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Caspase 3, apoptosis-related cysteine peptidase

 K7D0A9_PANTR            Unreviewed;       277 AA.
K7D0A9; A0A2J8L8A3;
09-JAN-2013, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 1.
17-JUN-2020, entry version 61.
SubName: Full=Caspase 3, apoptosis-related cysteine peptidase {ECO:0000313|EMBL:JAA25562.1};
Name=CASP3 {ECO:0000313|EMBL:JAA25562.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA25562.1};
[1] {ECO:0000313|EMBL:JAA25562.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA06869.1},
Skeletal muscle {ECO:0000313|EMBL:JAA36309.1},
Skin {ECO:0000313|EMBL:JAA25562.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA15963.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from NextGen
mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the peptidase C14A family.
{ECO:0000256|RuleBase:RU003971, ECO:0000256|SAAS:SAAS01080359}.
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EMBL; GABC01004469; JAA06869.1; -; mRNA.
EMBL; GABF01006182; JAA15963.1; -; mRNA.
EMBL; GABD01007538; JAA25562.1; -; mRNA.
EMBL; GABE01008430; JAA36309.1; -; mRNA.
EMBL; GABE01008429; JAA36310.1; -; mRNA.
RefSeq; NP_001012435.1; NM_001012433.1.
RefSeq; XP_009446812.1; XM_009448537.2.
RefSeq; XP_009446814.1; XM_009448539.2.
RefSeq; XP_016806491.1; XM_016951002.1.
RefSeq; XP_016806492.1; XM_016951003.1.
RefSeq; XP_016806493.1; XM_016951004.1.
SMR; K7D0A9; -.
GeneID; 461669; -.
KEGG; ptr:461669; -.
CTD; 836; -.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
HOGENOM; CLU_036904_2_0_1; -.
KO; K02187; -.
OMA; VALILNH; -.
OrthoDB; 984395at2759; -.
Bgee; ENSPTRG00000016640; Expressed in liver and 5 other tissues.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:Ensembl.
GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:Ensembl.
GO; GO:0061713; P:anterior neural tube closure; IEA:Ensembl.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0072734; P:cellular response to staurosporine; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0034349; P:glial cell apoptotic process; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
GO; GO:0046007; P:negative regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
GO; GO:0009411; P:response to UV; IEA:Ensembl.
GO; GO:0009611; P:response to wounding; IEA:Ensembl.
GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
2: Evidence at transcript level;
Hydrolase {ECO:0000256|SAAS:SAAS00710708};
Protease {ECO:0000256|SAAS:SAAS00710708};
Thiol protease {ECO:0000256|SAAS:SAAS00710708}.
DOMAIN 43..167
/note="CASPASE_P20"
/evidence="ECO:0000259|PROSITE:PS50208"
DOMAIN 183..277
/note="CASPASE_P10"
/evidence="ECO:0000259|PROSITE:PS50207"
REGION 1..20
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 277 AA; 31607 MW; 23B1CD3BCA3BF64A CRC64;
MENTENSVDS KSIKNLEPKI IHGSQSMDSG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG
MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS
HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETDSGVDD
DMACHKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN
RKVATEFESF SFDATFHAKK QIPCIVSMLT KELYFYH


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E08C0688 Canine Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E02C0688 Rat anti-Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E06C0688 Goat Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E04C0688 Rabbit Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E07C0688 Porcine Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
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CASP4 CASP2 Gene caspase 2, apoptosis-related cysteine peptidase
CASP5 CASP3 Gene caspase 3, apoptosis-related cysteine peptidase
201-20-0832 CASP9{caspase 9, apoptosis-related cysteine peptidase}rabbit.pAb 0.1ml
CASP6 CASP4 Gene caspase 4, apoptosis-related cysteine peptidase
CASP8AP2 CASP7 Gene caspase 7, apoptosis-related cysteine peptidase
CASP7 CASP5 Gene caspase 5, apoptosis-related cysteine peptidase
CASP8 CASP6 Gene caspase 6, apoptosis-related cysteine peptidase
201-20-0831 CASP8{caspase 8, apoptosis-related cysteine peptidase}rabbit.pAb 0.1ml
CASP14 CASP10 Gene caspase 10, apoptosis-related cysteine peptidase
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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP901: Apoptosis
WP1018: Apoptosis
WP1349: Wnt Signaling Pathway
WP822: Diurnally regulated genes with circadian orthologs
WP1772: Apoptosis Modulation and Signaling
WP2087: miRNA regulation of DNA Damage Response
WP1841: Intrinsic Pathway for Apoptosis
WP1346: IL-7 Signaling Pathway
WP1199: Apoptosis Modulation by HSP70
WP2414: Quercetin and Nf-kB/ AP-1 induced cell apoptosis
WP1290: Apoptosis
WP254: Apoptosis
WP426: Urea cycle and metabolism of amino groups
WP1965: VEGF-receptor Signal Transduction
WP1039: Glutathione metabolism
WP2085: miRNAs involved in DDR
WP730: Glutathione and one carbon metabolism
WP1497: Hedgehog-related genes
WP384: Apoptosis Modulation by HSP70
WP1322: IL-6 Signaling Pathway
WP1640: Cysteine and methionine metabolism
WP487: Apoptosis Modulation by HSP70
WP394: RNA interference and miRNA

Related Genes :
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[Cflar Cash] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1] NACHT, LRR and PYD domains-containing protein 1 (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain)
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[RNF34] E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)
[ATG4D APG4D AUTL4] Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagin-4) (Autophagy-related cysteine endopeptidase 4) (Autophagy-related protein 4 homolog D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[XIAP API3 BIRC4 IAP3] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[PYCARD ASC CARD5 TMS1] Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
[Casp1 Il1bc] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Casp6] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[CASP5 ICH3] Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP3] Caspase 3, apoptosis-related cysteine peptidase
[Drice ICE CG7788] Caspase (EC 3.4.22.-) (drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12]
[Casp1 Il1bc Il1bce] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[BIRC3 API2 MIHC RNF49] Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
[Casp12] Caspase-12 (CASP-12) (EC 3.4.22.-)
[TNFRSF10A APO2 DR4 TRAILR1] Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
[CASP9 MCH6] Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
[BIRC2 API1 MIHB RNF48] Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[TNFSF10 APO2L TRAIL] Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)

Bibliography :
[32144904] [Electroacupuncture improved learning-memory ability by reducing hippocampal apoptosis and suppressing JNK signaling in rats with vascular dementia].
[32021192] Daunorubicin-Loaded CdTe QDs Conjugated with Anti-CD123 mAbs: A Novel Delivery System for Myelodysplastic Syndromes Treatment.
[31880521] Rubimaillin decreases the viability of human ovarian cancer cells via mitochondria-dependent apoptosis.
[31874162] Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity.
[31839031] [Newly Diagnosed Acute Myeloid Leukemia Patients-Derived Bone Marrow Mesenchymal Stem Cells Suppress Daunorubicin Induced HL-60 Cell Apoptosis via Modulating Caspase-3/Survivin].
[31791417] Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs.
[31763811] DNA Nanosponge for Adsorption and Clearance of Intracellular miR-21 and Enhanced Antitumor Chemotherapy.
[31762232] [Molecular Mechanisms of Apoptosis of Leukemia Cell Induced by Reovirus].
[31753399] Synthesis and characterization of thiosemicarbazone-functionalized organoruthenium (II)-arene complexes: Investigation of antitumor characteristics in colorectal cancer cell lines.
[31594094] [Study on the effect and mechanism of hepatitis B virus X protein transactivates gene 4 in HepG2 cell apoptosis].