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Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]

 CASP3_RAT               Reviewed;         277 AA.
P55213; P70543; P97699; Q62993;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
13-FEB-2019, entry version 170.
RecName: Full=Caspase-3;
Short=CASP-3;
EC=3.4.22.56;
AltName: Full=Apopain;
AltName: Full=Cysteine protease CPP32;
Short=CPP-32;
AltName: Full=IRP;
AltName: Full=LICE;
AltName: Full=Protein Yama;
AltName: Full=SREBP cleavage activity 1;
Short=SCA-1;
Contains:
RecName: Full=Caspase-3 subunit p17;
Contains:
RecName: Full=Caspase-3 subunit p12;
Flags: Precursor;
Name=Casp3; Synonyms=Cpp32;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8761296;
Juan T.S.-C., McNiece I.K., Jenkins N.A., Gilbert D.J., Copeland N.G.,
Fletcher F.A.;
"Molecular characterization of mouse and rat CPP32 beta gene encoding
a cysteine protease resembling interleukin-1 beta converting enzyme
and CED-3.";
Oncogene 13:749-755(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=9030616;
Ni B., Wu X., Du Y., Su Y., Hamilton-Byrd E., Rockey P.K.,
Rosteck P. Jr., Poirier G.G., Paul S.M.;
"Cloning and expression of a rat brain interleukin-1beta-converting
enzyme (ICE)-related protease (IRP) and its possible role in apoptosis
of cultured cerebellar granule neurons.";
J. Neurosci. 17:1561-1569(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-264.
Yakovlev A.G.;
"Cloning of the rat cysteine protease p32-beta.";
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 30-241.
TISSUE=Ovary;
PubMed=7588240; DOI=10.1210/endo.136.11.7588240;
Flaws J.A., Kugu K., Trbovich A.M., Desanti A., Tilly K.I.,
Hirshfield A.N., Tilly J.L.;
"Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
mammalian cell death: dissociation of IRP-induced oligonucleosomal
endonuclease activity from morphological apoptosis in granulosa cells
of the ovarian follicle.";
Endocrinology 136:5042-5053(1995).
-!- FUNCTION: Involved in the activation cascade of caspases
responsible for apoptosis execution. At the onset of apoptosis it
proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a
'216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory
element binding proteins (SREBPs) between the basic helix-loop-
helix leucine zipper domain and the membrane attachment domain.
Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion
in sympathetic neurons through RET cleavage (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=Strict requirement for an Asp residue at positions P1 and
P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-
Asp-|- with a hydrophobic amino-acid residue at P2 and a
hydrophilic amino-acid residue at P3, although Val or Ala are
also accepted at this position.; EC=3.4.22.56;
-!- SUBUNIT: Heterotetramer that consists of two anti-parallel
arranged heterodimers, each one formed by a 17 kDa (p17) and a 12
kDa (p12) subunit. Interacts with BIRC6/bruce. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- TISSUE SPECIFICITY: Expressed in heart, brain, liver, and muscle
but not in kidney or testis.
-!- DEVELOPMENTAL STAGE: Highly expressed in neuron-enriched regions
of the developing brain, but down-regulated to low levels in the
adult brain.
-!- PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10
generates the two active subunits. Additional processing of the
propeptides is likely due to the autocatalytic activity of the
activated protease. Active heterodimers between the small subunit
of caspase-7 protease and the large subunit of caspase-3 also
occur and vice versa (By similarity). {ECO:0000250}.
-!- PTM: S-nitrosylated on its catalytic site cysteine in unstimulated
human cell lines and denitrosylated upon activation of the Fas
apoptotic pathway, associated with an increase in intracellular
caspase activity. Fas therefore activates caspase-3 not only by
inducing the cleavage of the caspase zymogen to its active
subunits, but also by stimulating the denitrosylation of its
active site thiol (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U49930; AAC52765.1; -; mRNA.
EMBL; U84410; AAB41792.1; -; mRNA.
EMBL; BC081854; AAH81854.1; -; mRNA.
EMBL; U58656; AAB02722.1; -; mRNA.
EMBL; U34685; AAC52261.1; -; mRNA.
PIR; I67437; I67437.
RefSeq; NP_037054.1; NM_012922.2.
RefSeq; XP_006253192.1; XM_006253130.3.
UniGene; Rn.10562; -.
ProteinModelPortal; P55213; -.
SMR; P55213; -.
BioGrid; 247437; 1.
ELM; P55213; -.
IntAct; P55213; 1.
MINT; P55213; -.
STRING; 10116.ENSRNOP00000014096; -.
ChEMBL; CHEMBL1075185; -.
MEROPS; C14.003; -.
iPTMnet; P55213; -.
PhosphoSitePlus; P55213; -.
jPOST; P55213; -.
PaxDb; P55213; -.
PRIDE; P55213; -.
Ensembl; ENSRNOT00000014095; ENSRNOP00000014096; ENSRNOG00000010475.
GeneID; 25402; -.
KEGG; rno:25402; -.
CTD; 836; -.
RGD; 2275; Casp3.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
GeneTree; ENSGT00940000153232; -.
HOGENOM; HOG000231878; -.
HOVERGEN; HBG050802; -.
InParanoid; P55213; -.
KO; K02187; -.
OMA; SAFHAKK; -.
OrthoDB; 984395at2759; -.
PhylomeDB; P55213; -.
TreeFam; TF102023; -.
BRENDA; 3.4.22.56; 5301.
Reactome; R-RNO-111469; SMAC, XIAP-regulated apoptotic response.
Reactome; R-RNO-205025; NADE modulates death signalling.
Reactome; R-RNO-211227; Activation of DNA fragmentation factor.
Reactome; R-RNO-264870; Caspase-mediated cleavage of cytoskeletal proteins.
Reactome; R-RNO-351906; Apoptotic cleavage of cell adhesion proteins.
Reactome; R-RNO-418889; Caspase activation via Dependence Receptors in the absence of ligand.
Reactome; R-RNO-449836; Other interleukin signaling.
PRO; PR:P55213; -.
Proteomes; UP000002494; Chromosome 16.
Bgee; ENSRNOG00000010475; Expressed in 10 organ(s), highest expression level in colon.
Genevisible; P55213; RN.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0031264; C:death-inducing signaling complex; IDA:RGD.
GO; GO:0045121; C:membrane raft; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:Ensembl.
GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; ISS:UniProtKB.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:Ensembl.
GO; GO:0008234; F:cysteine-type peptidase activity; IDA:RGD.
GO; GO:0005123; F:death receptor binding; IPI:RGD.
GO; GO:0016005; F:phospholipase A2 activator activity; IMP:RGD.
GO; GO:0002020; F:protease binding; IPI:RGD.
GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
GO; GO:0006915; P:apoptotic process; IMP:RGD.
GO; GO:0007413; P:axonal fasciculation; IMP:RGD.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
GO; GO:0072734; P:cellular response to staurosporine; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IBA:GO_Central.
GO; GO:0034349; P:glial cell apoptotic process; IEP:RGD.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEP:RGD.
GO; GO:0035556; P:intracellular signal transduction; IMP:RGD.
GO; GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IBA:GO_Central.
GO; GO:0007611; P:learning or memory; IMP:RGD.
GO; GO:0071887; P:leukocyte apoptotic process; IEP:RGD.
GO; GO:0001554; P:luteolysis; IEP:RGD.
GO; GO:0046007; P:negative regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IEP:RGD.
GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
GO; GO:1902004; P:positive regulation of amyloid-beta formation; IDA:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0006508; P:proteolysis; IDA:UniProtKB.
GO; GO:0031647; P:regulation of protein stability; IDA:UniProtKB.
GO; GO:0043200; P:response to amino acid; IEP:RGD.
GO; GO:0046677; P:response to antibiotic; IEP:RGD.
GO; GO:0032025; P:response to cobalt ion; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0009749; P:response to glucose; IDA:RGD.
GO; GO:0042542; P:response to hydrogen peroxide; IDA:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0010038; P:response to metal ion; IEP:RGD.
GO; GO:0035094; P:response to nicotine; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0010033; P:response to organic substance; IEP:RGD.
GO; GO:0009411; P:response to UV; IEA:Ensembl.
GO; GO:0010165; P:response to X-ray; IEP:RGD.
GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO; GO:0051146; P:striated muscle cell differentiation; IEP:RGD.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEP:RGD.
CDD; cd00032; CASc; 1.
InterPro; IPR015471; Casp3/7.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
PANTHER; PTHR10454:SF31; PTHR10454:SF31; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
2: Evidence at transcript level;
Acetylation; Apoptosis; Complete proteome; Cytoplasm; Hydrolase;
Phosphoprotein; Protease; Reference proteome; S-nitrosylation;
Thiol protease; Zymogen.
PROPEP 1 9 {ECO:0000250}.
/FTId=PRO_0000004589.
PROPEP 10 28 {ECO:0000250}.
/FTId=PRO_0000004590.
CHAIN 29 175 Caspase-3 subunit p17.
/FTId=PRO_0000004591.
CHAIN 176 277 Caspase-3 subunit p12.
/FTId=PRO_0000004592.
ACT_SITE 121 121 {ECO:0000250}.
ACT_SITE 163 163 {ECO:0000250}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P42574}.
MOD_RES 11 11 N6-acetyllysine.
{ECO:0000250|UniProtKB:P70677}.
MOD_RES 26 26 Phosphoserine.
{ECO:0000250|UniProtKB:P42574}.
MOD_RES 163 163 S-nitrosocysteine; in inhibited form.
{ECO:0000250|UniProtKB:P42574}.
CONFLICT 25 29 KSMDS -> QVD (in Ref. 4; AAB02722).
{ECO:0000305}.
CONFLICT 170 170 C -> S (in Ref. 5; AAC52261).
{ECO:0000305}.
CONFLICT 178 178 T -> A (in Ref. 5; AAC52261).
{ECO:0000305}.
CONFLICT 182 182 M -> V (in Ref. 5; AAC52261).
{ECO:0000305}.
CONFLICT 187 187 I -> K (in Ref. 5; AAC52261).
{ECO:0000305}.
CONFLICT 190 190 E -> G (in Ref. 2; AAB41792).
{ECO:0000305}.
CONFLICT 199 199 T -> S (in Ref. 5; AAC52261).
{ECO:0000305}.
CONFLICT 211 211 D -> G (in Ref. 5; AAC52261).
{ECO:0000305}.
CONFLICT 236 236 L -> I (in Ref. 4; AAB02722).
{ECO:0000305}.
CONFLICT 245 245 T -> M (in Ref. 2; AAB41792).
{ECO:0000305}.
SEQUENCE 277 AA; 31492 MW; ADABF418E2507402 CRC64;
MDNNETSVDS KSINNFETKT IHGSKSMDSG IYLDSSYKMD YPEMGLCIII NNKNFHKSTG
MSARNGTDVD AANLRETFMA LKYEVRNKND LTREEIMELM DSVSKEDHSK RSSFVCVILS
HGDEGVIFGT NGPVDLKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDD
DMACQKIPVE ADFLYAYSTA PGYYSWRNSR DGSWFIQSLC AMLKLYAHKL EFMHILTRVN
RKVATEFESF SLDATFHAKK QIPCIVSMLT KELYFYH


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Pathways :
WP1566: Citrate cycle (TCA cycle)
WP1644: DNA replication
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1693: Purine metabolism
WP1694: Pyrimidine metabolism
WP1965: VEGF-receptor Signal Transduction
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP88: Toll Like Receptor signaling
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1655: Geraniol degradation
WP1671: Methane metabolism
WP1680: Oxidative phosphorylation
WP1711: Trinitrotoluene degradation
WP1718: Vitamin B6 metabolism
WP2199: Seed Development
WP731: Sterol regulatory element binding protein related
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP128: Homocysteine and Cysteine Interconversion
WP1371: G Protein Signaling Pathways

Related Genes :
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[ced-3 C48D1.2] Cell death protein 3 (EC 3.4.22.60) (Caspase ced-3) [Cleaved into: Cell death protein 3 subunit p17; Cell death protein 3 subunit p15; Cell death protein 3 subunit p13]
[CASP14] Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP6 MCH2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[Casp6] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[Drice ICE CG7788] Caspase (EC 3.4.22.-) (drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12]
[Cflar Cash] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[casp3] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (xCPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27, alternate cleaved 1; Capsid protein p27, alternate cleaved 2; Spacer peptide (SP) (p3); Nucleocapsid protein p12; Protease p15 (EC 3.4.23.-); Reverse transcriptase, beta-subunit (RT-beta); Reverse transcriptase, alpha-subunit (RT-alpha) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (pp32); p4]
[csp-2 Y73B6BL.7] Putative inactive caspase B [Cleaved into: Putative inactive caspase B subunit p31; Putative inactive caspase B subunit p17; Putative inactive caspase subunit p14]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]

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