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Caspase-3

 O93417_CHICK            Unreviewed;       283 AA.
O93417;
01-NOV-1998, integrated into UniProtKB/TrEMBL.
01-NOV-1998, sequence version 1.
17-JUN-2020, entry version 148.
SubName: Full=Caspase-3 {ECO:0000313|EMBL:AAC32602.1};
Name=CASP3 {ECO:0000313|Ensembl:ENSGALP00000017288};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
Phasianinae; Gallus.
NCBI_TaxID=9031 {ECO:0000313|EMBL:AAC32602.1};
[1] {ECO:0000313|EMBL:AAC32602.1}
NUCLEOTIDE SEQUENCE.
PubMed=10684799;
Johnson A.L., Bridgham J.T.;
"Caspase-3 and -6 expression and enzyme activity in hen granulosa cells.";
Biol. Reprod. 62:589-598(2000).
[2] {ECO:0000313|Ensembl:ENSGALP00000017288, ECO:0000313|Proteomes:UP000000539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000017288,
ECO:0000313|Proteomes:UP000000539};
PubMed=15592404; DOI=10.1038/nature03154;
International Chicken Genome Sequencing Consortium;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide unique
perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[3] {ECO:0000313|Ensembl:ENSGALP00000017288}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000017288};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[4] {ECO:0000313|Ensembl:ENSGALP00000066684}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000066684};
Ensembl;
Submitted (JAN-2019) to UniProtKB.
-!- SIMILARITY: Belongs to the peptidase C14A family.
{ECO:0000256|RuleBase:RU003971, ECO:0000256|SAAS:SAAS01080359}.
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EMBL; AADN05000017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF083029; AAC32602.1; -; mRNA.
RefSeq; NP_990056.1; NM_204725.1.
RefSeq; XP_015131608.1; XM_015276122.1.
RefSeq; XP_015131609.1; XM_015276123.1.
STRING; 9031.ENSGALP00000042835; -.
MEROPS; C14.003; -.
Ensembl; ENSGALT00000017308; ENSGALP00000017288; ENSGALG00000010638.
Ensembl; ENSGALT00000100963; ENSGALP00000073476; ENSGALG00000010638.
Ensembl; ENSGALT00000103909; ENSGALP00000068843; ENSGALG00000010638.
Ensembl; ENSGALT00000106929; ENSGALP00000066684; ENSGALG00000010638.
GeneID; 395476; -.
KEGG; gga:395476; -.
CTD; 836; -.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
GeneTree; ENSGT00940000153232; -.
HOGENOM; CLU_036904_2_0_1; -.
KO; K02187; -.
OMA; YSWRSTA; -.
OrthoDB; 984395at2759; -.
TreeFam; TF102023; -.
BRENDA; 3.4.22.56; 1306.
Reactome; R-GGA-111465; Apoptotic cleavage of cellular proteins.
Reactome; R-GGA-111469; SMAC, XIAP-regulated apoptotic response.
Reactome; R-GGA-140342; Apoptosis induced DNA fragmentation.
Reactome; R-GGA-2028269; Signaling by Hippo.
Reactome; R-GGA-264870; Caspase-mediated cleavage of cytoskeletal proteins.
Reactome; R-GGA-351906; Apoptotic cleavage of cell adhesion proteins.
Reactome; R-GGA-449836; Other interleukin signaling.
Proteomes; UP000000539; Chromosome 4.
Bgee; ENSGALG00000010638; Expressed in spleen and 10 other tissues.
GO; GO:0005623; C:cell; IDA:AgBase.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:Ensembl.
GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:Ensembl.
GO; GO:0008234; F:cysteine-type peptidase activity; IDA:AgBase.
GO; GO:0061713; P:anterior neural tube closure; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0072734; P:cellular response to staurosporine; IEA:Ensembl.
GO; GO:0098586; P:cellular response to virus; IMP:AgBase.
GO; GO:0030218; P:erythrocyte differentiation; IBA:GO_Central.
GO; GO:0034349; P:glial cell apoptotic process; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IBA:GO_Central.
GO; GO:0046007; P:negative regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
GO; GO:0009411; P:response to UV; IEA:Ensembl.
GO; GO:0009611; P:response to wounding; IEA:Ensembl.
GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
2: Evidence at transcript level;
Hydrolase {ECO:0000256|SAAS:SAAS00710708};
Protease {ECO:0000256|SAAS:SAAS00710708};
Reference proteome {ECO:0000313|Proteomes:UP000000539};
Thiol protease {ECO:0000256|SAAS:SAAS00710708}.
DOMAIN 51..175
/note="CASPASE_P20"
/evidence="ECO:0000259|PROSITE:PS50208"
DOMAIN 190..281
/note="CASPASE_P10"
/evidence="ECO:0000259|PROSITE:PS50207"
REGION 1..35
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 283 AA; 31675 MW; 161242DDEFD4DC4F CRC64;
MMTDIKDGPR SGEDVSDARS FPGSKGMNLP ASKSVDSGIL PDDSYRMDYP EIGVCVIINN
KNFHRDTGLS SRSGTDADAA SVREVFMKLG YKVKLNNDLS SRDIFKLLKN VSEEDHSKRS
SFVCVLLSHG DEGLFYGTDG PLELKVLTSL FRGDKCRSLA GKPKLFFIQA CRGTELDSGI
EADSGPDETV CQKIPVEADF LYAYSTAPGY YSWRNAAEGS WFIQSLCRML KEHARKLELM
QILTRVNRRV AEYESCSTRQ DFNAKKQIPC IVSMLTKEFY FPC


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WP465: Tryptophan metabolism
WP88: Toll Like Receptor signaling
WP410: Diurnally regulated genes with circadian orthologs
WP2353: vitamin B9 (folate) biosynthesis pathway

Related Genes :
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Casp1 Il1bc] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[Casp6] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[Casp12] Caspase-12 (CASP-12) (EC 3.4.22.-)
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP9 MCH6] Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[Casp9 Mch6] Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
[CASP5 ICH3] Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10]
[CASP14] Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[Casp14] Caspase-14 (CASP-14) (EC 3.4.22.-) (Mini-ICE) (MICE) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Dronc Nc CG8091] Caspase Dronc (EC 3.4.22.-) (NEDD2-like caspase) [Cleaved into: Caspase Nc subunit 1; Caspase Nc subunit 2]
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[CASP1 IL1BC IL1BCE] Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
[CASP6 MCH2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[csp-1 Y48E1B.13] Caspase A (EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14]
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]

Bibliography :
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[32659346] The intrinsic apoptotic pathway lies upstream of oxidative stress in multiple organs.
[32658903] High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients.
[32657442] Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis.
[32656716] Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway.
[32656679] Seaweeds' neuroprotective potential set in vitro on a human cellular stress model.
[32655948] Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction.
[32655821] Long non-coding RNA KRT16P2/miR-1294/EGFR axis regulates laryngeal squamous cell carcinoma cell aggressiveness.