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Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]

 CASP1_MOUSE             Reviewed;         402 AA.
P29452;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
03-JUL-2019, entry version 188.
RecName: Full=Caspase-1;
Short=CASP-1;
EC=3.4.22.36;
AltName: Full=Interleukin-1 beta convertase;
Short=IL-1BC;
AltName: Full=Interleukin-1 beta-converting enzyme;
Short=ICE;
Short=IL-1 beta-converting enzyme;
AltName: Full=p45;
Contains:
RecName: Full=Caspase-1 subunit p20;
Contains:
RecName: Full=Caspase-1 subunit p10;
Flags: Precursor;
Name=Casp1; Synonyms=Il1bc;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1431103;
Nett-Fiordalisi M.A., Cerretti D.P., Berson D.R., Gilbert D.J.,
Jenkins N.A., Copeland N.G., Black R.A., Chaplin D.D.;
"Molecular cloning of the murine IL-1 beta converting enzyme cDNA.";
J. Immunol. 149:3254-3259(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8446594; DOI=10.1073/pnas.90.5.1809;
Molineaux S.M., Casano F.J., Rolando A.M., Peterson E.P., Limjuco G.,
Chin J., Griffin P.R., Calaycay J.R., Ding G.J.-F., Yamin T.-T.,
Palyha O.C., Luell S., Fletcher D., Miller D.K., Howard A.D.,
Thornberry N.A., Kostura M.J.;
"Interleukin 1 beta (IL-1 beta) processing in murine macrophages
requires a structurally conserved homologue of human IL-1 beta
converting enzyme.";
Proc. Natl. Acad. Sci. U.S.A. 90:1809-1813(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129;
PubMed=8034321; DOI=10.1006/geno.1994.1203;
Casano F.J., Rolando A.M., Mudgett J.S., Molineaux S.M.;
"The structure and complete nucleotide sequence of the murine gene
encoding interleukin-1 beta converting enzyme (ICE).";
Genomics 20:474-481(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
CHARACTERIZATION.
STRAIN=C3H/An;
PubMed=9038361; DOI=10.1016/S0014-5793(97)00026-4;
van de Craen M., Vandenabeele P., Declercq W., van den Brande I.,
van Loo G., Molemans F., Schotte P., van Criekinge W., Beyaert R.,
Fiers W.;
"Characterization of seven murine caspase family members.";
FEBS Lett. 403:61-69(1997).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-343, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryo;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
[8]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=28314590; DOI=10.1016/j.immuni.2017.02.011;
Wang Y., Ning X., Gao P., Wu S., Sha M., Lv M., Zhou X., Gao J.,
Fang R., Meng G., Su X., Jiang Z.;
"Inflammasome activation triggers caspase-1-mediated cleavage of cGAS
to regulate responses to DNA virus infection.";
Immunity 46:393-404(2017).
[9]
FUNCTION, AND INTERACTION WITH SERPINB1A; SERPINB1B AND SERPINB1C.
PubMed=30692621; DOI=10.1038/s41590-018-0303-z;
Choi Y.J., Kim S., Choi Y., Nielsen T.B., Yan J., Lu A., Ruan J.,
Lee H.R., Wu H., Spellberg B., Jung J.U.;
"SERPINB1-mediated checkpoint of inflammatory caspase activation.";
Nat. Immunol. 20:276-287(2019).
-!- FUNCTION: Thiol protease that cleaves IL-1 beta between an Asp and
an Ala, releasing the mature cytokine which is involved in a
variety of inflammatory processes. Important for defense against
pathogens. Cleaves and activates sterol regulatory element binding
proteins (SREBPs). Can also promote apoptosis (By similarity).
Upon inflammasome activation, during DNA virus infection but not
RNA virus challenge, controls antiviral immunity through the
cleavage of CGAS, rendering it inactive (PubMed:28314590). In
apoptotic cells, cleaves SPHK2 which is released from cells and
remains enzymatically active extracellularly (By similarity).
{ECO:0000250|UniProtKB:P29466, ECO:0000269|PubMed:28314590}.
-!- CATALYTIC ACTIVITY:
Reaction=Strict requirement for an Asp residue at position P1 and
has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.;
EC=3.4.22.36;
-!- SUBUNIT: Heterotetramer that consists of two anti-parallel
arranged heterodimers, each one formed by a 20 kDa (p20) and a 10
kDa (p10) subunit. The p20 subunit can also form a heterodimer
with the epsilon isoform which then has an inhibitory effect. May
be a component of the inflammasome, a protein complex which also
includes PYCARD, CARD8 and NALP2 and whose function would be the
activation of proinflammatory caspases. Both the p20 and p10
subunits interact with MEFV. Interacts with CARD17/INCA and
CARD18. Interacts with Serpinb1a, Serpinb1b and Serpinb1c; these
interactions regulate CASP1 activity.
{ECO:0000250|UniProtKB:P29466}.
-!- INTERACTION:
P18011:ipaB (xeno); NbExp=3; IntAct=EBI-489700, EBI-490239;
Q3UP24:Nlrc4; NbExp=2; IntAct=EBI-489700, EBI-16006652;
Q9EPB4:Pycard; NbExp=2; IntAct=EBI-489700, EBI-6253348;
Q56134:sipB (xeno); NbExp=2; IntAct=EBI-489700, EBI-489689;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P29466}.
Cell membrane {ECO:0000250|UniProtKB:P29466}.
-!- TISSUE SPECIFICITY: High level expression seen in spleen and lung,
low level expression seen in brain, heart, liver, kidney, testis
and skeletal muscle.
-!- PTM: The two subunits are derived from the precursor sequence by a
autocatalytic mechanism.
-!- DISRUPTION PHENOTYPE: Mutants are resitant to vaccinia virus
(VACV) but not vesicular somatitis virus (VSV) infection. They
show lower viral loads in the lungs compared to wild type mice,
they produce higher levels of type I IFN, IL6 and RSAD2/Viperin
after VCAV INFECTION. {ECO:0000269|PubMed:28314590}.
-!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L03799; AAA39306.1; -; mRNA.
EMBL; L28095; AAA20209.1; -; mRNA.
EMBL; U04269; AAA56992.1; -; Genomic_DNA.
EMBL; BC008152; AAH08152.1; -; mRNA.
CCDS; CCDS22798.1; -.
PIR; A46495; A46495.
RefSeq; NP_033937.2; NM_009807.2.
SMR; P29452; -.
BioGrid; 198492; 3.
CORUM; P29452; -.
DIP; DIP-34659N; -.
IntAct; P29452; 7.
MINT; P29452; -.
STRING; 10090.ENSMUSP00000027015; -.
BindingDB; P29452; -.
ChEMBL; CHEMBL4800; -.
MEROPS; C14.001; -.
iPTMnet; P29452; -.
PhosphoSitePlus; P29452; -.
SwissPalm; P29452; -.
EPD; P29452; -.
MaxQB; P29452; -.
PaxDb; P29452; -.
PeptideAtlas; P29452; -.
PRIDE; P29452; -.
Ensembl; ENSMUST00000027015; ENSMUSP00000027015; ENSMUSG00000025888.
GeneID; 12362; -.
KEGG; mmu:12362; -.
UCSC; uc009obr.1; mouse.
CTD; 834; -.
MGI; MGI:96544; Casp1.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
GeneTree; ENSGT00940000159114; -.
HOGENOM; HOG000234399; -.
InParanoid; P29452; -.
KO; K01370; -.
OMA; EYAWSCD; -.
OrthoDB; 1327703at2759; -.
PhylomeDB; P29452; -.
TreeFam; TF102023; -.
BRENDA; 3.4.22.36; 3474.
Reactome; R-MMU-168638; NOD1/2 Signaling Pathway.
Reactome; R-MMU-448706; Interleukin-1 processing.
PRO; PR:P29452; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000025888; Expressed in 131 organ(s), highest expression level in ileum.
Genevisible; P29452; MM.
GO; GO:0097169; C:AIM2 inflammasome complex; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0072557; C:IPAF inflammasome complex; IDA:UniProtKB.
GO; GO:0005739; C:mitochondrion; IEA:GOC.
GO; GO:0043005; C:neuron projection; ISO:MGI.
GO; GO:0072558; C:NLRP1 inflammasome complex; ISS:UniProtKB.
GO; GO:0072559; C:NLRP3 inflammasome complex; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0097179; C:protease inhibitor complex; ISO:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0050700; F:CARD domain binding; ISO:MGI.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IDA:MGI.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0004175; F:endopeptidase activity; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0019900; F:kinase binding; ISO:MGI.
GO; GO:0008233; F:peptidase activity; IDA:MGI.
GO; GO:0097110; F:scaffold protein binding; ISO:MGI.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
GO; GO:0071346; P:cellular response to interferon-gamma; ISO:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI.
GO; GO:0071310; P:cellular response to organic substance; ISO:MGI.
GO; GO:0097194; P:execution phase of apoptosis; IBA:GO_Central.
GO; GO:0032611; P:interleukin-1 beta production; IGI:MGI.
GO; GO:0060081; P:membrane hyperpolarization; IMP:MGI.
GO; GO:0007613; P:memory; ISO:MGI.
GO; GO:0001774; P:microglial cell activation; ISO:MGI.
GO; GO:0051882; P:mitochondrial depolarization; IMP:MGI.
GO; GO:0007520; P:myoblast fusion; ISO:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0046010; P:positive regulation of circadian sleep/wake cycle, non-REM sleep; ISO:MGI.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
GO; GO:0050715; P:positive regulation of cytokine secretion; IMP:MGI.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:UniProtKB.
GO; GO:0050717; P:positive regulation of interleukin-1 alpha secretion; IMP:MGI.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IMP:MGI.
GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; ISO:MGI.
GO; GO:0097300; P:programmed necrotic cell death; IDA:MGI.
GO; GO:0016540; P:protein autoprocessing; ISO:MGI.
GO; GO:0016485; P:protein processing; IDA:MGI.
GO; GO:0006508; P:proteolysis; ISO:MGI.
GO; GO:0070269; P:pyroptosis; IMP:MGI.
GO; GO:0010506; P:regulation of autophagy; IMP:MGI.
GO; GO:0050727; P:regulation of inflammatory response; IMP:MGI.
GO; GO:0033198; P:response to ATP; IMP:MGI.
GO; GO:0009617; P:response to bacterium; IMP:MGI.
GO; GO:0042493; P:response to drug; ISO:MGI.
GO; GO:0001666; P:response to hypoxia; IMP:MGI.
GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI.
GO; GO:0014070; P:response to organic cyclic compound; ISO:MGI.
GO; GO:1901998; P:toxin transport; IMP:MGI.
CDD; cd00032; CASc; 1.
InterPro; IPR001315; CARD.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
Pfam; PF00619; CARD; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00114; CARD; 1.
SMART; SM00115; CASc; 1.
SUPFAM; SSF47986; SSF47986; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS50209; CARD; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
1: Evidence at protein level;
Apoptosis; Cell membrane; Complete proteome; Cytoplasm; Hydrolase;
Membrane; Methylation; Phosphoprotein; Protease; Reference proteome;
Thiol protease; Zymogen.
PROPEP 1 ?118 {ECO:0000255}.
/FTId=PRO_0000004525.
CHAIN ?119 296 Caspase-1 subunit p20.
/FTId=PRO_0000004526.
PROPEP 297 314 {ECO:0000255}.
/FTId=PRO_0000004527.
CHAIN 315 402 Caspase-1 subunit p10.
/FTId=PRO_0000004528.
DOMAIN 1 91 CARD. {ECO:0000255|PROSITE-
ProRule:PRU00046}.
ACT_SITE 236 236 {ECO:0000250}.
ACT_SITE 284 284 {ECO:0000250}.
MOD_RES 301 301 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 343 343 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
CONFLICT 3 6 DKIL -> V (in Ref. 3; AAA56992).
{ECO:0000305}.
SEQUENCE 402 AA; 45640 MW; 3BEBCEFA67C69B03 CRC64;
MADKILRAKR KQFINSVSIG TINGLLDELL EKRVLNQEEM DKIKLANITA MDKARDLCDH
VSKKGPQASQ IFITYICNED CYLAGILELQ SAPSAETFVA TEDSKGGHPS SSETKEEQNK
EDGTFPGLTG TLKFCPLEKA QKLWKENPSE IYPIMNTTTR TRLALIICNT EFQHLSPRVG
AQVDLREMKL LLEDLGYTVK VKENLTALEM VKEVKEFAAC PEHKTSDSTF LVFMSHGIQE
GICGTTYSNE VSDILKVDTI FQMMNTLKCP SLKDKPKVII IQACRGEKQG VVLLKDSVRD
SEEDFLTDAI FEDDGIKKAH IEKDFIAFCS STPDNVSWRH PVRGSLFIES LIKHMKEYAW
SCDLEDIFRK VRFSFEQPEF RLQMPTADRV TLTKRFYLFP GH


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Pathways :
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP113: TGF Beta Signaling Pathway
WP249: Beta Oxidation of Unsaturated Fatty Acids
WP668: Octadecanoid Pathway
WP1434: Osteopontin Signaling
WP209: Fatty Acid Beta Oxidation Meta
WP433: tRNA Synthetases
WP219: Cytoplasmic tRNA Synthetases
WP471: Beta Oxidation of Unsaturated Fatty Acids
WP1177: Fatty Acid Beta Oxidation
WP262: EBV LMP1 signaling
WP812: TGF Beta Signaling Pathway
WP1225: estrogen signalling
WP32: Translation Factors
WP88: Toll Like Receptor signaling
WP499: Fatty Acid Beta Oxidation 3
WP1045: TGF-beta Receptor Signaling Pathway
WP537: Translation Factors
WP126: Fatty Acid Beta Oxidation 1
WP187: Fatty Acid Beta Oxidation 2
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP943: Fatty Acid Beta Oxidation
WP1367: TGF-beta Receptor Signaling Pathway

Related Genes :
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CARD16 COP COP1] Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme)
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP14] Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP6 MCH2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092] Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[ced-3 C48D1.2] Cell death protein 3 (EC 3.4.22.60) (Caspase ced-3) [Cleaved into: Cell death protein 3 subunit p17; Cell death protein 3 subunit p15; Cell death protein 3 subunit p13]
[CASP13] Caspase-13 (CASP-13) (EC 3.4.22.-) (Evolutionary related interleukin-1-beta-converting enzyme) (ERICE) [Cleaved into: Caspase-13 subunit 1; Caspase-13 subunit 2]
[csp-1 Y48E1B.13] Caspase A (EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14]
[Casp6] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Il1b] Interleukin-1 beta (IL-1 beta)
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[AMC4 AMC7 MCP2D At1g79340 YUP8H12R.4] Metacaspase-4 (AtMC4) (EC 3.4.22.-) (Metacaspase 2d) (AtMCP2d) (Metacaspase-7) [Cleaved into: Metacaspase-4 subunit p20; Metacaspase-4 subunit p10]
[Drice ICE CG7788] Caspase (EC 3.4.22.-) (drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12]
[IL33 C9orf26 IL1F11 NFHEV] Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
[IL37 FIL1Z IL1F7 IL1H4 IL1RP1] Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37)
[IL12RB1 IL12R IL12RB] Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212)

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