GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Caspase 8, apoptosis-related cysteine peptidase, like 2 (Fragment)

 A0A1A8DKZ3_9TELE        Unreviewed;       350 AA.
A0A1A8DKZ3;
05-OCT-2016, integrated into UniProtKB/TrEMBL.
05-OCT-2016, sequence version 1.
10-FEB-2021, entry version 14.
SubName: Full=Caspase 8, apoptosis-related cysteine peptidase, like 2 {ECO:0000313|EMBL:SBQ34183.1};
Flags: Fragment;
Name=CASP8L2 {ECO:0000313|EMBL:SBQ34183.1};
Nothobranchius kadleci.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Cyprinodontiformes; Nothobranchiidae;
Nothobranchius.
NCBI_TaxID=1051664 {ECO:0000313|EMBL:SBQ34183.1};
[1] {ECO:0000313|EMBL:SBQ34183.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Brain {ECO:0000313|EMBL:SBQ34183.1};
Lavstsen T., Jespersen J.S.;
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:SBQ34183.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Brain {ECO:0000313|EMBL:SBQ34183.1};
Reichwald K., Felder M., Petzold A., Koch P., Groth M., Platzer M.;
"The genome of a short-lived fish provides insights into sex chromosome
evolution and the genetic control of aging.";
Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the peptidase C14A family.
{ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; HAEA01005703; SBQ34183.1; -; Transcribed_RNA.
GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:InterPro.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR035701; Caspase_10.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
PANTHER; PTHR10454:SF26; PTHR10454:SF26; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
3: Inferred from homology;
Hydrolase {ECO:0000256|ARBA:ARBA00022807};
Protease {ECO:0000256|ARBA:ARBA00022807};
Thiol protease {ECO:0000256|ARBA:ARBA00022807};
Zymogen {ECO:0000256|ARBA:ARBA00023145}.
DOMAIN 108..234
/note="CASPASE_P20"
/evidence="ECO:0000259|PROSITE:PS50208"
DOMAIN 257..345
/note="CASPASE_P10"
/evidence="ECO:0000259|PROSITE:PS50207"
NON_TER 1
/evidence="ECO:0000313|EMBL:SBQ34183.1"
NON_TER 350
/evidence="ECO:0000313|EMBL:SBQ34183.1"
SEQUENCE 350 AA; 39646 MW; B25CAE07A4D19728 CRC64;
LEMEHLDLIS ESNLDKLEEI FNHICPALNK KITQYKEKQA HRLRSLSFPS ESNLISKPFL
RTGSLQSPVT IKHDVLESKA NLKNKTVVVP EPPRAAEALG KYQMTAANRG FCVIFNNNNF
SNSLEPLKDR VGTHTDEDSL KKVFEWLNFE VEIYRDCEKE KMLSVLKDLR GRDHSQMDCL
VCCVLSHGLE GSVYGVDGQT VKIEEMMALF DGKKCPTLVE KPKLFFIQAC QGTREQRAAQ
TDGIETEDKD ICSDARVPDT IPSRADFLLG MATVPSYVSY RDKKSGTWYI QSLCRNLIQM
VPQEVDLISI LTQVNADVSK MSADKWGQTK QMPQPAFSLR KRVVFPIPKP


Related products :

Catalog number Product name Quantity
E02C0688 Rat Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
18-783-76280 RABBIT ANTI HUMAN CASPASE-10 (C-TERMINAL) - FLICE 2; Caspase 10. apoptosis-related cysteine peptidase. isoform CRA_b Polyclonal 0.1 mg
E11C0688 Bovine Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E08C0688 Canine Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E02C0688 Rat anti-Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E01C0688 Human Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E07C0688 Porcine Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E06C0688 Goat Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E03C0688 Mouse Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E05C0688 Guinea Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E13C0688 Anserine Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E04C0688 Rabbit Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
201-20-0832 CASP9{caspase 9, apoptosis-related cysteine peptidase}rabbit.pAb 0.1ml
E1381498 Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) ELISA Kit 1
CASP3 CASP14 Gene caspase 14, apoptosis-related cysteine peptidase
E1381158 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) ELISA Kit 1
E03C0688 Mouse anti-Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E05C0688 Guinea anti-Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
E1381495 Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) ELISA Kit 1
201-20-0826 CASP10{caspase 10, apoptosis-related cysteine peptidase}rabbit.pAb 0.1ml
201-20-0831 CASP8{caspase 8, apoptosis-related cysteine peptidase}rabbit.pAb 0.1ml
201-20-0827 CASP2{caspase 2, apoptosis-related cysteine peptidase}rabbit.pAb 0.1ml
CASP4 CASP2 Gene caspase 2, apoptosis-related cysteine peptidase
201-20-0828 CASP3{caspase 3, apoptosis-related cysteine peptidase}rabbit.pAb 0.1ml
E01C0688 Human Anti-Caspase 4-apoptosis-related cysteine peptidase 96 Tests/kit
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP1018: Apoptosis
WP2435: Quercetin and Nf-kB/ AP-1 induced cell apoptosis
WP1783: Apoptosis Meta Pathway
WP1896: Regulation of Apoptosis
WP1199: Apoptosis Modulation by HSP70
WP384: Apoptosis Modulation by HSP70
WP1290: Apoptosis
WP731: Sterol regulatory element binding protein related
WP201: Ptf1a related regulatory pathway
WP2152: BDNF
WP1497: Hedgehog-related genes
WP88: Toll Like Receptor signaling
WP166: Apoptosis Modulation by HSP70
WP2328: Allograft rejection
WP2428: the quecetin and apoptosis pathway
WP1772: Apoptosis Modulation and Signaling
WP1841: Intrinsic Pathway for Apoptosis
WP1137: Apoptosis
WP256: Cysteine Biosynthesis from Homoserine
WP128: Homocysteine and Cysteine Interconversion
WP487: Apoptosis Modulation by HSP70
WP1965: VEGF-receptor Signal Transduction
WP2119: Interferon induced apoptosis
WP1392: Apoptosis Modulation by HSP70

Related Genes :
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[Cflar Cash] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1] NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]
[APP A4 AD1] Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[Nlrp1a Card7 Nalp1 Nalp1a Nlrp1] NACHT, LRR and PYD domains-containing protein 1a (EC 3.4.-.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1a, C-terminus (Nlrp1a-CT); NACHT, LRR and PYD domains-containing protein 1a, N-terminus (Nlrp1a-NT)]
[CASP14] Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[PYCARD ASC CARD5 TMS1] Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[csp-2 Y73B6BL.7] Putative inactive caspase B [Cleaved into: Putative inactive caspase B subunit p31; Putative inactive caspase B subunit p17; Putative inactive caspase subunit p14]
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[RET CDHF12 CDHR16 PTC RET51] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
[XIAP API3 BIRC4 IAP3] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[CARD8 DACAR KIAA0955 NDPP1] Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)]
[AIFM1 AIF PDCD8] Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
[ced-3 C48D1.2] Cell death protein 3 (EC 3.4.22.60) (Caspase ced-3) [Cleaved into: Cell death protein 3 subunit p17; Cell death protein 3 subunit p15; Cell death protein 3 subunit p13]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Diap2 DIHA Iap2 Ilp CG8293] Death-associated inhibitor of apoptosis 2 (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2)
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[BIRC3 API2 MIHC RNF49] Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
[BIRC2 API1 MIHB RNF48] Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]

Bibliography :