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Caspase A (EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14]

 CSP1_CAEEL              Reviewed;         536 AA.
G5EBM1; G5EBN4; G5EG94;
15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
14-DEC-2011, sequence version 1.
08-MAY-2019, entry version 72.
RecName: Full=Caspase A {ECO:0000305};
EC=3.4.22.36 {ECO:0000269|PubMed:9857046};
Contains:
RecName: Full=Caspase A subunit p16 {ECO:0000305|PubMed:9857046};
Contains:
RecName: Full=Caspase A subunit p14 {ECO:0000305|PubMed:9857046};
Flags: Precursor;
Name=csp-1 {ECO:0000303|PubMed:9857046,
ECO:0000312|WormBase:Y48E1B.13a};
ORFNames=Y48E1B.13 {ECO:0000312|WormBase:Y48E1B.13a};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
[1] {ECO:0000312|EMBL:AAC98292.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C), PARTIAL PROTEIN
SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBUNIT,
PROTEOLYTIC CLEAVAGE, ACTIVE SITE, AND MUTAGENESIS OF CYS-406.
STRAIN=Bristol N2 {ECO:0000312|EMBL:AAC98292.1};
PubMed=9857046; DOI=10.1074/jbc.273.52.35109;
Shaham S.;
"Identification of multiple Caenorhabditis elegans caspases and their
potential roles in proteolytic cascades.";
J. Biol. Chem. 273:35109-35117(1998).
[2] {ECO:0000312|Proteomes:UP000001940}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3] {ECO:0000305}
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=23721876; DOI=10.1016/j.neuro.2013.05.014;
Settivari R., VanDuyn N., LeVora J., Nass R.;
"The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1
inhibits dopamine neuron degeneration in a Caenorhabditis elegans
model of manganism.";
NeuroToxicology 38:51-60(2013).
[4] {ECO:0000305}
FUNCTION (ISOFORMS A; B AND C), AND DISRUPTION PHENOTYPE.
PubMed=23505386; DOI=10.1371/journal.pgen.1003341;
Denning D.P., Hatch V., Horvitz H.R.;
"Both the caspase CSP-1 and a caspase-independent pathway promote
programmed cell death in parallel to the canonical pathway for
apoptosis in Caenorhabditis elegans.";
PLoS Genet. 9:E1003341-E1003341(2013).
-!- FUNCTION: Cysteine protease which, in vitro, cleaves itself and
caspase ced-3 into their mature active forms (PubMed:9857046).
Also cleaves, in vitro, inactive caspase csp-2 isoform b
(PubMed:9857046). Required maternally to induce apoptosis in a
subset of cells fated to die during embryogenesis, mostly
independently of the ced-9, ced-4 and ced-3 canonical apoptosis
pathway (PubMed:23505386). Involved in the degeneration of
dopaminergic CEP neurons in response to high Mn(2+) levels
(PubMed:23721876). {ECO:0000269|PubMed:23505386,
ECO:0000269|PubMed:23721876, ECO:0000269|PubMed:9857046}.
-!- FUNCTION: Isoform a: Dispensable for regulating apoptosis during
embryogenesis. {ECO:0000269|PubMed:23505386}.
-!- CATALYTIC ACTIVITY:
Reaction=Strict requirement for an Asp residue at position P1 and
has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.;
EC=3.4.22.36; Evidence={ECO:0000269|PubMed:9857046};
-!- ACTIVITY REGULATION: Inhibited by cysteine protease inhibitor
iodoacetic acid (CH3COOI) but not by N-[N-(L-3-transcarboxirane-2-
carbonyl)-leucyl]-agmatine (E-64) or benzyloxycarbonyl-DEVD-
fluoro-methyl ketone (Z-DEVD-FMK). {ECO:0000269|PubMed:9857046}.
-!- SUBUNIT: Heterodimer formed by the tight association of the large
subunit p16 and the small subunit p14.
{ECO:0000303|PubMed:9857046}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=a {ECO:0000312|WormBase:Y48E1B.13a};
IsoId=G5EBM1-1; Sequence=Displayed;
Name=b {ECO:0000312|WormBase:Y48E1B.13b};
IsoId=G5EBM1-2; Sequence=VSP_058804;
Name=c {ECO:0000312|WormBase:Y48E1B.13c};
IsoId=G5EBM1-3; Sequence=VSP_058804, VSP_058805, VSP_058806;
-!- TISSUE SPECIFICITY: Isoform a: Expression is restricted to the
late germline pachytene stage of meiosis I in both L4 larvae and
adult hermaphrodite gonads. Isoform b: Expression is restricted to
the late germline pachytene stage of meiosis I in both L4 larvae
and adult hermaphrodite gonads. {ECO:0000269|PubMed:23505386}.
-!- PTM: Autocatalytic cleavage removes the propeptide and generates
the two active subunits p16 and p14 in vitro. Cannot be cleaved by
ced-3 in vitro. {ECO:0000269|PubMed:9857046}.
-!- DISRUPTION PHENOTYPE: Survival of touch neurons and several
pharyngeal cells is not affected during development and no extra
pharyngeal cells caused by impaired apoptosis are produced
(PubMed:23505386). Basal and ionizing radiation-induced germline
apoptosis are normal (PubMed:23505386). In a ced-3 n2427 mutant
background, more animals have the M4 sister cell that survives
(PubMed:23505386). In a csp-3 n4872, csp-2 n4871 and ced-3 n3692
mutant background where the canonical apoptotic pathway is
impaired, 16 percent of animals have still 1 or more cell corpses
that are morphologically apoptotic and are internalized by
engulfing cells (PubMed:23505386). In addition, apoptosis of the
male linker cell occurs normally (PubMed:23505386). RNAi-mediated
knockdown causes a 50 percent inhibition of Mn(2+)-induced
dopaminergic CEP neuron degeneration (PubMed:23721876).
{ECO:0000269|PubMed:23505386, ECO:0000269|PubMed:23721876}.
-!- SIMILARITY: Belongs to the peptidase C14A family.
{ECO:0000255|RuleBase:RU003971, ECO:0000255|SAAS:SAAS00535228}.
-----------------------------------------------------------------------
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EMBL; AF088285; AAC98292.1; -; mRNA.
EMBL; AF088286; AAC98293.1; -; mRNA.
EMBL; AF088287; AAC98294.1; -; mRNA.
EMBL; BX284602; CAB07698.2; -; Genomic_DNA.
EMBL; BX284602; CAD18879.1; -; Genomic_DNA.
EMBL; BX284602; CAD18880.1; -; Genomic_DNA.
PIR; T27021; T27021.
PIR; T43633; T43633.
PIR; T43637; T43637.
RefSeq; NP_001022452.1; NM_001027281.1. [G5EBM1-1]
RefSeq; NP_001022453.1; NM_001027282.1. [G5EBM1-2]
RefSeq; NP_001022454.1; NM_001027283.1. [G5EBM1-3]
SMR; G5EBM1; -.
STRING; 6239.Y48E1B.13a; -.
MEROPS; C14.A06; -.
EPD; G5EBM1; -.
PaxDb; G5EBM1; -.
EnsemblMetazoa; Y48E1B.13a; Y48E1B.13a; WBGene00000819. [G5EBM1-1]
EnsemblMetazoa; Y48E1B.13b; Y48E1B.13b; WBGene00000819. [G5EBM1-2]
EnsemblMetazoa; Y48E1B.13c; Y48E1B.13c; WBGene00000819. [G5EBM1-3]
GeneID; 175007; -.
KEGG; cel:CELE_Y48E1B.13; -.
CTD; 175007; -.
WormBase; Y48E1B.13a; CE29378; WBGene00000819; csp-1. [G5EBM1-1]
WormBase; Y48E1B.13b; CE30016; WBGene00000819; csp-1. [G5EBM1-2]
WormBase; Y48E1B.13c; CE30017; WBGene00000819; csp-1. [G5EBM1-3]
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
GeneTree; ENSGT00940000169659; -.
InParanoid; G5EBM1; -.
OrthoDB; 984395at2759; -.
PhylomeDB; G5EBM1; -.
Reactome; R-CEL-111465; Apoptotic cleavage of cellular proteins.
Reactome; R-CEL-198323; AKT phosphorylates targets in the cytosol.
Reactome; R-CEL-264870; Caspase-mediated cleavage of cytoskeletal proteins.
Reactome; R-CEL-448706; Interleukin-1 processing.
Reactome; R-CEL-5660668; CLEC7A/inflammasome pathway.
Reactome; R-CEL-75153; Apoptotic execution phase.
PRO; PR:G5EBM1; -.
Proteomes; UP000001940; Chromosome II.
Bgee; WBGene00000819; Expressed in 4 organ(s), highest expression level in germ line (C elegans).
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0043073; C:germ cell nucleus; IDA:UniProtKB.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IMP:UniProtKB.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IMP:UniProtKB.
GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
GO; GO:1905803; P:negative regulation of cellular response to manganese ion; IMP:UniProtKB.
GO; GO:1904747; P:positive regulation of apoptotic process involved in development; IMP:UniProtKB.
GO; GO:1905845; P:positive regulation of cellular response to gamma radiation; IGI:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:UniProtKB.
GO; GO:0016540; P:protein autoprocessing; IMP:UniProtKB.
GO; GO:0016485; P:protein processing; IMP:UniProtKB.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
InterPro; IPR006570; SPK_dom.
PANTHER; PTHR10454; PTHR10454; 1.
Pfam; PF04435; SPK; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SMART; SM00583; SPK; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
1: Evidence at protein level;
Alternative splicing; Apoptosis; Complete proteome;
Direct protein sequencing; Hydrolase; Protease; Reference proteome;
Thiol protease; Zymogen.
PROPEP 1 273 Removed in mature form by autoprocessing.
{ECO:0000269|PubMed:9857046}.
/FTId=PRO_0000439218.
CHAIN 274 418 Caspase A subunit p16.
{ECO:0000303|PubMed:9857046}.
/FTId=PRO_0000439219.
CHAIN 419 536 Caspase A subunit p14.
{ECO:0000303|PubMed:9857046}.
/FTId=PRO_0000439220.
ACT_SITE 364 364 {ECO:0000250|UniProtKB:P29466}.
ACT_SITE 406 406 {ECO:0000269|PubMed:9857046}.
VAR_SEQ 1 268 Missing (in isoform b and isoform c).
{ECO:0000305}.
/FTId=VSP_058804.
VAR_SEQ 411 417 LNMGVPV -> IEHGCSR (in isoform c).
{ECO:0000305}.
/FTId=VSP_058805.
VAR_SEQ 418 536 Missing (in isoform c). {ECO:0000305}.
/FTId=VSP_058806.
MUTAGEN 406 406 C->S: Loss of catalytic activity. Loss of
autoprocessing.
{ECO:0000269|PubMed:9857046}.
SEQUENCE 536 AA; 61467 MW; 089F72490C6AA69E CRC64;
MVLKTIEDNC KSQFDDDLVE DFNNFQTTSS MSSSTTISTE DFNTIEIEST FEICRSGSYT
EEPILGENDE FLIDFEMERF LKFLKDKTKQ VEKRKEPFSQ KEIYAVFQRR IKSELCIETV
KKKFQPLLPN AIQTCEFDEE TMIRMIYGAG IRIDSVDFWN RFTSKATISL DCYSRLISYS
SDSLTLSGTH RSGFTYHWIS TPPVTYHRTE NKDPNIQEPS PVEFLDVQSS LGSSMKPPIL
DKPTKLDDPA ETRHDCSYSL EEYDSQSRMP RTDAKKSNHK HKYCYEMNSN PRGTVLILSN
ENFKNMERRV GTKQDEVNLT KLFQKLQYTV ICKRNLEAES MLEAIKEFAE MAHTDSIILF
LLSHGDGAGS VFGIDDMPVN VMEVSTYLAY HQNLLLKPKW VAVSACRGGK LNMGVPVDGL
PALEDKCAPI SKFWNLMMSR IMPGTFTSLN ADVIISFSTT DGFTSYRDEE AGTWYIKSMC
KVFNKHSKTM HLLDILTETG RNVVTKYENV QGNVVLKQAP EILSRLTKQW HFSRSM


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WP1672: Mismatch repair
WP1694: Pyrimidine metabolism
WP1614: 1- and 2-Methylnaphthalene degradation
WP1644: DNA replication
WP1671: Methane metabolism
WP1693: Purine metabolism
WP1718: Vitamin B6 metabolism
WP1566: Citrate cycle (TCA cycle)
WP2292: Chemokine signaling pathway
WP1634: Butanoate metabolism
WP1663: Homologous recombination
WP1680: Oxidative phosphorylation
WP1711: Trinitrotoluene degradation
WP2272: Pathogenic Escherichia coli infection

Related Genes :
[csp-1 Y48E1B.13] Caspase A (EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[csp-2 Y73B6BL.7] Putative inactive caspase B [Cleaved into: Putative inactive caspase B subunit p31; Putative inactive caspase B subunit p17; Putative inactive caspase subunit p14]
[pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14; Protease (EC 3.4.23.-) (Retropepsin); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Exoribonuclease H) (EC 3.1.13.2); Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14; Protease (EC 3.4.23.-) (Retropepsin); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Exoribonuclease H) (EC 3.1.13.2); Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14; Protease (Retropepsin) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Exoribonuclease H) (EC 3.1.13.2); Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14; Protease (EC 3.4.23.-) (Retropepsin); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Exoribonuclease H) (EC 3.1.13.2); Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[Casp6] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CASP6 MCH2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p39); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16) (p35)]
[CASP14] Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Drice ICE CG7788] Caspase (EC 3.4.22.-) (drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]

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