biological effects.
[32869129] Cleavage of HSP90β induced by histone deacetylase inhibitor and proteasome inhibitor modulates cell growth and apoptosis.
[32822715] Probiotic Enterococcus faecalis AG5 mitigated high fat diet induced obesity and produced propionic acid stimulated apoptosis in 3T3-L1 pre-adipocyte.
[32661168] The pseudo-caspase FLIP(L) regulates cell fate following p53 activation.