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Caspase 3

 U3KB70_FICAL            Unreviewed;       282 AA.
U3KB70;
13-NOV-2013, integrated into UniProtKB/TrEMBL.
13-NOV-2013, sequence version 1.
17-JUN-2020, entry version 51.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFALP00000012274};
Name=CASP3 {ECO:0000313|Ensembl:ENSFALP00000012274};
Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012274, ECO:0000313|Proteomes:UP000016665};
[1] {ECO:0000313|Ensembl:ENSFALP00000012274}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2013) to UniProtKB.
-!- SIMILARITY: Belongs to the peptidase C14A family.
{ECO:0000256|RuleBase:RU003971, ECO:0000256|SAAS:SAAS01080359}.
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EMBL; AGTO01010750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_005045177.1; XM_005045120.2.
STRING; 59894.ENSFALP00000012274; -.
MEROPS; C14.003; -.
Ensembl; ENSFALT00000012324; ENSFALP00000012274; ENSFALG00000011745.
GeneID; 101808212; -.
KEGG; fab:101808212; -.
CTD; 836; -.
GeneTree; ENSGT00940000153232; -.
HOGENOM; CLU_036904_2_0_1; -.
KO; K02187; -.
OMA; WHYFTAT; -.
OrthoDB; 984395at2759; -.
Proteomes; UP000016665; Unplaced.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:Ensembl.
GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:Ensembl.
GO; GO:0061713; P:anterior neural tube closure; IEA:Ensembl.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0072734; P:cellular response to staurosporine; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0034349; P:glial cell apoptotic process; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
GO; GO:0046007; P:negative regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
GO; GO:0009411; P:response to UV; IEA:Ensembl.
GO; GO:0009611; P:response to wounding; IEA:Ensembl.
GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
3: Inferred from homology;
Hydrolase {ECO:0000256|SAAS:SAAS00710708};
Protease {ECO:0000256|SAAS:SAAS00710708};
Reference proteome {ECO:0000313|Proteomes:UP000016665};
Thiol protease {ECO:0000256|SAAS:SAAS00710708}.
DOMAIN 50..174
/note="CASPASE_P20"
/evidence="ECO:0000259|PROSITE:PS50208"
DOMAIN 189..282
/note="CASPASE_P10"
/evidence="ECO:0000259|PROSITE:PS50207"
SEQUENCE 282 AA; 31587 MW; DFE22CC435E9671E CRC64;
MTDIGDGPHL GQDLADAKSI PAFKGKNLPA SKSMDSGILP DHSYRMDYPE MGECVIINNK
NFHRHTGMSP RSGTDADAMS VREVFMKLGY KIKINNDLSC GDIFKLLKNV SEEDHSKRSS
FVCVLLSHGD EGLIYGTDGP LELKAITSLF RGDRCRSLAG KPKLFFIQAC RGTELDSGIE
TDSGPEESMC QKIPVEADFL YAYSTAPGYY SWRNSAEGSW FIQSLCKMLK EHAKNLELMQ
ILTRVNRRVA EYESCSTRQD FNAKKQIPCI VSMLTKEFYF PS


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Pathways :
WP426: Urea cycle and metabolism of amino groups
WP1039: Glutathione metabolism
WP1545: miRNAs involved in DDR
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1322: IL-6 Signaling Pathway
WP730: Glutathione and one carbon metabolism
WP240: Alanine and aspartate metabolism
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP394: RNA interference and miRNA
WP79: Tryptophan metabolism
WP562: Circadian Exercise
WP1530: miRNA regulation of DNA Damage Response
WP387: IL-6 signaling Pathway
WP100: Glutathione metabolism
WP153: Urea cycle and metabolism of amino groups
WP2085: miRNAs involved in DDR
WP1361: Mismatch repair
WP469: Glutathione metabolism
WP106: Alanine and aspartate metabolism
WP1126: Tryptophan metabolism
WP2287: Male mating
WP465: Tryptophan metabolism
WP88: Toll Like Receptor signaling
WP410: Diurnally regulated genes with circadian orthologs
WP2353: vitamin B9 (folate) biosynthesis pathway

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Bibliography :
[32629548] Xenogeneic mesenchymal stem cell transplantation for mandibular defect regeneration.
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[32629210] Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway.
[32629158] Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method.
[32629060] Characterization and antitumor activity of novel exopolysaccharide APS of Lactobacillus plantarum WLPL09 from human breast milk.
[32628869] KD025 Shifts Pulmonary Endothelial Cell Bioenergetics and Decreases Baseline Lung Permeability.
[32627954] Galectin-7 overexpression destroy airway epithelial barrier in transgenic mice.
[32627816] Ma xing shi gan Decoction (MXD) eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats.
[32627767] Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity.